公开(公告)号：US09326742B2

公开(公告)日：2016-05-03

申请号：US12595165

申请日：2007-12-28

Applicant: Alan D. Hirschman ,  Arthur E. Uber, III ,  David M. Reilly ,  John Kalafut ,  Frederick W. Trombley, III ,  Steven J. Remis ,  Scott Griffith ,  Douglas Descalzi ,  Richard Dewit ,  David M. Griffiths ,  Marc A. Mabie ,  Mark Trocki

Inventor： Alan D. Hirschman ,  Arthur E. Uber, III ,  David M. Reilly ,  John Kalafut ,  Frederick W. Trombley, III ,  Steven J. Remis ,  Scott Griffith ,  Douglas Descalzi ,  Richard Dewit ,  David M. Griffiths ,  Marc A. Mabie ,  Mark Trocki

IPC: A61M3/00 ,  A61B6/00 ,  A61B6/03 ,  A61B6/04 ,  A61M5/172 ,  G06F19/00 ,  G21G4/08 ,  A61B6/10 ,  A61B5/0205 ,  A61B5/00 ,  A61M5/00 ,  A61M5/145 ,  A61M5/168 ,  A61M5/178

CPC classification number: A61N5/1001 ,  A61B5/0205 ,  A61B5/055 ,  A61B5/7289 ,  A61B6/032 ,  A61B6/037 ,  A61B6/0478 ,  A61B6/107 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/4423 ,  A61B6/507 ,  A61B6/508 ,  A61B6/5288 ,  A61B6/548 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1456 ,  A61M5/16827 ,  A61M5/16881 ,  A61M5/1723 ,  A61M5/1785 ,  A61M2205/3576 ,  A61N5/1071 ,  A61N2005/1021 ,  A61N2005/1094 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17 ,  G21F5/015 ,  G21G4/08

Abstract: A hazardous fluid handling system which includes a housing having a radiation shielded internal chamber disposed therein which may accommodate a container holding a radioactive fluid, one or more radioactivity detectors positioned within the shielded internal chamber in operational proximity to the radioactive fluid in the container, and a dosimeter control device electronically coupled to the radioactivity detector(s) is disclosed. The dosimeter control device is operational for determining information regarding the radioactive fluid in the container based on individual measurements received from the one or more radioactivity detectors. The hazardous fluid handling system may be integrated into a patient support platform which includes a patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with the patient, and an integrated system controller.

Abstract translation: 一种危险的流体处理系统，其包括具有设置在其中的辐射屏蔽内部室的壳体，其可以容纳容纳放射性流体的容器，位于屏蔽内部室内的一个或多个放射性检测器，其操作接近容器中的放射性流体;以及 公开了一种电子耦合到放射性检测器的剂量计控制装置。 剂量计控制装置可操作用于基于从一个或多个放射性检测器接收的各个测量值来确定关于容器中的放射性流体的信息。 有害流体处理系统可以集成到患者支撑平台中，该患者支撑平台包括患者刺激装置，靠近患者支撑平台的成像器，用于将放射性药物流体输入患者的放射性药物流体输送系统， 病人和一个集成的系统控制器。

公开(公告)号：US09005166B2

公开(公告)日：2015-04-14

申请号：US13898680

申请日：2013-05-21

Applicant: Arthur E. Uber, III ,  Alan D. Hirschman ,  David M. Griffiths ,  Frederick W. Trombley, III ,  David M. Reilly

Inventor： Arthur E. Uber, III ,  Alan D. Hirschman ,  David M. Griffiths ,  Frederick W. Trombley, III ,  David M. Reilly

IPC: A61M37/00 ,  A61M5/142 ,  A61M5/00 ,  A61M5/14 ,  A61M5/145 ,  A61J1/20 ,  A61M5/44 ,  A61N5/10

CPC classification number: A61M25/0045 ,  A61J1/2096 ,  A61M5/007 ,  A61M5/1408 ,  A61M5/142 ,  A61M5/1452 ,  A61M5/44 ,  A61M2202/049 ,  A61N5/1001

