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公开(公告)号：US20070219526A1
公开(公告)日：2007-09-20
申请号：US11749522
申请日：2007-05-16
Applicant: Toby Freyman
Inventor： Toby Freyman
IPC: A61M31/00
CPC classification number: C12N5/0663 , A61K38/28 , A61K2035/124
Abstract: The present invention relates to methods for treating restenosis using mesenchymal stem cells, and in particular to treating restenosis following vascular surgery (e.g., angioplasty, stent implantation, rotoblation, atheroectomy, thrombectomy, or grafting).
Abstract translation: 本发明涉及使用间充质干细胞治疗再狭窄的方法，特别涉及血管手术（例如，血管成形术，支架植入，旋转索，动脉粥样硬化切除术，血栓切除术或移植）后的再狭窄治疗。
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公开(公告)号：US07244242B2
公开(公告)日：2007-07-17
申请号：US11086867
申请日：2005-03-22
Applicant: Toby Freyman
Inventor： Toby Freyman
IPC: A61M29/00
CPC classification number: A61M25/0075 , A61F2/2403 , A61F2/2412 , A61F2/2424 , A61F2/2433 , A61F2/2496 , A61F2250/0059 , A61M25/0029 , A61M25/007 , A61M25/1002 , A61M25/1011 , A61M2025/0034 , A61M2025/0076 , A61M2025/1047 , A61M2025/105 , A61M2025/1072
Abstract: The invention provides a catheter for insertion into a biological passage which contains a first flowing fluid, the catheter including a tubular member having a proximal end and a distal end; a fluid delivery lumen contained within the tubular member; an inflatable balloon assembly disposed at the distal end of the tubular member, the balloon assembly including an inflatable balloon member having an uninflated state and an inflated state, the balloon assembly including apertures in communication with the fluid delivery lumen; an inflation lumen in communication with the balloon member; and a valve contained within the inflatable balloon assembly. The inflatable balloon is assembly configured such that when the balloon member is in the inflated state: (i) sections of the balloon member contact the biological passage defining at least one containment pocket; (ii) the apertures are disposed in the containment pocket, (iii) a flow lumen is defined through the balloon member to allow the first fluid to flow through the balloon member; and (iv) the valve functions to allow the first flowing fluid to flow through the flow lumen in a physiologic direction, while blocking backflow of the first fluid through the flow lumen.
Abstract translation: 本发明提供一种用于插入生物通道中的导管，其包含第一流动流体，该导管包括具有近端和远端的管状构件; 容纳在管状构件内的流体输送腔; 设置在所述管状构件的远端的可充气球囊组件，所述球囊组件包括具有未膨胀状态和膨胀状态的可膨胀球囊构件，所述球囊组件包括与所述流体输送腔连通的孔; 与球囊构件连通的通气腔; 以及包含在可充气球囊组件内的阀。 充气气囊被组装成使得当球囊构件处于充气状态时：（i）球囊构件的部分接触限定至少一个容纳口袋的生物通道; （ii）孔口设置在容纳袋中，（iii）流动腔通过球囊构件限定，以允许第一流体流过球囊构件; 和（iv）所述阀的功能是允许所述第一流动流体在生理方向上流过所述流动腔，同时阻止所述第一流体通过所述流动腔的回流。
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公开(公告)号：US20070055352A1
公开(公告)日：2007-03-08
申请号：US11221647
申请日：2005-09-07
Applicant: Wendy Naimark , Peter Shank , Maria Palasis , Toby Freyman , Anastasia Panos , Samuel Epstein , Alexandra Rousseau
Inventor： Wendy Naimark , Peter Shank , Maria Palasis , Toby Freyman , Anastasia Panos , Samuel Epstein , Alexandra Rousseau
IPC: A61F2/90
CPC classification number: A61L31/16 , A61F2/91 , A61F2/915 , A61F2002/075 , A61F2002/91525 , A61F2002/91533 , A61F2002/91575 , A61F2210/0076 , A61F2220/0008 , A61F2230/0013 , A61F2250/0068 , A61L2300/606
Abstract: A medical device for: delivering a therapeutic agent to a body lumen is described. The device may generally be a stent with an inner sidewall surface and an outer sidewall surface, with a plurality of struts having a plurality of openings therein. An inner and outer layer may be applied to the stent, forming pockets within at least a portion of the openings. The pockets may be filled with at least one therapeutic agent. The pockets may take a variety of shapes and sizes, and may be designed for release or rupture in variety of ways.
