公开(公告)号：US4377685A

公开(公告)日：1983-03-22

申请号：US177209

申请日：1980-08-11

申请人： Albert Bouniot ,  Robert Couraud ,  Guy Lartigau

发明人： Albert Bouniot ,  Robert Couraud ,  Guy Lartigau

IPC分类号： C11D1/66 ,  C07H13/06 ,  C07H13/02

CPC分类号： C07H13/06

摘要： A method of preparing sucroglycerides by transesterification of sucrose and a triglyceride, whereby there is conducted a limited alcoholysis of the triglyceride before reaction with the sucrose. The sucroglycerides obtained have interesting emulsifying properties and can be used to advantage in foodstuffs.

摘要翻译： 通过蔗糖和甘油三酯的酯交换制备甘油三酸酯的方法，由此在与蔗糖反应之前进行甘油三酸酯的有限醇解。 获得的甘油三酯具有有趣的乳化性能，可用于食品中。

公开(公告)号：US4107425A

公开(公告)日：1978-08-15

申请号：US768916

申请日：1977-02-15

申请人： Philip E. Pfeffer ,  Gordon G. Moore

发明人： Philip E. Pfeffer ,  Gordon G. Moore

IPC分类号： C07H13/02

CPC分类号： C07H13/02

摘要： Anomerically pure 1-.alpha.- and 1-.beta.-esters of 2,3,4,6-Tetra-O-benzyl-D-glucopyranose have been prepared in high yield by controlling the stereochemistry of 1-O-acylation of appropriately protected D-glucose. 2,3,4,6-tetra-O-benzyl-D-glucopyranose is metalated with n-butyllithium in either tetrahydrofuran or anhydrous benzene and the metalated product acylated with an appropriate alkyl, alkenyl, or aryl acid chloride. Hydrogenation of the acyl glucopyranose, when derived from a saturated acid chloride, yields the appropriate 1-.alpha.- or 1-.beta.-D-glucose ester. Reaction in tetrahydrofuran produces the .alpha.-anomer while reaction in anhydrous benzene produces the .beta.-anomer.

摘要翻译： 通过控制适当保护的D的1-O-酰化的立体化学，已经以高产率制备了2,3,4,6-四-O-苄基-D-吡喃葡萄糖的异构纯的1α-和1-β- -葡萄糖。 2,3,4,6-四-O-苄基-D-吡喃葡萄糖与正丁基锂在四氢呋喃或无水苯中金属化，金属化产物用合适的烷基，烯基或芳基酰氯酰化。 当衍生自饱和酰氯时，酰基吡喃葡萄糖的氢化产生合适的1-α-或1-β-D-葡萄糖酯。 在四氢呋喃中的反应产生α-异头物，而在无水苯中的反应产生β-丁内酯。

公开(公告)号：US3812109A

公开(公告)日：1974-05-21

申请号：US27390472

申请日：1972-07-21

申请人： MERCK & CO INC

发明人： SHEN T ,  JONES H

IPC分类号： C07H7/02 ,  A61K31/00 ,  A61K31/70 ,  A61K31/7024 ,  A61P29/00 ,  C07C63/00 ,  C07C67/10 ,  C07C69/76 ,  C07C313/00 ,  C07C317/00 ,  C07D521/00 ,  C07H13/02 ,  C07H13/04 ,  C07H13/08 ,  C07D7/14

CPC分类号： C07C317/00

摘要： NEW SUBSTITUTED INDENYL ESTER, ANHYDRIDES AND SALTS THEREOF, WHICH HAVE ANTI-INFLAMMATORY, ANTI-PYRETIC AND ANALGESIC ACTIVITY. ALSO INCLUDED HEREIN ARE METHODS OF PREPARING SAID INDENYL ESTERS AND ANHYDRRIDES PHARMACEUTICAL COMPOSITIONS HAVING SAID INDENYL ESTERS AND ANHYDRIDES AS AN ACTIVE INGREDIENT AND METHODS OF TREATING INFLAMMATION BY ADMINISTERING THESE PARTICULAR COMPOSITIONS TO PATIENTS.

公开(公告)号：US20210338849A1

公开(公告)日：2021-11-04

申请号：US17115344

申请日：2020-12-08

申请人： The General Hospital Corporation

发明人： David R. Elmaleh ,  Timothy M. Shoup ,  Hongning Fu

IPC分类号： A61K51/04 ,  C07D471/10 ,  C07H13/10 ,  C07H15/26 ,  C07C43/253 ,  C07H13/02 ,  C07C43/192 ,  C07C43/196

摘要： One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.