Abstract: A system for delivering fluid to a patient includes a hazardous material enclosure suitable for holding a first container comprising a first fluid, and a pump device capable of pumping the first fluid from the first container and a second fluid from a second container. The hazardous materials enclosure has a cap which includes a flexible sealing member that cooperates with the first container to create a biohazard seal during connection of the first container to the cap. The system further includes a mixing device associated with the pump for mixing the first and second fluids for delivering the fluid mixture to the patient.

Abstract translation: 用于将流体输送到患者的系统包括适于保持包括第一流体的第一容器的危险材料外壳和能够从第一容器泵送第一流体的泵装置和来自第二容器的第二流体的泵装置。 危险材料外壳具有盖，该盖包括与第一容器配合的柔性密封构件，以在第一容器与盖连接期间产生生物危害密封。 该系统还包括与泵相关联的混合装置，用于混合第一和第二流体以将流体混合物输送给患者。

公开(公告)号：US08192397B2

公开(公告)日：2012-06-05

申请号：US11425497

申请日：2006-06-21

Applicant: David M. Griffiths ,  Rosemary Almon-Martin ,  Alan D. Hirschman ,  David M. Reilly ,  Frederick W. Trombley, III ,  Arthur E. Uber, III ,  William Jaecklein

Inventor： David M. Griffiths ,  Rosemary Almon-Martin ,  Alan D. Hirschman ,  David M. Reilly ,  Frederick W. Trombley, III ,  Arthur E. Uber, III ,  William Jaecklein

IPC: A61M29/00

CPC classification number: A61M25/10184 ,  A61M5/007 ,  A61M5/14566 ,  A61M5/16827 ,  A61M5/16854 ,  A61M25/007 ,  A61M25/104 ,  A61M2025/102 ,  A61M2025/1022

Abstract: A combined fluid injection and inflation system is disclosed and includes a fluid delivery system including at least one pressurizing device, a fluid path, and a control unit. The fluid path is adapted to connect the pressurizing device to a patient via a catheter including a balloon and inserted in the patient. The control unit is operable to control the fluid delivery system. In operation, the control unit selectively actuates the fluid delivery system to operate in a fluid injection mode or in a balloon inflation mode. In the fluid injection mode the pressurizing device delivers fluid to the fluid path for a fluid injection procedure. In the balloon inflation mode, the pressurizing device delivers fluid to the fluid path for inflating the balloon associated with the catheter. An operator control may be connected to the control unit for controlling the fluid delivery system and may be a handheld device.

Abstract translation: 公开了组合的流体注入和充气系统，并且包括包括至少一个加压装置，流体路径和控制单元的流体输送系统。 流体路径适于经由包括球囊并且插入患者体内的导管将加压装置连接到患者。 控制单元可操作以控制流体输送系统。 在操作中，控制单元选择性地致动流体输送系统以流体注射模式或气球充气模式操作。 在流体注射模式中，加压装置将流体输送到流体路径用于流体注射程序。 在球囊膨胀模式中，加压装置将流体输送到流体路径，用于使与导管相关联的球囊膨胀。 操作员控制可以连接到控制单元以控制流体输送系统，并且可以是手持装置。

公开(公告)号：US20110178359A1

公开(公告)日：2011-07-21

申请号：US12595165

申请日：2007-12-28

Applicant: Alan D. Hirschman ,  Arthur E. Uber, III ,  Kevin P. Cowan ,  David M. Reilly ,  Edward J. Rhinehart ,  John Kalafut ,  Bronwyn Uber ,  Frederick W. Trombley, III ,  Steven J. Remis ,  Paul D. Levin ,  Scott Griffith ,  Douglas Descalzi ,  Richard Dewit ,  David M. Griffiths

