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    Borrelia burgdorferi bacterin
    7.
    发明申请
    Borrelia burgdorferi bacterin 审中-公开
    博氏疏螺旋体菌

    公开(公告)号：US20020071851A1

    公开(公告)日：2002-06-13

    申请号：US09930657

    申请日：2001-08-14

    申请人： Solvay Animal Health, Inc.

    发明人： Jon B. Korshus ,  Paul L. Runnels ,  Richard L. Sharpee ,  Ronald F. Schell ,  Steven M. Callister

    IPC分类号： A61K039/02 ,  C12N001/21

    CPC分类号： A61K39/0225 ,  A61K39/00 ,  A61K2039/521 ,  A61K2039/55505 ,  C07K14/20 ,  Y02A50/401 ,  Y10S424/828 ,  Y10S514/825

    摘要： A bacterin including effective immunizing amounts of two non-crossprotective isolates of inactivated Borrelia burgdorferi, an adjuvant in an amount effective to enhance the immunogenicity of the inactivated Borrelia burgdorferi isolates and a suitable carrier is provided herein. The bacterin may also contain a third non-crossprotective isolate. A bacterin including effective immunizing amounts of an antigenic subunit derived from a first Borrelia burgdorferi isolate and a second, non-crossprotective Borrelia burgdorferi isolate, an adjuvant in an amount effective to enhance the immunogenicity of the antigenic subunits and a suitable carrier is also provided. The bacterin may also contain an effective immunizing amount of an antigenic subunit of a third Borrelia burgdorferi. Further provided is a bacterin which includes effective immunizing amounts of two non-crossprotective isolates of inactivated Borrelia burgdorferi and one or more antigenic subunits from the non-crossprotective isolates, an adjuvant in an amount effective to enhance the immunogenicity of the inactivated Borrelia burgdorferi and antigenic subunits and a suitable carrier.

    摘要翻译： 包括有效免疫​​量的两种非交叉保护性分离物灭活的疏螺旋体疏螺旋体的菌苗，这是一种有效提高灭活的勃氏疏螺旋体分离物的免疫原性的佐剂和合适的载体。 菌苗也可以含有第三种非交叉保护性分离物。 还提供了包含有效免疫量的衍生自第一疏螺旋体疏螺旋体分离物和第二非交叉保护性疏螺旋体疏螺旋体分离物的抗原亚单位的菌苗，其量为有效增强抗原亚单位的免疫原性的佐剂和合适的载体。 菌苗还可以含有有效免疫量的第三种布氏疏螺旋体的抗原亚单位。 进一步提供了一种菌苗，其包括有效免疫​​量的两种非交叉保护性分离物的失活的疏螺旋体疏螺旋体和一种或多种来自非交叉保护分离物的抗原亚基，一种有效增强灭活的疏螺旋体疏螺旋体和抗原性免疫原性的量的佐剂 亚基和合适的载体。

    Borrelia burgdorferi bacterin
    8.
    发明授权
    Borrelia burgdorferi bacterin 失效
    博氏疏螺旋体菌

    公开(公告)号：US06316005B1

    公开(公告)日：2001-11-13

    申请号：US08722013

    申请日：1997-01-21

    申请人： Jon B. Korshus ,  Paul L. Runnels ,  Richard L. Sharpee ,  Ronald F. Schell ,  Steven M. Callister

    发明人： Jon B. Korshus ,  Paul L. Runnels ,  Richard L. Sharpee ,  Ronald F. Schell ,  Steven M. Callister

    IPC分类号： A61K3902

    CPC分类号： A61K39/0225 ,  A61K39/00 ,  A61K2039/521 ,  A61K2039/55505 ,  C07K14/20 ,  Y02A50/401 ,  Y10S424/828 ,  Y10S514/825

    摘要： A bacterin including effective immunizing amounts of two non-crossprotective isolates of inactivated Borrelia burgdorferi, an adjuvant in an amount effective to enhance the immunogenicity of the inactivated Borrelia burgdorferi isolates and a suitable carrier is provided herein. The bacterin may also contain a third non-crossprotective isolate. A bacterin including effective immunizing amounts of an antigenic subunit derived from a first Borrelia burgdorferi isolate and a second, non-crossprotective Borrelia burgdorferi isolate, an adjuvant in an amount effective to enhance the immunogenicity of the antigenic subunits and a suitable carrier is also provided. The bacterin may also contain an effective immunizing amount of an antigenic subunit of a third Borrelia burgdorferi. Further provided is a bacterin which includes effective immunizing amounts of two non-crossprotective isolates of inactivated Borrelia burgdorferi and one or more antigenic subunits from the non-crossprotective isolates, an adjuvant in an amount effective to enhance the immunogenicity of the inactivated Borrelia burgdorferi and antigenic subunits and a suitable carrier. Methods of immunizing an animal against Borrelia burgdorferi infection which comprise administering to the animal a dose of a bacterin provided herein are also provided.

    摘要翻译： 包括有效免疫​​量的两种非交叉保护性分离物灭活的疏螺旋体疏螺旋体的菌苗，这是一种有效提高灭活的勃氏疏螺旋体分离物的免疫原性的佐剂和合适的载体。 菌苗还可以含有第三种非交叉保护性分离物。 还提供了包含有效免疫量的衍生自第一疏螺旋体疏螺旋体分离物和第二非交叉保护性疏螺旋体疏螺旋体分离物的抗原亚单位的菌苗，其量为有效增强抗原亚单位的免疫原性的佐剂和合适的载体。 菌苗还可以含有有效免疫量的第三种布氏疏螺旋体的抗原亚单位。 进一步提供了一种菌苗，其包括有效免疫​​量的两种非交叉保护性分离物的失活的疏螺旋体疏螺旋体和一种或多种来自非交叉保护分离物的抗原亚基，一种有效增强灭活的疏螺旋体疏螺旋体和抗原性免疫原性的量的佐剂 亚基和合适的载体。 还提供了免疫动物对布氏疏螺旋体感染的方法，其包括向动物施用一定剂量的本文提供的菌苗。