公开(公告)号：US09629944B2

公开(公告)日：2017-04-25

申请号：US15160999

申请日：2016-05-20

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

Inventor： O. Mikael Trollsas ,  Michael H. Ngo ,  David J. Sherman ,  Syed F. A. Hossainy

IPC: A61F2/00 ,  A61L31/16 ,  A61L27/34 ,  A61L31/10 ,  A61K31/33 ,  A61K31/497 ,  A61K31/56 ,  A61K38/13 ,  A61K38/44 ,  A61K45/06 ,  A61K47/34 ,  A61K9/50 ,  A61K31/436 ,  A61L31/14

CPC classification number: A61L31/10 ,  A61K9/5031 ,  A61K9/5089 ,  A61K31/33 ,  A61K31/436 ,  A61K31/497 ,  A61K31/56 ,  A61K38/13 ,  A61K38/446 ,  A61K45/06 ,  A61K47/34 ,  A61L27/34 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2420/02 ,  C08L71/02 ,  C08L67/04

Abstract: The present invention provides an implantable device having a coating including a slow dissolving polymer or material and the methods of making and using the same.

公开(公告)号：US09606117B2

公开(公告)日：2017-03-28

申请号：US13324963

申请日：2011-12-13

Applicant: Sarah Hamm-Alvarez

Inventor： Sarah Hamm-Alvarez

IPC: G01N33/53 ,  G01N33/564 ,  A61K38/13 ,  A61K31/4178 ,  A61K31/46 ,  A61K31/56

CPC classification number: G01N33/564 ,  A61K31/4178 ,  A61K31/46 ,  A61K31/56 ,  A61K38/13 ,  G01N2333/525 ,  G01N2333/5428 ,  G01N2333/5443 ,  G01N2800/24

Abstract: Provided are methods for aiding in diagnosing autoimmune diseases in a mammal, comprising contacting a biological sample that is not a tear sample from the mammal with an antibody that specifically binds to a first polypeptide selected from the group Ctss, Ctsh, Ctsr, Ctsw, Ctsz, Ifng, IL-6ra, IL-10, IL-10ra, IL-15, Tnfa, Apo-F, or Lcn-2 or a second polypeptide selected from the group lactoperoxidase, lactoferrin or lysozyme under conditions favoring the formation of an antibody-polypeptide complex, and determining the amount of complex formed, wherein an increased formation of antibody-first-polypeptide complex or a decreased formation of antibody-second-polypeptide complex as compared to a suitable control, indicates a likely positive diagnosis of an autoimmune disease for the mammal, thereby aiding in the diagnosis. Methods of treating the autoimmune diseases are also provided.

公开(公告)号：US09603895B2

公开(公告)日：2017-03-28

申请号：US14843119

申请日：2015-09-02

Applicant: Enanta Pharmaceuticals, Inc.

Inventor： Yat Sun Or ,  Guoqiang Wang ,  Jiang Long ,  Xuri Gao

IPC: A61K38/00 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00 ,  A61K38/13 ,  A61K31/7088 ,  A61K38/21 ,  A61K45/00 ,  C07K7/52 ,  A61K45/06 ,  C07K7/64

CPC classification number: A61K38/13 ,  A61K31/7088 ,  A61K38/21 ,  A61K45/00 ,  A61K45/06 ,  C07K7/52 ,  C07K7/645 ,  Y02A50/463

Abstract: The present invention relates to cyclosporin analogues having antiviral activity against HCV and useful in the treatment of HCV infections. More particularly, the invention relates to novel cyclosporin analogue compounds, compositions containing such compounds and methods for using the same, as well as processes for making such compounds.

公开(公告)号：US09579385B2

公开(公告)日：2017-02-28

申请号：US14152380

申请日：2014-01-10

Applicant: Allergan, Inc.

