公开(公告)号：US07090661B2

公开(公告)日：2006-08-15

申请号：US11017622

申请日：2004-12-20

申请人： Mary M. Morris ,  Duane Gerald Frion ,  Jeff Novotny ,  Douglas Hankner ,  Stuart Lahtinen

发明人： Mary M. Morris ,  Duane Gerald Frion ,  Jeff Novotny ,  Douglas Hankner ,  Stuart Lahtinen

IPC分类号： A61M5/32

CPC分类号： A61M25/02 ,  A61M5/1418 ,  A61M5/14276 ,  A61M2005/1416 ,  A61M2025/0213 ,  A61M2025/024 ,  A61M2025/028 ,  A61M2025/0286 ,  A61M2039/025 ,  A61M2210/0687 ,  A61M2210/0693

摘要： A catheter system and method for intracranial infusion of therapeutic substances to a patient. An anchor formed of generally flexible, elastomeric material is used to mount the catheter to the outer surface of the skull of the patient. The anchor has a through hole for receiving the catheter, a channel, extending substantially from the through hole, into which a portion of the catheter may be inserted to retain the portion substantially parallel to the surface of the skull, and at least one flange for engaging the outer surface of the skull. An anchor clip may be provided to engage the anchor adjacent the through hole to further stabilize the catheter.

公开(公告)号：US07063691B2

公开(公告)日：2006-06-20

申请号：US10801299

申请日：2004-03-16

申请人： Randall S. Nelson ,  Charles L. Truwit

发明人： Randall S. Nelson ,  Charles L. Truwit

IPC分类号： A61M9/22

CPC分类号： A61M5/14276 ,  A61M5/14236 ,  A61M5/14586 ,  A61M5/148 ,  A61M5/16881 ,  A61M5/1723 ,  A61M2205/3507 ,  A61M2205/3523 ,  A61M2210/0687 ,  A61M2210/0693

摘要： There is disclosed method and apparatus for retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject, including providing a deformable pouch or rigid cylinder for dispensing the therapeutic agent from the reservoir to a location in the body of the subject. In one embodiment, a pump is used to pump the agent from the reservoir to the location in the subject's body. In another example embodiment, there is provided method and apparatus for forming at least one cavity in the cranium of the subject, and placing at least a portion of the pump in the cavity. Power is applied to the pump in a variety of ways.

摘要翻译： 公开了一种用于在受试者的头皮和头颅之间保留用于治疗剂的贮存器的方法和装置，包括提供可变形袋或刚性圆柱体，用于将治疗剂从储存器分配到受试者体内的位置。 在一个实施例中，泵用于将药剂从储存器泵送到受检者体内的位置。 在另一个示例性实施例中，提供了用于在受试者的头颅中形成至少一个空腔并将泵的至少一部分放置在空腔中的方法和装置。 以各种方式对泵施加功率。

公开(公告)号：US20050080457A1

公开(公告)日：2005-04-14

申请号：US10938959

申请日：2004-09-10

申请人： Bradley Greger ,  Babak Kateb

发明人： Bradley Greger ,  Babak Kateb

IPC分类号： A61B5/04 ,  A61K9/22 ,  A61M5/142 ,  A61M5/145 ,  A61N1/05 ,  A61N1/00

CPC分类号： A61B5/4839 ,  A61B5/04001 ,  A61B5/4041 ,  A61M5/14276 ,  A61M2005/14513 ,  A61M2210/0687 ,  A61N1/05

摘要： An apparatus for simultaneously measuring electrophysiological signals in a target tissue and for infusing an agent into the target tissue comprises a body, a cannula mounted on the body, and at least one electrophysiological electrode in proximity to the cannula and mounted on the body so that the agent supplied to the cannula is provided to the proximity of the target tissue with which the at least one electrophysiological electrode is electrically coupled. The cannula and electrode are arranged and configured with respect to each in a selected configuration to allow the apparatus to be customized for optimal implantation in specific neurological sites.

