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1.发明申请公开(公告)号：US20180117320A1
公开(公告)日：2018-05-03
申请号：US15853350
申请日：2017-12-22
申请人： Jacob A. LEVINE , Michael A. FALTYS
发明人： Jacob A. LEVINE , Michael A. FALTYS
CPC分类号： A61N1/3606 , A61N1/36053 , A61N1/36139 , A61N1/36167 , A61N1/36175 , A61N1/37205
摘要： Described herein are systems and methods for applying extremely low duty-cycle stimulation sufficient to treat chronic inflammation using feedback to adjust the off times between stimulations. In particular, the feedback include an assessment of the level of inflammation by the patient or the healthcare provider, or by measure the level of an inflammatory analyte or biomarker, or by detecting nerve activity correlated with inflammation.
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公开(公告)号：US09833621B2
公开(公告)日：2017-12-05
申请号：US13338185
申请日：2011-12-27
申请人： Jacob A. Levine
发明人： Jacob A. Levine
CPC分类号： A61N1/36053 , A61K9/0009 , A61N1/36146
摘要： Systems, devices and methods for modulation of sirtuins by neurostimulation. In particular, sirtuins may be modulated by stimulation of the vagus nerve. Further described herein generally are methods, systems and devices, for specifically modulating sirtuins, including sub-sets (types or localized regions) of sirtuins by vagus nerve stimulation (VNS).
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公开(公告)号：US20170203103A1
公开(公告)日：2017-07-20
申请号：US15411933
申请日：2017-01-20
摘要： Methods and apparatuses for stimulation of the vagus nerve to treat inflammation including adjusting the stimulation based on one or more metric sensitive to patient response. The one or more metrics may include heart rate variability, level of T regulatory cells, particularly memory T regulatory cells, temperature, etc. Stimulation may be provided through an implantable microstimulator.
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公开(公告)号：US20160331952A1
公开(公告)日：2016-11-17
申请号：US15153639
申请日：2016-05-12
CPC分类号： A61N1/025 , A61N1/36053 , A61N1/36125 , A61N1/37205 , A61N1/37247 , A61N1/37252 , G06F1/12 , G16H40/40 , G16H40/63
摘要： An external programmer, such as an external clock synchronization tool, can be used to update or modify the stimulation protocol and/or parameters on an implanted electrical stimulator. In particular, described herein are external clock synchronization tools that can be used to calibrate a low-power clock of the implanted electrical stimulator. These tools may also be used to provide command overrides, including suspending or delaying neurostimulation, stopping neurostimulation, and/or on-demand neurostimulation.
摘要翻译： 诸如外部时钟同步工具的外部编程器可用于更新或修改植入的电刺激器上的刺激协议和/或参数。 特别地，这里描述的是外部时钟同步工具，其可用于校准植入的电刺激器的低功率时钟。 这些工具也可用于提供命令覆盖，包括暂停或延迟神经刺激，停止神经刺激和/或按需神经刺激。
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5.发明申请SYSTEMS AND METHODS FOR STIMULATING AND/OR MONITORING LOCI IN THE BRAIN TO TREAT INFLAMMATION AND TO ENHANCE VAGUS NERVE STIMULATION 审中-公开用于刺激和/或监测脑中位置以治疗炎症和增强VAGUS神经刺激的系统和方法公开(公告)号：US20160114165A1
公开(公告)日：2016-04-28
申请号：US14922022
申请日：2015-10-23
申请人： Jacob A. LEVINE , Michael A. FALTYS
发明人： Jacob A. LEVINE , Michael A. FALTYS
IPC分类号： A61N1/36 , A61N2/02 , A61N2/00 , A61B5/0476 , A61N1/05
CPC分类号： A61N1/36135 , A61B5/0476 , A61B5/0484 , A61B5/4041 , A61B5/4064 , A61N1/0526 , A61N1/0529 , A61N1/0534 , A61N1/0551 , A61N1/0556 , A61N1/36053 , A61N1/3606 , A61N1/36125 , A61N1/36139 , A61N1/36146 , A61N1/37205 , A61N1/37247 , A61N1/3756 , A61N1/3758 , A61N1/3787 , A61N2/006 , A61N2/02
摘要： Described herein are methods and systems for using EEG recordings to improve vagus nerve stimulation (VNS) therapy. In particular, described herein are methods and systems for using EEG recordings to detect P300 and/or activation of the nucleus basalis and/or the locus coeruleus to determine the efficacy of VNS. The EEG recordings can be used to provide feedback control to help optimize stimulation parameters and to screen for patients that respond well to VNS therapy.
摘要翻译： 本文描述了使用EEG记录来改善迷走神经刺激（VNS）治疗的方法和系统。 特别地，本文描述了使用EEG记录来检测P300和/或核碱基和/或基因座的活化以确定VNS的功效的方法和系统。 EEG记录可以用于提供反馈控制，以帮助优化刺激参数，并筛选对VNS治疗反应良好的患者。
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公开(公告)号：US20130253413A1
公开(公告)日：2013-09-26
申请号：US13851013
申请日：2013-03-26
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61N1/0556 , A61N1/326 , A61N1/36014 , A61N1/36175
摘要： Devices and methods for stimulation of the vagus nerve to modulate (e.g., reduce, suppress, etc.) bone erosion. Methods and apparatus for modulating bone erosion may modulate levels of Receptor Activator for Nuclear Factor κB Ligand (RANKL), and/or to modulate (increase, enhance, etc.) osteoprotegerin (OPG) and/or OPG/RANKL ratio. Devices may include electrical stimulation devices that may be implanted, and may be activated to apply current for a proscribed duration, followed by a period without stimulation.
