公开(公告)号：US09015087B2

公开(公告)日：2015-04-21

申请号：US13647422

申请日：2012-10-09

申请人： Kevin A. Li ,  Troy C. Meuninck ,  Robert Raymond Miller, II ,  James H. Pratt ,  Horst J. Schroeter ,  Behzad Shahraray

发明人： Kevin A. Li ,  Troy C. Meuninck ,  Robert Raymond Miller, II ,  James H. Pratt ,  Horst J. Schroeter ,  Behzad Shahraray

IPC分类号： G06N3/02 ,  G06F3/01

CPC分类号： G06N3/061 ,  G06F3/015

摘要： Methods, systems, and products provide interfaces between intrahost networks and interhost networks within biological hosts. Neuroregional translations are performed to route communications to and from the biological hosts. Bioregional translations may also be performed to route communications to and from the biological hosts.

摘要翻译： 方法，系统和产品提供了内部主机网络和生物主机内的主机间网络之间的接口。 执行神经学翻译以将生物宿主的通信路由到。 还可以进行生物学翻译以将生物宿主的通信路由到生物宿主。

公开(公告)号：US08712940B2

公开(公告)日：2014-04-29

申请号：US13149733

申请日：2011-05-31

申请人： Dharmendra S. Modha

发明人： Dharmendra S. Modha

IPC分类号： G06N5/00 ,  G06N3/063

CPC分类号： G06N3/04 ,  G06N3/049 ,  G06N3/061 ,  G06N3/063 ,  G06N3/0635 ,  G06N3/08 ,  G11C11/54 ,  Y10T428/2481

摘要： A neural system comprises multiple neurons interconnected via synapse devices. Each neuron integrates input signals arriving on its dendrite, generates a spike in response to the integrated input signals exceeding a threshold, and sends the spike to the interconnected neurons via its axon. The system further includes multiple noruens, each noruen is interconnected via the interconnect network with those neurons that the noruen's corresponding neuron sends its axon to. Each noruen integrates input spikes from connected spiking neurons and generates a spike in response to the integrated input spikes exceeding a threshold. There can be one noruen for every corresponding neuron. For a first neuron connected via its axon via a synapse to dendrite of a second neuron, a noruen corresponding to the second neuron is connected via its axon through the same synapse to dendrite of the noruen corresponding to the first neuron.

摘要翻译： 神经系统包括通过突触装置相互连接的多个神经元。 每个神经元将输入信号整合到其树突上，响应于超过阈值的积分输入信号产生尖峰，并通过其轴突将尖峰发送到相互连接的神经元。 该系统还包括多个诺基因，每个诺纶通过互连网络与诺基因对应的神经元发送其轴突的那些神经元相互连接。 每个noruen集成了来自连接的尖峰神经元的输入尖峰，并响应超过阈值的积分输入尖峰产生尖峰。 每个相应的神经元可以有一个noruen。 对于通过其轴突通过突触连接到第二神经元的树突的第一神经元，通过其轴突将对应于第二神经元的诺华通过相同的突触连接到对应于第一神经元的诺华诺的树突。

公开(公告)号：US20140101084A1

公开(公告)日：2014-04-10

申请号：US13647422

申请日：2012-10-09

申请人： AT&T INTELLECTUAL PROPERTY I, L.P.

发明人： Kevin A. Li ,  Troy C. Meuninck ,  Robert Raymond Miller, II ,  James H. Pratt ,  Horst J. Schroeter ,  Behzad Shahraray

IPC分类号： G06N3/02

CPC分类号： G06N3/061 ,  G06F3/015

摘要： Methods, systems, and products provide interfaces between intrahost networks and interhost networks within biological hosts. Neuroregional translations are performed to route communications to and from the biological hosts. Bioregional translations may also be performed to route communications to and from the biological hosts.

摘要翻译： 方法，系统和产品提供了内部主机网络和生物主机内的主机间网络之间的接口。 执行神经学翻译以将生物宿主的通信路由到。 还可以进行生物学翻译以将生物宿主的通信路由到生物宿主。

公开(公告)号：US20140081893A1

公开(公告)日：2014-03-20

申请号：US13149733

申请日：2011-05-31

申请人： Dharmendra S. Modha

发明人： Dharmendra S. Modha

IPC分类号： G06N3/06

CPC分类号： G06N3/04 ,  G06N3/049 ,  G06N3/061 ,  G06N3/063 ,  G06N3/0635 ,  G06N3/08 ,  G11C11/54 ,  Y10T428/2481

摘要： A neural system comprises multiple neurons interconnected via synapse devices. Each neuron integrates input signals arriving on its dendrite, generates a spike in response to the integrated input signals exceeding a threshold, and sends the spike to the interconnected neurons via its axon. The system further includes multiple noruens, each noruen is interconnected via the interconnect network with those neurons that the noruen's corresponding neuron sends its axon to. Each noruen integrates input spikes from connected spiking neurons and generates a spike in response to the integrated input spikes exceeding a threshold. There can be one noruen for every corresponding neuron. For a first neuron connected via its axon via a synapse to dendrite of a second neuron, a noruen corresponding to the second neuron is connected via its axon through the same synapse to dendrite of the noruen corresponding to the first neuron.

