公开(公告)号：US20110165084A1

公开(公告)日：2011-07-07

申请号：US12920451

申请日：2009-03-03

Applicant: E.J Delikatny ,  Anatoliy V. Popov ,  Gang Zheng ,  Theresa Mawn

Inventor： E.J Delikatny ,  Anatoliy V. Popov ,  Gang Zheng ,  Theresa Mawn

IPC: A61K49/00 ,  C12Q1/44 ,  C07D487/22 ,  C07F9/6584

CPC classification number: C12Q1/61 ,  A61K41/0071 ,  A61K49/0017 ,  A61K49/0032 ,  A61K49/0036 ,  G01N33/5011 ,  G01N33/542 ,  G01N33/57484

Abstract: The present invention is directed to a phospholipid-based NIR molecular beacon, having a phospholipid moiety; with an NIR fluorophore moiety covalently linked to a phospholipid glycerol backbone and a quencher moiety covalently linked to the phospholipid glycerol backbone. Additionally, provided herein is methods of analyzing a sample for the presence of a phospholipase and methods of identifying the activity of a phospholipase in vivo utilizing phospholipid-based NIR molecular beacon.

Abstract translation: 本发明涉及具有磷脂部分的基于磷脂的NIR分子信标; 与共价连接到磷脂甘油骨架的NIR荧光团部分和共价连接到磷脂甘油骨架的猝灭剂部分。 此外，本文提供了分析样品中磷脂酶的存在的方法和使用基于磷脂的NIR分子信标在体内鉴定磷脂酶活性的方法。

公开(公告)号：US20110137228A1

公开(公告)日：2011-06-09

申请号：US12849581

申请日：2010-08-03

Applicant: Joan W. Miller ,  Evangelos S. Gragoudas

Inventor： Joan W. Miller ,  Evangelos S. Gragoudas

IPC: A61F9/00

CPC classification number: A61F9/008 ,  A61K9/0019 ,  A61K9/1275 ,  A61K31/409 ,  A61K31/555 ,  A61K41/0071 ,  A61K49/0036 ,  A61K49/0084 ,  Y10S514/912

Abstract: Photodynamic therapy of conditions of the eye characterized by unwanted neovasculature, such as age-related macular degeneration, is effective using green porphyrins as photoactive agents, preferably as liposomal compositions.

Abstract translation: 使用绿色卟啉作为光活性剂，优选作为脂质体组合物，对以不想要的新血管系统为特征的眼睛疾病的光动力疗法如年龄相关性黄斑变性是有效的。

公开(公告)号：US07947672B2

公开(公告)日：2011-05-24

申请号：US10534692

申请日：2003-11-17

Applicant: Avigdor Scherz ,  Alexander Brandis ,  Ohad Mazor ,  Yoram Salomon ,  Hugo Scheer

Inventor： Avigdor Scherz ,  Alexander Brandis ,  Ohad Mazor ,  Yoram Salomon ,  Hugo Scheer

IPC: A61K31/555 ,  A01N55/02 ,  C07B47/00 ,  C07D487/22

CPC classification number: A61N5/062 ,  A61F9/0008 ,  A61K31/40 ,  A61K41/0071 ,  A61K41/0076 ,  A61K49/0036 ,  A61N5/0624 ,  C07F1/08 ,  C07F3/02 ,  C07F3/06 ,  C07F13/005 ,  C07F15/006 ,  C07F15/0066 ,  C07F15/045

Abstract: The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one, preferably two or three, negatively charged groups and/or acidic groups that are converted to negatively charged groups at the physiological pH, preferably Bchls having a group COO , COS , SO3 , PO3 , COOH, COSH, SO3H, and/or PO3H2 bound through an ester or amide bond to one or more of the positions 17 , 13 , and 3 of the tetracyclic or pentacyclic Bchl molecule, for photodynamic therapy and diagnosis.

Abstract translation: 本发明提供阴离子水溶性四环和五环类细菌叶绿素衍生物（Bchls），其含有至少一个，优选两个或三个带负电荷的基团和/或酸性基团，其在生理pH下转化为带负电荷的基团，优选具有基团的Bchls CO 3，SO 3 - ，SO 3 - ，PO 3 2-，COOH，COSH，SO 3 H和/或PO 3 H 2，其通过酯或酰胺键与一个或多个位置17 3， 13 3和3 2的四环或五环Bchl分子，用于光动力学治疗和诊断。

公开(公告)号：US20110117029A1

公开(公告)日：2011-05-19

申请号：US12942938

申请日：2010-11-09

Applicant: Avigdor SCHERZ ,  Alexander Brandis ,  Ohad Mazor ,  Yoram Salomon ,  Hugo Scheer

Inventor： Avigdor SCHERZ ,  Alexander Brandis ,  Ohad Mazor ,  Yoram Salomon ,  Hugo Scheer

