公开(公告)号：US20240316079A1

公开(公告)日：2024-09-26

申请号：US18261137

申请日：2021-02-26

Applicant: OBI PHARMA, INC.

Inventor： Jianxin Duan ,  Fanying Meng ,  Tianyang Qi ,  Chun-Chung Wang ,  Lu-Tzu Chen ,  Wan-Fen Li ,  Ming-Tain Lai

IPC: A61K31/675 ,  A61K31/404 ,  A61K31/513 ,  A61K31/573 ,  A61K31/58 ,  A61K31/7068 ,  A61P35/00

CPC classification number: A61K31/675 ,  A61K31/404 ,  A61K31/513 ,  A61K31/573 ,  A61K31/58 ,  A61K31/7068 ,  A61P35/00

Abstract: Provided are the use of the compound 1-(3-(3-N,N-dimethylaminocarbonyl)phenoxyl-4-mtrophenyl)-1-ethyl-N,N′-bis(ethylene)phosphoramidate, or a pharmaceutically acceptable salt, isotopic variant or solvate thereof in the manufacture of a medicament for treating cancer, and a composition which comprises the above compound and at least one anti-cancer drug.

公开(公告)号：US12090212B2

公开(公告)日：2024-09-17

申请号：US17133388

申请日：2020-12-23

Applicant: OBI Pharma, Inc.

Inventor： Michael Nientse Chang ,  Jiann-Shiun Lai ,  Wan-Fen Li ,  I-Ju Chen ,  Yi-Chien Tsai ,  Kai-Chuan Chen

IPC: A61K47/68 ,  A61K39/395 ,  A61K45/06 ,  A61K49/00 ,  A61K49/16 ,  A61K51/10 ,  A61P35/00 ,  A61P35/04 ,  C07K16/18 ,  C07K16/30 ,  C07K16/44 ,  C08B37/00 ,  G01N33/574 ,  A61K39/00

CPC classification number: A61K47/6855 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6817 ,  A61K47/6843 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6863 ,  A61K49/0058 ,  A61K49/16 ,  A61K51/1018 ,  A61K51/1051 ,  A61K51/1054 ,  A61K51/1057 ,  A61K51/1063 ,  A61P35/00 ,  A61P35/04 ,  C07K16/18 ,  C07K16/3076 ,  C07K16/44 ,  C08B37/0006 ,  G01N33/57492 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  A61K39/39558 ,  A61K2300/00

Abstract: Antibody drug conjugates (ADC's) comprising a drug conjugated to antibody or antigen binding fragments thereof that bind to Globo series antigen disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as sarcoma, skin cancer, leukemia, lymphoma, brain cancer, glioblastoma, lung cancer, breast cancer, oral cancer, head-and-neck cancer, nasopharyngeal cancer, esophagus cancer, stomach cancer, liver cancer, bile duct cancer, gallbladder cancer, bladder cancer, pancreatic cancer, intestinal cancer, colorectal cancer, kidney cancer, cervix cancer, endometrial cancer, ovarian cancer, testical cancer, buccal cancer, oropharyngeal cancer, laryngeal cancer and prostate cancer.

公开(公告)号：US20180193481A1

公开(公告)日：2018-07-12

申请号：US15820309

申请日：2017-11-21

Applicant: OBI Pharma, Inc.

Inventor： Michael Nientse Chang ,  Jiann-Shiun Lai ,  Wan-Fen Li ,  I-Ju Chen ,  Yi-Chien Tsai ,  Kai-Chuan Chen

IPC: A61K47/68 ,  A61P35/00 ,  C08B37/00 ,  A61K45/06 ,  A61K39/395 ,  G01N33/574 ,  A61K51/10 ,  A61K49/16 ,  A61K49/00 ,  A61P35/04 ,  C07K16/18 ,  C07K16/30