Abstract translation: 描述了用于将治疗剂递送到体腔的医疗装置。 该装置通常可以是具有内侧壁表面和外侧壁表面的支架，多个支柱在其中具有多个开口。 内层和外层可以施加到支架上，在开口的至少一部分内形成袋。 口袋可以填充有至少一种治疗剂。 口袋可以采取各种形状和尺寸，并且可以设计为以各种方式释放或破裂。
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公开(公告)号：US07097833B2
公开(公告)日：2006-08-29
申请号：US10198101
申请日：2002-07-19
Applicant: Toby Freyman
Inventor： Toby Freyman
IPC: C12N5/00
Abstract: This invention provides methods of increasing blood flow to tissue in a subject in need thereof, methods of regenerating tissue in a subject, methods of treating diseased tissue in a subject, methods of forming new blood vessels in tissue and new tissue, such as myocardial tissue, in a subject in need thereof, methods of increasing angiogenesis in diseased tissue in a subject, and methods of preventing heart failure in a subject, which methods comprise: a) isolating autologous mononuclear cells from the subject; b) selecting from the isolated autologous mononuclear cells of step (a) lineage negative (Lin−) mononuclear cells; and c) transplanting locally into or adjacent to the tissue an effective amount of the Lin− autologous mononuclear cells, resulting in formation of new blood vessels in the tissue and formation of new tissue. Additional methods provided for such uses further select from the isolated autologous mononuclear cells of step (a) lineage negative (Lin−) mononuclear cells a subset of Lin− mononuclear side population (SP) cells and transplant locally into or adjacent to the tissue an effective amount of the Lin− SP cells. In other aspects, methods using tissue other than mononuclear cells for these uses are provided, which comprise (a) obtaining a cell suspension from the tissue or a second tissue of the subject; (b) selecting from the cell suspension step (a) side population (SP) cells; and (c) transplanting locally into or adjacent to the tissue an effective amount of the SP cells, resulting in formation of new blood vessels in the tissue and formation of new tissue.
Abstract translation: 本发明提供了在有需要的受试者中增加血液流向组织的方法，在受试者中再生组织的方法，治疗受试者中的患病组织的方法，在组织中形成新血管的方法和新组织如心肌组织 在有需要的受试者中，增加受试者患病组织中血管生成的方法，以及预防受试者心脏衰竭的方法，所述方法包括：a）从受试者中分离自体单核细胞; b）从步骤（a）谱系阴性（Lin - >）单核细胞的分离的自体单核细胞中选择; 和c）在组织中或附近移植有效量的自身单核细胞，导致在组织中形成新血管并形成新组织。 为这种用途提供的另外的方法进一步从步骤（a）分离的自体单核细胞中选择一个亚单位的单核细胞侧群体（LIN SP）细胞，并将其局部移植到组织中或与组织相邻的有效量的Lin SP细胞。 在其他方面，提供了使用除了单核细胞以外的组织用于这些用途的方法，其包括（a）从受试者的组织或第二组织获得细胞悬浮液; （b）从细胞悬浮液步骤（a）选择侧群体（SP）细胞; 和（c）在组织中或附近移植有效量的SP细胞，导致在组织中形成新血管并形成新组织。
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公开(公告)号：US20050209580A1
公开(公告)日：2005-09-22
申请号：US11086867
申请日：2005-03-22
Applicant: Toby Freyman
Inventor： Toby Freyman
CPC classification number: A61M25/0075 , A61F2/2403 , A61F2/2412 , A61F2/2424 , A61F2/2433 , A61F2/2496 , A61F2250/0059 , A61M25/0029 , A61M25/007 , A61M25/1002 , A61M25/1011 , A61M2025/0034 , A61M2025/0076 , A61M2025/1047 , A61M2025/105 , A61M2025/1072