摘要翻译： 用于刺激迷走神经以调节（例如，减少，抑制等）骨侵蚀的装置和方法。 用于调节骨侵蚀的方法和装置可以调节核因子κB配体（RANKL）的受体活化剂的水平和/或调节（增加，增强等）骨保护素（OPG）和/或OPG / RANKL比例。 装置可以包括可以植入的电刺激装置，并且可以被激活以将电流施加到禁止的持续时间，之后是没有刺激的时期。
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公开(公告)号：US20170113044A1
公开(公告)日：2017-04-27
申请号：US15398615
申请日：2017-01-04
摘要： Devices and methods for stimulation of the vagus nerve to modulate (e.g., reduce, suppress, etc.) bone erosion. Methods and apparatus for modulating bone erosion may modulate levels of Receptor Activator for Nuclear Factor κB Ligand (RANKL), and/or to modulate (increase, enhance, etc.) osteoprotegerin (OPG) and/or OPG/RANKL ratio. Devices may include electrical stimulation devices that may be implanted, and may be activated to apply current for a proscribed duration, followed by a period without stimulation.
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8.发明申请公开(公告)号：US20160096017A1
公开(公告)日：2016-04-07
申请号：US14968702
申请日：2015-12-14
申请人： Jacob A. LEVINE , Michael A. FALTYS
发明人： Jacob A. LEVINE , Michael A. FALTYS
CPC分类号： A61N1/3606 , A61N1/36053 , A61N1/36139 , A61N1/36167 , A61N1/36175 , A61N1/37205
摘要： Described herein are systems and methods for applying extremely low duty-cycle stimulation sufficient to treat chronic inflammation using feedback to adjust the off times between stimulations. In particular, the feedback include an assessment of the level of inflammation by the patient or the healthcare provider, or by measure the level of an inflammatory analyte or biomarker, or by detecting nerve activity correlated with inflammation.
摘要翻译： 本文描述的系统和方法是应用极低的占空比刺激，足以使用反馈来治疗慢性炎症以调节刺激之间的关闭时间。 特别地，反馈包括对患者或医疗保健提供者的炎症水平的评估，或通过测量炎性分析物或生物标志物的水平，或通过检测与炎症相关的神经活动。
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9.发明申请公开(公告)号：US20140330349A1
公开(公告)日：2014-11-06
申请号：US14336942
申请日：2014-07-21
申请人： Jacob A. LEVINE , Michael A. FALTYS
发明人： Jacob A. LEVINE , Michael A. FALTYS
IPC分类号： A61N1/36
CPC分类号： A61N1/3606 , A61N1/36053 , A61N1/36139 , A61N1/36167 , A61N1/36175 , A61N1/37205
摘要： Described herein are systems and methods for applying extremely low duty-cycle stimulation sufficient to treat chronic inflammation with progressively longer delays (off periods) from an initial stimulation. In particular, described herein are supra-threshold pulses of electrical stimulation sufficient to result in a long-lasting (e.g., >48 hours) inhibition of pro-inflammatory cytokines and/or effects of chronic inflammation; the delay between initial doses (which may be single-pulse doses) may be extended for subsequent doses, potentially dramatically enhancing battery and device longevity.
摘要翻译： 本文描述的系统和方法是应用极低的占空比刺激，以足以治疗来自初始刺激的逐渐更长的延迟（关闭周期）的慢性炎症。 特别地，本文描述的电刺激的超阈值脉冲足以导致促炎细胞因子的长期（例如> 48小时）抑制和/或慢性炎症的作用; 初始剂量（可能是单脉冲剂量）之间的延迟可以延长以用于随后的剂量，潜在地显着地增强电池和设备的使用寿命。
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10.发明授权公开(公告)号：US08788034B2
公开(公告)日：2014-07-22
申请号：US13467928
申请日：2012-05-09
申请人： Jacob A. Levine , Michael A. Faltys
发明人： Jacob A. Levine , Michael A. Faltys
IPC分类号： A61N1/00
CPC分类号： A61N1/36053 , A61N1/3606 , F04C2270/0421
摘要： Described herein are methods and systems for applying extremely low duty-cycle stimulation sufficient to treat chronic inflammation. In particular, described herein are single supra-threshold pulses of electrical stimulation sufficient to result in a long-lasting (e.g., >4 hours, greater than 12 hours, greater than 24 hours, greater than 48 hours) inhibition of pro-inflammatory cytokines and/or effects of chronic inflammation. These methods and devices are particularly of interest in treatment of inflammatory bowel disease (IBD).
摘要翻译： 本文描述的是应用极低的占空比刺激足以治疗慢性炎症的方法和系统。 特别地，本文描述的是电刺激的单一超阈值脉冲，其足以导致促炎细胞因子的持久（例如> 4小时，大于12小时，大于24小时，大于48小时）的抑制 和/或慢性炎症的作用。 这些方法和装置在治疗炎症性肠病（IBD）中特别有意义。
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