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192 条记录 (耗时 0.014 秒)

    Process for the preparation of a spermicidal agent
    61.
    发明授权
    Process for the preparation of a spermicidal agent 失效
    杀精剂的制备方法

    公开(公告)号：US06333058B1

    公开(公告)日：2001-12-25

    申请号：US09007837

    申请日：1998-01-15

    申请人： Govindaswamy Ilavazhagan ,  Chakra Devakumar

    发明人： Govindaswamy Ilavazhagan ,  Chakra Devakumar

    IPC分类号： A61K3578

    CPC分类号： A61K36/58 ,  Y10S424/12 ,  Y10S424/14 ,  Y10S514/841 ,  Y10S514/842 ,  Y10S514/843

    摘要： A process for preparing a spermicidal agent from neem oil includes (a) mixing neem oil with an aliphatic hydrocarbon solvent so that a precipitate forms, and filtering the mixture to separate the filtrate solution from the precipitate; (b) contacting the filtrate solution of step (a) with a polar extractant solvent whereby a spermicidal agent is extracted from the filtrate solution into the polar extractant solvent; and (c) removing solvent from the polar extractant solvent to produce a concentrated solution containing extract a spermicidal agent.

    摘要翻译： 从楝树油制备杀精剂的方法包括（a）将楝树油与脂族烃溶剂混合，形成沉淀，并过滤混合物以将滤液与沉淀物分离; （b）使步骤（a）的滤液与极性萃取剂溶剂接触，由此将杀精剂从滤液中提取到极性萃取剂溶剂中; 和（c）从极性萃取剂溶剂中除去溶剂以产生含有提取物的浓缩溶液杀精剂。

    Process for the preperation of spermicidal agents and other biologically active materials
    62.
    发明授权
    Process for the preperation of spermicidal agents and other biologically active materials 失效
    杀精剂和其他生物活性物质的制备方法

    公开(公告)号：US6083506A

    公开(公告)日：2000-07-04

    申请号：US14703

    申请日：1998-01-28

    申请人： Govindaswamy Ilavazhagan ,  Chakra Devakumar

    发明人： Govindaswamy Ilavazhagan ,  Chakra Devakumar

    IPC分类号： A01N65/00 ,  A61K36/58 ,  A61K35/78 ,  A01N25/00

    CPC分类号： A61K36/58 ,  A01N65/26 ,  Y10S514/841

    摘要： A process for the preparation of spermicidal agents and other biologically active materials from neem oil or extractives by subjecting a neem feed obtained from neem oil to the step of enrichment. Such a step of enrichment is carried out in a chromatographic column containing a sorbant, and the feed is eluted with a non polar followed by a polar solvent or mixtures thereof. In accordance with one embodiment, the feed is formed by subjecting neem oil to the step of solvent partition, the precipitate being removed therefrom and the filterate forming the feed. In accordance with another embodiment, the feed is formed by adding a polar solvent to the filterate of the first embodiment, the lower layer formed therefrom being subjected to the step of distillation for removal of the solvent to obtain a feed.

    摘要翻译： 一种从楝树油或提取物中制备杀精剂和其它生物活性物质的方法，该方法是将从楝树油获得的楝树饲料进行富集步骤。 这样的富集步骤在含有吸附剂的色谱柱中进行，并且进料以非极性洗脱，然后用极性溶剂或其混合物洗脱。 根据一个实施方案，通过使楝树油经受溶剂分配的步骤，从其中除去沉淀物并形成进料的过滤器来形成进料。 根据另一个实施方案，通过向第一实施方案的过滤器中加入极性溶剂形成进料，由其形成的下层进行蒸馏步骤以除去溶剂以获得进料。

    Hot-water extracts of neem bark
    66.
    发明授权
    Hot-water extracts of neem bark 失效
    楝树皮热水提取物

    公开(公告)号：US4537774A

    公开(公告)日：1985-08-27

    申请号：US541479

    申请日：1983-10-13

    申请人： Masaki Shimizu ,  Tadashi Sudo ,  Takeo Nomura

    发明人： Masaki Shimizu ,  Tadashi Sudo ,  Takeo Nomura

    IPC分类号： A61K36/00 ,  A61K36/58 ,  A61K35/78

    CPC分类号： A61K36/58

    摘要： Hot-water extracts of the neem bark produced by treating the bark of neem with water at a temperature from 0.degree. to 40.degree. C. and subjecting the residue from said pre-extraction treatment to extraction treatment with hot water. Purification of the extract thus produced by means of alcohol precipitation or dialysis gives products of a higher purity. Moreover, treatments prior to the pre-extraction treatment with water at 0.degree.-40.degree. C. with a non-polar organic solvent having a dielectric constant of 10 or lower and a polar organic solvent having a dielectric constant from 15 to 35 yields neem extracts of a further higher purity. The hot-water extracts of the neem bark according to the present invention possess activity against mouse L-5178Y cells and transplanted sarcoma 180 tumors.

    摘要翻译： 通过在0℃至40℃的温度下用水处理楝树皮产生的楝树皮的热水提取物，并将来自所述预萃取处理的残余物用热水进行提取处理。 通过醇沉淀或透析纯化由此产生的提取物，产生更高纯度的产物。 此外，在用0至-40℃的水用介电常数为10或更低的非极性有机溶剂和介电常数为15至35的极性有机溶剂进行预萃取处理之前的处理产生neem 提取物具有更高的纯度。 根据本发明的楝树皮的热水提取物具有针对小鼠L-5178Y细胞和移植肉瘤180肿瘤的活性。