公开(公告)号：US20130282633A1

公开(公告)日：2013-10-24

申请号：US13915303

申请日：2013-06-11

申请人： Neuric Technologies, LLC

发明人： JENNIFER SEALE ,  HANNAH LINDSLEY ,  TIMOTHY ALLEN MARGHEIM

IPC分类号： G06N3/06

CPC分类号： G06N3/061 ,  G06N3/08 ,  G06N3/10

摘要： A method for defining a network of nodes is provided, each representing a unique concept, and making connections between individual concepts through unique relationships to other concepts. Each of the nodes is operable to store a unique identifier in the network and information regarding the concept in addition to the unique relationships.

摘要翻译： 提供了一种用于定义节点网络的方法，每个节点都代表一个独特的概念，并通过与其他概念的独特关系，在各个概念之间进行连接。 每个节点可操作以在网络中存储唯一的标识符，以及除了独特关系之外关于概念的信息。

公开(公告)号：US07826894B2

公开(公告)日：2010-11-02

申请号：US11086534

申请日：2005-03-22

申请人： Sam Musallam ,  Richard A. Andersen ,  Brian D. Corneil ,  Bradley Greger ,  Hansjorg Scherberger

发明人： Sam Musallam ,  Richard A. Andersen ,  Brian D. Corneil ,  Bradley Greger ,  Hansjorg Scherberger

IPC分类号： A61B5/04

CPC分类号： G06F3/015 ,  A61F2/68 ,  A61F2002/704 ,  G06N3/061

摘要： In an embodiment, the invention relates to neural prosthetic devices in which control signals are based on the cognitive activity of the prosthetic user. The control signals may be used to control an array of external devices, such as prosthetics, computer systems, and speech synthesizers. Data obtained from monkeys' movement intentions were recorded, decoded with a computer algorithm, and used to position cursors on a computer screen. Not only the intended goals, but also the value of the reward the animals expected to receive at the end of each trial, were decoded from the recordings. The results indicate that brain activity related to cognitive variables can be a viable source of signals for the control of a cognitive-based neural prosthetic.

摘要翻译： 在一个实施例中，本发明涉及神经修复装置，其中控制信号基于假肢使用者的认知活动。 控制信号可用于控制诸如假肢，计算机系统和语音合成器之类的外部设备阵列。 记录从猴子运动意图获得的数据，用计算机算法解码，并用于将光标定位在计算机屏幕上。 不仅预期的目标，而且每个试验结束时期望收到的动物的奖励价值都从录音中解码出来。 结果表明，与认知变量相关的脑活动可以成为用于控制基于认知的神经假体的信号的可行来源。

公开(公告)号：US07809432B2

公开(公告)日：2010-10-05

申请号：US10964560

申请日：2004-10-12

申请人： Bjorn-Oliver Eversmann ,  Martin Jenkner ,  Christian Paulus ,  Roland Thewes

发明人： Bjorn-Oliver Eversmann ,  Martin Jenkner ,  Christian Paulus ,  Roland Thewes

IPC分类号： A61B5/00

CPC分类号： A61B5/7264 ,  A61B5/04001 ,  A61B5/7203 ,  A61B5/7232 ,  A61B5/7282 ,  A61B2562/0209 ,  A61B2562/046 ,  G06N3/061

摘要： Apparatus for measuring neural network activity with a textured semiconductor substrate. Sensor elements have a respective detection electrode on the substrate surface for detecting neural network signals, and the detected neural signals are a basis for outputting electrical sensor output signals via respective sensor element outputs. Each amplifier element has an input and an output. Each of the sensor elements has associated therewith one of the amplifier elements whose input is connected to the sensor output of the respective sensor element. The amplified sensor output signal is output the amplifier output as an amplifier output signal. An activity evaluator has an input, which is connected to at least one of the amplifier outputs, and an output. The activity evaluation device produces an activity signal, which is a measure of activity of the neural network, based on the amplifier output signal, and outputs the amplifier output signal via the evaluation output.

