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公开(公告)号：US20220092869A1
公开(公告)日：2022-03-24
申请号：US17423287
申请日：2019-01-17
Inventor： Wim ABBELOOS , Davy NEVEN , Bert DE BRABANDERE , Marc PROESMANS , Luc VAN GOOL
IPC: G06V10/26 , G06V10/82 , G06V10/762 , G06V20/70 , G06V10/764 , G06V10/774 , G06N3/08
Abstract: A system for generating a mask for object instances in an image is provided. The system includes a first module comprising a trained neural network and configured to input the image to the neural network, wherein the neural network is configured to generate: pixel offset vectors for the pixels of the object instance configured to point towards a unique center of an object instance, the pixel offset vectors thereby forming a cluster with a cluster distribution, and for each object instance an estimate of said cluster distribution defining a margin for determining which pixels belong to the object instance. A method for training a neural network map to be used for generating a mask for object instances in an image is also provided.
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公开(公告)号：US11052387B2
公开(公告)日：2021-07-06
申请号：US13625247
申请日：2012-09-24
Inventor： Ben Jones , Paolo Fiorini , Hiroyuki Tanaka
Abstract: A micro-fluidic device is described. The micro-fluidic device includes a semiconductor substrate; at least one micro-reactor in the semiconductor substrate; one or more micro-fluidic channels in the semiconductor substrate, connected to the at least one micro-reactor; a cover layer bonded to the semiconductor substrate for sealing the one or more micro-fluidic channels; and at least one through-substrate trench surrounding the at least one micro-reactor and the one or more micro-fluidic channels.
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公开(公告)号：US09908943B2
公开(公告)日：2018-03-06
申请号：US14023586
申请日：2013-09-11
Inventor： Bart De Strooper , Els Marjaux , Lujia Zhou , Serge Muyldermans
IPC: C07K16/40
CPC classification number: C07K16/40 , C07K2317/22 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/92
Abstract: Described are single domain antibodies with a specificity for BACE1. More specifically, described are single variable-domain antibodies derived from camelids that bind to BACE1 and are capable of inhibiting the activity of BACE1. The antibodies can be used for research and medical applications. Specific applications include the use of BACE1-specific antibodies for the treatment of Alzheimer's disease.
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公开(公告)号：US20180051345A1
公开(公告)日：2018-02-22
申请号：US15555752
申请日：2016-03-04
Applicant: VIB VZW , KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D , LIFE SCIENCES RESEARCH PARTNERS VZW
Inventor： Diether LAMBRECHTS , Bernard THIENPONT
IPC: C12Q1/68
CPC classification number: C12Q1/6886 , C12Q2600/154
Abstract: The present application relates to the field of cancer, particular to hypoxic tumors. It was found that hypoxia is an important driver for hypermethylation of (promoters of) tumor suppressor genes. As this hypermethylation is a stable signature that is also present in circulating tumor DNA in peripheral blood, detecting this methylation pattern is a surrogate marker for tumor hypoxia. This can be used to adapt therapy as well.
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5.发明申请公开(公告)号：US20160158231A1
公开(公告)日：2016-06-09
申请号：US14959317
申请日：2015-12-04
Applicant: VIB VZW , ACETYLON PHARMACEUTICALS, INC. , LIFE SCIENCES RESEARCH PARTNERS VZW , Katholieke Universiteit Leuven, K.U. Leuven R&D
Inventor： Matthew Blaire Jarpe , Ludo Van Den Bosch , Veronick Benoy , Lawrence Van Helleputte
IPC: A61K31/505
CPC classification number: A61K31/505
Abstract: The invention relates to HDAC inhibitors for the treatment of peripheral neuropathy in a subject in need thereof. Also provided herein are methods for treating peripheral neuropathy in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an HDAC inhibitor.
Abstract translation: 本发明涉及用于治疗有需要的受试者的周围神经病变的HDAC抑制剂。 本文还提供了治疗有需要的受试者的周围神经病变的方法，包括向受试者施用治疗有效量的HDAC抑制剂。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20150301068A1
公开(公告)日：2015-10-22
申请号：US14375426
申请日：2013-01-29
Applicant: VIB VZW , KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D
Inventor： Bart DE STROOPER , Francesc GUIX
CPC classification number: G01N33/6896 , A61K38/10 , A61K38/177 , C07K14/70596 , C07K16/28 , C12N15/1138 , C12N2310/14 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2800/2821
Abstract: The disclosure provides an extracellular target for Alzheimer's disease selected from the tetraspanin web family. The disclosure also provides diagnostic methods for the use as a target for detection of Alzheimer's disease in a subject. In addition, screening methods are provided for selecting compounds that bind or down-regulate the expression of the target.
