-
公开(公告)号：US20210116369A1
公开(公告)日：2021-04-22
申请号：US17077643
申请日：2020-10-22
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： EVAN THRUSH , NING LIU , CARL MARLOWE , WILLIAM BRADLEY STRONG
IPC: G01N21/552 , G06T7/00
Abstract: The invention relates to methods for characterizing the binding interactions between binding partners. The invention pertains to methods comprising contacting a first binding partner with a second binding partner that exhibits fast-off rate binding characteristics with the first binding partner to generate the binding interaction between the first binding partner and the second binding partner, wherein the first binding partner is immobilized onto a substrate that is designed to enhance the fluorescence signal of fluorescent molecules located near the substrate's surface, and wherein the second binding partner is a molecule that emits a fluorescent signal or is conjugated to molecule that emits a fluorescent signal. The interactions between the two binding partners can be analyzed based on multiple transient interactions between the two binding partners.
-
公开(公告)号：US10954558B2
公开(公告)日：2021-03-23
申请号：US16168395
申请日：2018-10-23
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Arkadiusz Bibillo , Pranav Patel
IPC: C12Q1/686 , C12N9/12 , C12Q1/6844 , C12N15/10 , C12Q1/68 , C12P19/34 , C12Q1/6806
Abstract: The present disclosure provides methods and systems for amplifying and analyzing nucleic acid samples. The present disclosure provides methods for preparing cDNA and/or DNA molecules and cDNA and/or DNA libraries using modified reverse transcriptases.
-
公开(公告)号：US10934366B2
公开(公告)日：2021-03-02
申请号：US15714736
申请日：2017-09-25
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： Jiali Liao , Tom Berkelman
Abstract: Methods and kits for purifying protein-nanoparticle conjugates are provided. In some embodiments, a multimodal medium having a size exclusion mode and a capture mode is used to purify the protein-nanoparticle conjugates.
-
公开(公告)号：US20210041432A1
公开(公告)日：2021-02-11
申请号：US16937908
申请日：2020-07-24
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Michael L. Samuels , Darren Roy Link
IPC: G01N33/543 , C40B40/04 , C40B70/00 , G01N33/532 , C40B40/00 , C12Q1/6874
Abstract: The invention generally relates to performing sandwich assays in droplets. In certain embodiments, the invention provides methods for detecting a target analyte that involve forming a compartmentalized portion of fluid including a portion of a sample suspected of containing a target analyte and a sample identifier, a first binding agent having a target identifier, and a second binding agent specific to the target analyte under conditions that produce a complex of the first and second binding agents with the target analyte, separating the complexes, and detecting the complexes, thereby detecting the target analyte.
-
公开(公告)号：US20210040382A1
公开(公告)日：2021-02-11
申请号：US16987441
申请日：2020-08-07
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： CHRISTOPHER BELISLE , PRAVEENA D. GARIMELLA , LEILA AMERY RANIS
IPC: C09K11/02 , C09K11/06 , G01N33/545
Abstract: Polymer dots comprising a functionalized fluorescent polymer and an amphiphilic molecule are provided.
-
Patent Agency Ranking
公开(公告)号：US20210039100A1
公开(公告)日：2021-02-11
申请号：US16532798
申请日：2019-08-06
Applicant: Bio-Rad Laboratories, Inc.
Abstract: A microfluidic device may be provided. The microfluidic device comprises a processing surface having an aperture. The microfluidic device comprises a liquid ejection channel. The liquid ejection channel guides to the aperture. The microfluidic device comprises a first liquid injection channel guiding to the liquid ejection channel. The first liquid injection channel has a first end and a second end and is arranged to provide a fluid flow from the first end to the second end. At least a portion of the first liquid injection channel is closer to the processing surface than (both) the first and second ends to sediment particles.
-
87.发明申请公开(公告)号：US20210039083A1
公开(公告)日：2021-02-11
申请号：US16532766
申请日：2019-08-06
Applicant: BIO-RAD LABORATORIES, INC.
IPC: B01L3/02 , B01L3/00 , G01N33/543
Abstract: A microfluidic probe head is provided. The microfluidic probe head comprises a processing surface. The processing surface has a first and second aperture and a fluid injection channel, which leads to the first aperture. The microfluidic probe head comprises also a first fluid aspiration channel which leads to the second aperture. Thereby, the second aperture forms a slot in the processing surface. Furthermore, a microfluidic probe may be provided comprising the microfluidic probe head.
-
公开(公告)号：US10914712B2
公开(公告)日：2021-02-09
申请号：US15123307
申请日：2015-03-03
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： James W. Xu
IPC: B01J20/04 , B01J20/282 , B01J20/30 , B01J20/28 , C01B25/32 , B01J20/281
Abstract: Highly spherical sorbents of porous hydroxyapatite materials and methods of producing these sorbents are disclosed. The sorbents of the present invention have good mechanical stability and are useful as chromatography media for the separation of biomolecules, such as proteins and nucleic acids.
-
公开(公告)号：US20210017504A1
公开(公告)日：2021-01-21
申请号：US16928915
申请日：2020-07-14
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Arkadiusz Bibillo , Pranav Patel
Abstract: Hybrid reverse transcriptases are provided that comprise a non-retroviral retrotransposon, or a fragment of the non-retroviral retrotransposon having reverse transcriptase activity, joined to a nucleic acid binding protein. Also provided are methods of using the hybrid reverse transcriptases to prepare a cDNA molecule library.
-
公开(公告)号：US20210002703A1
公开(公告)日：2021-01-07
申请号：US17020041
申请日：2020-09-14
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Darren Roy Link , Benjamin J. Miller
IPC: C12Q1/686
Abstract: The invention generally relates to detecting target molecules.
-
-
-
-
-
-
-
-
-
Search Results
1227
records
(took 0.027 seconds)
