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1.发明公开公开(公告)号：US20240261443A1
公开(公告)日：2024-08-08
申请号：US18603721
申请日：2024-03-13
IPC分类号： A61K51/04
CPC分类号： A61K51/0427
摘要： Provided herein are compounds and compositions useful for imaging, detecting, and/or diagnosing oxidative stress and/or a ROS modulated illness by detection of gamma radiation emitted by the compound, as well as intermediate compounds and methods useful to make the compounds and/or compositions, and methods of use thereof.
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公开(公告)号：US11993785B2
公开(公告)日：2024-05-28
申请号：US16533300
申请日：2019-08-06
CPC分类号： C12N5/0062 , B33Y10/00 , B33Y70/00 , B33Y80/00 , C12M21/08 , C12N5/0697 , C12N13/00 , G01N33/5088 , C12N2513/00
摘要： Provided are methods of preparing organoids and compositions for use in such methods. In some embodiments, a method of depositing a plurality of the cells into a reservoir are provided, the method comprising depositing a gelatin composition into a reservoir; adding a composition comprising a plurality of cells into the gelatin composition, wherein the composition is added into the gelatin composition at a position below the surface of the gelatin composition and at least a portion of the composition and/or plurality of cells are suspended in the gelatin composition; curing at least a portion of the composition comprising the plurality of cells in the gelatin composition; and removing at least a portion of the gelatin composition in the reservoir, thereby depositing the plurality of cells in the reservoir.
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公开(公告)号：US20240165380A1
公开(公告)日：2024-05-23
申请号：US18454673
申请日：2023-08-23
CPC分类号： A61M25/10188 , A61M5/1723 , A61M2005/1726 , A61M2025/0002 , A61M2025/1052 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429
摘要： A method for automatically controlling an expandable member in a blood vessel of a subject may comprise obtaining, using a controller, proximal sensor data from a proximal pressure sensor and distal sensor data from a distal pressure sensor, comparing the obtained proximal sensor data to a proximal pressure threshold value, adjusting, using the controller, a volume of the expandable member based on the distal sensor data in response to determining that the proximal sensor data is above or at the proximal pressure threshold value, and adjusting, using the controller, the volume of the expandable member based on the proximal sensor data in response to determining that the proximal sensor data is below the proximal pressure threshold value.
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公开(公告)号：US11976101B2
公开(公告)日：2024-05-07
申请号：US17465145
申请日：2021-09-02
发明人： Waldemar Debinski , Hetal Pandya , Denise Gibo
IPC分类号： C07K14/54 , A61K47/64 , C07K14/005 , C07K14/195 , C07K14/21 , C07K14/34 , C07K19/00 , G01N33/50 , G01N33/532 , G01N33/68 , A61K38/00
CPC分类号： C07K14/5437 , A61K47/642 , C07K14/005 , C07K14/195 , C07K14/21 , C07K14/34 , C07K19/00 , G01N33/5008 , G01N33/5091 , G01N33/532 , G01N33/6869 , A61K38/00 , C07K2319/01 , C07K2319/09 , C07K2319/74 , G01N2333/025 , G01N2333/195 , G01N2333/5437
摘要： A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an IL-13Rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more effector molecules); optionally but preferably, a cytosol localization element covalently coupled between said binding ligand and said at least one effector molecule; and a subcellular compartment localization signal element covalently coupled between said binding ligand and said at least one effector molecule (and preferably with said cytosol localization element between said binding ligand and said subcellular compartment localization signal element). Methods of using such compounds and formulations containing the same are also described.
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公开(公告)号：US20240066067A1
公开(公告)日：2024-02-29
申请号：US18129399
申请日：2023-03-31
申请人： Wake Forest University Health Sciences , Emory University , Children's Healthcare of Atlanta, Inc.
发明人： Maria Graca N.D. Almeida-Porada , Christopher D. Porada , Anthony Atala , Christopher B. Doering , H. Trent Spencer
IPC分类号： A61K35/28 , C07K14/755 , C12N5/0775
CPC分类号： A61K35/28 , C07K14/755 , C12N5/0668
摘要： Disclosed herein are method of treating hemophilia A in a subject comprising injecting the subject with mesenchymal stromal/stem cells (MSC) modified to express high levels of Factor VIII protein. The MSC are injected into the subject prenatally. The modified MSC may also express high levels von Willebrand factor protein.
