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公开(公告)号：US20170276674A1
公开(公告)日：2017-09-28
申请号：US15451214
申请日：2017-03-06
Applicant: Sarah Hamm-Alvarez
Inventor： Sarah Hamm-Alvarez
IPC: G01N33/564 , A61K31/56 , A61K38/13 , A61K31/46 , A61K31/4178
CPC classification number: G01N33/564 , A61K31/4178 , A61K31/46 , A61K31/56 , A61K38/13 , G01N2333/525 , G01N2333/5428 , G01N2333/5443 , G01N2800/24
Abstract: Provided are methods for aiding in diagnosing autoimmune diseases in a mammal, comprising contacting a biological sample that is not a tear sample from the mammal with an antibody that specifically binds to a first polypeptide selected from the group Ctss, Ctsh, Ctsr, Ctsw, Ctsz, Ifng, IL-6ra, IL-10, IL-10ra, IL-15, Tnfa, Apo-F, or Lcn-2 or a second polypeptide selected from the group lactoperoxidase, lactoferrin or lysozyme under conditions favoring the formation of an antibody-polypeptide complex, and determining the amount of complex formed, wherein an increased formation of antibody-first-polypeptide complex or a decreased formation of antibody-second-polypeptide complex as compared to a suitable control, indicates a likely positive diagnosis of an autoimmune disease for the mammal, thereby aiding in the diagnosis. Methods of treating the autoimmune diseases are also provided.
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公开(公告)号：US20120171221A1
公开(公告)日：2012-07-05
申请号：US13382286
申请日：2010-07-06
Applicant: Sarah Hamm-Alvarez , Kaijin Wu , Maria Charlotta Edman
Inventor： Sarah Hamm-Alvarez , Kaijin Wu , Maria Charlotta Edman
IPC: A61K39/395 , C40B30/04 , C12Q1/37 , A61K38/13 , A61K31/439 , A61K31/4178 , A61K31/56 , A61P19/02 , A61P1/00 , A61P3/10 , A61P29/00 , A61P17/00 , A61P1/04 , C12Q1/02 , G01N21/64 , G01N33/559 , G01N27/447 , H01J49/26 , G01N33/566
Abstract: Provided are methods for aiding in diagnosing autoimmune diseases in a mammal, comprising contacting a sample of tear from the mammal with an antibody that specifically binds to a first polypeptide selected from the group Ctss, Ctsh, Ctsr, Ctsw, Ctsz, Ifng, Il16ra, Il10, Il10ra, Il15, Tnfa, Apo-F, or Lcn-2 or a second polypeptide selected from the group lactoperoxidase, lactoferrin or lysozyme under conditions favoring the formation of an antibody-polypeptide complex, and determining the amount of complex formed, wherein an increased formation of antibody-first-polypeptide complex or a decreased formation of antibody-second-polypeptide complex as compared to a suitable control, indicates a likely positive diagnosis of an autoimmune disease for the mammal, thereby aiding in the diagnosis. Methods of treating the autoimmune diseases are also provided.
Abstract translation: 提供了帮助诊断哺乳动物自身免疫性疾病的方法，包括将来自哺乳动物的泪液样品与特异性结合选自Ctss，Ctsh，Ctsr，Ctsw，Ctsz，Ifng，Il16ra， Il10，Il10ra，Il15，Tnfa，Apo-F或Lcn-2或选自乳过氧化物酶，乳铁蛋白或溶菌酶的第二种多肽，在有利于形成抗体 - 多肽复合物的条件下，并测定形成的复合物的量，其中 与合适的对照相比，抗体 - 第一 - 多肽复合物的增加的形成或抗体 - 第二 - 多肽复合物的形成减少，表示对哺乳动物的自身免疫性疾病的可能的阳性诊断，从而有助于诊断。 还提供了治疗自身免疫性疾病的方法。
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公开(公告)号：US20120183568A1
公开(公告)日：2012-07-19
申请号：US13324963
申请日：2011-12-13
Applicant: Sarah Hamm-Alvarez
Inventor： Sarah Hamm-Alvarez
IPC: A61K39/00 , C12Q1/37 , C12Q1/28 , C40B30/00 , A61K38/13 , G01N33/559 , A61K31/46 , A61K31/4178 , A61P19/02 , A61P29/00 , A61P37/06 , G01N33/566 , A61K31/56
CPC classification number: G01N33/564 , A61K31/4178 , A61K31/46 , A61K31/56 , A61K38/13 , G01N2333/525 , G01N2333/5428 , G01N2333/5443 , G01N2800/24
Abstract: Provided are methods for aiding in diagnosing autoimmune diseases in a mammal, comprising contacting a biological sample that is not a tear sample from the mammal with an antibody that specifically binds to a first polypeptide selected from the group Ctss, Ctsh, Ctsr, Ctsw, Ctsz, Ifng, IL-6ra, IL-10, IL-10ra, IL-15, Tnfa, Apo-F, or Lcn-2 or a second polypeptide selected from the group lactoperoxidase, lactoferrin or lysozyme under conditions favoring the formation of an antibody-polypeptide complex, and determining the amount of complex formed, wherein an increased formation of antibody-first-polypeptide complex or a decreased formation of antibody-second-polypeptide complex as compared to a suitable control, indicates a likely positive diagnosis of an autoimmune disease for the mammal, thereby aiding in the diagnosis. Methods of treating the autoimmune diseases are also provided.
