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公开(公告)号：US20170203103A1
公开(公告)日：2017-07-20
申请号：US15411933
申请日：2017-01-20
摘要： Methods and apparatuses for stimulation of the vagus nerve to treat inflammation including adjusting the stimulation based on one or more metric sensitive to patient response. The one or more metrics may include heart rate variability, level of T regulatory cells, particularly memory T regulatory cells, temperature, etc. Stimulation may be provided through an implantable microstimulator.
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公开(公告)号：US20160331952A1
公开(公告)日：2016-11-17
申请号：US15153639
申请日：2016-05-12
CPC分类号： A61N1/025 , A61N1/36053 , A61N1/36125 , A61N1/37205 , A61N1/37247 , A61N1/37252 , G06F1/12 , G16H40/40 , G16H40/63
摘要： An external programmer, such as an external clock synchronization tool, can be used to update or modify the stimulation protocol and/or parameters on an implanted electrical stimulator. In particular, described herein are external clock synchronization tools that can be used to calibrate a low-power clock of the implanted electrical stimulator. These tools may also be used to provide command overrides, including suspending or delaying neurostimulation, stopping neurostimulation, and/or on-demand neurostimulation.
摘要翻译： 诸如外部时钟同步工具的外部编程器可用于更新或修改植入的电刺激器上的刺激协议和/或参数。 特别地，这里描述的是外部时钟同步工具，其可用于校准植入的电刺激器的低功率时钟。 这些工具也可用于提供命令覆盖，包括暂停或延迟神经刺激，停止神经刺激和/或按需神经刺激。
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63.发明申请SYSTEMS AND METHODS FOR STIMULATING AND/OR MONITORING LOCI IN THE BRAIN TO TREAT INFLAMMATION AND TO ENHANCE VAGUS NERVE STIMULATION 审中-公开用于刺激和/或监测脑中位置以治疗炎症和增强VAGUS神经刺激的系统和方法公开(公告)号：US20160114165A1
公开(公告)日：2016-04-28
申请号：US14922022
申请日：2015-10-23
申请人： Jacob A. LEVINE , Michael A. FALTYS
发明人： Jacob A. LEVINE , Michael A. FALTYS
IPC分类号： A61N1/36 , A61N2/02 , A61N2/00 , A61B5/0476 , A61N1/05
CPC分类号： A61N1/36135 , A61B5/0476 , A61B5/0484 , A61B5/4041 , A61B5/4064 , A61N1/0526 , A61N1/0529 , A61N1/0534 , A61N1/0551 , A61N1/0556 , A61N1/36053 , A61N1/3606 , A61N1/36125 , A61N1/36139 , A61N1/36146 , A61N1/37205 , A61N1/37247 , A61N1/3756 , A61N1/3758 , A61N1/3787 , A61N2/006 , A61N2/02
摘要： Described herein are methods and systems for using EEG recordings to improve vagus nerve stimulation (VNS) therapy. In particular, described herein are methods and systems for using EEG recordings to detect P300 and/or activation of the nucleus basalis and/or the locus coeruleus to determine the efficacy of VNS. The EEG recordings can be used to provide feedback control to help optimize stimulation parameters and to screen for patients that respond well to VNS therapy.
摘要翻译： 本文描述了使用EEG记录来改善迷走神经刺激（VNS）治疗的方法和系统。 特别地，本文描述了使用EEG记录来检测P300和/或核碱基和/或基因座的活化以确定VNS的功效的方法和系统。 EEG记录可以用于提供反馈控制，以帮助优化刺激参数，并筛选对VNS治疗反应良好的患者。
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公开(公告)号：US20150066123A1
公开(公告)日：2015-03-05
申请号：US14536461
申请日：2014-11-07
CPC分类号： A61N1/0556 , A61N1/0558 , A61N1/36114 , A61N1/37205 , A61N1/375 , A61N1/3756
摘要： An extravascular nerve cuff that is configured to hold a leadless, integral, implantable microstimulator. The nerve cuff may include a cuff body having a pocket or pouch for removably receiving the implantable device within. The nerve cuff can be secured around the nerve such that the electrodes of the device are stably positioned relative to the nerve. Furthermore, the nerve cuff drives the majority of the current from the stimulation device into the nerve, while shielding surrounding tissues from unwanted stimulation.
摘要翻译： 构造成保持无引导，整体的可植入微型刺激器的血管外神经袖带。 神经箍可以包括具有用于在其内可移除地接收可植入装置的袋或袋的袖带体。 神经袖口可以固定在神经周围，使得装置的电极相对于神经被稳定地定位。 此外，神经袖带将大部分电流从刺激装置驱动到神经中，同时屏蔽周围组织免受不必要的刺激。
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公开(公告)号：US08886339B2
公开(公告)日：2014-11-11
申请号：US12797452
申请日：2010-06-09
CPC分类号： A61N1/0556 , A61N1/0558 , A61N1/36114 , A61N1/37205 , A61N1/375 , A61N1/3756
摘要： An extravascular nerve cuff that is configured to hold a leadless, integral, implantable microstimulator. The nerve cuff may include a cuff body having a pocket or pouch for removably receiving the implantable device within. The nerve cuff can be secured around the nerve such that the electrodes of the device are stably positioned relative to the nerve. Furthermore, the nerve cuff drives the majority of the current from the stimulation device into the nerve, while shielding surrounding tissues from unwanted stimulation.
