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1.发明申请SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR 有权作为神经元Y2受体的调节剂的替代哌嗪和哌啶公开(公告)号：US20070100141A1
公开(公告)日：2007-05-03
申请号：US11553556
申请日：2006-10-27
Applicant: Pascal Bonaventure , Nicholas Carruthers , Wenying Chai , Curt Dvorak , Jill Jablonowski , Dale Rudolph , Mark Seierstad , Chandravadan Shah , Devin Swanson , Victoria Wong
Inventor： Pascal Bonaventure , Nicholas Carruthers , Wenying Chai , Curt Dvorak , Jill Jablonowski , Dale Rudolph , Mark Seierstad , Chandravadan Shah , Devin Swanson , Victoria Wong
IPC: C07D413/02 , C07D403/02 , C07D401/02
CPC classification number: C07D295/15 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/27 , C07D207/34 , C07D211/14 , C07D211/16 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/58 , C07D211/70 , C07D213/55 , C07D213/56 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/14 , C07D237/20 , C07D239/28 , C07D239/48 , C07D241/04 , C07D261/08 , C07D261/14 , C07D285/01 , C07D295/135 , C07D295/155 , C07D295/185 , C07D307/24 , C07D307/52 , C07D307/68 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/08
Abstract: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; sleep/wake disorders; cardiovascular disease; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
Abstract translation: 本发明提供了用于治疗或预防：抗焦虑障碍或抑郁症的新型非肽性NPY Y2受体抑制剂; 受伤的哺乳动物神经组织; 通过施用神经营养因子对治疗有反应的病症; 神经系统疾病; 骨质疏松 物质相关疾病; 睡眠/觉醒障碍 心血管疾病; 肥胖; 或肥胖相关疾病。 本发明的化合物还可用于调节内分泌功能，特别是由垂体和下丘脑腺体控制的内分泌功能，因此可用于治疗或预防未排卵和不育症。
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公开(公告)号：US20050288323A1
公开(公告)日：2005-12-29
申请号：US11205958
申请日：2005-08-17
Applicant: Richard Apodaca , Nicholas Carruthers , John Carson , Wenying Chai , Annette Kwok , Xiaobing Li , Timothy Lovenberg , Dale Rudolph , Chandravadan Shah
Inventor： Richard Apodaca , Nicholas Carruthers , John Carson , Wenying Chai , Annette Kwok , Xiaobing Li , Timothy Lovenberg , Dale Rudolph , Chandravadan Shah
IPC: A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/517 , A61K45/00 , A61K49/00 , A61K51/04 , A61P1/08 , A61P1/14 , A61P11/02 , A61P11/06 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/28 , A61P37/08 , A61P43/00 , C07D455/02 , C07D455/03 , C07D471/04 , C07D487/04 , A61K31/4745
CPC classification number: C07D487/04 , A61K51/0455 , A61K51/0459 , C07D455/00 , C07D471/04
Abstract: The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
Abstract translation: 本发明具有取代的稠合双环化合物，含有它们的药物组合物，以及使用它们治疗或预防组胺介导的疾病和病症的方法。
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公开(公告)号：US20050222129A1
公开(公告)日：2005-10-06
申请号：US11095225
申请日：2005-03-31
Applicant: Nicholas Carruthers , Chandravadan Shah , Devin Swanson
Inventor： Nicholas Carruthers , Chandravadan Shah , Devin Swanson
IPC: A61K31/496 , A61K31/506 , A61K31/551 , C07D207/34 , C07D263/34 , C07D277/56 , C07D307/68 , C07D333/38 , C07D43/14
CPC classification number: C07D263/34 , C07D207/34 , C07D277/56 , C07D307/68 , C07D333/38
Abstract: Certain non-imidazole heterocyclic compounds are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.
Abstract translation: 某些非咪唑杂环化合物是可用于治疗组胺H 3受体介导的疾病的组胺H 3 N调节剂。
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公开(公告)号：US20050043348A1
公开(公告)日：2005-02-24
申请号：US10960248
申请日：2004-10-07
Applicant: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
Inventor： J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
IPC: A61K31/423 , A61P25/00 , C07D209/12 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/02 , A61K31/4745
CPC classification number: C07D401/12 , A61K31/423 , C07D209/12 , C07D403/12 , C07D471/04
Abstract: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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公开(公告)号：US20080103132A1
公开(公告)日：2008-05-01
申请号：US11924277
申请日：2007-10-25
Applicant: Nicholas Carruthers , Wenying Chai , Xiaohu Deng , Curt Dvorak , Annette Kwok , Jimmy Liang , Neelakandha Mani , Dale Rudolph , Victoria Wong
Inventor： Nicholas Carruthers , Wenying Chai , Xiaohu Deng , Curt Dvorak , Annette Kwok , Jimmy Liang , Neelakandha Mani , Dale Rudolph , Victoria Wong
IPC: A61K31/55 , A61K31/437 , A61P25/00
CPC classification number: C07D487/04
Abstract: Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
Abstract translation: 某些稠合的含吡咯和吡唑的杂环化合物是可用于治疗5-羟色胺介导的疾病的血清素调节剂。
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Patent Agency Ranking
公开(公告)号：US20070185131A1
公开(公告)日：2007-08-09
申请号：US11735311
申请日：2007-04-13
Applicant: Hui Cai , Nicholas Carruthers , Curt Dvorak , James Edwards , Annette Kwok , Jianmei Wei
Inventor： Hui Cai , Nicholas Carruthers , Curt Dvorak , James Edwards , Annette Kwok , Jianmei Wei
IPC: A61K31/496 , C07D491/02
CPC classification number: C07D491/04 , C07D495/04
Abstract: Certain thienopyrrolyl and furanopyrrolyl compounds are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis.