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公开(公告)号：US11806228B2
公开(公告)日：2023-11-07
申请号：US17186307
申请日：2021-02-26
发明人： Keith Andrew Walter , Kurt Weber
CPC分类号： A61F2/148 , A61F2/0095 , A61F2/142 , A61F9/007
摘要： Medical kits and methods for performing small incision DLEK include a corneal transplantation donor tissue graft formed into an implantable and compact rolled configuration using the flexible substrate.
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公开(公告)号：US11779464B2
公开(公告)日：2023-10-10
申请号：US16618926
申请日：2018-06-12
发明人： Phillip Kim , Anthony Atala , David James Mccoul
CPC分类号： A61F2/2481 , A61B34/10 , G06F30/20 , G16H30/40 , G16H50/50 , A61B2034/102 , A61B2034/105 , A61B2034/108 , A61F2240/002 , A61F2250/0097 , B33Y50/02 , B33Y80/00
摘要： Provided herein is a method of forming a ventricular support device for a diseased heart, including providing imaging data of the diseased heart, forming a three-dimensional (3D) heart model based on the imaging data, providing strain data including a plurality of strain estimates for at least one segment of the diseased heart, mapping the plurality of strain estimates onto corresponding portions of the 3D heart model to form a 3D diseased heart model, based on the 3D diseased heart model, forming a model of the ventricular support device configured to surround at least a portion of the diseased heart and provide support based upon said strain estimates, and converting the model of the ventricular support device to a digital file useful for directing a 3D printer device to print said ventricular support device for said diseased heart. Also provided is a customized ventricular support device so produced.
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公开(公告)号：US20230272033A1
公开(公告)日：2023-08-31
申请号：US18316672
申请日：2023-05-12
IPC分类号： C07K14/705 , C07K14/52 , C07K14/54 , G01N33/574
CPC分类号： C07K14/705 , C07K14/52 , C07K14/5437 , G01N33/57492 , C07K2319/33 , C07K2319/01 , C07K2319/55 , C07K2319/74 , A61K38/00
摘要： Provided herein is a construct comprising, in combination: an EphA3, EphA2 and/or EphB2 binding ligand; and at least one effector molecule. In some embodiments, the at least one effector molecule comprises a therapeutic agent, a nanoparticle, a detectable group, a lipid, or a liposome. In some embodiments, the construct is a fusion protein and/or a covalent conjugate. Further provided is a construct comprising, in combination: a ligand that binds to EphA2, EphA3 and/or EphB2; a ligand that binds to IL-13Rα2; and at least one effector molecule. Also provided are methods of use thereof for treating cancer.
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公开(公告)号：US11697675B2
公开(公告)日：2023-07-11
申请号：US16947154
申请日：2020-07-21
IPC分类号： C07K14/705 , C07K14/52 , A61K38/00 , C07K14/54 , G01N33/574
CPC分类号： C07K14/705 , C07K14/52 , C07K14/5437 , G01N33/57492 , A61K38/00 , C07K2319/01 , C07K2319/06 , C07K2319/09 , C07K2319/30 , C07K2319/33 , C07K2319/55 , C07K2319/74
摘要： Provided herein is a construct comprising, in combination: an EphA3, EphA2 and/or EphB2 binding ligand; and at least one effector molecule. In some embodiments, the at least one effector molecule comprises a therapeutic agent, a nanoparticle, a detectable group, a lipid, or a liposome. In some embodiments, the construct is a fusion protein and/or a covalent conjugate. Further provided is a construct comprising, in combination: a ligand that binds to EphA2, EphA3 and/or EphB2; a ligand that binds to IL-13Rα2; and at least one effector molecule. Also provided are methods of use thereof for treating cancer.
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公开(公告)号：US20230149732A1
公开(公告)日：2023-05-18
申请号：US17989669
申请日：2022-11-17
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61N2005/0663 , A61N2005/0651
摘要： A method for inhibiting device thrombosis for a patient may include circulating blood through an extracorporeal circuit coupled to the patient, infusing nitrite into the flow of blood such that the nitrite is bioactivated by red blood cells to form nitric oxide, and illuminating the flow of blood with far-red light to increase bioactivation of the nitrite by the red blood cells. A system for inhibiting device thrombosis for a patient may include an extracorporeal circuit configured to circulate a flow of blood, a nitrite infusion device coupled to the extracorporeal circuit and configured to infuse nitrite into the flow of blood, and one or more light sources disposed along the extracorporeal circuit and configured to illuminate the flow of blood with far-red light.
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