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    Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine
    1.
    发明授权
    Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine 失效
    流感嗜血杆菌B多糖 - 白喉类毒素结合疫苗

    公开(公告)号：US4644059A

    公开(公告)日：1987-02-17

    申请号：US691895

    申请日：1985-01-16

    申请人： Lance K. Gordon

    发明人： Lance K. Gordon

    IPC分类号： A61K39/102 ,  C08B37/00

    CPC分类号： A61K39/102 ,  A61K2039/6037 ,  Y10S424/831

    摘要： A water-soluble covalent polysaccharide-diphtheria toxoid conjugate having a molecular weight between 140,000 and 4,500,000 dalton and a ribose/protein ratio between 0.25 and 0.75, capable of producing T-cell dependent antibody response to polysaccharide from H. influenzae b, is prepared by mixing a derivatized diphtheria toxoid in a substantially cyanogen halide-free solution with a cyanogen halide-activated capsular H. influenzae b polysaccharide hapten consisting of approximately equal parts of ribose, ribitol and phosphate, which polysaccharide had previously been heat sized until more than 60% attained a molecular size between 200,000 and 2,000,000 dalton.

    摘要翻译： 通过以下方法制备分子量在140,000至4,500,000道尔顿之间的水溶性共价多糖 - 白喉类毒素结合物，以及能够产生对来自流感嗜血杆菌b的多糖产生T细胞依赖性抗体应答的核糖/蛋白质比例在0.25和0.75之间的核糖/蛋白质比例 将衍生的白喉类毒素在基本上不含卤化卤的溶液中与卤氰化物活化的荚膜流感嗜血杆菌b多糖半抗原混合，所述多糖半乳糖苷由约等份的核糖，核糖醇和磷酸酯组成，该多糖预先被加热至60％ 达到分子大小在20万至2,000,000道尔顿之间。

    Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine
    2.
    发明授权
    Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine 失效
    流感嗜血杆菌b多糖 - 白喉类毒素结合疫苗

    公开(公告)号：US4496538A

    公开(公告)日：1985-01-29

    申请号：US395743

    申请日：1982-01-06

    申请人： Lance K. Gordon

    发明人： Lance K. Gordon

    IPC分类号： A61K39/145 ,  A61K39/05 ,  A61K39/08 ,  A61K39/102 ,  A61K39/108 ,  A61K39/385 ,  A61P31/12 ,  A61P31/16 ,  C07K1/113 ,  C07K14/00 ,  C07K14/195 ,  C07K14/41 ,  C08B37/00 ,  C07G7/00

    CPC分类号： A61K39/102 ,  A61K2039/6037 ,  Y10S424/831 ,  Y10S530/806 ,  Y10S530/807 ,  Y10S530/825

    摘要： A water-soluble covalent polysaccharide-diphtheria toxoid conjugate having a molecular weight between 140,000 and 4,500,000 dalton and a ribose/protein ratio between 0.25 and 0.75, capable of producing T-cell dependent antibody response to polysaccharide from H. influenzae b, prepared by mixing a derivatized diphtheria toxoid in a substantially cyanogen halide-free solution with a cyanogen halide-activated capsular H. influenzae b polysaccharide hapten consisting of approximately equal parts of ribose, ribitol and phosphate, which polysaccharide had previously been heat sized until more than 60% attained a molecular size between 200,000 and 2,000,000 dalton.

    摘要翻译： 一种水溶性共价多糖 - 白喉类毒素结合物，其分子量为140,000至4,500,000道尔顿，核糖/蛋白质比为0.25至0.75，能够产生通过混合制备的来自流感嗜血杆菌b的多糖的T细胞依赖性抗体应答 在基本上不含卤化氰的溶液中具有衍生的白喉类毒素，其中卤化氰活化的荚膜流感嗜血杆菌b多糖半抗原由约等份的核糖，核糖醇和磷酸酯组成，该多糖预先被加热至达到达到60％以上 分子大小在20万至2,000,000道尔顿之间。