Invention Grant
- Patent Title: Nanoparticulate probe for in vivo monitoring of tissue oxygenation
- Patent Title (中): 纳米微粒探针用于体内监测组织氧合
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Application No.: US12688767Application Date: 2010-01-15
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Publication No.: US08568694B2Publication Date: 2013-10-29
- Inventor: Periannan Kuppusamy , Ramasamy P. Pandian , Narasimham L. Parinandi , Jay L. Zweier
- Applicant: Periannan Kuppusamy , Ramasamy P. Pandian , Narasimham L. Parinandi , Jay L. Zweier
- Applicant Address: US OH Columbus
- Assignee: The Ohio State University Research Foundation
- Current Assignee: The Ohio State University Research Foundation
- Current Assignee Address: US OH Columbus
- Agency: Harter Secrest & Emery LLP
- Agent Brian B. Shaw, Esq.; Andrew J. Anderson, Esq.
- Main IPC: A61B5/055
- IPC: A61B5/055 ; C07B47/00 ; C07D487/22
Abstract:
A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.
Public/Granted literature
- US20100172843A1 NANOPARTICULATE PROBE FOR IN VIVO MONITORING OF TISSUE OXYGENATION Public/Granted day:2010-07-08
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