公开(公告)号：US20160324578A1

公开(公告)日：2016-11-10

申请号：US15152122

申请日：2016-05-11

Applicant: The General Hospital Corporation

Inventor： Dieter Manstein ,  Richard Anderson

IPC: A61B18/20 ,  A61B18/22

CPC classification number: A61B18/203 ,  A61B2017/00765 ,  A61B2018/00005 ,  A61B2018/00023 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2018/00577 ,  A61B2018/20351 ,  A61B2018/205545 ,  A61B2018/2065 ,  A61B2018/208 ,  A61B2090/0436 ,  A61B2090/0454 ,  A61B2090/049 ,  A61N5/0616 ,  A61N2005/0665

Abstract: A system and method for performing fractional resurfacing of a target area of skin using electromagnetic radiation are provided. An electromagnetic radiation is generated by an electromagnetic radiation source. The electromagnetic radiation is caused to be applied to a particular portion of a target area of skin. The electromagnetic radiation can be impeded from affecting another portion of the target area of the skin by a mask. Alternatively, the electromagnetic radiation may be applied to portions of the target area of the skin, other than the particular portion.

Abstract translation: 提供了一种使用电磁辐射进行皮肤目标区域的分数表面重建的系统和方法。 由电磁辐射源产生电磁辐射。 使电磁辐射施加到皮肤的目标区域的特定部分。 可以通过掩模阻止电磁辐射影响皮肤的目标区域的另一部分。 或者，除了特定部分之外，电磁辐射可以施加到皮肤的目标区域的部分。

公开(公告)号：US20160310395A1

公开(公告)日：2016-10-27

申请号：US14946512

申请日：2015-11-19

Applicant: The Trustees of the University of Pennsylvania

Inventor： George COTSARELIS ,  Mayumi Ito

IPC: A61K8/49 ,  A61K35/36 ,  A61K9/00 ,  A61M37/00 ,  A61K31/517 ,  A61K31/65 ,  A61K38/18 ,  A61Q7/00 ,  A61K31/506

CPC classification number: A61K8/4953 ,  A61B2017/00765 ,  A61B2018/00452 ,  A61K8/65 ,  A61K9/0014 ,  A61K31/506 ,  A61K31/517 ,  A61K31/65 ,  A61K35/36 ,  A61K38/1825 ,  A61K2800/74 ,  A61K2800/805 ,  A61M37/00 ,  A61M2037/0007 ,  A61Q5/00 ,  A61Q5/10 ,  A61Q7/00

Abstract: The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

Abstract translation: 本发明提供了治疗受试者的秃发并产生新的毛囊的方法，包括表皮破坏和施用促进将未表达的表皮细胞分化为毛囊细胞的化合物。 本发明还提供了脱毛和诱导毛发色素沉着的方法。

公开(公告)号：US09463308B2

公开(公告)日：2016-10-11

申请号：US14354275

申请日：2012-10-30

Applicant: LUMENIS LTD.

Inventor： Yoni Iger

IPC: A61B17/20 ,  A61M37/00 ,  A61N7/00 ,  A61B17/00 ,  A61B18/20 ,  A61B18/00

CPC classification number: A61M37/0092 ,  A61B18/203 ,  A61B2017/00747 ,  A61B2017/00765 ,  A61B2018/0047 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0007 ,  A61N7/00 ,  A61N2007/0034 ,  A61N2007/0039

Abstract: Disclosed herein is a method of fractional treatment of tissue, the method comprising: creating at least one micro hole in a target tissue; and either a) applying pressure on said target tissue to decrease the patency of said at least one micro hole; administering material and/or fluid and/or drug onto said target tissue; releasing said applied pressure on said target tissue to increase the patency of said at least one micro hole; and propelling said material and/or fluid and/or drug into said at least one micro hole; or b) administering material and/or fluid and/or drug onto said target tissue under sub-atmospheric pressure conditions, the patency of said at least one micro hole being decreased; increasing the atmospheric pressure to atmospheric or above atmospheric conditions to thereby increase the patency of said at least one micro hole; and propelling said material and/or fluid/and/or drug into said at least one micro hole.

