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公开(公告)号：US20250066424A1
公开(公告)日：2025-02-27
申请号：US18797277
申请日：2024-08-07
Applicant: VIB VZW , Vrije Universiteit Brussel , Oxford Nanopore Technologies PLC
Inventor： Han Remaut , Sander Egbert Van Der Verren , Nani Van Gerven , Lakmal Nishantha Jayasinghe , Elizabeth Jayne Wallace , Pratik Raj Singh , Richard George Hambley , Michael Robert Jordan , John Joseph Kilgour
Abstract: The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
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公开(公告)号：US12215310B2
公开(公告)日：2025-02-04
申请号：US16646936
申请日：2018-09-14
Applicant: VIB VZW , KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D
Inventor： Johan Thevelein , Benjamin Offei , Maria Remedios Foulquié Moreno , Paul Vandecruys
IPC: C12N1/18 , A23L33/14 , A61K36/064 , C07K14/395 , C12P7/54
Abstract: Described herein are probiotics, more particularly [to] the probiotic yeast Saccharomyces boulardii. Even more particularly described herein are enhanced probiotic potency S. boulardii. Also described here are mutant alleles useful to develop yeast strains with enhanced production of acetic acid. In addition, described here is the use of such yeast strains for the production of dietary supplements or pharmaceutical compositions to improve gastrointestinal comfort.
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公开(公告)号：US20240417398A1
公开(公告)日：2024-12-19
申请号：US18666100
申请日：2024-05-16
Applicant: SpringWorks Therapeutics, Inc. , KATHOLIEKE UNIVERSITEIT LEUVEN , VIB vzw
Inventor： Brian LAWHORN , Arnaud MARCHAND , Bart VANDERHOYDONCK , Stephen L. GWALTNEY , Stéphane SPIESER
IPC: C07D471/04 , A61K31/4375 , A61K31/444 , A61K31/4709 , A61K31/472 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K45/06 , A61P35/00 , C07D217/04 , C07D401/12
Abstract: The present disclosure relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to a method for the prevention or treatment of said diseases comprising the use of the novel compounds.
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公开(公告)号：US20240336975A1
公开(公告)日：2024-10-10
申请号：US18579415
申请日：2022-07-13
Applicant: VIB VZW , Katholieke Universiteit Leuven
Inventor： Diether Lambrechts , Ayse Bassez , Hanne Vos , Ann Smeets
IPC: C12Q1/6886
CPC classification number: C12Q1/6886 , C12Q2600/106 , C12Q2600/158
Abstract: The invention relates to methods of breast tumor analysis relying on the detection of expression levels of specific genes. Such methods find application in, amongst other, predicting the response of a breast cancer patient to immunotherapy or to immunogenic therapy, and in following up such responses. The expression levels of the genes can thus be used in determining which breast cancer patients are most likely to respond to immunotherapy or immunogenic therapy. The genes serving as biomarkers are individually highly performant in predicting the response of a breast tumor to immunotherapy or to immunogenic therapy, but are weak in predicting the response of melanoma to immunotherapy or to immunogenic therapy. Diagnostic kits are likewise part of the invention.
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公开(公告)号：US12019076B2
公开(公告)日：2024-06-25
申请号：US17817908
申请日：2022-08-05
Applicant: VIB VZW , Universiteit Gent
Inventor： Nico Callewaert , Sven Eyckerman , Simon Devos
CPC classification number: G01N33/6812 , C12N9/485 , C12N9/641 , G01N33/68 , G01N33/6818 , G01N33/6824
Abstract: The present invention relates to the field of biochemistry, more particularly to proteomics, more particularly to protein sequencing, even more particularly to single molecule peptide sequencing. The invention discloses methods for single molecule protein sequencing and/or amino acid identification using cleavage inducing agents which are not specific for one particular amino acid, cleave polypeptides step by step from the N-terminus onwards and provide information on the identity of the cleaved amino acids based on the kinetics.