Abstract translation: 本公开提供了选自四叶蛋白网络家族的阿尔茨海默氏病的细胞外靶标。 本公开还提供了用作在受试者中检测阿尔茨海默氏病的靶标的诊断方法。 此外，提供了选择结合或下调靶标表达的化合物的筛选方法。
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7.发明申请Nonvolatile Memory Device Comprising a Metal-to-Insulator Transition Material 审中-公开包括金属到绝缘体转换材料的非易失性存储器件公开(公告)号：US20130187113A1
公开(公告)日：2013-07-25
申请号：US13744613
申请日：2013-01-18
Applicant: IMEC , Katholieke Universiteit Leuven, K.U. LEUVEN R&D
Inventor： Koen Martens , Iuliana Radu
IPC: H01L45/00
CPC classification number: H01L45/1286 , H01L45/04 , H01L45/1206 , H01L45/146
Abstract: A nonvolatile memory device is disclosed comprising a metal-to-insulator transition material thermally coupled to a Peltier element. During programming, a selected current is flowing through the Peltier element, the level thereof determining whether the temperature of the Peltier element and hence of the thermally coupled metal-to-insulator transition material decreases or increases. In response to this temperature change, the metal-to-insulator transition material will change from one electrical conduction phase to another. The memory device is read by applying current through the metal-to-insulator transition material, the current level being selected to maintain the phase of the metal-to-insulator transition material.
Abstract translation: 公开了一种非易失性存储器件，其包括热耦合到珀尔帖元件的金属至绝缘体转变材料。 在编程期间，所选择的电流流过珀尔帖元件，其电平确定珀尔帖元件的温度和因此热耦合的金属至绝缘体转变材料的温度是否降低或增加。 响应于这种温度变化，金属对绝缘体的过渡材料将从一个导电相变到另一个。 通过施加通过金属至绝缘体转变材料的电流来读取存储器件，选择电流电平以维持金属至绝缘体转变材料的相位。
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公开(公告)号：US11872262B2
公开(公告)日：2024-01-16
申请号：US16612121
申请日：2018-05-09
Applicant: VIB VZW , Katholieke Universiteit Leuven, K.U. Leuven R&D
Inventor： Joost Schymkowitz , Frederic Rousseau
Abstract: The present invention relates to non-naturally occurring anti-bacterial peptides. More specifically the peptides can be used to treat multi-drug resistant bacterial infections. In addition, the present invention provides methods for producing anti-bacterial peptides.
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公开(公告)号：US11466270B2
公开(公告)日：2022-10-11
申请号：US16332575
申请日：2017-10-03
Applicant: VIB VZW , Katholieke Universiteit Leuven, K.U. Leuven R&D
Inventor： Massimiliano Mazzone , Anne-Theres Henze
IPC: C12N15/113 , A61P31/00 , A61P33/02 , C12Q1/6876
Abstract: The present application relates to the field of inflammatory diseases, particularly to inflammatory diseases characterized by an M1 macrophage response, even more particularly to sepsis and to Trypanosoma infection. The invention provides substances modulating miR210 expression and/or activity, in particular RNA molecules inhibiting miR210 expression and/or activity and medical uses of these miR210 inhibitors. Methods are disclosed to screen for medicaments for treating sepsis.
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公开(公告)号：US20210087554A1
公开(公告)日：2021-03-25
申请号：US16332575
申请日：2017-10-03
Applicant: VIB VZW , Katholieke Universiteit Leuven, K.U. Leuven R&D
Inventor： Massimiliano MAZZONE , Anne-Theres HENZE
IPC: C12N15/113 , A61P31/00 , A61P33/02 , C12Q1/6876
Abstract: The present application relates to the field of inflammatory diseases, particularly to inflammatory diseases characterized by an M1 macrophage response, even more particularly to sepsis and to Trypanosoma infection. The invention provides substances modulating miR210 expression and/or activity, in particular RNA molecules inhibiting miR210 expression and/or activity and medical uses of these miR210 inhibitors. Methods are disclosed to screen for medicaments for treating sepsis.
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