摘要翻译： 用于同时测量目标组织中的电生理信号并将试剂注入靶组织的装置包括：身体，安装在身体上的套管，以及靠近插管的至少一个电生理电极，并安装在身体上， 提供给套管的药剂提供给目标组织的附近，所述至少一个电生理电极与该组织电耦合。 套管和电极相对于每一个以所选择的构型布置和配置，以允许该装置被定制以在特定神经系统部位中进行最佳植入。

公开(公告)号：US20040176750A1

公开(公告)日：2004-09-09

申请号：US10801299

申请日：2004-03-16

申请人： iSurgical, LLC and Regents of the University of Minnesota

发明人： Randall S. Nelson ,  Charles L. Truwit

IPC分类号： A61K009/22

CPC分类号： A61M5/14276 ,  A61M5/14236 ,  A61M5/14586 ,  A61M5/148 ,  A61M5/16881 ,  A61M5/1723 ,  A61M2205/3507 ,  A61M2205/3523 ,  A61M2210/0687 ,  A61M2210/0693

摘要： There is disclosed method and apparatus for retaining a reservoir for a therapeutic agent between the scalp and cranium of a subject, including providing a deformable pouch or rigid cylinder for dispensing the therapeutic agent from the reservoir to a location in the body of the subject. In one embodiment, a pump is used to pump the agent from the reservoir to the location in the subject's body. In another example embodiment, there is provided method and apparatus for forming at least one cavity in the cranium of the subject, and placing at least a portion of the pump in the cavity. Power is applied to the pump in a variety of ways.

公开(公告)号：US5788713A

公开(公告)日：1998-08-04

申请号：US918680

申请日：1997-08-21

申请人： Mark Dubach ,  Yves Nlevergelt

发明人： Mark Dubach ,  Yves Nlevergelt

IPC分类号： A61B17/34 ,  A61B19/00 ,  A61M5/00 ,  A61M25/00 ,  A61M25/01 ,  A61M25/02 ,  A61M25/088 ,  A61M25/09

CPC分类号： A61B17/3421 ,  A61B90/10 ,  A61M25/0041 ,  A61M25/0105 ,  A61M25/02 ,  A61B2017/003 ,  A61B2017/00331 ,  A61M2025/028 ,  A61M2210/0687 ,  A61M2210/0693

摘要： A device for the percutaneous localization of a foreign object in a body has a base collar mount and one or more movable collar mounts all located on at least one perpendicular guide rail. The base collar mount has a guide-tube cannula affixed to it. A series of tubings and wire lengths extend through the guide-tube cannula as the movable collar mounts are advanced. As the tubings and wire are exposed from the guide-tube cannula, they assume their native curvature thus forming a compound trajectory for the insertion of a foreign object in a body.

摘要翻译： 用于体外异物经皮定位的装置具有底座套环和一个或多个位于至少一个垂直导轨上的可移动套环安装件。 基座安装座有一个固定在其上的导管套管。 当可移动轴环安装座前进时，一系列管道和线材长度延伸穿过导管插管。 当管和导线从导管插管暴露时，它们假设它们的天然曲率，从而形成用于将异物插入体内的复合轨迹。

公开(公告)号：US5611767A

公开(公告)日：1997-03-18

申请号：US307165

申请日：1994-09-16

申请人： Jeffery A. Williams

发明人： Jeffery A. Williams

IPC分类号： A61F7/12 ,  A61B17/00 ,  A61F2/958 ,  A61M1/00 ,  A61M5/42 ,  A61M27/00 ,  A61M36/00 ,  A61M36/06 ,  A61M37/00 ,  A61M39/02 ,  A61N1/40 ,  A61N5/00 ,  A61N5/10 ,  A61N7/02 ,  A61N5/02

CPC分类号： A61M25/1011 ,  A61M39/0208 ,  A61N1/40 ,  A61N1/403 ,  A61N5/1015 ,  A61N7/02 ,  A61B2017/00084 ,  A61M2025/1013 ,  A61M2039/0211 ,  A61M2205/32 ,  A61M2210/0687 ,  A61M2210/0693 ,  A61M27/006 ,  A61M39/0247 ,  A61M5/427 ,  A61N2005/1021 ,  A61N5/1014

摘要： Methods and apparatus are provided for radiation treatment of a tumor using an inflatable treatment device placed in an incision adjacent the tumor. The inflatable device is filled with a radioactive treatment fluid.

