公开(公告)号：US5855866A

公开(公告)日：1999-01-05

申请号：US205330

申请日：1994-03-02

申请人： Philip E. Thorpe ,  Francis J. Burrows

发明人： Philip E. Thorpe ,  Francis J. Burrows

IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K45/00 ,  A61K47/42 ,  A61K47/48 ,  A61K49/00 ,  A61K49/08 ,  A61K49/16 ,  A61K51/10 ,  A61P35/00 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  C12P21/08 ,  A61K39/395 ,  C07K16/00

CPC分类号： A61K49/16 ,  A61K47/48438 ,  A61K47/48561 ,  A61K47/48569 ,  A61K49/085 ,  A61K51/1045 ,  C07K16/22 ,  C07K16/28 ,  C07K16/2818 ,  C07K16/2833 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3015 ,  A61K2039/505 ,  A61K2123/00 ,  A61K38/00 ,  C07K2317/31 ,  C07K2317/55

摘要： The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunologically-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.

摘要翻译： 本发明一般涉及使用基于免疫学的试剂靶向实体瘤脉管系统的方法和组合物。 在特定方面，携带诊断或治疗剂的抗体通过识别肿瘤血管系相关抗原（例如通过内皮糖蛋白结合）或通过血管内皮细胞表面抗原的特异性诱导来靶向实体肿瘤块的脉管系统 实体瘤内皮细胞。

公开(公告)号：US5084266A

公开(公告)日：1992-01-28

申请号：US305539

申请日：1989-02-02

申请人： Ian F. C. McKenzie ,  Joe J. Tjandra

发明人： Ian F. C. McKenzie ,  Joe J. Tjandra

IPC分类号： A61K47/48 ,  A61K49/16 ,  A61K51/10

CPC分类号： A61K51/1045 ,  A61K47/48538 ,  A61K47/48569 ,  A61K49/16 ,  A61K51/1018 ,  A61K2123/00 ,  Y10S436/806 ,  Y10T436/24

摘要： A method for identifying and/or determining the location of a tumor which produces or is associated with a cytoplasmic, intra-cellular or cell surface marker substance, is disclosed, which comprises the steps of:(a) injecting a human or animal subject with tumor specific antibody or a fragment thereof specific for the marker and labelled with a radioactive isotope of an element or a paramagnetic conjugate; and an irrelevant (non-tumor reactive) antibody which has been labelled with a non-radioactive isotope of the same or other element, or a non-paramagnetic conjugate; and(b) after a period of time sufficient for selective binding of the labelled tumor specific antibody to the tumor scanning the human or animal subject with a detector to locate the site or sites of uptake of labelled antibody or fragments thereof.Imaging compositions are also described.

公开(公告)号：US4804529A

公开(公告)日：1989-02-14

申请号：US640160

申请日：1984-08-10

申请人： Andre Bardy ,  Maria-Louisa Conti ,  Jacques Courtieu ,  Evelyne Mathieu ,  Joelle Grzyb

发明人： Andre Bardy ,  Maria-Louisa Conti ,  Jacques Courtieu ,  Evelyne Mathieu ,  Joelle Grzyb

IPC分类号： A61B10/00 ,  A61B5/055 ,  A61K49/06 ,  A61K49/16 ,  A61K51/00 ,  C07F5/00 ,  G01R33/28 ,  A61K49/00

CPC分类号： G01R33/5601 ,  A61K49/06 ,  A61K49/16 ,  C07F5/003 ,  Y10T436/24

摘要： The invention relates to specific relaxation agents for organs or pathologies, which can be used for modifying the contrasts in medical imaging by nuclear magnetic resonance.These agents are constituted by a complex of a paramagnetic element having a biologically active ligand or a ligand coupled to a biologically active molecule and which is specific to an organ or pathology. Thus, they are selectively fixed to the organs and make it possible to modify the contrasts in imaging by nuclear magnetic resonance, due to the presence of the paramagnetic element, which modifies the relaxation times.For example, when examining the kidney, the complex can be constituted by dimercaptosuccinate or gadolinium diethylene triaminopentaacetate, whilst gadolinium phytate is used in examinations of the liver.