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Patent Agency Ranking
公开(公告)号：US20240174767A1
公开(公告)日：2024-05-30
申请号：US18516777
申请日：2023-11-21
Applicant: VIB VZW , Vrije Universiteit Brussel
Inventor： Jan Steyaert , Els Pardon , Tomasz Uchanski , Wim Vranken
IPC: C07K16/46 , C07K14/005 , C07K14/195 , C07K14/705 , C12N7/00 , G01N23/20 , G01N33/68
CPC classification number: C07K16/465 , C07K14/005 , C07K14/195 , C07K14/705 , C12N7/00 , G01N23/20 , G01N33/6845 , C07K2299/00 , C07K2317/569 , C07K2319/03 , C07K2319/30 , C12N2795/00022 , C12N2795/00023
Abstract: The present invention relates to the field of structural biology. More specifically, the present invention relates to novel antigen-binding chimeric proteins, their uses and methods in three-dimensional structural analysis of macromolecules, such as X-ray crystallography and high-resolution Cryo-EM, and their use as a therapeutic, diagnostic, or imaging tool. Even more specifically, the invention relates to a fusion of a scaffold protein and an antigen-binding domain wherein the scaffold protein of said fusion interrupts the Immunoglobulin domain topology to form a rigid chimer.
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公开(公告)号：US20240052044A1
公开(公告)日：2024-02-15
申请号：US18259141
申请日：2021-12-23
Applicant: VIB VZW , VRIJE UNIVERSITEIT BRUSSEL
Inventor： Hui Qi Lu , Catelijne Stortelers , Nadia Van Boxel , Shanna Van Zwam , Jimmy Borloo , Bruno Dombrecht , Jo Van Ginderachter , Pascal Merchiers , Rosa Martin
CPC classification number: C07K16/2866 , A61P35/00 , A61K2039/505
Abstract: The present invention relates to human CCR8 (hCCR8) binders, wherein the hCCR8 binder is a non-blocking binder of hCCR8. Such binders are particularly useful for the depletion of intra-tumoural regulatory T-cells and immunotherapy in general tumour
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公开(公告)号：US20240018248A1
公开(公告)日：2024-01-18
申请号：US18255433
申请日：2021-11-30
Inventor： Gabriele Bergers , Elizabeth Allen , Bruno Dombrecht , Pascal Merchiers , Jo Van Ginderachter
CPC classification number: C07K16/2866 , A61P35/00 , C07K16/2878 , C07K16/2818 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/732 , C07K2317/35 , A61K2039/507
Abstract: The present invention relates to a combination comprising a Treg depletor and an LTBR agonist. Such a combination is particularly useful for use in the treatment of a cancer.
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公开(公告)号：US20230375534A1
公开(公告)日：2023-11-23
申请号：US18247865
申请日：2021-10-05
Inventor： Jeroen Raes , Sebastian Proost , Gwen Falony , Sara Manuel Araujo Vieira Da Silva , Nicholas John Timpson , David Allen Hughes
IPC: G01N33/53
CPC classification number: G01N33/5308 , G01N2800/06
Abstract: The disclosure relates to the field of the human gut microbiome, more particularly, to its effect on health and disease. Provided herein are means and methods to diagnose and treat or reduce the severity of gut flora dysbiosis as well as of gastro-intestinal inflammation and inflammation-associated disorders or conditions in a subject in need thereof.
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公开(公告)号：US11814688B2
公开(公告)日：2023-11-14
申请号：US17728506
申请日：2022-04-25
Applicant: VIB VZW , Katholieke Universiteit Leuven, K.U. Leuven R&D , Life Sciences Research Partners VZW
Inventor： Diether Lambrechts , Bernard Thienpont
IPC: C12Q1/6886
CPC classification number: C12Q1/6886 , C12Q2600/154
Abstract: The present application relates to the field of cancer, particular to hypoxic tumors. It was found that hypoxia is an important driver for hypermethylation of (promoters of) tumor suppressor genes. As this hypermethylation is a stable signature that is also present in circulating tumor DNA in peripheral blood, detecting this methylation pattern is a surrogate marker for tumor hypoxia. This can be used to adapt therapy as well.
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