Abstract translation: 本发明公开了一种分组处理组织的方法，该方法包括：在靶组织中产生至少一个微孔; 以及a）对所述目标组织施加压力以降低所述至少一个微孔的通畅度; 将物质和/或流体和/或药物施用到所述靶组织上; 释放对所述目标组织施加的压力以增加所述至少一个微孔的通畅度; 并且将所述材料和/或流体和/或药物推进所述至少一个微孔中; 或b）在低于大气压的条件下将材料和/或流体和/或药物施用到所述目标组织上，所述至少一个微孔的通畅被减小; 将大气压增加到大气或大气条件下，从而增加所述至少一个微孔的通畅度; 并且将所述材料和/或流体/和/或药物推进所述至少一个微孔。

公开(公告)号：US20160270850A1

公开(公告)日：2016-09-22

申请号：US15166632

申请日：2016-05-27

Applicant: The General Hospital Corporation

Inventor： Dieter MANSTEIN ,  Richard Anderson

IPC: A61B18/20

CPC classification number: A61B18/203 ,  A61B2017/00765 ,  A61B2018/00005 ,  A61B2018/00023 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2018/00577 ,  A61B2018/20351 ,  A61B2018/205545 ,  A61B2018/2065 ,  A61B2018/208 ,  A61B2090/0436 ,  A61B2090/0454 ,  A61B2090/049 ,  A61N5/0616 ,  A61N2005/0665

Abstract: A system and method for performing fractional resurfacing of a target area of skin using electromagnetic radiation are provided. An electromagnetic radiation is generated by an electromagnetic radiation source. The electromagnetic radiation is caused to be applied to a particular portion of a target area of skin. The electromagnetic radiation can be impeded from affecting another portion of the target area of the skin by a mask. Alternatively, the electromagnetic radiation may be applied to portions of the target area of the skin, other than the particular portion.

Abstract translation: 提供了一种使用电磁辐射进行皮肤目标区域的分数表面重建的系统和方法。 由电磁辐射源产生电磁辐射。 使电磁辐射施加到皮肤的目标区域的特定部分。 可以通过掩模阻止电磁辐射影响皮肤的目标区域的另一部分。 或者，除了特定部分之外，电磁辐射可以施加到皮肤的目标区域的部分。

公开(公告)号：US09044582B2

公开(公告)日：2015-06-02

申请号：US14257288

申请日：2014-04-21

Applicant: Franklin J. Chang ,  Henry Ping Chang

Inventor： Franklin J. Chang ,  Henry Ping Chang

IPC: A61M37/00 ,  A61N1/32 ,  A61B18/00

CPC classification number: A61M37/00 ,  A61B17/545 ,  A61B2017/00765 ,  A61B2018/00452 ,  A61B2217/005 ,  A61B2218/001 ,  A61M37/0015 ,  A61M37/0092 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61N1/0472 ,  A61N1/325 ,  A61N1/327 ,  A61N1/328

Abstract: An apparatus for transdermal fluid delivery includes a handle and a tip, having a skin applying surface, being driven to move by a driving unit. A fluid delivery structure has an aperture formed at the skin applying surface and a vacuum entry port. An abrading structure, an electrode structure, and a micro-needling structure are selectively provided at the skin applying surface with the fluid delivery structure to provide multiple functions of the tip. A flow of fluid is delivered onto the skin applying surface through the fluid delivery structure to interact with the abrading elements and the electrodes before the fluid is returned and collected, so that three different skin treatments of abrasive peeling, electrical stimulation, and liquid infusion are achieved in one single structure for improving a skin structure.

Abstract translation: 用于透皮流体输送的装置包括具有皮肤施用表面的手柄和尖端，被驱动以由驱动单元移动。 流体输送结构具有形成在皮肤施加表面上的孔和真空进入口。 在皮肤涂敷表面上选择性地提供研磨结构，电极结构和微针刺结构以提供流体输送结构以提供尖端的多种功能。 流体流动通过流体输送结构输送到皮肤施加表面上，以在返回和收集流体之前与研磨元件和电极相互作用，从而研磨剥离，电刺激和液体输注的三种不同的皮肤处理是 在单一结构中实现了改善皮肤结构。

公开(公告)号：US20150088050A1

公开(公告)日：2015-03-26

申请号：US14257288

申请日：2014-04-21

Applicant: Franklin J. Chang ,  Henry Ping Chang

Inventor： Franklin J. Chang ,  Henry Ping Chang

IPC: A61M37/00

CPC classification number: A61M37/00 ,  A61B17/545 ,  A61B2017/00765 ,  A61B2018/00452 ,  A61B2217/005 ,  A61B2218/001 ,  A61M37/0015 ,  A61M37/0092 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61N1/0472 ,  A61N1/325 ,  A61N1/327 ,  A61N1/328