摘要翻译： 用纹理化半导体衬底测量神经网络活动的装置。 传感器元件在基板表面上具有检测电极，用于检测神经网络信号，检测到的神经信号是经由各个传感器元件输出输出电传感器输出信号的基础。 每个放大器元件都有一个输入和一个输出。 每个传感器元件都具有一个放大器元件，其输入端连接到相应传感器元件的传感器输出端。 放大的传感器输出信号作为放大器输出信号输出放大器输出。 活动评估器具有连接到至少一个放大器输出的输入和输出。 活动评估装置基于放大器输出信号产生作为神经网络的活动度量的活动信号，并通过评估输出输出放大器输出信号。

公开(公告)号：US20080058223A1

公开(公告)日：2008-03-06

申请号：US11846810

申请日：2007-08-29

申请人： Wu Ma ,  Jinny Liu ,  Thomas O'Shaughnessy

发明人： Wu Ma ,  Jinny Liu ,  Thomas O'Shaughnessy

IPC分类号： C40B50/06

CPC分类号： C40B50/06 ,  C12N5/0623 ,  C12N2501/115 ,  C12N2501/13 ,  C12N2531/00 ,  C12N2533/32 ,  C12N2533/52 ,  G01N33/5058 ,  G06N3/061

摘要： This invention comprises a method for generating functional neural networks using neural progenitor cells on microelectrode arrays (MEAs). The method involves dissociating neural progenitor cells from an embryo, propagating the neural progenitor cells, passaging the neural progenitor cells and seeding the neural progenitor cells on MEAs to produce a functional neural network. The neural progenitor cells may be continuously passaged to propagate an endless supply of neural progenitor cells. The resultant passaged progenitor cell derived neural network MEA may be used to detect and/or quantify various biological or chemical toxins.

摘要翻译： 本发明包括使用微电极阵列（MEA）上的神经祖细胞产生功能性神经网络的方法。 该方法包括从胚胎中分离神经祖细胞，传播神经祖细胞，传代神经祖细胞并将神经祖细胞接种在MEA上以产生功能性神经网络。 可以连续传代神经祖细胞以传播无限供应的神经祖细胞。 所得到的传代祖细胞衍生的神经网络MEA可用于检测和/或定量各种生物或化学毒素。

公开(公告)号：US20070016151A1

公开(公告)日：2007-01-18

申请号：US11485742

申请日：2006-07-13

申请人： Guillaume Mernier ,  Carmen Bartic

发明人： Guillaume Mernier ,  Carmen Bartic

IPC分类号： A61M37/00

CPC分类号： A61M5/14276 ,  A61M2205/0244 ,  A61M2210/0693 ,  B82Y30/00 ,  G06N3/061

摘要： The present invention provides a system for the release of neurotransmitters and a method for the manufacturing of such a system. The system according to the present invention allows for local release of neurotransmitters and therefore makes it possible to activate single neurons. Furthermore, the system according to the invention is efficient, reproducible, and has a low power supply.

摘要翻译： 本发明提供了用于释放神经递质的系统和用于制造这种系统的方法。 根据本发明的系统允许神经递质的局部释放，因此使得可以激活单个神经元。 此外，根据本发明的系统是高效的，可再现的并且具有低电源。

公开(公告)号：US07147865B2

公开(公告)日：2006-12-12

申请号：US10713565

申请日：2003-11-13

申请人： Harvey A. Fishman ,  David Bloom ,  Stacey F. Bent ,  Mark C. Peterman ,  Jaan Noolandi ,  Neville Mehenti

发明人： Harvey A. Fishman ,  David Bloom ,  Stacey F. Bent ,  Mark C. Peterman ,  Jaan Noolandi ,  Neville Mehenti

IPC分类号： A61F2/14

CPC分类号： G06N3/061 ,  A61N1/0543 ,  A61N1/30 ,  A61N1/326 ,  A61N1/36046 ,  C12N5/0619 ,  C12N2503/00 ,  C12N2535/10

摘要： Devices and methods are provided for administering a fluid to a neuronal site. The device comprises a reservoir, an aperture in fluid connection to the reservoir, and electrical means for moving to the fluid to or through the aperture. The electrical means may take the form of electroosmotic force, piezoelectric movement of a diaphragm or electrolysis of a solution. The electrical means may be external to the host, implanted in the host or may be photodiodes activated by light, particularly where the neuronal site is associated with the retina.

摘要翻译： 提供了用于向神经元部位施用流体的装置和方法。 该装置包括储存器，与储存器流体连接的孔，以及用于将流体移动到或穿过孔的电气装置。 电气装置可以采取电渗力的形式，隔膜的压电运动或溶液的电解。 电气装置可以在宿主外部，植入宿主中，或者可以是由光激活的光电二极管，特别是在神经元部位与视网膜相关联的地方。