IPC: A61K31/555 ,  C07D487/22 ,  C07K17/02 ,  A61K49/00 ,  A01N55/02 ,  A61K39/44 ,  A61P35/00 ,  A61P27/02 ,  A01P1/00

CPC classification number: A61N5/062 ,  A61F9/0008 ,  A61K31/40 ,  A61K41/0071 ,  A61K41/0076 ,  A61K49/0036 ,  A61N5/0624 ,  C07F1/08 ,  C07F3/02 ,  C07F3/06 ,  C07F13/005 ,  C07F15/006 ,  C07F15/0066 ,  C07F15/045

Abstract: The invention provides anionic water-soluble tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one, preferably two or three, negatively charged groups and/or acidic groups that are converted to negatively charged groups at the physiological pH, preferably Bchls having a group COO , COS , SO3 , PO3 , COOH, COSH, SO3H, and/or PO3H2 bound through an ester or amide bond to one or more of the positions 17 , 13 , and 3 of the tetracyclic or pentacyclic Bchl molecule, for photodynamic therapy and diagnosis.

Abstract translation: 本发明提供阴离子水溶性四环和五环类细菌叶绿素衍生物（Bchls），其含有至少一个，优选两个或三个带负电荷的基团和/或酸性基团，其在生理pH下转化为带负电荷的基团，优选具有基团的Bchls CO 3，SO 3 - ，SO 3 - ，PO 3 2-，COOH，COSH，SO 3 H和/或PO 3 H 2，其通过酯或酰胺键与一个或多个位置17 3， 13 3和3 2的四环或五环Bchl分子，用于光动力学治疗和诊断。

公开(公告)号：US20110014125A1

公开(公告)日：2011-01-20

申请号：US12920771

申请日：2009-03-03

Applicant: Stefan H. Bossmann ,  Deryl L. Troyer ,  Matthew T. Basel

Inventor： Stefan H. Bossmann ,  Deryl L. Troyer ,  Matthew T. Basel

IPC: A61K49/00 ,  C12N11/00 ,  C12N11/14 ,  C12N11/02 ,  C12Q1/37

CPC classification number: A61K49/0067 ,  A61K49/0036 ,  A61K49/0056 ,  A61K49/0065 ,  A61K49/0093 ,  B82Y15/00 ,  C07K5/1021 ,  C07K7/06 ,  C07K7/08 ,  C12Q1/37 ,  G01N33/588 ,  G01N2800/7028 ,  Y10S977/773 ,  Y10S977/774 ,  Y10S977/92

Abstract: The present invention provides a diagnostic reagent or assay for assessing the activity of a protease in vivo or in vitro and methods of detecting the presence of a cancerous or precancerous cell. The assays are comprised of two particles linked via an oligopeptide linkage that comprises a consensus sequence specific for the target protease. Cleavage of the sequence by the target protease can be detected visually or using various sensors, and the diagnostic results can be correlated with cancer prognosis.

Abstract translation: 本发明提供用于评估蛋白酶在体内或体外的活性的诊断试剂或测定法，以及检测癌性或癌前细胞的存在的方法。 测定由通过寡肽连接的两个颗粒组成，其包含对靶蛋白酶特异性的共有序列。 可以目测或使用各种传感器检测靶蛋白酶序列的切割，诊断结果可与癌症预后相关。

公开(公告)号：US20100255523A1

公开(公告)日：2010-10-07

申请号：US12584691

申请日：2009-09-10

Applicant: Egbert G. Mik ,  Michiel Sinaasappel

Inventor： Egbert G. Mik ,  Michiel Sinaasappel

IPC: C12Q1/02 ,  C12M1/34

CPC classification number: A61K49/0036 ,  A61K49/0021 ,  A61K49/0056 ,  G01N21/6408 ,  Y10T436/207497

Abstract: Described are methods for determining a concentration of a substance in a compartment comprising exciting an endogenous compound, or a functional part, derivative, analogue or precursor thereof, measuring the lifetime of the luminescence and/or transient absorption exhibited by the compound, functional part, derivative, analogue and/or precursor, and correlating the lifetime with the concentration of the substance.

Abstract translation: 描述了用于测定室内物质浓度的方法，包括激发内源化合物或其功能部分，衍生物，类似物或前体，测量化合物，功能部分所显示的发光和/或瞬时吸收的寿命， 衍生物，类似物和/或前体，并将寿命与物质的浓度相关联。

公开(公告)号：US07700717B2

公开(公告)日：2010-04-20

申请号：US10950378

申请日：2004-09-24

Applicant: Thomas A. Bonasera ,  Nurit Livnah ,  Yoseph Salitra ,  Tamar Yechezkel

Inventor： Thomas A. Bonasera ,  Nurit Livnah ,  Yoseph Salitra ,  Tamar Yechezkel

IPC: A61K38/16

CPC classification number: A61K41/0057 ,  A61K38/00 ,  A61K41/0071 ,  A61K49/0036 ,  A61K49/0041 ,  A61K49/0043 ,  A61K49/0056 ,  C07K14/6555

Abstract: Novel photo-active labeled diagnostic and therapeutic peptides which are conformationally constrained backbone cyclized somatostatin analogs, having improved somatostatin receptor subtype affinity and selectivity are disclosed. The backbone cyclized peptide analogs disclosed possess unique and superior properties over other analogs, such as chemical and metabolic stability, selectivity, increased bioavailability and improved pharmacokinetics. Furthermore, the unique patterns of receptor subtype selectivity provide compounds having improved diagnostic and therapeutic utilities. Pharmaceutical compositions comprising the photo-active backbone cyclized somatostatin analogs, reagents for synthesizing same, and methods of using such compositions for diagnostic and therapeutic purposes including optical imaging and photodynamic therapy are also disclosed.