公开(公告)号：US10899782B2

公开(公告)日：2021-01-26

申请号：US16082848

申请日：2017-03-07

申请人： GLYCOM A/S

发明人： Martin Matwiejuk ,  Nikolay Khanzhin ,  Pierre Chassagne ,  Markus Jondelius Hederos

IPC分类号： C07H1/08 ,  C07H1/06 ,  B01D61/14 ,  C08B37/00 ,  B01D61/16 ,  C07H13/04 ,  A23L33/195 ,  B01D15/36 ,  C07H23/00 ,  C12P19/04 ,  C12P19/18 ,  B01D61/02 ,  B01D61/58 ,  C07H13/02

摘要： The present invention relates to a method for separating sialylated oligosaccharides from a fermentation broth in which they are produced by a genetically modified microorganism The separation comprises the steps of: i) ultrafiltration; ii) nano-filtration; iii) optionally, activated charcoal treatment; and iv) treatment with strong anion and/or cation exchange resin.

公开(公告)号：US09221898B2

公开(公告)日：2015-12-29

申请号：US13578445

申请日：2011-02-11

申请人： Christine Szymanski ,  Harald Nothaft

发明人： Christine Szymanski ,  Harald Nothaft

IPC分类号： C07G17/00 ,  A61K39/02 ,  C07K16/12 ,  C07H13/02 ,  C08B37/00 ,  G01N33/569

CPC分类号： C07K16/121 ,  A61K39/105 ,  C07H13/02 ,  C08B37/00 ,  G01N33/56922 ,  G01N2333/205

摘要： An isolated or purified compound is provided, comprising A-GlcNAc[GlcNAc]-GalNAc-GalNAc-QuiNAc4NAc, wherein A is GlcNAc or Glc. There is further provided a vaccine based on such compound, having particular use to treat or prevent an infection caused by a Campylobacter organism. There is also provided an antibody or antisera against the compound, having particular use to diagnose the presence of an infection caused by a Campylobacter organism.

摘要翻译： 提供了分离或纯化的化合物，其包含A-GlcNAc [GlcNAc] -GalNAc-GalNAc-QuiNAc4NAc，其中A是GlcNAc或Glc。 还提供了一种基于这种化合物的疫苗，其特别用于治疗或预防由弯曲杆菌生物引起的感染。 还提供了针对该化合物的抗体或抗血清，其特别用于诊断由弯曲杆菌生物引起的感染的存在。

公开(公告)号：US08551958B2

公开(公告)日：2013-10-08

申请号：US13015980

申请日：2011-01-28

申请人： Maria Grazia Rimoli ,  Antonio Calignano ,  Rosario Cuomo ,  Gianpiero Boatto ,  Enrico Abignente ,  Daniela Melisi ,  Annalisa Curcio ,  Elvira Luongo ,  Giovanna La Rana ,  Oscar Sasso ,  Giovanni Sarnelli ,  Roberto Russo ,  Maria Nieddu ,  Carla Cirillo ,  Salvatore De Lucia

发明人： Maria Grazia Rimoli ,  Antonio Calignano ,  Rosario Cuomo ,  Gianpiero Boatto ,  Enrico Abignente ,  Daniela Melisi ,  Annalisa Curcio ,  Elvira Luongo ,  Giovanna La Rana ,  Oscar Sasso ,  Giovanni Sarnelli ,  Roberto Russo ,  Maria Nieddu ,  Carla Cirillo ,  Salvatore De Lucia

IPC分类号： A61K31/7024 ,  C07H13/02 ,  C07H13/04 ,  C07H13/08 ,  C07H13/10

CPC分类号： A61K31/7024 ,  A61K47/549 ,  C07H13/02 ,  C07H13/04 ,  C07H13/08 ,  C07H13/10

摘要： Pro-drugs of all non-steroidal anti-inflammatories with free acid function derivatized with an ester group, which have the general structural formula given below (I) where A is: aspirin, diflunisal, benorylate, ibufenac, diclofenac, indomethacin, sulindac, ketorolac, ibuprofen, naproxen, ketoprofen, fenoprofen, flurbiprofen, mefenamic acid, meclof enamic acid, flufenamic acid, niflumic acid, and where in the ester group R can be a sugar (amongst which aldose, or ketose pentose, or esose selected from a group of D- and L-enantioiuers of ribose, glucose, galactose, mannose, arabinose, xilose, allose, altrose, gulose, idose and talose and substituted derivatives thereof, such as glucosamine, galactosamine, N-acetyl glucosamine, N-acetyl galactosamine, N-acetyl ribosamine), a disaccharide, a trisaccharide or an oligosaccharide.