摘要翻译： 构造成保持无引导，整体的可植入微型刺激器的血管外神经袖带。 神经箍可以包括具有用于在其内可移除地接收可植入装置的袋或袋的袖带体。 神经袖口可以固定在神经周围，使得装置的电极相对于神经被稳定地定位。 此外，神经袖带将大部分电流从刺激装置驱动到神经中，同时屏蔽周围组织免受不必要的刺激。
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公开(公告)号：US08612002B2
公开(公告)日：2013-12-17
申请号：US12978250
申请日：2010-12-23
申请人： Michael A. Faltys , Jesse M. Simon , Yiming Liu
发明人： Michael A. Faltys , Jesse M. Simon , Yiming Liu
IPC分类号： A61N1/00
CPC分类号： A61N1/3787 , A61N1/0556 , A61N1/36053 , A61N1/3606 , A61N1/36125 , A61N1/36142 , A61N1/36175 , A61N1/37205 , A61N1/37235 , A61N1/375 , A61N1/3756
摘要： A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject's neck to rapidly (
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公开(公告)号：US20130253413A1
公开(公告)日：2013-09-26
申请号：US13851013
申请日：2013-03-26
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61N1/0556 , A61N1/326 , A61N1/36014 , A61N1/36175
摘要： Devices and methods for stimulation of the vagus nerve to modulate (e.g., reduce, suppress, etc.) bone erosion. Methods and apparatus for modulating bone erosion may modulate levels of Receptor Activator for Nuclear Factor κB Ligand (RANKL), and/or to modulate (increase, enhance, etc.) osteoprotegerin (OPG) and/or OPG/RANKL ratio. Devices may include electrical stimulation devices that may be implanted, and may be activated to apply current for a proscribed duration, followed by a period without stimulation.
摘要翻译： 用于刺激迷走神经以调节（例如，减少，抑制等）骨侵蚀的装置和方法。 用于调节骨侵蚀的方法和装置可以调节核因子κB配体（RANKL）的受体活化剂的水平和/或调节（增加，增强等）骨保护素（OPG）和/或OPG / RANKL比例。 装置可以包括可以植入的电刺激装置，并且可以被激活以将电流施加到禁止的持续时间，之后是没有刺激的时期。
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公开(公告)号：US08503685B2
公开(公告)日：2013-08-06
申请号：US12953159
申请日：2010-11-23
CPC分类号： H04R25/70 , A61N1/36036 , G06F19/00 , H04R1/406 , H04R25/606 , H04R2225/021 , H04R2225/67 , H04R2430/20
摘要： A method and system for implementing an acoustical front end customization are disclosed. The customization is implemented to optimize the sound level for each individual cochlear implant user. A known audio signal is generated using a sound source and captured by a microphone system. The captured sound signal is sampled at one or more locations along the signal processing pathway, and a spectrum is determined for the sampled signal and the known signal. A ratio of the two spectrums is related to the undesired transformation of the sampled signal, and a digital filter is designed based on the ratio to filter out the undesired transformation.
摘要翻译： 公开了一种用于实现声学前端定制的方法和系统。 实施定制以优化每个单独的人工耳蜗使用者的声级。 使用声源产生已知的音频信号，并由麦克风系统捕获。 捕获的声音信号在沿着信号处理路径的一个或多个位置被采样，并且对采样信号和已知信号确定频谱。 两个频谱的比率与采样信号的不期望的变换有关，并且基于该比率设计数字滤波器以滤除不希望的变换。
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公开(公告)号：US08150527B2
公开(公告)日：2012-04-03
申请号：US12495593
申请日：2009-06-30
IPC分类号： H04R25/00
CPC分类号： H04R25/70 , A61N1/36036
摘要： Methods and systems for modifying the parameters of at least one hearing device for a patient with residual hearing provide needed orchestration of acoustic and electric stimulation of patients wearing such devices.
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公开(公告)号：US20110255725A1
公开(公告)日：2011-10-20
申请号：US13172980
申请日：2011-06-30
IPC分类号： H04R25/00
CPC分类号： H04R25/407 , H04R25/606
摘要： A system and method for generating a beamforming signal is disclosed. A beam forming signal is generated by disposing a first microphone and a second microphone in horizontal coplanar alignment. The first and second microphones are used to detect a known signal to generate a first response and a second response. The first response is processed along a first signal path communicatively linked to the first microphone, and the second response is processed along a second signal path communicatively linked to the second microphone. The first and second responses are matched, and the matched responses are combined to generate the beamforming signal on a combined signal path.
摘要翻译： 公开了一种用于产生波束形成信号的系统和方法。 通过在水平共面对准中设置第一麦克风和第二麦克风来产生波束形成信号。 第一和第二麦克风用于检测已知信号以产生第一响应和第二响应。 沿着与第一麦克风通信地链接的第一信号路径处理第一响应，并且沿着通信地链接到第二麦克风的第二信号路径来处理第二响应。 第一和第二响应被匹配，并且匹配的响应被组合以在组合的信号路径上产生波束成形信号。
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