公开(公告)号：US07351336B2

公开(公告)日：2008-04-01

申请号：US11046554

申请日：2005-01-29

Applicant: Hap Nguyen ,  William Murray Fowler ,  Howard Roop ,  Ronald Yoshio Nishida

Inventor： Hap Nguyen ,  William Murray Fowler ,  Howard Roop ,  Ronald Yoshio Nishida

IPC: C02F1/32 ,  B63B13/00

CPC classification number: B63J4/002 ,  C02F1/001 ,  C02F1/325 ,  C02F1/444 ,  C02F2103/008 ,  C02F2201/008 ,  C02F2201/3227 ,  C02F2201/324 ,  C02F2201/326 ,  C02F2209/02 ,  C02F2209/40 ,  G06Q30/02 ,  Y02A90/40 ,  Y10S210/931

Abstract: Ballast water treatment apparatus and methods for preventing foreign aquatic invasive species form entering marine ecological zones by translocation in ship's ballast water. The apparatus includes a housing, a filter member, and UV water treatment chambers. Methods include use of a ship's fire hydrant system for moving ballast water from the ship's ballast tanks into the apparatus for filtration and treatment. In-port service vessels and dock-side service vehicles are equipped with the treatment and filtration apparatus to provided in-port or dock-side ballast water treatment services. Related methods are also provided.

Abstract translation: 压载水处理装置和防止外来水生侵入物种通过船舶压载水易位进入海洋生态区的方法。 该装置包括壳体，过滤构件和UV水处理室。 方法包括使用船舶的消防栓系统将压载水从船舶压载舱移动到过滤和处理设备中。 港口服务船舶和码头侧服务车辆配备了处理和过滤装置，提供港口或码头侧压载水处理服务。 还提供了相关方法。

公开(公告)号：US20060288745A1

公开(公告)日：2006-12-28

申请号：US11512810

申请日：2006-08-29

Applicant: William Murray ,  Stewart Carl ,  Arthur Zarnowitz

Inventor： William Murray ,  Stewart Carl ,  Arthur Zarnowitz

IPC: E05B73/00

CPC classification number: E05B73/0005 ,  E05B67/383 ,  E05B73/0082 ,  Y10T70/40 ,  Y10T70/5009 ,  Y10T70/5973

Abstract: An apparatus which inhibits the theft of equipment such as personal computers is disclosed. The equipment must have an external wall provided with a specially designed, approximately rectangular slot having preselected dimensions. An attachment mechanism includes a housing for a spindle having a first portion rotatable within the housing, a shaft extending outwardly from the housing, and a crossmember at the end of the shaft having peripheral dimensions closely conforming to the internal dimensions of the slot. An abutment mechanism also emanates from the housing, and is located on opposite sides of the shaft intermediate the housing and the crossmember. The peripheral cross-sectional dimensions of the abutment mechanism and the shaft in combination closely conform to the dimensions of the slot. The length of the shaft from the housing to the crossmember is approximately equal to the thickness of the external wall of equipment. The crossmember is aligned with the abutment mechanism so that the crossmember can be inserted through the slot with the shaft and the abutment mechanism occupying the slot. The spindle is then rotated 90° to misalign the crossmember with the slot, thereby attaching the attachment mechanism rigidly to the external wall. A cable is secured to the housing and to an immovable object so that the equipment cannot be stolen.

公开(公告)号：US07053078B2

公开(公告)日：2006-05-30

申请号：US10030188

申请日：2001-06-12

Applicant: John Walter Liebeschuetz ,  Christopher William Murray ,  Stephen Clinton Young ,  Nicholas Paul Camp ,  Stuart Donald Jones ,  William Alexander Wylie ,  John Joseph Masters ,  Michael Robert Wiley ,  Scott Martin Sheehan ,  David Birenbaum Engel ,  Brian Morgan Watson

Inventor： John Walter Liebeschuetz ,  Christopher William Murray ,  Stephen Clinton Young ,  Nicholas Paul Camp ,  Stuart Donald Jones ,  William Alexander Wylie ,  John Joseph Masters ,  Michael Robert Wiley ,  Scott Martin Sheehan ,  David Birenbaum Engel ,  Brian Morgan Watson

IPC: A61K31/33 ,  A61K31/445 ,  C07D211/00 ,  C07D401/00 ,  C07D209/04

CPC classification number: C07D401/04 ,  C07D207/12 ,  C07D211/26 ,  C07D211/46 ,  C07D211/58 ,  C07D211/62 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D417/14

Abstract: Compounds of formula (I) in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders.

