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1.发明授权Optically interrogated solid state biosensors incorporating porous materials—devices 有权光纤询问的固态生物传感器包含多孔材料 - 器件公开(公告)号：US08263986B2
公开(公告)日：2012-09-11
申请号：US12827216
申请日：2010-06-30
IPC分类号： H01L31/0232
CPC分类号： B82Y15/00 , G01N21/7703
摘要： Quantitative understanding of neural and biological activity at a sub-millimeter scale requires an integrated probe platform that combines biomarker sensors together with electrical stimulus/recording sites. Optically addressed biomarker sensors within such an integrated probe platform allows remote interrogation from the activity being measured. Monolithic or hybrid integrated silicon probe platforms would beneficially allow for accurate control of neural prosthetics, brain machine interfaces, etc as well as helping with complex brain diseases and disorders. According to the invention a silicon probe platform is provided employing ultra-thin silicon in conjunction with optical waveguides, optoelectronic interfaces, porous filter elements, and integrated CMOS circuitry. Such probes allowing simultaneously analysis of both neural electrical activities along with chemical activity derived from multiple biomolecular sensors with porous membrane filters. Such porous silicon and polymer filters providing biomolecular filtering and optical filtering being compatible with post-processing wafers with integrated CMOS electronics.
摘要翻译： 对亚毫米级的神经和生物活性的定量了解需要一个集生物标记物传感器与电刺激/记录位点结合在一起的综合探针平台。 在这样的集成探头平台内的光学寻踪生物标志物传感器允许远程询问从被测量的活动。 单片或混合集成硅探针平台将有益地允许精确控制神经假体，脑机接口等，以及帮助复杂的脑疾病和障碍。 根据本发明，提供了采用超薄硅结合光波导，光电接口，多孔滤波器元件和集成CMOS电路的硅探针平台。 这样的探针允许同时分析神经电活动以及多孔膜过滤器从多个生物分子传感器衍生的化学活性。 这种多孔硅和聚合物过滤器提供生物分子过滤和光学过滤，与具有集成CMOS电子器件的后处理晶片兼容。
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公开(公告)号：US20050228515A1
公开(公告)日：2005-10-13
申请号：US11086534
申请日：2005-03-22
CPC分类号： G06F3/015 , A61F2/68 , A61F2002/704 , G06N3/061
摘要： In an embodiment, the invention relates to neural prosthetic devices in which control signals are based on the cognitive activity of the prosthetic user. The control signals may be used to control an array of external devices, such as prosthetics, computer systems, and speech synthesizers. Data obtained from monkeys' movement intentions were recorded, decoded with a computer algorithm, and used to position cursors on a computer screen. Not only the intended goals, but also the value of the reward the animals expected to receive at the end of each trial, were decoded from the recordings. The results indicate that brain activity related to cognitive variables can be a viable source of signals for the control of a cognitive-based neural prosthetic.
摘要翻译： 在一个实施例中，本发明涉及神经修复装置，其中控制信号基于假肢使用者的认知活动。 控制信号可用于控制诸如假肢，计算机系统和语音合成器之类的外部设备阵列。 记录从猴子运动意图获得的数据，用计算机算法解码，并用于将光标定位在计算机屏幕上。 不仅预期的目标，而且每个试验结束时期望收到的动物的奖励价值都从录音中解码出来。 结果表明，与认知变量相关的脑活动可以成为用于控制基于认知的神经假体的信号的可行来源。
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公开(公告)号：US07826894B2
公开(公告)日：2010-11-02
申请号：US11086534
申请日：2005-03-22
IPC分类号： A61B5/04
CPC分类号： G06F3/015 , A61F2/68 , A61F2002/704 , G06N3/061
摘要： In an embodiment, the invention relates to neural prosthetic devices in which control signals are based on the cognitive activity of the prosthetic user. The control signals may be used to control an array of external devices, such as prosthetics, computer systems, and speech synthesizers. Data obtained from monkeys' movement intentions were recorded, decoded with a computer algorithm, and used to position cursors on a computer screen. Not only the intended goals, but also the value of the reward the animals expected to receive at the end of each trial, were decoded from the recordings. The results indicate that brain activity related to cognitive variables can be a viable source of signals for the control of a cognitive-based neural prosthetic.
摘要翻译： 在一个实施例中，本发明涉及神经修复装置，其中控制信号基于假肢使用者的认知活动。 控制信号可用于控制诸如假肢，计算机系统和语音合成器之类的外部设备阵列。 记录从猴子运动意图获得的数据，用计算机算法解码，并用于将光标定位在计算机屏幕上。 不仅预期的目标，而且每个试验结束时期望收到的动物的奖励价值都从录音中解码出来。 结果表明，与认知变量相关的脑活动可以成为用于控制基于认知的神经假体的信号的可行来源。
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4.发明申请Optically Interrogated Solid State Biosensors Incorporating Porous Materials - Devices and Methods of Fabrication 有权结合多孔材料的光学询问固体生物传感器 - 器件和制造方法公开(公告)号：US20110024771A1
公开(公告)日：2011-02-03
申请号：US12827216
申请日：2010-06-30
IPC分类号： H01L31/0232 , H01L21/02 , H01L21/306
CPC分类号： B82Y15/00 , G01N21/7703
摘要： Quantitative understanding of neural and biological activity at a sub-millimeter scale requires an integrated probe platform that combines biomarker sensors together with electrical stimulus/recording sites. Optically addressed biomarker sensors within such an integrated probe platform allows remote interrogation from the activity being measured. Monolithic or hybrid integrated silicon probe platforms would beneficially allow for accurate control of neural prosthetics, brain machine interfaces, etc as well as helping with complex brain diseases and disorders. According to the invention a silicon probe platform is provided employing ultra-thin silicon in conjunction with optical waveguides, optoelectronic interfaces, porous filter elements, and integrated CMOS circuitry. Such probes allowing simultaneously analysis of both neural electrical activities along with chemical activity derived from multiple biomolecular sensors with porous membrane filters. Such porous silicon and polymer filters providing biomolecular filtering and optical filtering being compatible with post-processing wafers with integrated CMOS electronics.
摘要翻译： 对亚毫米级的神经和生物活性的定量了解需要一个集生物标记物传感器与电刺激/记录位点结合在一起的综合探针平台。 在这样的集成探头平台内的光学寻踪生物标志物传感器允许远程询问从被测量的活动。 单片或混合集成硅探针平台将有益地允许精确控制神经假体，脑机接口等，以及帮助复杂的脑疾病和障碍。 根据本发明，提供了采用超薄硅结合光波导，光电接口，多孔滤波器元件和集成CMOS电路的硅探针平台。 这样的探针允许同时分析神经电活动以及多孔膜过滤器从多个生物分子传感器衍生的化学活性。 这种多孔硅和聚合物过滤器提供生物分子过滤和光学过滤，与具有集成CMOS电子器件的后处理晶片兼容。
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