Abstract: The invention provides a catheter for insertion into a biological passage which contains a first flowing fluid, the catheter including a tubular member having a proximal end and a distal end; a fluid delivery lumen contained within the tubular member; an inflatable balloon assembly disposed at the distal end of the tubular member, the balloon assembly including an inflatable balloon member having an uninflated state and an inflated state, the balloon assembly including apertures in communication with the fluid delivery lumen; an inflation lumen in communication with the balloon member; and a valve contained within the inflatable balloon assembly. The inflatable balloon is assembly configured such that when the balloon member is in the inflated state: (i) sections of the balloon member contact the biological passage defining at least one containment pocket; (ii) the apertures are disposed in the containment pocket, (iii) a flow lumen is defined through the balloon member to allow the first fluid to flow through the balloon member; and (iv) the valve functions to allow the first flowing fluid to flow through the flow lumen in a physiologic direction, while blocking backflow of the first fluid through the flow lumen.
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Patent Agency Ranking
公开(公告)号：US20050096636A1
公开(公告)日：2005-05-05
申请号：US10700569
申请日：2003-11-05
Applicant: Toby Freyman , Maria Palasis
Inventor： Toby Freyman , Maria Palasis
CPC classification number: A61M25/00 , A61M5/14228 , A61M2025/0057
Abstract: An apparatus and method for delivering a viscous liquid therapeutic material fluid through a lumen in a catheter that selectively narrows the lumen at a plurality of axial locations along the lumen.
Abstract translation: 一种用于通过导管中的内腔递送粘性液体治疗物质流体的装置和方法，所述导管在沿着内腔的多个轴向位置选择性地缩小内腔。
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公开(公告)号：US20150224235A1
公开(公告)日：2015-08-13
申请号：US14492393
申请日：2014-09-22
Applicant: Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Rany Busold , Toby Freyman , Robert J. Caulkins , Quynh P. Pham , Changchen You , Jeffrey D. Carbeck
Inventor： Upma Sharma , Irina Gitlin , Gregory T. Zugates , Adam Rago , Parisa Zamiri , Rany Busold , Toby Freyman , Robert J. Caulkins , Quynh P. Pham , Changchen You , Jeffrey D. Carbeck
CPC classification number: A61L31/06 , A61B17/12031 , A61B17/12163 , A61B17/12186 , A61B2017/12004 , A61J1/2093 , A61L27/18 , A61L27/56 , A61L27/58 , A61L31/141 , A61L31/146 , A61L31/148 , A61L2400/04 , A61L2400/06 , A61L2400/18 , A61M37/00 , C08L63/00 , C08L67/04
Abstract: Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).
