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公开(公告)号：US06004554A
公开(公告)日：1999-12-21
申请号：US295868
申请日：1994-12-02
IPC分类号： A61K38/00 , A61K39/00 , A61K45/00 , A61K47/42 , A61K47/48 , A61K49/00 , A61K49/08 , A61K49/16 , A61K51/10 , A61P35/00 , C07K16/22 , C07K16/28 , C07K16/30 , C12P21/08 , A61K39/395 , A61K39/40 , A61K39/42
CPC分类号： A61K49/16 , A61K47/48438 , A61K47/48561 , A61K47/48569 , A61K49/085 , A61K51/1045 , C07K16/22 , C07K16/28 , C07K16/2818 , C07K16/2833 , C07K16/2896 , C07K16/30 , C07K16/3015 , A61K2039/505 , A61K2123/00 , A61K38/00 , C07K2317/31 , C07K2317/55
摘要： The present invention relates generally to methods and compositions for targeting the vasulature of solid tumors using immunologcially-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
摘要翻译： PCT No.PCT / US93 / 01956 Sec。 371日期1994年12月2日第 102（e）日期1994年12月2日PCT 1993年3月5日PCT公布。 出版物WO93 / 17715 日期1993年9月16日本发明一般涉及使用基于免疫学试剂靶向实体瘤血管的方法和组合物。 在特定方面，携带诊断或治疗剂的抗体通过识别肿瘤血管系相关抗原或通过实体瘤中血管内皮细胞上的内皮细胞表面抗原的特异性诱导来靶向实体肿瘤块的脉管系统。
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2.发明授权
公开(公告)号：US5965132A
公开(公告)日：1999-10-12
申请号：US350212
申请日：1994-12-05
IPC分类号： A61K38/00 , A61K47/48 , A61K49/08 , A61K51/10 , A61P35/00 , C07K16/22 , C07K16/28 , C07K16/30 , C12P21/08 , A61K51/00
CPC分类号： A61K47/48438 , A61K47/48476 , A61K47/48561 , A61K47/48569 , A61K47/48584 , A61K49/085 , A61K49/16 , A61K51/1045 , C07K16/22 , C07K16/28 , C07K16/2818 , C07K16/2833 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/46 , A61K2039/505 , A61K2123/00 , A61K38/00 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/77 , C07K2319/33 , C07K2319/55 , Y10S530/807 , Y10S530/828
摘要： The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
摘要翻译： 本发明一般涉及使用基于免疫学和生长因子的试剂靶向实体瘤脉管系统的方法和组合物。 在特定方面，携带诊断或治疗剂的抗体通过识别肿瘤血管系相关抗原（例如通过内皮糖蛋白结合）或通过血管内皮细胞表面抗原的特异性诱导来靶向实体肿瘤块的脉管系统 实体瘤内皮细胞。
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公开(公告)号：US5855866A
公开(公告)日：1999-01-05
申请号：US205330
申请日：1994-03-02
IPC分类号： A61K38/00 , A61K39/00 , A61K45/00 , A61K47/42 , A61K47/48 , A61K49/00 , A61K49/08 , A61K49/16 , A61K51/10 , A61P35/00 , C07K16/22 , C07K16/28 , C07K16/30 , C12P21/08 , A61K39/395 , C07K16/00
CPC分类号： A61K49/16 , A61K47/48438 , A61K47/48561 , A61K47/48569 , A61K49/085 , A61K51/1045 , C07K16/22 , C07K16/28 , C07K16/2818 , C07K16/2833 , C07K16/2896 , C07K16/30 , C07K16/3015 , A61K2039/505 , A61K2123/00 , A61K38/00 , C07K2317/31 , C07K2317/55
摘要： The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunologically-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
摘要翻译： 本发明一般涉及使用基于免疫学的试剂靶向实体瘤脉管系统的方法和组合物。 在特定方面，携带诊断或治疗剂的抗体通过识别肿瘤血管系相关抗原（例如通过内皮糖蛋白结合）或通过血管内皮细胞表面抗原的特异性诱导来靶向实体肿瘤块的脉管系统 实体瘤内皮细胞。
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公开(公告)号：US5660827A
公开(公告)日：1997-08-26
申请号：US457229
申请日：1995-06-01
IPC分类号： A61K38/00 , A61K47/48 , A61K49/08 , A61K51/10 , A61P35/00 , C07K16/22 , C07K16/28 , C07K16/30 , C12P21/08 , A61K39/395 , C07K16/00
CPC分类号： A61K49/16 , A61K47/48438 , A61K47/48561 , A61K47/48569 , A61K49/085 , A61K51/1045 , C07K16/22 , C07K16/28 , C07K16/2818 , C07K16/2833 , C07K16/2896 , C07K16/30 , C07K16/3015 , A61K2039/505 , A61K2123/00 , A61K38/00 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/73
摘要： Disclosed are antibodies that specifically bind to endoglin. Conjugates of the antibodies linked to diagnostic or therapeutic agents are also provided. Methods of using the antibodies and conjugates are also disclosed, including methods of targeting the vasculature of solid tumors through recognition of the tumor vasculature-associated antigen, endoglin.