Abstract translation: 其中R 2，X，Y，Cy，L和Lp（D）n N具有本说明书中给出的含义的式（I）化合物是 丝氨酸蛋白酶，因子Xa，可用于治疗心血管疾病。

公开(公告)号：US20050272784A1

公开(公告)日：2005-12-08

申请号：US11123977

申请日：2005-05-06

Applicant: Xiaobing Li ,  William Murray ,  Mark Macielag ,  Qunying Guan

Inventor： Xiaobing Li ,  William Murray ,  Mark Macielag ,  Qunying Guan

IPC: A61K31/421 ,  A61K31/4245 ,  A61P31/04 ,  C07D231/14 ,  C07D233/90 ,  C07D249/10 ,  C07D263/34 ,  C07D277/56 ,  C07D413/02 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10

CPC classification number: C07D263/34 ,  C07D231/14 ,  C07D233/90 ,  C07D249/10 ,  C07D277/56 ,  C07D413/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10

Abstract: In accordance with the present invention, compounds that inhibit Type III protein secretion have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of Type III protein secretion and/or in the treatment and prevention of bacterial infections, particularly Gram-negative bacterial infections, are provided. In another aspect of the invention, methods are provided for the inhibition of Type III protein secretion and/or the treatment and prevention of bacterial infections, particularly Gram-negative bacterial infections using the compounds of the invention.

Abstract translation: 根据本发明，已经鉴定了抑制III型蛋白质分泌的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制III型蛋白质分泌和/或治疗和预防细菌感染，特别是革兰氏阴性细菌感染的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制III型蛋白质分泌和/或治疗和预防细菌感染，特别是革兰氏阴性细菌感染的方法。

公开(公告)号：US20050150262A1

公开(公告)日：2005-07-14

申请号：US11009335

申请日：2004-12-09

Applicant: William Murray ,  Stewart Carl ,  Arthur Zarnowitz

Inventor： William Murray ,  Stewart Carl ,  Arthur Zarnowitz

IPC: E05B73/00

CPC classification number: E05B73/0005 ,  E05B67/383 ,  E05B73/0082 ,  Y10T70/40 ,  Y10T70/5009 ,  Y10T70/5973

Abstract: An apparatus which inhibits the theft of equipment such as personal computers is disclosed. The equipment must have an external wall provided with a specially designed, approximately rectangular slot having preselected dimensions. An attachment mechanism includes a housing for a spindle having a first portion rotatable within the housing, a shaft extending outwardly from the housing, and a crossmember at the end of the shaft having peripheral dimensions closely conforming to the internal dimensions of the slot. An abutment mechanism also emanates from the housing, and is located on opposite sides of the shaft intermediate the housing and the crossmember. The peripheral cross-sectional dimensions of the abutment mechanism and the shaft in combination closely conform to the dimensions of the slot. The length of the shaft from the housing to the crossmember is approximately equal to the thickness of the external wall of equipment. The crossmember is aligned with the abutment mechanism so that the crossmember can be inserted through the slot with the shaft and the abutment mechanism occupying the slot. The spindle is then rotated 90° to misalign the crossmember with the slot, thereby attaching the attachment mechanism rigidly to the external wall. A cable is secured to the housing and to an immovable object so that the equipment cannot be stolen.

公开(公告)号：US20050070534A1

公开(公告)日：2005-03-31

申请号：US10949055

申请日：2004-09-24

Applicant: Nicholas Carruthers ,  Wenying Chai ,  Scott Dax ,  Jill Jablonowski ,  Xiaobing Li ,  Timothy Lovenberg ,  William Murray ,  Dale Rudolph ,  Mark Seierstad ,  Mark Youngman

Inventor： Nicholas Carruthers ,  Wenying Chai ,  Scott Dax ,  Jill Jablonowski ,  Xiaobing Li ,  Timothy Lovenberg ,  William Murray ,  Dale Rudolph ,  Mark Seierstad ,  Mark Youngman

IPC: A61K31/404 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/497 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/541 ,  A61P3/04 ,  A61P15/08 ,  A61P25/22 ,  A61P25/24 ,  C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D413/02 ,  C07D417/02 ,  C07D473/02 ,  C07D43/02

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D409/14

Abstract: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.

Abstract translation: 本发明提供了用于治疗或预防：抗焦虑障碍或抑郁症的新型非肽性NPY Y2受体抑制剂; 受伤的哺乳动物神经组织; 通过施用神经营养因子治疗反应的病症; 神经系统疾病; 骨质疏松 物质相关疾病; 肥胖; 或肥胖相关疾病。 本发明的化合物还可用于调节内分泌功能，特别是由垂体和下丘脑腺体控制的内分泌功能，因此可用于治疗或预防排卵和不育症。

公开(公告)号：US20050009799A1

公开(公告)日：2005-01-13

申请号：US10858435

申请日：2004-06-01

Applicant: Nareshkumar Jain ,  Weigin Jiang ,  Mark Macielag ,  William Murray ,  Raymond Ng ,  Zhihua Sui

Inventor： Nareshkumar Jain ,  Weigin Jiang ,  Mark Macielag ,  William Murray ,  Raymond Ng ,  Zhihua Sui

IPC: A61P5/30 ,  C07C37/055 ,  C07C39/17 ,  C07C43/215 ,  C07C43/23 ,  C07C45/69 ,  C07C69/757 ,  C07C217/18 ,  C07D209/04 ,  C07D295/092 ,  A61K31/56