Inventor： Alan D. Hirschman ,  Arthur E. Uber, III ,  Kevin P. Cowan ,  David M. Reilly ,  Edward J. Rhinehart ,  John Kalafut ,  Bronwyn Uber ,  Frederick W. Trombley, III ,  Steven J. Remis ,  Paul D. Levin ,  Scott Griffith ,  Douglas Descalzi ,  Richard Dewit ,  David M. Griffiths

IPC: A61M36/06

CPC classification number: A61N5/1001 ,  A61B5/0205 ,  A61B5/055 ,  A61B5/7289 ,  A61B6/032 ,  A61B6/037 ,  A61B6/0478 ,  A61B6/107 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/4423 ,  A61B6/507 ,  A61B6/508 ,  A61B6/5288 ,  A61B6/548 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1456 ,  A61M5/16827 ,  A61M5/16881 ,  A61M5/1723 ,  A61M5/1785 ,  A61M2205/3576 ,  A61N5/1071 ,  A61N2005/1021 ,  A61N2005/1094 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17 ,  G21F5/015 ,  G21G4/08

Abstract: An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.

Abstract translation: 公开了一种集成的放射性药物患者治疗系统，其包括具有相关联的患者刺激装置的患者支撑平台，靠近患者支撑平台的成像器，用于将放射性药物流体输入患者的放射性药物流体输送系统，与 患者以及与患者刺激装置，成像器，放射性药物流体输送系统和患者监护器可操作地相关联以控制和协调其操作的集成系统控制器。 在患者治疗系统内，可以包括放射性药物流体递送系统，包括放射性核素供应模块，放射性药物处理模块，质量控制模块，患者注射模块和控制器。 进一步公开了一种危险的流体处理系统，其包括对接站和适于与对接站可拆卸地对接的危险流体输送装置。

公开(公告)号：US20100174183A1

公开(公告)日：2010-07-08

申请号：US12515981

申请日：2007-11-28

Applicant: Robert S. Schwartz ,  Robert A. Van Tassel ,  Eugene A. Gelblum ,  Alan D. Hirschman ,  John F. Kalafut ,  David M. Reilly ,  Edward J. Rhinehart ,  Frederick W. Trombley, III ,  Arthur E. Uber, III

Inventor： Robert S. Schwartz ,  Robert A. Van Tassel ,  Eugene A. Gelblum ,  Alan D. Hirschman ,  John F. Kalafut ,  David M. Reilly ,  Edward J. Rhinehart ,  Frederick W. Trombley, III ,  Arthur E. Uber, III

IPC: A61B6/00 ,  A61M25/00

CPC classification number: A61M25/007 ,  A61M25/003

Abstract: A method and device for the simultaneous or sequential introduction of multiple fluids into the bloodstream including a multiple lumen catheter with corresponding multiple hole sets. By introducing a second fluid such as saline, the concentration and bolus of a first fluid, such as a contrast agent, can be controlled and optimized.

Abstract translation: 一种用于同时或顺序地将多种流体引入血流中的方法和装置，包括具有相应多孔组的多腔导管。 通过引入诸如盐水的第二流体，可以控制和优化第一流体如造影剂的浓度和推注。

公开(公告)号：US07672710B2

公开(公告)日：2010-03-02

申请号：US11196806

申请日：2005-08-02

Applicant: Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Karen Zelenski

Inventor： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Karen Zelenski

IPC: A61B6/00 ,  A61M5/30 ,  A61M5/00

CPC classification number: A61B8/481 ,  A61B6/481 ,  A61B6/504 ,  A61B8/06 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1723 ,  A61M2205/581 ,  A61M2205/80 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3468

Abstract: A system for producing a contrast-enhanced medical image of a patient includes a source of a contrast or enhancement medium, a pressurizing unit in fluid connection with the source of contrast or enhancement medium, an energy source operable to apply energy to a region of the patient, an imaging unit providing a visual display of an internal view of the patient based upon a signal resulting from the energy applied to the region of the patient, and a control unit. In an embodiment, the signal is affected by a condition of the contrast or enhancement medium in the patient. To control the procedures, the control unit adjusts the condition of the contrast or enhancement medium in the patient based upon the signal. A communication interface preferably enables information between an injector subsystem and an imaging subsystem.