摘要翻译： 本发明涉及用于器官或病理学的特定松弛剂，其可用于通过核磁共振改变医学成像中的对比度。 这些试剂由具有生物活性配体或与生物活性分子偶联的配体的顺磁元件的复合物构成，并且其特异于器官或病理学。 因此，它们被选择性地固定到器官，并且由于存在修饰弛豫时间的顺磁元件，可以通过核磁共振改变成像对比度。 例如，当检查肾脏时，复合物可以由二巯基琥珀酸盐或二亚乙基三氨基五乙酸钆构成，而钆肌酸钙用于肝脏的检查。

公开(公告)号：US4659839A

公开(公告)日：1987-04-21

申请号：US659456

申请日：1984-10-10

申请人： Robert A. Nicolotti ,  Richard T. Dean

发明人： Robert A. Nicolotti ,  Richard T. Dean

IPC分类号： G01N33/534 ,  A61K47/48 ,  A61K49/16 ,  A61K51/00 ,  A61K51/10 ,  C07D207/44 ,  C07D207/452 ,  G01N33/563 ,  C07D207/40 ,  A61K43/00 ,  A61K49/00

CPC分类号： C07D207/452 ,  A61K47/48715 ,  A61K49/16 ,  A61K51/1093 ,  A61K2123/00

摘要： Bifunctional coupling agent for joining radionuclide metal ions to biologically useful molecules, including antibody Fab' fragments are disclosed. The coupling agents contain a maleimide moiety and a paramagnetic or radionuclide chelating moiety. The maleimide can be used to selectively bind to free sulfhydryl groups, or amine groups.

公开(公告)号：US20240350677A1

公开(公告)日：2024-10-24

申请号：US18596815

申请日：2024-03-06

申请人： On Target Laboratories, Inc.

发明人： Sumith A. Kularatne

IPC分类号： A61K49/00 ,  A61K49/16 ,  C07D209/20 ,  C07K5/062 ,  C07K5/065 ,  C07K5/072 ,  C07K5/078 ,  C07K5/083 ,  C07K5/087 ,  C07K5/09 ,  C07K5/11 ,  C07K7/02 ,  C07K7/06 ,  G01N21/64 ,  G01N33/574 ,  G01N33/58

CPC分类号： A61K49/0052 ,  A61K49/0032 ,  A61K49/0034 ,  A61K49/0056 ,  C07D209/20 ,  C07K5/06026 ,  C07K5/0606 ,  C07K5/06078 ,  C07K5/06095 ,  C07K5/06121 ,  C07K5/06147 ,  C07K5/06156 ,  C07K5/0806 ,  C07K5/0812 ,  C07K5/0817 ,  C07K5/1019 ,  C07K7/02 ,  C07K7/06 ,  G01N21/6428 ,  G01N33/57434 ,  G01N33/57492 ,  G01N33/582 ,  A61K49/0017 ,  A61K49/16 ,  C12Y304/17021 ,  G01N2021/6439 ,  G01N2333/948

摘要： The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

公开(公告)号：US20240343820A1

公开(公告)日：2024-10-17

申请号：US18597752

申请日：2024-03-06

申请人： Kite Pharma, Inc.

发明人： Michael E. Coon ,  Christa Cortesio ,  Stuart A. Sievers

IPC分类号： C07K16/28 ,  A61K49/00 ,  A61K49/16 ,  A61K51/10 ,  C07K14/725

CPC分类号： C07K16/2887 ,  A61K49/0058 ,  A61K49/16 ,  A61K51/1027 ,  C07K14/7051

摘要： The present disclosure describes antigen binding molecules, including antibodies, that specifically bind to the anti-CD20 scFv-14 or Gibbon ape leukemia virus gp70 protein, as well as molecules comprising the described sequences and cells presenting such molecules. The antigen binding molecules may be used in research, diagnostic, clinical, and other applications.

公开(公告)号：US12090212B2

公开(公告)日：2024-09-17

申请号：US17133388

申请日：2020-12-23

申请人： OBI Pharma, Inc.

