公开(公告)号：US09738606B2

公开(公告)日：2017-08-22

申请号：US14123452

申请日：2012-06-04

申请人： Derek A. Pratt ,  Jason J. Hanthorn ,  Luca Valgimigli

发明人： Derek A. Pratt ,  Jason J. Hanthorn ,  Luca Valgimigli

IPC分类号： C07D213/74 ,  C07D239/48 ,  C07D401/12 ,  C07C7/20 ,  C07C67/62 ,  C08K5/3462 ,  C08K5/3432 ,  C09K15/30 ,  C07D239/42 ,  C07D239/47 ,  C10M169/04

CPC分类号： C07D213/74 ,  C07C7/20 ,  C07C67/62 ,  C07D239/42 ,  C07D239/47 ,  C07D239/48 ,  C07D401/12 ,  C08K5/3432 ,  C08K5/3462 ,  C09K15/30 ,  C10M169/04

摘要： A compound of Formula I, Formula IA, Formula IB, or Formula II, or an acid or base addition salt thereof, and use of these compounds as antioxidants.In one embodiment, a compound of Formula II, wherein each of X, Y, and Z are independently a carbon or nitrogen atom; R1 and R2 are each independently a hydrogen or an electron donating group, but are not both hydrogen, and wherein R1, and R2 are each bonded to a carbon atom in their own respective aryl ring.

公开(公告)号：US09157071B2

公开(公告)日：2015-10-13

申请号：US12953528

申请日：2010-11-24

申请人： Gabriella Campadelli ,  Laura Menotti

发明人： Gabriella Campadelli ,  Laura Menotti

IPC分类号： A61K35/76 ,  C12N15/79 ,  A61K35/00 ,  C12N7/01 ,  A61K49/00 ,  C12N7/00 ,  C07K14/005 ,  A61K35/763

CPC分类号： A61K35/763 ,  A61K49/04 ,  C07K14/005 ,  C07K2317/622 ,  C07K2319/33 ,  C07K2319/61 ,  C07K2319/74 ,  C12N7/00 ,  C12N2710/16621 ,  C12N2710/16622 ,  C12N2710/16632 ,  C12N2710/16633 ,  C12N2710/16651 ,  C12N2710/16722 ,  C12N2810/85 ,  Y02A50/407

摘要： A modified Herpes Simplex Virus (HSV), which has a portion of gD (glycoprotein D) of the glycoproteic envelope deleted and a heterologous single chain antibody inserted in place of such deleted portion; the modified HSV is capable of infecting cells through receptor HER2/ErbB2 but not through receptors HVEM/HveA and nectin1/HveC; uses of the modified HSV and a process of the preparation thereof are also disclosed.

摘要翻译： 修饰的单纯疱疹病毒（HSV），其具有缺失的糖蛋白包膜的一部分gD（糖蛋白D）和插入该缺失部分的异源单链抗体; 修饰的HSV能够通过受体HER2 / ErbB2感染细胞，但不能通过受体HVEM / HveA和nectin1 / HveC感受细胞; 还公开了改性HSV的用途及其制备方法。

公开(公告)号：US08919191B2

公开(公告)日：2014-12-30

申请号：US13881557

申请日：2011-10-26

申请人： Sara Bonacchi ,  Marco Montalti ,  Luca Prodi ,  Nelsi Zacheroni ,  Francesco Zerbetto ,  Matteo Calvaresi ,  Daniele Cauzzi

发明人： Sara Bonacchi ,  Marco Montalti ,  Luca Prodi ,  Nelsi Zacheroni ,  Francesco Zerbetto ,  Matteo Calvaresi ,  Daniele Cauzzi

IPC分类号： G01L5/04 ,  G01K11/00 ,  C09K9/02 ,  G01K11/20

CPC分类号： G01K11/00 ,  C09K9/02 ,  G01K11/20

摘要： Use for measuring temperatures of a coordination complex presenting formula I, wherein M1, M2, M3, M4, M5 are chosen, each independently of the others, in the group consisting of: CuI, AgI, AuI, PdII; n is equal to the sum of the oxidation states of M1, M2, M3, M4, M5 minus 3; II represents a respective portion of each tridentate ligand having the formula III in which R1 is chosen in the group consisting of: Ph, C1-C4 alkyl, halo-alkyl C1-C4 substituted phenyl; R2 is chosen in the group consisting of: Ph, C1-C4 alkyl, C1-C4 halo-alkyl-, substituted phenyl; R3 is chosen in the group consisting of: C1-C18 alkyl, benzyl, substituted benzyl, C1-C20 hydroxy-alkyl, C1-C20 alkoxy silane.