Abstract translation: 通常描述与聚合物泡沫有关的系统和方法。 一些实施方案涉及用于制备聚合物泡沫的组合物和方法，以及使用聚合物泡沫体的方法。 聚合物泡沫可以施加到体腔并且与例如组织，损伤的组织，内部器官等接触。在一些实施方案中，聚合物泡沫可以在体腔内形成（即，原位泡沫形成 ）。 此外，发泡聚合物可能能够在体腔的内表面上施加压力，并且能够防止或限制体液（例如血液等）的移动。
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公开(公告)号：US20140316367A1
公开(公告)日：2014-10-23
申请号：US14215988
申请日：2014-03-17
Applicant: Gregory T. Zugates , Adam Rago , Toby Freyman , Upma Sharma , Rany Busold , John Caulkins , Parisa Zamiri , Jennifer Mortensen , Meghan McGill , Daniel K. Bonner
Inventor： Gregory T. Zugates , Adam Rago , Toby Freyman , Upma Sharma , Rany Busold , John Caulkins , Parisa Zamiri , Jennifer Mortensen , Meghan McGill , Daniel K. Bonner
CPC classification number: A61L24/0015 , A61L24/0036 , A61L24/046 , A61L27/14 , A61L27/56 , A61L31/04 , A61L31/146 , A61L2300/418 , A61L2400/04 , A61L2430/22 , C08L75/04
Abstract: The present invention relates generally to systems and methods and systems for generating polymer foams within body cavities to locate and/or control bleeding. The present invention further relates to methods and systems for generating polymer foams within non-compressible wounds to control or stop bleeding. The present invention further relates to the use of foams and gels for medical and cosmetic purposes.
Abstract translation: 本发明一般涉及用于在体腔内产生聚合物泡沫以定位和/或控制出血的系统和方法和系统。 本发明还涉及用于在不可压缩伤口内产生聚合物泡沫以控制或止血的方法和系统。 本发明还涉及泡沫和凝胶用于医疗和化妆用途的用途。
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公开(公告)号：US08790920B2
公开(公告)日：2014-07-29
申请号：US12021625
申请日：2008-01-29
Applicant: Toby Freyman
Inventor： Toby Freyman
IPC: C12N5/00
CPC classification number: A61L27/3683 , A61K35/28 , A61K38/00 , A61L27/28 , A61L27/3633 , A61L31/08
Abstract: The invention is directed to compositions comprising decellularized bone marrow extracellular matrix and uses thereof. Methods for repairing or regenerating defective, diseased, damaged or ischemic tissues or organs in a subject, preferably a human, using the decellularized bone marrow extracellular matrix of the invention are also provided. The invention is further directed to a medical device, preferably a stent or an artificial heart, and biocompatible materials, preferably a tissue regeneration scaffold, comprising decellularized bone marrow extracellular matrix for implantation into a subject.
Abstract translation: 本发明涉及包含脱细胞的骨髓细胞外基质及其用途的组合物。 还提供了使用本发明的脱细胞化骨髓细胞外基质修复或再生受治疗者，优选人的有缺陷，患病，损伤或缺血组织或器官的方法。 本发明进一步涉及医疗装置，优选支架或人造心脏，以及生物相容性材料，优选组织再生支架，其包括用于植入受试者的脱细胞骨髓细胞外基质。
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公开(公告)号：US20130110066A1
公开(公告)日：2013-05-02
申请号：US13536557
申请日：2012-06-28
Applicant: Upma Sharma , Irina Gitlin , Parisa Zamiri , Toby Freyman , Rany Busold , Lee Core , Janet Chie Komatsu , Jennifer Mortensen
Inventor： Upma Sharma , Irina Gitlin , Parisa Zamiri , Toby Freyman , Rany Busold , Lee Core , Janet Chie Komatsu , Jennifer Mortensen
CPC classification number: A61L24/0015 , A61L24/0036 , A61L24/046 , A61L27/14 , A61L27/56 , A61L31/04 , A61L31/146 , A61L2300/418 , A61L2400/04 , A61L2430/22 , C08L75/04
Abstract: Medical implants and methods useful in treating postpartum hemorrhage are disclosed. The implants, in some embodiments, comprise polyurethane foams having advantageous mechanical and other properties selected to promote hemostasis when brought in contact with an inner wall of a uterus. Methods of making and deploying such implants are also disclosed.
Abstract translation: 公开了用于治疗产后出血的医疗植入物和方法。 在一些实施方案中，植入物包含具有有利的机械和其他性质的聚氨酯泡沫，当与子宫的内壁接触时，其被选择用于促进止血。 还公开了制造和部署这种植入物的方法。
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