Abstract: An apparatus for transdermal fluid delivery includes a handle and a tip, having a skin applying surface, being driven to move by a driving unit. A fluid delivery structure has an aperture formed at the skin applying surface and a vacuum entry port. An abrading structure, an electrode structure, and a micro-needling structure are selectively provided at the skin applying surface with the fluid delivery structure to provide multiple functions of the tip. A flow of fluid is delivered onto the skin applying surface through the fluid delivery structure to interact with the abrading elements and the electrodes before the fluid is returned and collected, so that three different skin treatments of abrasive peeling, electrical stimulation, and liquid infusion are achieved in one single structure for improving a skin structure.

Abstract translation: 用于透皮流体输送的装置包括具有皮肤施用表面的手柄和尖端，被驱动以由驱动单元移动。 流体输送结构具有形成在皮肤施加表面上的孔和真空进入口。 在皮肤涂敷表面上选择性地提供研磨结构，电极结构和微针刺结构以提供流体输送结构以提供尖端的多种功能。 流体流动通过流体输送结构输送到皮肤施加表面上，以在返回和收集流体之前与研磨元件和电极相互作用，从而研磨剥离，电刺激和液体输注的三种不同的皮肤处理是 在单一结构中实现了改善皮肤结构。

公开(公告)号：US20140031801A1

公开(公告)日：2014-01-30

申请号：US14040720

申请日：2013-09-29

Applicant: Joseph Giovannoli

Inventor： Joseph Giovannoli

IPC: A61B18/20

CPC classification number: A61B18/20 ,  A61B17/32093 ,  A61B18/203 ,  A61B2017/00747 ,  A61B2017/00761 ,  A61B2017/00765 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2018/00601 ,  A61B2018/00619 ,  A61B2018/00625 ,  A61B2018/208

Abstract: A method for reducing human or animal tissue includes making a plurality of excisions to collectively form a patch of tissue to be reduced, instead of making a single large excision in the patch. Thus, scarring after healing is less noticeable. The treated regions of tissue may be arranged such that a total area of all removed tissue segments taken in a direction perpendicular to an axis of the patch changes gradually along said axis. The removed regions of tissue may be navicular in shape, and the patches may be navicular in shape in the event an elongated excision is made. The removal of tissue regions can be realized by proper treatment methods such as incisions and laser treatment.

Abstract translation: 减少人或动物组织的方法包括制作多个切口以共同形成要减少的组织块，而不是在贴片中进行单次大的切除。 因此，愈合后的瘢痕形成不太明显。 组织的处理区域可以被布置成使得沿垂直于贴片的轴线的方向截取的所有去除的组织区段的总面积沿所述轴线逐渐变化。 去除的组织区域可以是舟形的，并且在进行细长切除的情况下，斑块可以是舟形的。 组织区域的去除可以通过适当的治疗方法如切口和激光治疗来实现。

公开(公告)号：US08386027B2

公开(公告)日：2013-02-26

申请号：US12110034

申请日：2008-04-25

Applicant: Han Chuang ,  Juan P. Eslava ,  James P. Hurley ,  Debashis Ghosh ,  Keith Krystyniak ,  Scott C. Kellogg

Inventor： Han Chuang ,  Juan P. Eslava ,  James P. Hurley ,  Debashis Ghosh ,  Keith Krystyniak ,  Scott C. Kellogg

IPC: A61B5/05 ,  A61B5/00 ,  A61B17/20 ,  A61N1/30 ,  A61N1/00

CPC classification number: A61B18/14 ,  A61B5/0531 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/442 ,  A61B5/7239 ,  A61B17/54 ,  A61B18/20 ,  A61B18/203 ,  A61B2017/00761 ,  A61B2017/00765 ,  A61B2017/320004 ,  A61B2018/00452 ,  A61B2018/00642 ,  A61M2037/0007 ,  A61N1/042 ,  A61N1/0424 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/30 ,  A61N1/327 ,  A61N1/328

Abstract: Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. The feedback control mechanism may be an internal feedback control mechanism or an external feedback control. The kit contains the controlled abrasion-device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time, until the desired level of permeability is reached. Then the abrasion device is removed, and a drug delivery composition or device or an analyte sensor is applied to the treated site.