摘要翻译： 用于测量呈现式I的配位络合物的温度，其中M1，M2，M3，M4，M5各自独立地选自：CuI，AgI，AuI，PdII; n等于M1，M2，M3，M4，M5的氧化态的总和减去3; II表示具有式III的每个三齿配体的相应部分，其中R 1选自：Ph，C 1 -C 4烷基，卤代烷基C 1 -C 4取代的苯基; R2选自：Ph，C 1 -C 4烷基，C 1 -C 4卤代烷基 - 取代的苯基; R3选自：C 1 -C 18烷基，苄基，取代的苄基，C 1 -C 20羟基 - 烷基，C 1 -C 20烷氧基硅烷。

公开(公告)号：US20140082777P1

公开(公告)日：2014-03-20

申请号：US13987767

申请日：2013-08-29

申请人： Universita' Degli Studi Di Udine ,  Alma Mater Studiorum-Universita' Di Bologna

发明人： Guglielmo Costa ,  Raffaele Testolin ,  Guido Cipriani

IPC分类号： A01H5/00

CPC分类号： A01H5/08

摘要： A new and distinct Actinidia chinensis Planchon cultivar named AC1536 is disclosed, characterized by distinctive large, oblong fruit, and an earlier time of maturity for harvesting.

摘要翻译： 披露了一种新颖独特的中华猕猴桃品种AC1536，其特征是具有独特的大型长圆形果实，并且成熟期较早。

公开(公告)号：US20120328128A1

公开(公告)日：2012-12-27

申请号：US13518465

申请日：2010-12-23

申请人： Lamberto Tronchin ,  Andrea Venturi

发明人： Lamberto Tronchin ,  Andrea Venturi

IPC分类号： G10H1/00

CPC分类号： G10H3/187 ,  G10H1/16

摘要： A method for artificially reproducing an output signal of a non-linear time invariant system includes the steps of inserting an input signal of exponential sine sweep type in the non-linear time invariant system, acquiring an output signal of the non-linear time invariant system corresponding to the input signal, obtaining a mathematical function that characterizes the non-linear time invariant system on the basis of the output signal and applying the mathematical function to a further signal to obtain a still further signal which reproduces the output signal that would be obtained from the non-linear time invariant system if it were driven by the further signal.

摘要翻译： 一种用于人工再现非线性时变不变系统的输出信号的方法包括以下步骤：在非线性时不变系统中插入指数正弦扫描类型的输入信号，获取非线性时不变系统的输出信号 对应于输入信号，获得基于输出信号表征非线性时间不变系统的数学函数，并将数学函数应用于另外的信号以获得进一步再现将被获得的输出信号的信号 从非线性时间不变系统，如果它是由进一步的信号驱动。

公开(公告)号：US08263359B2

公开(公告)日：2012-09-11

申请号：US12299350

申请日：2007-04-30

申请人： Pierluigi Reschiglian ,  Barbara Roda ,  Gian Paolo Bagnara ,  Andrea Zattoni

发明人： Pierluigi Reschiglian ,  Barbara Roda ,  Gian Paolo Bagnara ,  Andrea Zattoni

IPC分类号： C12N5/074 ,  C12N5/077 ,  C12Q1/02 ,  C12Q1/24

CPC分类号： C12N5/0663 ,  C12N5/0664 ,  C12N5/0667 ,  C12N5/0668 ,  G01N30/0005 ,  G01N2030/0015 ,  G01N2030/0055

摘要： A method and the relevant instrumentation to fractionate living, adherent stem cells, particularly of human origin, from different sources is disclosed, said method is based on the non-equilibrium, dynamic fractionation of cells assisted by the Earth gravity field.