Abstract translation: 用于产生患者的对比度增强的医学图像的系统包括对比度或增强介质的源，与对比度或增强介质源流体连接的加压单元，可操作以将能量施加到所述对比度或增强介质的区域的能量源 患者，成像单元，其基于由施加到患者的区域的能量产生的信号以及控制单元提供患者的内部视图的视觉显示。 在一个实施例中，该信号受到患者中的对比度或增强介质的状况的影响。 为了控制程序，控制单元基于该信号来调整患者的对比度或增强介质的状况。 通信接口优选地实现注射器子系统和成像子系统之间的信息。

公开(公告)号：US07462166B2

公开(公告)日：2008-12-09

申请号：US10466418

申请日：2002-01-16

Applicant: Kevin P. Cowan ,  Barry Iddon ,  Michael J. Yanniello ,  John A. Brosovich ,  Alan D. Hirschman

Inventor： Kevin P. Cowan ,  Barry Iddon ,  Michael J. Yanniello ,  John A. Brosovich ,  Alan D. Hirschman

IPC: A61M37/00

CPC classification number: A61M5/14546 ,  A61M5/14566 ,  A61M2205/6072

Abstract: A syringe for use with a powered injector to inject a fluid into a patient inclides an encoder. The encoder includes at least a first indicator positioned on the encoder. The first indicator is adapted to interact with at least a portion of energy being propagated through or adjacent the encoder in a manner that is detectable. The presence (or absence) of the first indicator provides or corresponds to information about the syringe configuration. The indicator(s) of the present invention can, for example, provide information about syringe configuration by the number and/or position thereof. A plurality or set of such syringes can be provided, with the configuration of each such syringe being represented by the presence or absence of indicator(s) of that syringe.

Abstract translation: 用于与动力注射器一起使用以将流体注入患者的注射器包括编码器。 编码器至少包括位于编码器上的第一指示器。 第一指示符适于与以可检测的方式与正在传播或邻近编码器的能量的至少一部分相互作用。 第一个指示器的存在（或不存在）提供或对应于关于注射器配置的信息。 例如，本发明的指示器可以通过其数量和/或位置提供关于注射器构造的信息。 可以提供多个或一组这样的注射器，每个这样的注射器的构造由该注射器的指示器的存在或不存在表示。

公开(公告)号：US20080086050A1

公开(公告)日：2008-04-10

申请号：US11868552

申请日：2007-10-08

Applicant: George J. Misic ,  Alan D. Hirschman

Inventor： George J. Misic ,  Alan D. Hirschman

IPC: A61B5/05

CPC classification number: A61B5/055 ,  A61B18/12 ,  A61B2018/0016 ,  A61B2018/183 ,  A61B2090/374 ,  G01R33/34084 ,  G01R33/4804

Abstract: Hyperthermia has been applied by, for example, separate ultrasound transducers, RF or microwave transmitters and heated fluids. Imaging by separate MRI imaging coils is usually used to view the anatomical region under treatment. Separate temperature probes (needles, catheters) are often used to monitor tissue temperature. Control of the temperature profile required for effective hyperthermia treatment is usually done by trial and error, involving a human operator. The present invention combines all of these capabilities into a single device, which is MRI compatible and safe. It also allows for automatic control of the RF energy to achieve a prescribed tissue hyperthermia.