摘要翻译： 提供了使用放置在与肿瘤相邻的切口中的可充气治疗装置对肿瘤进行放射治疗的方法和装置。 充气装置充满放射性处理液。

公开(公告)号：US5554148A

公开(公告)日：1996-09-10

申请号：US453571

申请日：1995-05-26

申请人： Patrick Aebischer ,  Paul C. DiCesare ,  Moses Goddard ,  Paul J. Mulhauser

发明人： Patrick Aebischer ,  Paul C. DiCesare ,  Moses Goddard ,  Paul J. Mulhauser

IPC分类号： A61F2/02 ,  A61K9/00 ,  A61K9/22 ,  A61K35/12 ,  A61K35/30 ,  A61M31/00 ,  B01J13/02 ,  C12N5/00 ,  C12N5/071 ,  C12N5/0793 ,  C12N11/04

CPC分类号： A61K9/0092 ,  A61F2/022 ,  A61K35/12 ,  A61K35/30 ,  A61K38/1825 ,  A61K9/0024 ,  A61K9/0085 ,  A61M31/002 ,  B01J13/02 ,  C12N11/04 ,  C12N5/0012 ,  C12N5/0614 ,  C12N5/0619 ,  C12N5/0676 ,  A61K2035/126 ,  A61M2210/0687 ,  A61M2210/0693 ,  C12N2533/30

摘要： Refillable immunoisolatory neurological therapy devices for local and controlled delivery of a biologically active factor to the brain of a patient. The devices include a cell chamber adapted for infusion with nsecretory cells and having at least one semipermeable or permselective surface across which biologically active factors secreted by the cells can be delivered to the brain. The devices also include means for introducing secretory cells into the cell chamber, and means for renewing the cells or cell medium.

摘要翻译： 用于局部和控制地将生物活性因子递送到患者脑部的可补充的免疫隔离神经治疗装置。 所述装置包括适于与分泌细胞一起输注并具有至少一个半透性或选择性选择性表面的细胞室，细胞分泌的生物活性因子可以被输送到脑。 所述装置还包括用于将分泌细胞引入细胞室的装置和用于更新细胞或细胞培养基的装置。

公开(公告)号：US5389535A

公开(公告)日：1995-02-14

申请号：US169169

申请日：1993-12-17

申请人： Patrick Aebischer ,  Lars Wahlberg

发明人： Patrick Aebischer ,  Lars Wahlberg

IPC分类号： A61F2/02 ,  A61K9/00 ,  A61K9/48 ,  A61K35/12 ,  A61M31/00 ,  B01J13/02 ,  B01J13/04 ,  C12N5/00 ,  C12N5/071 ,  C12N5/0793 ,  C12N11/04 ,  C12N11/08 ,  C12M1/40

CPC分类号： A61K9/0092 ,  A61F2/022 ,  A61K35/12 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/4816 ,  A61K9/4833 ,  A61M31/002 ,  B01J13/02 ,  B01J13/04 ,  C12N11/04 ,  C12N11/08 ,  C12N5/0012 ,  C12N5/0614 ,  C12N5/0619 ,  A61K2035/126 ,  A61K2035/128 ,  A61M2210/0687 ,  A61M2210/0693 ,  C12N2533/30

摘要： Methods and systems are disclosed for encapsulating viable cells which produce biologically-active factors. The cells are encapsulated within a semipermeable, polymeric membrane by co-extruding an aqueous cell suspension and a polymeric solution through a common port to form a tubular extrudate having a polymeric outer coating which encapsulates the cell suspension. For example, the cell suspension and the polymeric solution can be extruded through a common extrusion port having at least two concentric bores, such that the cell suspension is extruded through the inner bore and the polymeric solution is extruded through the outer bore. The polymeric solution coagulates to form an outer coating. As the outer coating is formed, the ends of the tubular extrudate can be sealed to form a cell capsule. In one embodiment, the tubular extrudate is sealed at intervals to define separate cell compartments connected by polymeric links.