Abstract translation: 公开了具有改善的生长抑素受体亚型亲和性和选择性的新型光活性标记的诊断和治疗肽，其是构象约束的骨架环化生长抑素类似物。 所公开的骨架环化肽类似物具有优于其它类似物的独特且优异的性质，例如化学和代谢稳定性，选择性，增加的生物利用度和改善的药代动力学。 此外，受体亚型选择性的独特模式提供具有改进的诊断和治疗效用的化合物。 还公开了包含光活性骨架环化的生长抑素类似物的药物组合物，用于合成它们的试剂，以及使用这些组合物用于包括光学成像和光动力疗法在内的诊断和治疗目的的方法。

公开(公告)号：US07682603B2

公开(公告)日：2010-03-23

申请号：US10777552

申请日：2004-02-12

Applicant: Daniel A. Hammer ,  Michael J. Therien ,  Paiman Peter Ghoroghchian

Inventor： Daniel A. Hammer ,  Michael J. Therien ,  Paiman Peter Ghoroghchian

IPC: A61B5/00 ,  A61B10/00

CPC classification number: A61K49/0036 ,  A61K49/0021 ,  A61K49/0041 ,  A61K49/0086

Abstract: The instant invention concerns compositions comprising polymersomes, visible or near infrared emissive agents, and optionally a targeting moiety associated with a surface of the polymersome. The invention also relates to use of these compositions in the treatment of disease and in imaging methodology.

Abstract translation: 本发明涉及包含聚合物单体，可见或近红外发射剂和任选的与聚合物的表面相关的靶向部分的组合物。 本发明还涉及这些组合物在治疗疾病和成像方法中的用途。

公开(公告)号：US07662362B2

公开(公告)日：2010-02-16

申请号：US10935297

申请日：2004-09-07

Applicant: Periannan Kuppusamy ,  Ramasamy P. Pandian ,  Narasimham L. Parinandi ,  Jay L. Zweier

Inventor： Periannan Kuppusamy ,  Ramasamy P. Pandian ,  Narasimham L. Parinandi ,  Jay L. Zweier

IPC: A61B5/055 ,  C07B47/00 ,  C07D487/22

CPC classification number: A61K49/10 ,  A61K49/0036 ,  A61K49/1818 ,  A61K49/20 ,  B82Y5/00 ,  C07F1/02 ,  G01R33/5601 ,  G01R33/60 ,  G01R33/62

Abstract: A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.

Abstract translation: 一类新型的微粒子和纳米颗粒顺磁性自旋探针，特别适用于磁共振成像技术，包括电子顺磁共振（EPR）和磁共振成像（MRI）。 探针是锂酞菁衍生物化合物。 还提供了包含锂酞菁衍生物探针的悬浮液和乳液。 还提供了用于在体内或体外测量特定组织，器官或细胞中的氧浓度，氧分压，氧代谢和一氧化氮浓度的无创方法的非侵入性方法。

公开(公告)号：US20090098058A1

公开(公告)日：2009-04-16

申请号：US12040478

申请日：2008-02-29

Applicant: Kwang Sup Soh ,  Cheon Joo Choi ,  Min Soo Kim ,  Baeck Kyoung Sung ,  Vyacheslav Ogay

Inventor： Kwang Sup Soh ,  Cheon Joo Choi ,  Min Soo Kim ,  Baeck Kyoung Sung ,  Vyacheslav Ogay

IPC: A61K49/00

CPC classification number: A61K49/0036 ,  A61B5/4854 ,  A61K41/0004 ,  A61K49/0041 ,  A61K49/006 ,  A61K49/0093 ,  Y10S128/907

Abstract: Provided are a method of injecting a visualizing material into a point in the vicinity of the Jung-Wan and a method of visualizing arrival of liquid agent in order to verify that the visualizing material injected arrives at internal organs. A point having the lowest electric resistance is found in the vicinity of Jung-Wan of the subject by using an electro acupuncture point detector. The visualizing material is injected into the point by means of an injecting instrument and then verified at least one point of the pancreas and the threadlike structures on top of the surface of the pancreas. The visualizing material is an alcian blue solution or a nanoparticle-containing solution labeled with fluorescent organic material.

Abstract translation: 提供了将可视化材料注入到Jung-Wan附近的点中的方法以及可视化液体剂的到达的方法，以便验证注入的可视化材料到达内部器官。 通过使用电针穴检测器，在受试者的Jung-Wan附近发现具有最低电阻的点。 通过注射器将可视化材料注入点，然后验证胰腺表面至少一个点和胰腺表面上的线状结构。 可视化材料是用荧光有机材料标记的阿尔卑斯蓝色溶液或含纳米颗粒的溶液。