公开(公告)号：US20220157554A1

公开(公告)日：2022-05-19

申请号：US17454998

申请日：2021-11-15

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Sang Ju LEE ,  Myoung Choul CHOI ,  Chang Min CHOI ,  Aram HONG ,  Ji Young BAEK

IPC: H01J37/08

Abstract: A mixed gas cluster ion beam generator may include a nozzle chamber to contain a first mixed gas which is a mixed gas that is a mix of a first gas and a second gas, a cluster nozzle to spray gas received from the nozzle chamber in a cluster form, an ionizer to ionize a gas cluster sprayed by the cluster nozzle, and an ion accelerator to emit an ion beam to the outside by accelerating the gas cluster ionized by the ionizer by generating a potential difference to the ionized gas cluster.

公开(公告)号：US20220133913A1

公开(公告)日：2022-05-05

申请号：US17431357

申请日：2019-07-24

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Ki-Yuk CHANG ,  Kwan-Soo HONG ,  Chan-Woo KIM ,  Hyeon-Seung LEE ,  Hyun-Min KIM

IPC: A61K49/00 ,  G01N33/574 ,  C07K16/28

Abstract: Disclosed are an αvβ3 integrin targeting single-domain antibody and various applications thereof. The αvβ3 integrin targeting single-domain antibody exhibits high binding ability to αvβ3 integrin related to angiogenesis, excellent tissue permeability, and biostability compared to conventional antibodies. Further, the single-domain antibody may be combined with fluorescent particles and thus may be easily measured in vitro, in vivo or ex vivo, and may be effective in detecting angiogenesis and diagnosing angiogenesis related diseases, therefore it may be usefully used in related industries.

公开(公告)号：US11215620B2

公开(公告)日：2022-01-04

申请号：US16296154

申请日：2019-03-07

Applicant: Korea Basic Science Institute

Inventor： Jin Young Kim ,  Gun Wook Park ,  Eun Sun Ji ,  Jong Shin Yoo

IPC: G01N33/68 ,  G16B15/00 ,  G06F17/16

Abstract: The preset invention relates to a high resolution mass spectrometry based novel bioinformatics platform for the identification of glycation proteins and advanced glycation end-product. Particularly, the bioinformatics platform of the present invention facilitates an efficient and accurate investigation of quantitative changes of glycation proteins and advanced glycation end-products which are included in various types of samples but had not been informed yet, and uses a high resolution mass spectrometry, and thereby can be effectively used for the prediction or diagnosis of a disease including cancer by examining a disease marker in a sample.

公开(公告)号：US11069506B2

公开(公告)日：2021-07-20

申请号：US16177213

申请日：2018-10-31

Applicant: Korea Basic Science Institute

Inventor： Sang-Chul Lee ,  Jongman Jeong ,  Jin-Gyu Kim ,  Cheolsu Han

IPC: H01J37/20 ,  H01J37/26 ,  G02B21/24

Abstract: A sample stage includes a sample holder that accommodates a sample and a first drive module, a second drive module, and a third drive module that are radially connected to the sample holder and allow the sample holder to have translational degrees of freedom in three directions and rotational degrees of freedom in at least two directions.

公开(公告)号：US10983080B2

公开(公告)日：2021-04-20

申请号：US16161999

申请日：2018-10-16

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Yeon Suk Choi ,  Soo Yeol Jeong

IPC: G01N1/42 ,  B26F1/40 ,  B26F1/44 ,  G01N25/48 ,  B01L3/00 ,  B26D1/00 ,  G01N1/28 ,  B01L3/02 ,  G01N25/18 ,  G01K17/00

Abstract: Disclosed is an apparatus for quantitively supplying a high-viscosity fluid sample, the apparatus including a cylinder body in which a high-viscosity fluid is to be stored, a cylinder head detachably attached to the cylinder body, a piston configured to slide in a longitudinal direction of the cylinder body, and a cutter disposed below the cylinder head and configured to cut a high-viscosity fluid discharged from the cylinder head.

公开(公告)号：US20200018759A1

公开(公告)日：2020-01-16

申请号：US15545552

申请日：2017-04-27

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Jong Shin Yoo ,  Kwang Hoe Kim ,  Jin Young Kim ,  Ju Yeon Lee

IPC: G01N33/574 ,  G01N33/68

Abstract: The present invention relates to a diagnosis method of liver cancer using mass spectrometry of α-fetoprotein derived glycopeptide. Particularly, according to the AFP glycopeptide analysis method of the invention, fucosylation rate of the glycopeptide having the sequence composed of Val-Asn-Phe-Thr-Glu-Ile-Gln-Lys is analyzed to diagnose liver cancer in the early developmental grade. In particular, fucosylation rate is higher in the liver cancer patients than in other liver disease patients, so that the comparison of the fucosylation rate can be useful to diagnose or distinguish liver cancer from other liver diseases in the early HCC patients.