Abstract translation: 已经通过例如单独的超声换能器，RF或微波发射器和加热流体应用了热疗。 单独MRI成像线圈的成像通常用于观察治疗前的解剖区域。 单独的温度探针（针，导管）通常用于监测组织温度。 控制有效热疗治疗所需的温度曲线通常是通过试验和错误的方式进行的，涉及人类操作者。 本发明将所有这些功能组合成单个设备，其是MRI兼容且安全的。 它还允许自动控制RF能量以实现规定的组织热疗。

公开(公告)号：US07351221B2

公开(公告)日：2008-04-01

申请号：US11394946

申请日：2006-03-31

Applicant: Frederick W. Trombley, III ,  Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  Alan D. Hirschman

Inventor： Frederick W. Trombley, III ,  Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  Alan D. Hirschman

IPC: A61M37/00 ,  B01F5/00

CPC classification number: A61M5/142 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/14566 ,  A61M5/445 ,  A61M2205/3673 ,  B01F9/103 ,  B01F13/005

Abstract: A system for dispensing a medium includes at least a first container to hold the medium, a pressurizing device, such as a pump, in fluid connection with the container for pressurizing the medium, and an agitation mechanism or device to maintain the components of the medium in a mixed state. The container and the pressurizing device can be separate units, as in the case of an bag or bottle in fluid connection with a peristaltic or other type of pump. The container and the pump can also be combined in a single unit, as in the case of a syringe, wherein the syringe barrel of the syringe acts to contain the medium and the syringe plunger pressurizes the medium within the syringe barrel. A method of injecting a multi-component medium includes the step of agitating the medium (for example, as described above) before or during an injection procedure to maintain the components of the medium in a mixed state.

Abstract translation: 用于分配介质的系统至少包括用于保持介质的第一容器，与容器流体连接的用于对介质加压的加压装置，例如泵，以及用于维持介质的组分的搅拌机构或装置 处于混合状态。 容器和加压装置可以是分离的单元，如在与蠕动或其它类型的泵流体连接的袋或瓶的情况下。 容器和泵也可以在单个单元中组合，如在注射器的情况下，其中注射器的注射器筒用于容纳介质，并且注射器柱塞对注射器筒内的介质加压。 注射多组分培养基的方法包括在注射过程之前或过程中搅拌培养基（例如，如上所述）以将培养基的组分维持在混合状态的步骤。

公开(公告)号：US06970735B2

公开(公告)日：2005-11-29

申请号：US10134858

申请日：2002-04-29

Applicant: Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

Inventor： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

IPC: A61B6/00 ,  A61B8/00 ,  A61M5/00 ,  A61M5/145 ,  A61M5/172

CPC classification number: A61B8/481 ,  A61B6/481 ,  A61B6/504 ,  A61B8/06 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1723 ,  A61M2205/581 ,  A61M2205/80 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3468

Abstract: A system for producing a contrast-enhanced medical image of a patient includes a source of a contrast or enhancement medium, a pressurizing unit in fluid connection with the source of contrast or enhancement medium, an energy source operable to apply energy to a region of the patient, an imaging unit providing a visual display of an internal view of the patient based upon a signal resulting from the energy applied to the region of the patient, and a control unit. In an embodiment, the signal is affected by a condition of the contrast or enhancement medium in the patient. To control the procedures, the control unit adjusts the condition of the contrast or enhancement medium in the patient based upon the signal. A communication interface preferably enables information between an injector subsystem and an imaging subsystem.

Abstract translation: 用于产生患者的对比度增强的医学图像的系统包括对比度或增强介质的源，与对比度或增强介质源流体连接的加压单元，可操作以将能量施加到所述对比度或增强介质的区域的能量源 患者，成像单元，其基于由施加到患者的区域的能量产生的信号以及控制单元提供患者的内部视图的视觉显示。 在一个实施例中，该信号受到患者中的对比度或增强介质的状况的影响。 为了控制程序，控制单元基于该信号来调整患者的对比度或增强介质的状况。 通信接口优选地实现喷射器子系统和成像子系统之间的信息。