CPC classification number: A61K47/6855 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6817 ,  A61K47/6843 ,  A61K47/6857 ,  A61K47/6859 ,  A61K47/6863 ,  A61K49/0058 ,  A61K49/16 ,  A61K51/1018 ,  A61K51/1051 ,  A61K51/1054 ,  A61K51/1057 ,  A61K51/1063 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  A61P35/00 ,  A61P35/04 ,  C07K16/18 ,  C07K16/3076 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C08B37/0006 ,  G01N33/57492 ,  A61K2300/00

Abstract: Antibody drug conjugates (ADC's) comprising a drug conjugated to antibody or antigen binding fragments thereof that bind to Globo series antigen disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as sarcoma, skin cancer, leukemia, lymphoma, brain cancer, glioblastoma, lung cancer, breast cancer, oral cancer, head-and-neck cancer, nasopharyngeal cancer, esophagus cancer, stomach cancer, liver cancer, bile duct cancer, gallbladder cancer, bladder cancer, pancreatic cancer, intestinal cancer, colorectal cancer, kidney cancer, cervix cancer, endometrial cancer, ovarian cancer, testicle cancer, buccal cancer, oropharyngeal cancer, laryngeal cancer and prostate cancer.

公开(公告)号：US11000601B2

公开(公告)日：2021-05-11

申请号：US15820309

申请日：2017-11-21

Applicant: OBI Pharma, Inc.

Inventor： Michael Nientse Chang ,  Jiann-Shiun Lai ,  Wan-Fen Li ,  I-Ju Chen ,  Yi-Chien Tsai ,  Kai-Chuan Chen

IPC: A61K47/68 ,  C08B37/00 ,  A61K45/06 ,  A61K39/395 ,  G01N33/574 ,  A61K51/10 ,  A61K49/16 ,  A61K49/00 ,  A61P35/04 ,  C07K16/18 ,  C07K16/30 ,  A61P35/00 ,  C07K16/44 ,  A61K39/00

Abstract: Antibody drug conjugates (ADC's) comprising a drug conjugated to antibody or antigen binding fragments thereof that bind to Globo series antigen disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as sarcoma, skin cancer, leukemia, lymphoma, brain cancer, glioblastoma, lung cancer, breast cancer, oral cancer, head-and-neck cancer, nasopharyngeal cancer, esophagus cancer, stomach cancer, liver cancer, bile duct cancer, gallbladder cancer, bladder cancer, pancreatic cancer, intestinal cancer, colorectal cancer, kidney cancer, cervix cancer, endometrial cancer, ovarian cancer, testical cancer, buccal cancer, oropharyngeal cancer, laryngeal cancer and prostate cancer.

公开(公告)号：US20210113711A1

公开(公告)日：2021-04-22

申请号：US17133388

申请日：2020-12-23

Applicant: OBI Pharma, Inc.

Inventor： Michael Nientse Chang ,  Jiann-Shiun Lai ,  Wan-Fen Li ,  I-Ju CHEN ,  Yi-Chien Tsai ,  Kai-Chuan Chen

IPC: A61K47/68 ,  C08B37/00 ,  A61K45/06 ,  A61K39/395 ,  G01N33/574 ,  A61K51/10 ,  A61K49/16 ,  A61K49/00 ,  A61P35/04 ,  C07K16/18 ,  C07K16/30 ,  A61P35/00 ,  C07K16/44

Abstract: Antibody drug conjugates (ADC's) comprising a drug conjugated to antibody or antigen binding fragments thereof that bind to Globo series antigen disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as sarcoma, skin cancer, leukemia, lymphoma, brain cancer, glioblastoma, lung cancer, breast cancer, oral cancer, head-and-neck cancer, nasopharyngeal cancer, esophagus cancer, stomach cancer, liver cancer, bile duct cancer, gallbladder cancer, bladder cancer, pancreatic cancer, intestinal cancer, colorectal cancer, kidney cancer, cervix cancer, endometrial cancer, ovarian cancer, testical cancer, buccal cancer, oropharyngeal cancer, laryngeal cancer and prostate cancer.