摘要翻译： 所有具有由酯基衍生的游离酸功能的所有非甾体抗炎药的前药具有下面给出的一般结构式（I），其中A是：阿司匹林，二氟尼柳，苯磺酸盐，异丙酸，双氯芬酸，吲哚美辛，舒林酸， 酮咯酸，布洛芬，萘普生，酮洛芬，非诺洛芬，氟比洛芬，甲芬那酸，甲酰胺酸，氟芬那酸，尼氟酸，其中酯基R中的糖可以是糖（其中醛糖或酮糖戊糖或选自 核糖，葡萄糖，半乳糖，甘露糖，阿拉伯糖，半乳糖，阿洛糖，阿卓糖，古洛糖，阿糖和托洛糖及其取代衍生物的D-和L-对映体组如葡萄糖胺，半乳糖胺，N-乙酰葡糖胺，N-乙酰半乳糖胺 ，N-乙酰基核糖胺），二糖，三糖或寡糖。

公开(公告)号：US20110305730A1

公开(公告)日：2011-12-15

申请号：US13162335

申请日：2011-06-16

申请人： Lucas Alfonsus, T. Hilgers ,  Anneke Georgine Blom

发明人： Lucas Alfonsus, T. Hilgers ,  Anneke Georgine Blom

IPC分类号： A61K47/26 ,  C07C35/16 ,  C07H11/04 ,  C07H13/02 ,  C07H13/12

CPC分类号： C07H13/06 ,  A61K9/0019 ,  A61K39/39 ,  A61K47/26

摘要： The present invention relates to a novel family of monosaccharide derivatives and disaccharide derivatives and to a method of preparation thereof. A mono- and disaccharide derivatives according to the invention comprises at least one fatty acid ester and may further comprise one or more anionic groups and are useful for, inter alia, medical, pharmaceutical, cosmetic and food applications.

摘要翻译： 本发明涉及一种新型的单糖衍生物和二糖衍生物家族及其制备方法。 根据本发明的单糖和二糖衍生物包含至少一种脂肪酸酯，并且还可以包含一个或多个阴离子基团，并且尤其可用于医药，制药，化妆品和食品应用。

公开(公告)号：US20110144317A1

公开(公告)日：2011-06-16

申请号：US12922113

申请日：2009-03-12

申请人： Laurence Mulard ,  Isabelle Andre ,  Elise Champion ,  Claire Moulis ,  Sandrine Morel ,  Pierre Monsan ,  Magali Remaud-Simeon ,  Julien Boutet

发明人： Laurence Mulard ,  Isabelle Andre ,  Elise Champion ,  Claire Moulis ,  Sandrine Morel ,  Pierre Monsan ,  Magali Remaud-Simeon ,  Julien Boutet

IPC分类号： C12P19/12 ,  C12N9/10 ,  C12N9/24 ,  C07H21/00 ,  C12N15/63 ,  C12P19/26 ,  C07H15/04 ,  C07H13/02 ,  C07H9/04

CPC分类号： C12P19/16 ,  C12N9/1051 ,  C12N9/2402 ,  C12P19/18 ,  C12Y204/01004 ,  C12Y302/01048

摘要： Method for preparing the disaccharide [α-D-Gldp(1→3)]-α-L-Rhap-YR wherein Y is selected from —O— and —S— and R is selected from the group consisting of: C1-C6 alkyl, C1-C6 alkenyl, aryl, allyl, —CO-alkyl (C1-C6), —CO-alkenyl (C1-C6), —CO-aryl comprising the step of using a mutant of a wild type glycoside hydrolase.

摘要翻译： 制备二糖[α-D-Gldp（1→3）] -a-L-Rhap-YR的方法，其中Y选自-O-和-S-，R选自：C 1 -C 6 烷基，C 1 -C 6烯基，芳基，烯丙基，-CO-烷基（C 1 -C 6），-CO-烯基（C 1 -C 6），-CO-芳基，包括使用野生型糖苷水解酶突变体的步骤。

公开(公告)号：US07943761B2

公开(公告)日：2011-05-17

申请号：US11550796

申请日：2006-10-19

申请人： Chien-Tien Chen

发明人： Chien-Tien Chen

IPC分类号： C08B3/00 ,  C08B3/06 ,  C08B3/08 ,  C08B5/00 ,  C08B7/00 ,  C07H11/00 ,  C07H11/04 ,  C07H13/02 ,  C07H13/08 ,  C07H13/10

CPC分类号： C07H11/00 ,  C08B3/10 ,  C08B3/16 ,  C08B5/00 ,  C08L1/10 ,  C08L1/16

摘要： The present invention discloses a cellulose based optical film material with the following structure: wherein R1 is —H or —C(O)R4, R4 is alkyl or aryl; R2 is —C(O)R5, R5 is alkyl or aryl; R3 comprises one of the group consisting of: phosphinate based group, phosphonate based group, phosphonamide based group, phosphate based group, phosphoramide based group, carbamate based group, carbonate based group, and ester based group. Further, this invention also discloses a method for forming the cellulose based optical film material.

摘要翻译： 本发明公开了具有以下结构的纤维素基光学薄膜材料：其中R1是-H或-C（O）R4，R4是烷基或芳基; R2是-C（O）R5，R5是烷基或芳基; R3包括以下各项之一：次膦酸酯基，膦酸酯基，膦酰胺基，磷酸酯基，磷酰胺基，氨基甲酸酯基，碳酸酯基和酯基。 此外，本发明还公开了一种形成基于纤维素的光学薄膜材料的方法。