公开(公告)号：US10386299B2

公开(公告)日：2019-08-20

申请号：US15660166

申请日：2017-07-26

Applicant: KOREA BASIC SCIENCE INSTITUTE

Inventor： Dong Uk Kim ,  Ki Soo Chang ,  Geon Hee Kim ,  Joo Ran Lee

IPC: G01N21/64 ,  G06T5/00 ,  G06T5/20

Abstract: Provided is a fluorescence image acquisition apparatus for acquiring fluorescence images and phase images using optical signals that are modulated at the same frequency and that have different time delays. The fluorescence image acquisition apparatus may include a light source configured to generate, at different time delays, a plurality of optical signals that are modulated at the same frequency, an illuminator configured to control paths of the plurality of modulated optical signals so that the plurality of modulated optical signals are illuminated onto a sample including a plurality of fluorescent materials, a photodetector configured to detect a plurality of fluorescence signals that are emitted from the plurality of fluorescent materials, respectively, and a controller configured to acquire a plurality of fluorescence images and a plurality of phase images from the plurality of detected fluorescence signals.

公开(公告)号：US10266898B2

公开(公告)日：2019-04-23

申请号：US14600419

申请日：2015-01-20

Applicant: Korea Basic Science Institute

Inventor： Gun-Hwa Kim ,  Giwon Kim ,  Soohyun Kim ,  Seung II Kim ,  Edmond Changkyun Park

IPC: C12Q1/68 ,  C12P19/34 ,  C12Q1/6886

Abstract: The present invention relates to a recurring glioblastoma multiforme marker miRNA for diagnosing recurring glioblastoma multiforme, and more specifically, to a composition for screening the miRNA marker, which is specific to the recurring glioblastoma multiforme and comprises an agent for detecting the presence of the marker, a kit, and to a method for diagnosing the recurring glioblastoma multiforme using same. The method for diagnosing the recurring glioblastoma multiforme by using the recurring glioblastoma multiforme marker miRNA, according to the present invention, provides glioblastoma markers, which can diagnose the occurrence of the recurring glioblastoma multiforme, thereby providing useful material for managing treatment and prognosis of the recurring glioblastoma multiforme. In addition, the diagnosis markers for the recurring glioblastoma multiforme can be used for development and research of an anticancer agent specific to the recurring glioblastoma multiforme.

公开(公告)号：US10037876B2

公开(公告)日：2018-07-31

申请号：US15320953

申请日：2015-12-09

Applicant: Korea Basic Science Institute

Inventor： Seung Yong Kim ,  Mo Yang ,  Hyun Sik Kim

IPC: H01J49/00 ,  H01J49/08 ,  H01J49/42

CPC classification number: H01J49/08 ,  H01J49/147 ,  H01J49/422 ,  H01J49/424

Abstract: The present invention relates to an electron bean injection control of a mass spectrometer. A mass spectrometer of the present invention includes: a reference waveform generator configured to generate a reference waveform signal having one type of a square wave and a sine wave, a waveform generator configured to generate a sync signal synchronized with the reference waveform signal; an RF module configured to generate an RF voltage signal from the reference waveform signal and apply the RF voltage signal to an RF electrode in the ion trap, an electron beam generator configured to control an operation of an ultraviolet (UV) diode for generating an electron beam injected into the ion trap according to an input control signal, and a control circuit configured to generate the control signal by using the square wave signal.

公开(公告)号：US10001363B2

公开(公告)日：2018-06-19

申请号：US15385886

申请日：2016-12-21

Applicant: Korea Basic Science Institute

Inventor： Kye Sung Lee ,  Gun Hee Kim ,  Hwan Hur ,  I Jong Kim ,  Ki Soo Chang

IPC: G01B9/02

CPC classification number: G01B9/02091 ,  G01B9/02007 ,  G01B9/02023 ,  G01B9/02044 ,  G01B9/02054 ,  G01B9/02057 ,  G01B2290/30

Abstract: Provided is a common-path optical fiber-based handheld parallel optical coherence tomography (OCT) apparatus, including a probe configured to receive the light from a broadband light source and illuminate a measurement target, wherein the probe may include an inner space through which the light passes, a collimator configured to collimate the light incident to the inner space, a diffraction grating configured to diffract the light having passed through the collimator, a galvanometer scanner configured to reflect the light having passed through the diffraction grating, an objective lens configured to concentrate the reflected light on a focal point, and an interferer configured to acquire an interfered light by reflecting at least a portion of the light having passed through the objective lens.