发明人： Michael Nientse Chang ,  Jiann-Shiun Lai ,  Wan-Fen Li ,  I-Ju Chen ,  Yi-Chien Tsai ,  Kai-Chuan Chen

IPC分类号： A61K47/68 ,  A61K39/395 ,  A61K45/06 ,  A61K49/00 ,  A61K49/16 ,  A61K51/10 ,  A61P35/00 ,  A61P35/04 ,  C07K16/18 ,  C07K16/30 ,  C07K16/44 ,  C08B37/00 ,  G01N33/574 ,  A61K39/00

CPC分类号： A61K47/6855 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6817 ,  A61K47/6843 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6863 ,  A61K49/0058 ,  A61K49/16 ,  A61K51/1018 ,  A61K51/1051 ,  A61K51/1054 ,  A61K51/1057 ,  A61K51/1063 ,  A61P35/00 ,  A61P35/04 ,  C07K16/18 ,  C07K16/3076 ,  C07K16/44 ,  C08B37/0006 ,  G01N33/57492 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  A61K39/39558 ,  A61K2300/00

摘要： Antibody drug conjugates (ADC's) comprising a drug conjugated to antibody or antigen binding fragments thereof that bind to Globo series antigen disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as sarcoma, skin cancer, leukemia, lymphoma, brain cancer, glioblastoma, lung cancer, breast cancer, oral cancer, head-and-neck cancer, nasopharyngeal cancer, esophagus cancer, stomach cancer, liver cancer, bile duct cancer, gallbladder cancer, bladder cancer, pancreatic cancer, intestinal cancer, colorectal cancer, kidney cancer, cervix cancer, endometrial cancer, ovarian cancer, testical cancer, buccal cancer, oropharyngeal cancer, laryngeal cancer and prostate cancer.

公开(公告)号：US20230144838A1

公开(公告)日：2023-05-11

申请号：US17778242

申请日：2020-11-17

申请人： UNIVERSITAT POLITÈCNICA DE VALÈNCIA ,  CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS

发明人： Pablo BOTELLA ASUNCIÓN ,  Eva María RIVERO BUCETA

IPC分类号： A61K47/68 ,  A61K47/69 ,  A61K51/12 ,  A61K49/00 ,  A61K49/18 ,  A61K49/16 ,  A61K51/10

CPC分类号： A61K47/6871 ,  A61K47/6941 ,  A61K51/1244 ,  A61K49/0093 ,  A61K49/1878 ,  A61K49/16 ,  A61K51/1075

摘要： The invention relates to a multifunctional system stable in a physiological medium, which includes in the same platform an anti-carcinogenic molecule, an imaging agent and a directing molecule that interacts specifically with cancer-cell membrane receptors, the system allowing pathological tissue imaging and pharmacological action to be carried out jointly with high specificity. The intratumoral administration of the system facilitates selective diffusion to cancer cells and minimises the disadvantages of chemotherapy.

公开(公告)号：US20220175977A1

公开(公告)日：2022-06-09

申请号：US17376670

申请日：2021-07-15

申请人： Soricimed Biopharma Inc.

发明人： John M. STEWART

IPC分类号： A61K51/10 ,  A61K45/06 ,  A61K49/00 ,  A61K49/14 ,  A61K49/18 ,  B82Y5/00 ,  C07K16/28 ,  G01N33/574 ,  G01N33/68 ,  A61K47/64 ,  A61K47/68 ,  A61K33/24 ,  A61K31/337 ,  A61K39/00 ,  A61K49/16

摘要： Compounds containing TRPV6-binding peptides and their use in the detection and diagnosis of cancer are described. Also described are methods for detecting and staging cancer that use the compounds of the invention. Compounds containing TRPV6-binding peptides are useful for the delivery of diagnostic and therapeutic agents to cells or tumors that express TRPV6.

公开(公告)号：US11191851B2

公开(公告)日：2021-12-07

申请号：US16572260

申请日：2019-09-16

申请人： MUSC Foundation for Research Development ,  The United States Government as Represented by the Department of Veterans Affairs ,  The Regents of the University of Colorado, a body corporate ,  Universitat de Barcelona

发明人： Stephen Tomlinson ,  V. Michael Holers ,  Pablo Engel

IPC分类号： A61K49/00 ,  A61K51/10 ,  C07K16/18 ,  G01N33/569 ,  A61K49/16 ,  C07K16/28 ,  G01N33/534

摘要： Provided herein, inter alia, are compositions and methods of using the same for detecting complement activation.