公开(公告)号：US12122767B2

公开(公告)日：2024-10-22

申请号：US17038148

申请日：2020-09-30

申请人： Incyte Corporation

发明人： Oleg Vechorkin ,  Hai Fen Ye ,  Wenqing Yao

IPC分类号： C07D403/14 ,  C07D231/56 ,  C07D401/04 ,  C07D403/04 ,  A61K45/06

CPC分类号： C07D403/14 ,  C07D231/56 ,  C07D401/04 ,  C07D403/04 ,  A61K45/06

摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR3 enzyme and are useful in the treatment of FGFR3-associated diseases such as cancer.

公开(公告)号：US20240309095A1

公开(公告)日：2024-09-19

申请号：US18576936

申请日：2022-07-07

申请人： Incyte Corporation ,  SPECIFICA INC.

发明人： Fortunato Ferrara ,  Michael Frank Erasmus ,  Andre Azevedo Reis Teixeira ,  Andrew Raymon Morton Bradbury

IPC分类号： C07K16/28 ,  A61K47/68

CPC分类号： C07K16/2827 ,  A61K47/6849 ,  C07K2317/565 ,  C07K2317/92

摘要： Anti-B7-H4 antibodies are disclosed. Also disclosed are related nucleic acids, vectors, cells, kits, and pharmaceutical compositions. Methods of treating cancer with the anti-B7-H4 antibodies are also disclosed.

公开(公告)号：US12084449B2

公开(公告)日：2024-09-10

申请号：US17575371

申请日：2022-01-13

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Jincong Zhuo ,  Meizhong Xu ,  Chunhong He ,  Colin Zhang ,  Ding-Quan Qian ,  David M. Burns ,  Yun-Long Li ,  Brian Metcalf ,  Wenqing Yao

IPC分类号： A61P35/00 ,  A61K31/4709 ,  A61K31/53 ,  C07D403/06 ,  C07D487/04

CPC分类号： C07D487/04 ,  A61K31/4709 ,  A61K31/53 ,  A61P35/00 ,  C07D403/06

摘要： The present invention is directed to imidazo[1,2-b][1,2,4]triazines and imidazo[1,2-a]pyrimidines, and pharmaceutical compositions thereof, which are inhibitors of kinases such as c-Met and are useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways.

公开(公告)号：US20240293411A1

公开(公告)日：2024-09-05

申请号：US18430205

申请日：2024-02-01

申请人： Incyte Corporation

发明人： Michael Peel ,  Paul Smith

IPC分类号： A61K31/519 ,  A61K31/517 ,  A61P37/06

CPC分类号： A61K31/519 ,  A61K31/517 ,  A61P37/06

摘要： The present application provides combination therapies comprising a JAK inhibitor and a ROCK inhibitor, and methods of using the same to treat disorders such as graft versus host disease (GVHD), restrictive allograft syndrome (RAS), chronic lung allograft dysfunction (CLAD), and systemic sclerosis (scleroderma).

公开(公告)号：US12043614B2

公开(公告)日：2024-07-23

申请号：US17981887

申请日：2022-11-07

申请人： Incyte Corporation

发明人： Zhongjiang Jia ,  Ganfeng Cao ,  Qiyan Lin ,  Yongchun Pan ,  Lei Qiao ,  Vaqar Sharief ,  Chongsheng Eric Shi ,  Michael Xia ,  Changsheng Zheng ,  Jiacheng Zhou ,  Qun Li

IPC分类号： C07D401/14 ,  A61K31/4545 ,  C07D401/12 ,  C07F7/18

CPC分类号： C07D401/14 ,  A61K31/4545 ,  C07D401/12 ,  C07F7/1804 ,  C07B2200/13

摘要： The present invention relates to salt forms of the Pim kinase inhibitor N-{(7R)-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide, including methods of preparation thereof, and intermediates in the preparation thereof, where the compound is useful in the treatment of Pim kinase-related diseases such as cancer.

公开(公告)号：US20240228508A1

公开(公告)日：2024-07-11

申请号：US18523516

申请日：2023-11-29

申请人： Incyte Corporation ,  Incyte Holdings Corporation

发明人： Yun-Long Li ,  Wenyu Zhu ,  Song Mei ,  Joseph Glenn

IPC分类号： C07D495/14 ,  A61K31/437 ,  C07D495/12

CPC分类号： C07D495/14 ,  A61K31/437 ,  C07D495/12

摘要： The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

公开(公告)号：US12030885B2

公开(公告)日：2024-07-09

申请号：US17183253

申请日：2021-02-23

申请人： Incyte Corporation

发明人： Andrew W. Buesking ,  Richard B. Sparks ,  Andrew P. Combs ,  Brent Douty ,  Nikoo Falahatpisheh ,  Lixin Shao ,  Stacey Shepard ,  Eddy W. Yue ,  Artem Shvartsbart ,  David M. Burns ,  Daniel Levy

IPC分类号： A61K31/53 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D519/00 ,  C07B2200/13

摘要： This application relates to compounds of Formula (I):






or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20240190982A1

公开(公告)日：2024-06-13

申请号：US18386380

申请日：2023-11-02

申请人： Incyte Corporation

发明人： Sonia Ioannidis ,  Nawel Bourayou

IPC分类号： C07K16/28 ,  A61P35/00

CPC分类号： C07K16/2878 ,  A61P35/00 ,  C07K16/2818 ,  A61K2039/505

摘要： Methods of treating a cancer by administering to a subject an anti-GITR antibody in combination with at least one of a PD-1 inhibitor (e.g., an anti-PD-1 inhibitor), a PD-L1 inhibitor (e.g., an anti-PD-L1 antibody), or a CTLA-4 inhibitor (e.g., an anti-CTLA-4 antibody) are disclosed herein.

公开(公告)号：US12005067B2

公开(公告)日：2024-06-11

申请号：US17541601

申请日：2021-12-03

申请人： INCYTE CORPORATION

发明人： Paul Smith ,  Zheng Zhang ,  Melissa Parker ,  James Fidge

IPC分类号： A61K31/593 ,  A61K31/519 ,  A61K45/06 ,  A61P17/06

CPC分类号： A61K31/593 ,  A61K31/519 ,  A61K45/06 ,  A61P17/06

摘要： The present disclosure relates to topical treatment of skin diseases, such as psoriasis, atopic dermatitis, alopecia, vitiligo, Reiter's syndrome, pityriasis rubra pilaris, epidermolysis bullosa simplex, palmoplantar keratoderma, pachyonychia congenita, steatocystoma multiplex, cutaneous lichen planus, cutaneous T-cell lymphoma, hidradenitis suppurativa, contact dermatitis, ichthyosis, and a disorder of keratinization, using (a) a JAK inhibitor, or a pharmaceutically acceptable salt thereof, and (b) vitamin D3, a vitamin D3 analog, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11981671B2

公开(公告)日：2024-05-14

申请号：US17845142

申请日：2022-06-21

申请人： Incyte Corporation

发明人： Joshua Hummel ,  Jingwei Li ,  Ding-Quan Qian ,  Liangxing Wu

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  C07D487/04 ,  C07D519/00

摘要： The present application provides bicyclic amines of Formula (I):




or a pharmaceutically acceptable salt thereof, that are inhibitors of cyclin-dependent kinase 2 (CDK2), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.