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公开(公告)号：US20100172843A1
公开(公告)日：2010-07-08
申请号：US12688767
申请日：2010-01-15
Applicant: Periannan Kuppusamy , Ramasamy P. Pandian , Narasimham L. Parinandi , Jay L. Zweier
Inventor： Periannan Kuppusamy , Ramasamy P. Pandian , Narasimham L. Parinandi , Jay L. Zweier
CPC classification number: A61K49/10 , A61K49/0036 , A61K49/1818 , A61K49/20 , B82Y5/00 , C07F1/02 , G01R33/5601 , G01R33/60 , G01R33/62
Abstract: A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.
Abstract translation: 一类新型的微粒子和纳米颗粒顺磁性自旋探针，特别适用于磁共振成像技术，包括电子顺磁共振（EPR）和磁共振成像（MRI）。 探针是锂酞菁衍生物化合物。 还提供了包含锂酞菁衍生物探针的悬浮液和乳液。 还提供了用于在体内或体外测量特定组织，器官或细胞中的氧浓度，氧分压，氧代谢和一氧化氮浓度的非侵入性方法的非侵入性方法。
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公开(公告)号：US08568694B2
公开(公告)日：2013-10-29
申请号：US12688767
申请日：2010-01-15
Applicant: Periannan Kuppusamy , Ramasamy P. Pandian , Narasimham L. Parinandi , Jay L. Zweier
Inventor： Periannan Kuppusamy , Ramasamy P. Pandian , Narasimham L. Parinandi , Jay L. Zweier
IPC: A61B5/055 , C07B47/00 , C07D487/22
CPC classification number: A61K49/10 , A61K49/0036 , A61K49/1818 , A61K49/20 , B82Y5/00 , C07F1/02 , G01R33/5601 , G01R33/60 , G01R33/62
Abstract: A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.
Abstract translation: 一类新型的微粒子和纳米颗粒顺磁性自旋探针，特别适用于磁共振成像技术，包括电子顺磁共振（EPR）和磁共振成像（MRI）。 探针是锂酞菁衍生物化合物。 还提供了包含锂酞菁衍生物探针的悬浮液和乳液。 还提供了用于在体内或体外测量特定组织，器官或细胞中的氧浓度，氧分压，氧代谢和一氧化氮浓度的无创方法的非侵入性方法。
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公开(公告)号：US07662362B2
公开(公告)日：2010-02-16
申请号：US10935297
申请日：2004-09-07
Applicant: Periannan Kuppusamy , Ramasamy P. Pandian , Narasimham L. Parinandi , Jay L. Zweier
Inventor： Periannan Kuppusamy , Ramasamy P. Pandian , Narasimham L. Parinandi , Jay L. Zweier
IPC: A61B5/055 , C07B47/00 , C07D487/22
CPC classification number: A61K49/10 , A61K49/0036 , A61K49/1818 , A61K49/20 , B82Y5/00 , C07F1/02 , G01R33/5601 , G01R33/60 , G01R33/62
Abstract: A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.
Abstract translation: 一类新型的微粒子和纳米颗粒顺磁性自旋探针，特别适用于磁共振成像技术，包括电子顺磁共振（EPR）和磁共振成像（MRI）。 探针是锂酞菁衍生物化合物。 还提供了包含锂酞菁衍生物探针的悬浮液和乳液。 还提供了用于在体内或体外测量特定组织，器官或细胞中的氧浓度，氧分压，氧代谢和一氧化氮浓度的无创方法的非侵入性方法。
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