Abstract translation: 提供了帮助诊断哺乳动物自身免疫性疾病的方法，包括将不是来自哺乳动物的泪液样品的生物样品与特异性结合选自Ctss，Ctsh，Ctsr，Ctsw，Ctsz的第一种多肽的抗体接触 ，在有利于形成抗体的条件下，Ifng，IL-6ra，IL-10，IL-10ra，IL-15，Tnfa，Apo-F或Lcn-2或选自乳过氧化物酶，乳铁蛋白或溶菌酶的第二多肽 并且确定形成的复合物的量，其中与合适的对照相比，抗体 - 第一 - 多肽复合物的增加的形成或抗体 - 第二 - 多肽复合物的形成减少，表明自身免疫疾病的可能的阳性诊断 为哺乳动物，从而有助于诊断。 还提供了治疗自身免疫性疾病的方法。
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公开(公告)号：US20110257103A1
公开(公告)日：2011-10-20
申请号：US12931601
申请日：2011-02-03
Applicant: Sarah Hamm-Alvarez
Inventor： Sarah Hamm-Alvarez
CPC classification number: A61K38/17 , A61K31/436
Abstract: This invention provides a method of inducing a lacrimal acinar cell in a tissue to degrade a secretory vesicle and its content protein or proteins from the trans-Golgi network (TGN) by contacting the cells with an effective amount of an agent that induces autophagy. Also provided is a method for treating a mammal suffering from defective trans-Golgi network-secretory vesicle (TGN-SV) sorting by administering to the mammal an effective amount of an agent that induces autophagy in the tissue having the defective TGN-SV.
Abstract translation: 本发明提供了通过使细胞与有效量的诱导自噬的药剂接触来诱导组织中的泪腺细胞降解分泌囊泡及其来自反式高尔基网络（TGN）的蛋白质或蛋白质的方法。 还提供了一种通过向哺乳动物施用有效量的在具有缺陷型TGN-SV的组织中诱导自噬的试剂来治疗患有有缺陷的转高尔基网络分泌囊泡（TGN-SV）分类的哺乳动物的方法。
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公开(公告)号：US09687523B2
公开(公告)日：2017-06-27
申请号：US12931601
申请日：2011-02-03
Applicant: Sarah Hamm-Alvarez
Inventor： Sarah Hamm-Alvarez
IPC: A61P27/02 , A61P37/06 , A61K38/17 , A61K31/436
CPC classification number: A61K38/17 , A61K31/436
Abstract: This invention provides a method of inducing a lacrimal acinar cell in a tissue to degrade a secretory vesicle and its content protein or proteins from the trans-Golgi network (TGN) by contacting the cells with an effective amount of an agent that induces autophagy. Also provided is a method for treating a mammal suffering from defective trans-Golgi network-secretory vesicle (TGN-SV) sorting by administering to the mammal an effective amount of an agent that induces autophagy in the tissue having the defective TGN-SV.
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公开(公告)号：US10704096B2
公开(公告)日：2020-07-07
申请号：US13382286
申请日：2010-07-06
Applicant: Sarah Hamm-Alvarez , Kaijin Wu , Maria Charlotta Edman
Inventor： Sarah Hamm-Alvarez , Kaijin Wu , Maria Charlotta Edman
IPC: C12Q1/6883
Abstract: Provided are methods for aiding in diagnosing autoimmune diseases in a mammal, comprising contacting a sample of tear from the mammal with an antibody that specifically binds to a first polypeptide selected from the group Ctss, Ctsh, Ctsr, Ctsw, Ctsz, Ifng, Il16ra, Il10, Il10ra, Il15, Tnfa, Apo-F, or Lcn-2 or a second polypeptide selected from the group lactoperoxidase, lactoferrin or lysozyme under conditions favoring the formation of an antibody-polypeptide complex, and determining the amount of complex formed, wherein an increased formation of antibody-first-polypeptide complex or a decreased formation of antibody-second-polypeptide complex as compared to a suitable control, indicates a likely positive diagnosis of an autoimmune disease for the mammal, thereby aiding in the diagnosis. Methods of treating the autoimmune diseases are also provided.