Abstract translation: 本文描述了用于增加由测量的皮肤电参数控制的皮肤渗透性的装置，系统，试剂盒和方法。 它们可用于透皮药物递送和/或分析物提取或测量。 受控磨损装置包括（i）手件，（ii）研磨尖端，（iii）反馈控制机构，（iv）两个或更多个电极，和（v）电动机。 反馈控制机构可以是内部反馈控制机构或外部反馈控制。 该套件包含受控的磨损装置，一个或多个研磨尖端，任选地具有润湿流体。 增加皮肤渗透性的方法需要将受控的磨损装置施用于皮肤表面的一部分短时间，直至达到所需的渗透性水平。 然后去除磨损装置，并将药物递送组合物或装置或分析物传感器施加到处理部位。

公开(公告)号：US08376984B2

公开(公告)日：2013-02-19

申请号：US11183000

申请日：2005-07-14

Applicant: Terry L. James

Inventor： Terry L. James

IPC: A61B17/20

CPC classification number: A61B17/205 ,  A61B2017/00747 ,  A61B2017/00765 ,  A61M37/0015 ,  A61M2037/0023

Abstract: An apparatus for delivering a bioactive material to a subterranean layer of a skin architecture is provided that includes a head including one or more needles that are operable to penetrate a stratum corneum of a skin. A bioactive material is disposed on one or more of the needles, whereby movement of the head operates to pick up the bioactive material and to deliver a portion of the bioactive material to a selected location, the selected location being a dermis, or an epidermis, or both the dermis and the epidermis. In more particular embodiments, the bioactive material is a macromolecule substance that is part of a group of substances, the group consisting of a protein, a vitamin, a gene, a growth agent, a drug, and a peptide. The needles create an injury that triggers collagen production from one or more fibroblasts in the skin.

Abstract translation: 提供了一种用于将生物活性材料输送到皮肤结构的地下层的装置，其包括头部，头部包括可操作以穿透皮肤角质层的一个或多个针头。 生物活性材料设置在一个或多个针上，由此头部的移动操作以拾取生物活性材料并将一部分生物活性材料输送到选定位置，所选择的位置是真皮或表皮， 或真皮和表皮两者。 在更具体的实施方案中，生物活性物质是作为一组物质的一部分的大分子物质，其由蛋白质，维生素，基因，生长剂，药物和肽组成。 针头产生一种伤害，从而触发皮肤中一种或多种成纤维细胞产生胶原蛋白。

公开(公告)号：US08123701B2

公开(公告)日：2012-02-28

申请号：US12779317

申请日：2010-05-13

Applicant: Joel S. Douglas ,  Jeffrey N. Roe ,  Ryszard Radwanski ,  Brent G. Duchon

Inventor： Joel S. Douglas ,  Jeffrey N. Roe ,  Ryszard Radwanski ,  Brent G. Duchon

IPC: A61B5/00

CPC classification number: A61B10/0045 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150755 ,  A61B5/150824 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15117 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/157 ,  A61B2010/0003 ,  A61B2010/008 ,  A61B2017/00765 ,  A61B2562/0295

Abstract: A sampling device for sampling body fluid includes a lancet for making an incision, a capillary tube for drawing-up body fluid from the incision, and a test strip affixed to an upper end of the capillary tube for receiving the fluid. An absorbent pad can be disposed between the test strip and capillary tube for spreading-out the fluid being transferred to the test strip. An onsite analyzer such as an optical analyzer and/or an electrochemical analyzer can be mounted in the device for analyzing the fluid. Alternatively, a test strip can be slid through a slot formed in the bottom end of the device so that by passing the device against the skin after an incision has been formed, the test strip will directly contact body fluid emanating from the incision.

Abstract translation: 用于体液取样的采样装置包括用于切开的刺血针，用于从切口吸取体液的毛细管，以及固定到毛细管的上端以接收流体的测试条。 可以在测试条和毛细管之间设置吸收垫，以便将被传送到测试条的流体展开。 诸如光学分析仪和/或电化学分析仪的现场分析仪可以安装在用于分析流体的装置中。 或者，测试条可以滑动通过形成在装置的底端的槽，使得通过在形成切口之后使装置抵靠皮肤，测试条将直接接触从切口发出的体液。