CPC classification number: C07D295/088 ,  C07C29/12 ,  C07C29/60 ,  C07C37/055 ,  C07C39/17 ,  C07C39/23 ,  C07C41/18 ,  C07C41/20 ,  C07C41/22 ,  C07C41/26 ,  C07C41/30 ,  C07C43/215 ,  C07C43/23 ,  C07C45/69 ,  C07C69/757 ,  C07C217/18 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07C2602/10 ,  C07D209/04 ,  C07C49/683 ,  C07C47/47 ,  C07C43/225 ,  C07C33/38

Abstract: The present invention is directed to novel cyclohexyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and diseases mediated by an estrogen receptor.

Abstract translation: 本发明涉及新颖的环己基衍生物，含有它们的药物组合物及其在治疗由雌激素受体介导的病症和疾病中的用途。

公开(公告)号：US06755157B1

公开(公告)日：2004-06-29

申请号：US09699850

申请日：2000-10-30

Applicant: William M. Stevens ,  William Murray Black ,  Stephens Nicholls ,  Markus Liedel ,  Thomas Helming ,  Peter Bruder ,  Hugo Hermann ,  Britt Weigand ,  Klaus Weickenmeier ,  Jens Ulrich

Inventor： William M. Stevens ,  William Murray Black ,  Stephens Nicholls ,  Markus Liedel ,  Thomas Helming ,  Peter Bruder ,  Hugo Hermann ,  Britt Weigand ,  Klaus Weickenmeier ,  Jens Ulrich

IPC: F01P710

CPC classification number: F04D29/582 ,  F01P2070/50 ,  F04D29/646

Abstract: The motor of an automotive cooling fan system is attached to a housing by either bayonet mount, screw mount, or axial-snap features on both motor and housing, as well as a cradle structure on the housing.

公开(公告)号：US06593474B1

公开(公告)日：2003-07-15

申请号：US09591814

申请日：2000-06-12

Applicant: Linda Jolliffe ,  William Murray ,  Virginia Pulito ,  Linda Mulcahy ,  Xiaobing Li ,  Allen Reitz ,  Cynthia Maryanoff ,  Frank Villani

Inventor： Linda Jolliffe ,  William Murray ,  Virginia Pulito ,  Linda Mulcahy ,  Xiaobing Li ,  Allen Reitz ,  Cynthia Maryanoff ,  Frank Villani

IPC: C07D29514

CPC classification number: C07D207/27 ,  C07D207/28 ,  C07D209/48 ,  C07D211/76 ,  C07D223/10 ,  C07D295/13

Abstract: This invention relates to a series of arylsubstituted piperazines, of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the &agr;-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.

Abstract translation: 本发明涉及一系列芳基取代的哌嗪，含有它们的式I药物组合物和用于其制备的中间体。 本发明的化合物选择性地抑制与α-1a肾上腺素能受体的结合，α受体是与良性前列腺增生有关的受体。 因此，这些化合物在治疗这种疾病和其他疾病中潜在有用。

公开(公告)号：US06071915A

公开(公告)日：2000-06-06

申请号：US74789

申请日：1998-05-08

Applicant: Linda Jolliffe ,  William Murray ,  Virginia Pulito ,  Allen Reitz ,  Xiaobing Li ,  Linda Mulcahy ,  Cynthia Maryanoff ,  Frank Villani

Inventor： Linda Jolliffe ,  William Murray ,  Virginia Pulito ,  Allen Reitz ,  Xiaobing Li ,  Linda Mulcahy ,  Cynthia Maryanoff ,  Frank Villani

IPC: C07D295/12 ,  A61K31/397 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/445 ,  A61K31/496 ,  A61K31/55 ,  A61P13/08 ,  C07D205/08 ,  C07D207/12 ,  C07D207/26 ,  C07D207/27 ,  C07D207/28 ,  C07D209/44 ,  C07D209/48 ,  C07D211/40 ,  C07D211/76 ,  C07D221/20 ,  C07D223/10 ,  C07D225/02 ,  C07D225/08 ,  C07D241/04 ,  C07D295/08 ,  C07D295/13 ,  C07D401/12 ,  C07D403/12 ,  C07D401/06 ,  C07D403/06

CPC classification number: C07D207/27 ,  C07D207/28 ,  C07D209/48 ,  C07D211/76 ,  C07D223/10 ,  C07D295/13

Abstract: This invention relates to a series of arylsubstituted piperazines, of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the .alpha.-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.

Abstract translation: 本发明涉及一系列含有它们的式I药物组合物和其制备中使用的中间体的芳基取代哌嗪。 本发明的化合物选择性地抑制与α-1肾上腺素能受体的结合，所述α-1肾上腺素能受体是与前列腺增生有关的受体。 因此，这些化合物在治疗这种疾病和其他疾病中潜在有用。