Inventor： Anuradha V. Gore ,  Chetan P. Pujara ,  Richard S. Graham ,  Melissa Gulmezian ,  Kristin Prinn ,  Ramakrishnan Srikumar

IPC: A61K38/00 ,  A61K47/32 ,  A61K9/00 ,  A61K9/08 ,  A61K31/498 ,  A61K31/5575 ,  A61K31/407 ,  A61K31/417 ,  A61K31/4178 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/568 ,  A61K31/573 ,  A61K38/13 ,  A61K47/02 ,  A61K47/18

CPC classification number: A61K47/32 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/407 ,  A61K31/417 ,  A61K31/4178 ,  A61K31/496 ,  A61K31/498 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/5575 ,  A61K31/568 ,  A61K31/573 ,  A61K38/13 ,  A61K47/02 ,  A61K47/186 ,  A61K2300/00

Abstract: Compositions and methods related to ophthalmic use of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymers and therapeutic uses are described herein.

Abstract translation: 本文描述了与眼用乙烯基己内酰胺 - 聚乙酸乙烯酯 - 聚乙二醇接枝共聚物和治疗用途有关的组合物和方法。

公开(公告)号：US20170049728A1

公开(公告)日：2017-02-23

申请号：US15227436

申请日：2016-08-03

Applicant: UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE ,  CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS C.S.I.C.

Inventor： Carlos BELMONTE MARTÍNEZ ,  Juana GALLAR MARTÍNEZ ,  Antonio FERRER MONTIEL ,  Asia FERNÁNDEZ CARVAJAL ,  Félix VIANA DE LA IGLESIA

IPC: A61K31/167 ,  A61K45/06

CPC classification number: A61K31/045 ,  A61K9/0048 ,  A61K31/00 ,  A61K31/047 ,  A61K31/07 ,  A61K31/075 ,  A61K31/16 ,  A61K31/164 ,  A61K31/167 ,  A61K31/17 ,  A61K31/196 ,  A61K31/215 ,  A61K31/22 ,  A61K31/221 ,  A61K31/245 ,  A61K31/27 ,  A61K31/352 ,  A61K31/357 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/505 ,  A61K31/55 ,  A61K31/662 ,  A61K31/7105 ,  A61K31/713 ,  A61K38/13 ,  A61K45/00 ,  A61K45/06

Abstract: The invention relates to therapeutic compositions for the treatment of dry eye, more specifically to compositions comprising a TRPM8 receptor agonist ligand. Furthermore, the invention relates to therapeutic compositions for the treatment of epiphora, more specifically to compositions comprising a TRPM8 receptor antagonist.

公开(公告)号：US09561258B2

公开(公告)日：2017-02-07

申请号：US14185471

申请日：2014-02-20

Applicant: Stealth Peptides International, Inc.

Inventor： D. Travis Wilson

IPC: A61K38/04 ,  A61K38/07 ,  C07K7/00 ,  C07K5/04 ,  A61K38/13 ,  A61K38/06 ,  A61K38/08

CPC classification number: A61K38/13 ,  A61K38/06 ,  A61K38/07 ,  A61K38/08 ,  A61K2300/00

Abstract: The invention provides compositions and methods for preventing or treating an ischemia-reperfusion injury, such as occurs during acute myocardial infarction and organ transplant in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide or a pharmaceutically acceptable salt thereof, and one or more additional active agents such as cyclosporine.

Abstract translation: 本发明提供了用于预防或治疗缺血再灌注损伤的组合物和方法，例如在哺乳动物受试者的急性心肌梗死和器官移植期间发生的。 所述方法包括向受试者施用有效量的芳族 - 阳离子肽或其药学上可接受的盐，以及一种或多种另外的活性剂如环孢菌素。

公开(公告)号：US20160374920A1

公开(公告)日：2016-12-29

申请号：US15112021

申请日：2015-01-14

Applicant: MARUHO CO., LTD.

Inventor： Hiroki SAKIYAMA ,  Noriaki KANEDA ,  Tomomi SHIGENO

IPC: A61K8/64 ,  A61Q7/00 ,  A61K8/37 ,  A61K8/35 ,  A61K8/34

CPC classification number: A61K8/64 ,  A61K8/34 ,  A61K8/35 ,  A61K8/37 ,  A61K9/0014 ,  A61K38/13 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61Q7/00

Abstract: The present invention aims to provide a cyclosporine external preparation showing improved transdermal absorbability of cyclosporine. The present invention provides an external preparation containing cyclosporine and a ketone.