Abstract translation: 公开了某些噻吩并吡喃基和呋喃并吡咯基化合物可用于治疗或预防由组胺H 4受体介导的病症和病症，包括过敏性鼻炎。
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公开(公告)号：US20060235049A1
公开(公告)日：2006-10-19
申请号：US11453422
申请日：2006-06-15
Applicant: Richard Apodaca , Nicholas Carruthers , Curt Dvorak , Dale Rudolph , Chandravadan Shah , Wei Xiao
Inventor： Richard Apodaca , Nicholas Carruthers , Curt Dvorak , Dale Rudolph , Chandravadan Shah , Wei Xiao
IPC: C07D211/20 , A61K31/445 , A61K31/40 , C07D207/04 , A61K31/138
CPC classification number: C07D207/325 , A61K31/4402 , A61K31/4465 , A61K45/06 , C07C217/22 , C07C323/25 , C07C335/32 , C07D207/335 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/36 , C07D213/74 , C07D215/06 , C07D231/12 , C07D233/42 , C07D233/54 , C07D233/56 , C07D233/84 , C07D233/88 , C07D235/06 , C07D235/26 , C07D239/34 , C07D249/08 , C07D257/04 , C07D277/36 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D307/52 , C07D317/28 , C07D333/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D471/08 , A61K2300/00
Abstract: Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
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公开(公告)号：US20050222151A1
公开(公告)日：2005-10-06
申请号：US11095398
申请日：2005-03-31
Applicant: Nicholas Carruthers , Chandravadan Shah , Devin Swanson
Inventor： Nicholas Carruthers , Chandravadan Shah , Devin Swanson
IPC: A61K31/4545 , A61K31/496 , A61K31/5377 , C07D213/38 , C07D213/64 , C07D213/65 , C07D213/66 , C07D213/81 , C07D213/82 , C07D213/83 , C07D241/24 , C07D261/08 , C07D261/12 , C07D413/14 , C07D43/14
CPC classification number: C07D261/12 , C07D213/38 , C07D213/64 , C07D213/65 , C07D213/66 , C07D213/81 , C07D213/82 , C07D213/83 , C07D241/24 , C07D261/08
Abstract: Certain non-imidazole heterocyclic compounds are histamine H3 modulators useful in the treatment of histamine H3 receptor mediated diseases.
Abstract translation: 某些非咪唑杂环化合物是可用于治疗组胺H 3受体介导的疾病的组胺H 3 N调节剂。
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9.发明授权Intermediates in the preparation of alpha1(((1,1-dimethylethyl) amino) methyl)-4-hydroxy-1,3-benzenedimethanol 失效制备α1（（（1,1-二甲基乙基）氨基）甲基）-4-羟基-1,3-苯二甲醇的中间体
公开(公告)号：US4952729A
公开(公告)日：1990-08-28
申请号：US431264
申请日：1989-11-03
Applicant: Esther Babad , Nicholas Carruthers , Martin Steinman
Inventor： Esther Babad , Nicholas Carruthers , Martin Steinman
Abstract: There is disclosed an improved process for preparing albuterol which comprises reacting a 5-(haloacetyl)-2-hydroxybenzaldehyde with 1,1-dimethylethanamine in an organic solvent and in an inert atmosphere to form 5-[[(1,1-dimethylethyl)amino]acetyl]-2-hydroxybenzaldehyde and reducing the carbonyl functions to the corresponding hydroxy groups to form albuterol.
Abstract translation: 公开了一种用于制备沙丁胺醇的改进方法，其包括使5-（卤代乙酰基）-2-羟基苯甲醛与1,1-二甲基乙胺在有机溶剂中并在惰性气氛中反应以形成5 - [[（1,1-二甲基乙基） 氨基]乙酰基] -2-羟基苯甲醛，并将羰基官能团还原成相应的羟基，形成沙丁胺醇。
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公开(公告)号：US20050090523A1
公开(公告)日：2005-04-28
申请号：US10960363
申请日：2004-10-07
Applicant: J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
Inventor： J. Breitenbucher , Nicholas Carruthers , Xiaobing Li , Laura McAtee , Chandravadan Shah , Ronald Wolin
IPC: A61K31/423 , A61P25/00 , C07D209/12 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/02 , A61K31/4745
CPC classification number: C07D401/12 , A61K31/423 , C07D209/12 , C07D403/12 , C07D471/04
Abstract: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
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