摘要翻译： 公开了用于包封产生生物活性因子的活细胞的方法和系统。 通过将水性细胞悬浮液和聚合物溶液共挤出通过共同的口以形成具有封装细胞悬浮液的聚合物外涂层的管状挤出物，将细胞包封在半透膜聚合物膜内。 例如，细胞悬浮液和聚合物溶液可以通过具有至少两个同心孔的共同挤出口挤出，使得细胞悬浮液通过内孔挤出并且聚合物溶液通过外孔挤出。 聚合物溶液凝结形成外涂层。 当形成外涂层时，管状挤出物的端部可被密封以形成电池盒。 在一个实施方案中，管状挤出物间隔密封以限定通过聚合物连接物连接的分离的细胞室。

公开(公告)号：US5158881A

公开(公告)日：1992-10-27

申请号：US461999

申请日：1990-01-08

申请人： Patrick Aebischer ,  Lars Wahlberg

发明人： Patrick Aebischer ,  Lars Wahlberg

IPC分类号： A61J3/07 ,  A61F2/02 ,  A61K9/00 ,  A61K9/48 ,  A61K9/50 ,  A61K35/12 ,  A61K35/13 ,  A61M31/00 ,  B01J13/02 ,  B01J13/04 ,  C12N5/00 ,  C12N5/071 ,  C12N5/0793 ,  C12N11/04 ,  C12N11/08

CPC分类号： A61K9/0024 ,  A61F2/022 ,  A61K35/13 ,  A61K9/0085 ,  A61K9/0092 ,  A61K9/4816 ,  A61K9/4833 ,  A61M31/002 ,  B01J13/02 ,  B01J13/04 ,  C12N11/04 ,  C12N11/08 ,  C12N5/0012 ,  C12N5/0614 ,  C12N5/0619 ,  A61M2210/0687 ,  A61M2210/0693 ,  C12N2533/30

摘要： Methods and systems are disclosed for encapsulating viable cells which produce biologically-active factors. The cells are encapsulated within a semipermeable, polymeric membrane by co-extruding an aqueous cell suspension and a polymeric solution through a common port to form a tubular extrudate having a polymeric outer coating which encapsulates the cell suspension. For example, the cell suspension and the polymeric solution can be extruded through a common extrusion port having at least two concentric bores, such that the cell suspension is extruded through the inner bore and the polymeric solution is extruded through the outer bore. The polymeric solution coagulates to form an outer coating. As the outer coating is formed, the ends of the tubular extrudate can be sealed to form a cell capsule. In one embodiment, the tubular extrudate is sealed at intervals to define separate cell compartments connected by polymeric links.

摘要翻译： 公开了用于包封产生生物活性因子的活细胞的方法和系统。 通过将水性细胞悬浮液和聚合物溶液共挤出通过共同的口以形成具有封装细胞悬浮液的聚合物外涂层的管状挤出物，将细胞包封在半透膜聚合物膜内。 例如，细胞悬浮液和聚合物溶液可以通过具有至少两个同心孔的共同挤出口挤出，使得细胞悬浮液通过内孔挤出并且聚合物溶液通过外孔挤出。 聚合物溶液凝结形成外涂层。 当形成外涂层时，管状挤出物的端部可被密封以形成电池盒。 在一个实施方案中，管状挤出物间隔密封以限定通过聚合物连接物连接的分离的细胞室。

公开(公告)号：US11850390B2

公开(公告)日：2023-12-26

申请号：US17317027

申请日：2021-05-11

申请人： CEREVASC, INC.

发明人： Adel M. Malek ,  Carl B. Heilman ,  David A. Rezac ,  Jack B. Sattell ,  Alexander Bonin

IPC分类号： A61M39/02 ,  A61M25/00 ,  A61B34/10 ,  A61B90/00

CPC分类号： A61M39/0208 ,  A61M25/00 ,  A61M39/0247 ,  A61B2034/105 ,  A61B2034/107 ,  A61B2090/365 ,  A61M2039/0223 ,  A61M2039/0232 ,  A61M2039/0238 ,  A61M2205/32 ,  A61M2210/0687

摘要： Endovascular drug delivery systems and methods are disclosed herein for delivering a therapeutic agent to the intracranial subarachnoid space of a patient, and/or deploying an endovascular drug delivery device distal portion in the intracranial subarachnoid space and a portion of the drug delivery device body in a dural venous sinus such that a therapeutic agent is delivered from the deployed drug delivery device into the intracranial subarachnoid space.