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公开(公告)号：US20170252400A1
公开(公告)日：2017-09-07
申请号：US15598216
申请日：2017-05-17
Applicant: Sarah Hamm-Alvarez
Inventor： Sarah Hamm-Alvarez
IPC: A61K38/17 , A61K31/436
CPC classification number: A61K38/17 , A61K31/436
Abstract: This invention provides a method of inducing a lacrimal acinar cell in a tissue to degrade a secretory vesicle and its content protein or proteins from the trans-Golgi network (TGN) by contacting the cells with an effective amount of an agent that induces autophagy. Also provided is a method for treating a mammal suffering from defective trans-Golgi network-secretory vesicle (TGN-SV) sorting by administering to the mammal an effective amount of an agent that induces autophagy in the tissue having the defective TGN-SV.
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公开(公告)号：US09606117B2
公开(公告)日：2017-03-28
申请号：US13324963
申请日：2011-12-13
Applicant: Sarah Hamm-Alvarez
Inventor： Sarah Hamm-Alvarez
IPC: G01N33/53 , G01N33/564 , A61K38/13 , A61K31/4178 , A61K31/46 , A61K31/56
CPC classification number: G01N33/564 , A61K31/4178 , A61K31/46 , A61K31/56 , A61K38/13 , G01N2333/525 , G01N2333/5428 , G01N2333/5443 , G01N2800/24
Abstract: Provided are methods for aiding in diagnosing autoimmune diseases in a mammal, comprising contacting a biological sample that is not a tear sample from the mammal with an antibody that specifically binds to a first polypeptide selected from the group Ctss, Ctsh, Ctsr, Ctsw, Ctsz, Ifng, IL-6ra, IL-10, IL-10ra, IL-15, Tnfa, Apo-F, or Lcn-2 or a second polypeptide selected from the group lactoperoxidase, lactoferrin or lysozyme under conditions favoring the formation of an antibody-polypeptide complex, and determining the amount of complex formed, wherein an increased formation of antibody-first-polypeptide complex or a decreased formation of antibody-second-polypeptide complex as compared to a suitable control, indicates a likely positive diagnosis of an autoimmune disease for the mammal, thereby aiding in the diagnosis. Methods of treating the autoimmune diseases are also provided.
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9.发明申请
公开(公告)号：US20160017004A1
公开(公告)日：2016-01-21
申请号：US14811720
申请日：2015-07-28
Applicant: Sarah Hamm-Alvarez , John Andrew MacKay , Guoyong Sun , Pang-Yu Hsueh
Inventor： Sarah Hamm-Alvarez , John Andrew MacKay , Guoyong Sun , Pang-Yu Hsueh
IPC: C07K14/00 , C07K14/005 , C12N7/00 , C07K16/28
CPC classification number: C07K14/001 , A61K38/00 , A61K47/6435 , A61K49/0043 , A61K49/0056 , C07K14/005 , C07K16/28 , C07K16/283 , C07K2319/33 , C07K2319/74 , C12N7/00 , C12N2710/10033
Abstract: Disclosed herein are novel methods and compositions for targeting drug delivery systems to specific cells. One aspect relates to a drug delivery system comprising an elastin-like peptide (ELP) component and a ligand selected from the group consisting of mIgA and knob capable of either drug encapsulation or drug attachment. Further aspects relate to drug delivery systems comprising an elastin-like peptide (ELP) component and a ligand; wherein the ligand specifically binds to a receptor selected from the group consisting of CAR and pIgR. Further aspects include the novel transcytosing properties of the elastin-like peptide and the ligand, knob. Also provided are methods and pharmaceutical compositions comprising the disclosed therapeutics.
Abstract translation: 本文公开了用于将药物递送系统靶向特定细胞的新方法和组合物。 一个方面涉及包含弹性蛋白样肽（ELP）组分和选自能够药物包封或药物附着的mIgA和旋钮的配体的药物递送系统。 其它方面涉及包含弹性蛋白样肽（ELP）组分和配体的药物递送系统; 其中所述配体特异性结合选自CAR和pIgR的受体。 其他方面包括弹性蛋白样肽和配体旋钮的新型转码特性。 还提供了包含所公开的治疗剂的方法和药物组合物。
