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公开(公告)号:US12215326B2
公开(公告)日:2025-02-04
申请号:US15632067
申请日:2017-06-23
Applicant: The Broad Institute, Inc. , Massachusetts Institute of Technology , President and Fellows of Harvard College
Inventor: Feng Zhang , Patrick Hsu , Jonathan S. Gootenberg , Aaron Smargon
Abstract: The invention provides for systems, methods, and compositions for targeting RNA. In particular, the invention provides a non-naturally occurring or engineered RNA-targeting system comprising an RNA-targeting Cas protein and at least one RNA-targeting guide RNA, wherein said RNA-targeting guide RNA is capable of hybridizing with a target RNA in a cell.
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公开(公告)号:US12209292B2
公开(公告)日:2025-01-28
申请号:US16328548
申请日:2017-08-25
Applicant: THE BROAD INSTITUTE, INC. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Inventor: Mary Lynn Baniecki , Hayden Metsky , Pardis Sabeti
IPC: C12Q1/68 , C12Q1/6893 , C12Q1/70 , G16B30/00 , G16B30/10
Abstract: The present invention relates to a method for generating primers and/or probes for use in analyzing a sample which may comprise a pathogen target sequence comprising providing a set of input genomic sequence to one or more target pathogens, generating a set of target sequences from the set of input genomic sequences, identifying one or more highly conserved target sequences, and generating one or more primers, one or more probes, or a primer pair and probe combination based on the one or more conserved target sequences.
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公开(公告)号:US12180546B2
公开(公告)日:2024-12-31
申请号:US16494911
申请日:2018-03-19
Applicant: Massachusetts Institute of Technology
Inventor: Alexander K. Shalek , Alexander S. Genshaft , Carly G. K. Ziegler , Jeffrey F. Van Humbeck , Ryan Philip King
IPC: C12Q1/6881 , C07D405/12 , C07D495/04 , C12Q1/6869 , G01N1/28 , G16B45/00
Abstract: The present invention provides tools and methods for the systematic analysis of genetic interactions between cells. The present invention provides tools and methods for modulating cell phenotypes and compositions, combinatorial probing of cellular circuits, for dissecting cellular circuitry, for delineating molecular pathways, and/or for identifying relevant targets for therapeutics development.
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公开(公告)号:US12131803B2
公开(公告)日:2024-10-29
申请号:US16757329
申请日:2018-10-17
Inventor: Giulio Genovese , Po-Ru Loh , Steven McCarroll
IPC: G16B20/10 , C12Q1/6883 , C12Q1/6886 , G16B5/00 , G16B20/20 , G16H10/40
CPC classification number: G16B20/10 , G16B5/00 , G16B20/20 , G16H10/40 , C12Q1/6883 , C12Q1/6886
Abstract: Embodiments disclosed herein provide methods, systems, and computer program products that utilize long-range phase information to detect subtle chromosome imbalances in genotype data. Clonal expansions result from mutation followed by selective proliferation, and the embodiments disclosed herein may be used to somatic structural variant events (SVs) predictive or diagnostic of cancer and other diseases.
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公开(公告)号:US12089765B2
公开(公告)日:2024-09-17
申请号:US17031274
申请日:2020-09-24
Applicant: Philip DiTrolio
Inventor: Philip DiTrolio
CPC classification number: A47H1/142 , E04H1/1272
Abstract: The present coupler-mounted connector enables industry standard hooks on horizontal rods to rest at such a height as to provide uniform appearance to the top of drape walls. The coupler-mounted connector includes an adaptor to support couplers for the drape rods to be mounted on a vertically disposed, affixed coupler, such as a coupler on a pipe, a flat-mounted coupler, or any other coupler. The body of the coupler-mounted connector is positioned around the affixed coupler. The coupler-mounted connector includes a spanning element with a lower wedge to mate with the openings in the upper body of the affixed coupler. The coupler-mounted connector is secured in the coupler with the accessories protruding to one or more sides of the coupler-mounted connector. The accessories are connected to the coupler-mounted connector by one or more connection bridges.
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公开(公告)号:US12046151B2
公开(公告)日:2024-07-23
申请号:US17100149
申请日:2020-11-20
Applicant: Edward Via College of Osteopathic Medicine
Inventor: Jeremy Jason White
CPC classification number: G09B23/30 , G09B23/285
Abstract: Described and demonstrated herein are embodiments of a self-supporting wearable device that can be used for medical training and simulations. Also described herein are methods of using the wearable device described herein.
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公开(公告)号:US12041945B2
公开(公告)日:2024-07-23
申请号:US18516686
申请日:2023-11-21
Applicant: WTI, INC.