摘要翻译： 公开了从不同来源分离生物，特别是人源的粘附干细胞的方法和相关仪器，所述方法基于由地球重力场辅助的细胞的非平衡动态分级。

公开(公告)号：US20050261345A1

公开(公告)日：2005-11-24

申请号：US10510833

申请日：2003-04-11

申请人： Vincenza Andrisano ,  Manuela Bartolini ,  Maria Bolognesi ,  Andrea Cavalli ,  Carlo Melchiorre ,  Maurizio Recanatini

发明人： Vincenza Andrisano ,  Manuela Bartolini ,  Maria Bolognesi ,  Andrea Cavalli ,  Carlo Melchiorre ,  Maurizio Recanatini

IPC分类号： A61K31/132 ,  A61K31/341 ,  A61P25/28 ,  C07B61/00 ,  C07C221/00 ,  C07C225/28 ,  C07D307/52 ,  A61K31/444 ,  A61K31/137 ,  A61K31/34 ,  A61K31/381 ,  C07D41/02 ,  C07D49/02

CPC分类号： C07D307/52 ,  C07C225/28

摘要： 2,5-bis-diamine-[1,4]benzoquinonic derivatives, having a general formula (I) have proved useful for the treatment of Alzheimer's disease; a method for preparing them and intermediates used in said method are also described.

摘要翻译： 具有通式（I）的2,5-双 - 二胺 - [1,4]苯醌衍生物已被证明可用于治疗阿尔茨海默病; 还描述了用于制备它们的方法和用于所述方法的中间体。

公开(公告)号：US20240353406A1

公开(公告)日：2024-10-24

申请号：US18693672

申请日：2022-09-21

申请人： UNIVERSITA' DEGLI STUDI DI MESSINA ,  ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA

发明人： Sabrina CONOCI ,  Salvatore GUGLIELMINO ,  Matteo CALVARESI ,  Alberto DANIELLI ,  Luca PRODI ,  Enza FAZIO ,  Annapaola PETROSINO ,  Matteo DI GIOSIA

IPC分类号： G01N33/569 ,  G01N21/64 ,  G01N33/543

CPC分类号： G01N33/56911 ,  G01N21/6486 ,  G01N33/54326 ,  G01N2333/01 ,  G01N2333/21

摘要： A method for detecting cellular or molecular analytes is provided. The method uses two types of engineered phages: a “capture” phage (bait phage) and a “signal” phage (reporter phage). Through this method it is possible to selectively bind a target analyte and thus recognize said target analyte.

公开(公告)号：US20240341393A1

公开(公告)日：2024-10-17

申请号：US18682252

申请日：2022-08-09

申请人： ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA

发明人： Martino Colonna ,  Mariafederica Parisi ,  Giuseppe La Fauci

IPC分类号： A42B3/12 ,  F16F9/32

CPC分类号： A42B3/122 ,  A42B3/124 ,  F16F9/3214 ,  F16F2222/12

摘要： The shock-absorbing device (10), particularly intended to be installed in protective devices such as helmets of any type whatsoever, comprises a hermetically closed container (11) containing in turn a non-Newtonian shock-absorbing fluid (13). The invention also concerns a helmet (30) comprising an internal component (31) to be placed resting on the head of a user and an external component (32) located mobile around the internal component (31), and at least one shock-absorbing device inserted between the internal (31) and external (32) components.

公开(公告)号：US20230326499A1

公开(公告)日：2023-10-12

申请号：US17718755

申请日：2022-04-12

申请人： STMicroelectronics S.r.l. ,  Alma Mater Studiorum - Universita' Di Bologna

发明人： Marco PASOTTI ,  Marcella CARISSIMI ,  Alessio ANTOLINI ,  Eleonora FRANCHI SCARSELLI ,  Antonio GNUDI ,  Andrea LICO

IPC分类号： G11C7/10 ,  G11C7/12 ,  G11C7/16 ,  G11C7/14 ,  G11C8/08

CPC分类号： G11C7/1063 ,  G11C7/12 ,  G11C8/08 ,  G11C7/14 ,  G11C7/16

摘要： An in-memory computation (IMC) circuit includes a memory array formed by memory cells arranged in row-by-column matrix. Computational weights for an IMC operation are stored in the memory cells. Each column includes a bit line connected to the memory cells. A switching circuit is connected between each bit line and a corresponding column output. The switching circuit is controlled to turn on to generate the analog signal dependent on the computational weight and for a time duration controlled by the coefficient data signal. A column combining circuit combines (by addition and/or subtraction) and integrates analog signals at the column outputs of the biasing circuits. The addition/subtraction is dependent on one or more a sign of the coefficient data and a sign of the computational weight and may further implement a binary weighting function.