摘要翻译： 公开了特异性结合内皮糖蛋白的抗体。 还提供了与诊断或治疗剂相关的抗体的缀合物。 还公开了使用抗体和缀合物的方法，包括通过识别肿瘤血管系相关抗原内皮糖蛋白来靶向实体瘤脉管系统的方法。
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5.发明授权Combined methods for tumor vasculature targeting and tumor treatment with radiotherapy 失效用于放射治疗的肿瘤血管系统靶向和肿瘤治疗的组合方法公开(公告)号：US07125541B2
公开(公告)日：2006-10-24
申请号：US09738970
申请日：2000-12-14
IPC分类号： A61K51/10 , A61K39/395 , C07K16/00
CPC分类号： C07K16/46 , A61K38/00 , A61K47/6817 , A61K47/6827 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K49/085 , A61K49/16 , A61K51/1045 , A61K2039/505 , A61K2123/00 , C07K16/22 , C07K16/28 , C07K16/2818 , C07K16/2833 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/77 , C07K2319/33 , C07K2319/55 , Y10S530/807 , Y10S530/828
摘要： The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
摘要翻译： 本发明一般涉及使用基于免疫学和生长因子的试剂靶向实体瘤脉管系统的方法和组合物。 在特定方面，携带诊断或治疗剂的抗体通过识别肿瘤血管系相关抗原（例如通过内皮糖蛋白结合）或通过血管内皮细胞表面抗原的特异性诱导来靶向实体肿瘤块的脉管系统 实体瘤内皮细胞。
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公开(公告)号：US07112317B2
公开(公告)日：2006-09-26
申请号：US10376194
申请日：2003-02-27
IPC分类号： A61K51/10 , A61K39/395 , C07K16/00
CPC分类号： C07K16/46 , A61K38/00 , A61K47/6817 , A61K47/6827 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K49/085 , A61K49/16 , A61K51/1045 , A61K2039/505 , A61K2123/00 , C07K16/22 , C07K16/28 , C07K16/2818 , C07K16/2833 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/77 , C07K2319/33 , C07K2319/55 , Y10S530/807 , Y10S530/828
摘要： The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
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公开(公告)号：US5863538A
公开(公告)日：1999-01-26
申请号：US457487
申请日：1995-06-01
IPC分类号： A61K38/00 , A61K47/48 , A61K49/08 , A61K51/10 , A61P35/00 , C07K16/22 , C07K16/28 , C07K16/30 , C12P21/08 , A61K39/395 , C07K16/00
CPC分类号： A61K47/48438 , A61K47/48476 , A61K47/48561 , A61K47/48569 , A61K47/48584 , A61K49/085 , A61K49/16 , A61K51/1045 , C07K16/22 , C07K16/28 , C07K16/2818 , C07K16/2833 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/46 , A61K2039/505 , A61K2123/00 , A61K38/00 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/77 , C07K2319/33 , C07K2319/55 , Y10S530/807 , Y10S530/828
摘要： The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
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公开(公告)号：US5776427A
公开(公告)日：1998-07-07
申请号：US456495
申请日：1995-06-01
IPC分类号： A61K38/00 , A61K47/48 , A61K49/08 , A61K51/10 , A61P35/00 , C07K16/22 , C07K16/28 , C07K16/30 , C12P21/08 , A61K39/395 , C07K16/00
CPC分类号： A61K49/16 , A61K47/48438 , A61K47/48561 , A61K47/48569 , A61K49/085 , A61K51/1045 , C07K16/22 , C07K16/28 , C07K16/2818 , C07K16/2833 , C07K16/2896 , C07K16/30 , C07K16/3015 , A61K2039/505 , A61K2123/00 , A61K38/00 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/73
摘要： The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
摘要翻译： 本发明一般涉及使用基于免疫学和生长因子的试剂靶向实体瘤脉管系统的方法和组合物。 在特定方面，携带诊断或治疗剂的抗体通过识别肿瘤血管系相关抗原（例如通过内皮糖蛋白结合）或通过血管内皮细胞表面抗原的特异性诱导来靶向实体肿瘤块的脉管系统 实体瘤内皮细胞。
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公开(公告)号：US06261535B1
公开(公告)日：2001-07-17
申请号：US09207277
申请日：1998-12-08
IPC分类号： A61K5110
CPC分类号： C07K16/46 , A61K38/00 , A61K47/6817 , A61K47/6827 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K49/085 , A61K49/16 , A61K51/1045 , A61K2039/505 , A61K2123/00 , C07K16/22 , C07K16/28 , C07K16/2818 , C07K16/2833 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/77 , C07K2319/33 , C07K2319/55 , Y10S530/807 , Y10S530/828
摘要： The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
摘要翻译： 本发明一般涉及使用基于免疫学和生长因子的试剂靶向实体瘤脉管系统的方法和组合物。 在特定方面，携带诊断或治疗剂的抗体通过识别肿瘤血管系相关抗原（例如通过内皮糖蛋白结合）或通过血管内皮细胞表面抗原的特异性诱导来靶向实体肿瘤块的脉管系统 实体瘤内皮细胞。
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公开(公告)号：US06051230A
公开(公告)日：2000-04-18
申请号：US457869
申请日：1995-06-01
IPC分类号： A61K38/00 , A61K47/48 , A61K49/08 , A61K51/10 , A61P35/00 , C07K16/22 , C07K16/28 , C07K16/30 , C12P21/08 , A61K39/395 , C07K16/00
CPC分类号： A61K47/48438 , A61K47/48476 , A61K47/48561 , A61K47/48569 , A61K47/48584 , A61K49/085 , A61K49/16 , A61K51/1045 , C07K16/22 , C07K16/28 , C07K16/2818 , C07K16/2833 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/46 , A61K2039/505 , A61K2123/00 , A61K38/00 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/73 , C07K2317/77 , C07K2319/33 , C07K2319/55 , Y10S530/807 , Y10S530/828
摘要： The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
摘要翻译： 本发明一般涉及使用基于免疫学和生长因子的试剂靶向实体瘤脉管系统的方法和组合物。 在特定方面，携带诊断或治疗剂的抗体通过识别肿瘤血管系相关抗原（例如通过内皮糖蛋白结合）或通过血管内皮细胞表面抗原的特异性诱导来靶向实体肿瘤块的脉管系统 实体瘤内皮细胞。
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