Inventor: Wolf Peter Ludwig
IPC: A23L27/24 , A23B4/027 , A23B4/12 , A23B4/20 , A23B4/24 , A23L3/3472 , A23L3/3508 , A23L27/00 , A23P10/40
CPC classification number: A23B4/027 , A23B4/12 , A23B4/20 , A23B4/24 , A23L3/3472 , A23L3/3508 , A23L27/24 , A23L27/82 , A23P10/40 , A23V2002/00 , Y02A40/90
Abstract: A method of processing is disclosed that provides improved water retention and enhanced coloring and flavor, while preserving the meat and preventing bacterial contamination. In an exemplary embodiment, the method includes: (a) providing a body of meat at a first temperature; (b) contacting the body of meat of step (a), in at least one treating vessel, with a brine solution at a second temperature, wherein the second temperature is greater than the first temperature, and wherein the brine solution comprises a vinegar-derived food additive and/or a reddening agent, wherein the reddening agent comprises nitrite; (c) agitating the body of meat at the second temperature for a time sufficient to distribute the solution throughout the body of meat; (d) cooling the body of meat in at least one cooling vessel to a third temperature, wherein the third temperature is less than the second temperature; (e) agitating the body of meat at the third temperature; (f) contacting the body of meat of step (e) with the brine solution at the third temperature and agitating the body of meat at the third temperature until the brine solution is substantially absorbed by the body of meat; and (g) recovering the body of meat in a dry state at the third temperature.
In one embodiment, the aforementioned brine solution comprises a vinegar-variety food additive, such as a vinegar-derived acetate composition. In another embodiment, the reddening agent comprises nitrate derived from plant material comprising nitrate.-
公开(公告)号:US11963966B2
公开(公告)日:2024-04-23
申请号:US16499393
申请日:2018-03-30
Applicant: Dana-Farber Cancer Institute, Inc. , The Broad Institute, Inc. , Massachusetts Institute of Technology
Inventor: Levi Garraway , Benjamin Izar , Aviv Regev , Orit Rozenblatt-Rosen , Asaf Rotem , Elizabeth Stover , Itay Tirosh
IPC: A61K31/575 , A61K9/00 , A61K33/243 , A61K35/17 , A61K39/395
CPC classification number: A61K31/575 , A61K9/0019 , A61K33/243 , A61K35/17 , A61K39/39533
Abstract: Described herein are compositions and methods of using single-cell RNA-sequencing to identify treatment resistance in patients with ovarian cancer. Also, described herein are compositions and methods for treatment targeting resistance in patients with ovarian cancer.
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公开(公告)号:US11943215B1
公开(公告)日:2024-03-26
申请号:US17334186
申请日:2021-05-28
Applicant: CITIGROUP TECHNOLOGY, INC.
Inventor: Sandeep Nair , Matthew E. Nunn , Julio Caraballo , Jason Edward Morris , Udaya Chandupatia , Partha S. Peddi
CPC classification number: H04L63/083 , G06F8/65 , H04L9/3226 , H04L9/3268 , H04L63/0823 , H04L63/0869
Abstract: Machines, devices, and other objects are configured to use authorization tokens to verify object identities without human input. In examples, the object uses a password to validate the object's identity to an authorization server to obtain an access token for use in multiple applications. In another example, the object uses a certificate to validate the object's identity to an authorization server to obtain an access token. In other examples, any other suitable identifying data may be used to validate the object's identity to an authorization server to obtain an access token. The process of using passwords, certificates, or other validation processes to obtain tokens or other authorization mechanisms allows the object to authenticate themselves without human interaction and to use a single identity to access services from multiple service providers that trust a central authorization server.
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公开(公告)号:US11943096B1
公开(公告)日:2024-03-26
申请号:US18376051
申请日:2023-10-03
Applicant: CITIBANK, N.A.
Inventor: Raja Balasubramanian , Rene Wilfredo Villatoro Escalante , Chike Gideon Okechukwu , Terry John Jenkins , Scott Taylor
IPC: H04B10/03 , H04B10/079 , H04L41/069 , H04L41/22
CPC classification number: H04L41/069 , H04B10/03 , H04B10/07955 , H04L41/22
Abstract: The technology may be utilized in network environments that use fiber optic cables to connect components. Components of the network perform functions as transceivers that transmit and receive light signals via the fiber cable. When optic power data received from the transceivers is recognized as a fault, an event is identified. The system logs each received event and converts all measurements into a common unit of measurement. The system analyzes aggregated data from the transceivers to detect patterns and trends, monitor the received data and provide real time fault predictions. For example, a machine learning process may recognize subtle trends or patterns in the data, and use the recognition to predict potential failures. The system uses the received data to create a graphical user interface (“GUI”) that represents the health of the network.
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