Abstract translation: 本发明旨在提供一种环孢菌素外用制剂，其显示出环孢菌素的经皮吸收能力。 本发明提供含有环孢菌素和酮的外用制剂。

公开(公告)号：US20160367624A1

公开(公告)日：2016-12-22

申请号：US15153035

申请日：2016-05-12

Applicant: Elisabete Goncalves ,  Karin Rapp ,  Bertrand Sutter ,  Frank Stowasser ,  Bjoern Trupp ,  Sebastian Chabaut ,  Julien Thorens

Inventor： Elisabete Goncalves ,  Karin Rapp ,  Bertrand Sutter ,  Frank Stowasser ,  Bjoern Trupp ,  Sebastian Chabaut ,  Julien Thorens

IPC: A61K38/13 ,  A61K9/48 ,  A61K9/00

CPC classification number: A61K38/13 ,  A61K9/0053 ,  A61K9/0095 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/4858 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26

Abstract: The invention provides lipid-based pharmaceutical compositions comprising alisporivir.

Abstract translation: 本发明提供了包含alisporivir的基于脂质的药物组合物。

公开(公告)号：US20160361259A1

公开(公告)日：2016-12-15

申请号：US15226364

申请日：2016-08-02

Applicant: Indu JAVERI ,  Kaliappanadar NELLAIAPPAN ,  Bharat DIXIT

Inventor： Indu JAVERI ,  Kaliappanadar NELLAIAPPAN ,  Bharat DIXIT

IPC: A61K9/127 ,  A61K9/16 ,  C07K16/32 ,  A61K38/13 ,  A61K31/165 ,  A61K38/40 ,  A61K31/352 ,  A61K9/19 ,  C07K16/24

CPC classification number: A61K9/127 ,  A61K9/0095 ,  A61K9/1278 ,  A61K9/1623 ,  A61K9/19 ,  A61K31/165 ,  A61K31/337 ,  A61K31/352 ,  A61K38/13 ,  A61K38/40 ,  C07K16/241 ,  C07K16/32 ,  C07K2317/21 ,  C07K2317/24 ,  Y10S977/773 ,  Y10S977/906 ,  Y10S977/907

Abstract: Provided herein are methods for preparing liposomes and uses thereof. In certain embodiments, liposomes are prepared without using heat, organic solvents, proteins, and/or inorganic salts in the process. In certain embodiments, the liposomal preparation contains one or more active agents. In certain embodiments, the liposomal preparations are used in the treatment of diseases or disorders.

Abstract translation: 本文提供了制备脂质体的方法及其用途。 在某些实施方案中，在该方法中不使用热，有机溶剂，蛋白质和/或无机盐制备脂质体。 在某些实施方案中，脂质体制剂含有一种或多种活性剂。 在某些实施方案中，脂质体制剂用于治疗疾病或病症。

公开(公告)号：US20160346212A1

公开(公告)日：2016-12-01

申请号：US15233794

申请日：2016-08-10

Applicant: MannKind Corporation

Inventor： Mark Hokenson ,  Keith A. Oberg

IPC: A61K9/16 ,  A61K9/50 ,  A61K9/00 ,  A61K38/29 ,  A61K38/26 ,  A61K38/13 ,  A61K38/28 ,  A61K38/22

CPC classification number: A61K9/1676 ,  A61K9/0073 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1623 ,  A61K9/167 ,  A61K9/5052 ,  A61K9/5089 ,  A61K38/13 ,  A61K38/22 ,  A61K38/25 ,  A61K38/26 ,  A61K38/27 ,  A61K38/28 ,  A61K38/29

Abstract: Methods are provided for promoting the adsorption of an active agent to microparticles by modifying the structural properties of the active agent in order to facilitate favorable association to the microparticle.