公开(公告)号：US08000436B2

公开(公告)日：2011-08-16

申请号：US12080860

申请日：2008-04-07

申请人： Edward J. Seppi ,  John Ford ,  Marcel Marc

发明人： Edward J. Seppi ,  John Ford ,  Marcel Marc

IPC分类号： G01N23/00

CPC分类号： G01V5/005 ,  G01N23/046 ,  G01N2223/419

摘要： A scanning unit for inspecting objects comprises in one example a radiation source, a movable platform to support an object, and a detector positioned to receive radiation after interaction of radiation with the object. The platform is movable at least partially within a cavity defined, at least partially, below at least one of the source or the detector. In another scanning unit, a first conveyor conveys an object to a movable platform, and second and third conveyors convey the object from the platform. The second and third conveyors are at different vertical heights. In another scanning unit, images from an energy sensitive detector and a spatial detector are fused. In a method, scanning parameters during CT scanning are changed and images reconstructed before and after the change. In another method, an object is scanned with X-ray beams having first and second energy distributions, generated by the same X-ray source.

摘要翻译： 用于检查物体的扫描单元在一个示例中包括辐射源，用于支撑物体的可移动平台以及定位成在辐射与物体相互作用之后接收辐射的检测器。 该平台至少部分地在至少部分地在源或检测器中的至少一个之下限定的空腔内移动。 在另一个扫描单元中，第一输送器将物体传送到可移动平台，第二和第三输送机从平台传送物体。 第二和第三输送机处于不同的垂直高度。 在另一个扫描单元中，来自能量敏感检测器和空间检测器的图像被融合。 在一种方法中，CT扫描期间的扫描参数被改变，并且在改变之前和之后重建图像。 在另一种方法中，用具有由相同X射线源产生的第一和第二能量分布的X射线束扫描物体。

公开(公告)号：US20100087428A1

公开(公告)日：2010-04-08

申请号：US12550860

申请日：2009-08-31

申请人： Mushtaq Mulla ,  Derek Edward John ,  Richard John Hamlyn ,  Sasha Louise Garrett ,  Basil Hartzoulakis ,  David Madge ,  John Ford

发明人： Mushtaq Mulla ,  Derek Edward John ,  Richard John Hamlyn ,  Sasha Louise Garrett ,  Basil Hartzoulakis ,  David Madge ,  John Ford

IPC分类号： A61K31/415 ,  C07D231/04 ,  C07D233/66 ,  C07D213/62 ,  C07D265/36 ,  A61K31/4164 ,  A61K31/44 ,  A61K31/538 ,  A61P19/02 ,  A61P17/06 ,  A61P37/00

CPC分类号： C07C311/21 ,  C07C311/46 ,  C07C317/32 ,  C07C317/40 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07D207/12 ,  C07D209/08 ,  C07D211/16 ,  C07D211/34 ,  C07D211/44 ,  C07D213/36 ,  C07D213/40 ,  C07D213/71 ,  C07D231/12 ,  C07D231/18 ,  C07D231/56 ,  C07D233/61 ,  C07D233/64 ,  C07D233/84 ,  C07D265/30 ,  C07D265/36 ,  C07D271/08 ,  C07D277/28 ,  C07D277/36 ,  C07D277/46 ,  C07D285/12 ,  C07D285/135 ,  C07D307/79 ,  C07D311/70 ,  C07D317/62 ,  C07D319/18 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

摘要： The present invention provides a compound of formula (I) or its salts or pharmaceutically acceptable derivatives thereof wherein; X1 is selected from a group consisting of CH2, C(═O), C(═NH), NC(═O), R1 is selected from the group consisting of optionally substituted arylalkyl, and optionally substituted heteroarylalkyl R2 is selected from the group consisting of optionally substituted alkyl, optionally substituted aryl or heteroaryl or NR24R25 R3 is selected from the group consisting of hydrogen, halogen, hydroxyl, alkoxy, aryloxy, optionally substituted alkyl, optionally substituted amino, optionally substituted amino sulfonyl or nitrile; R4 is selected from the group consisting of optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted acyl, optionally substituted sulfonyl, optionally substituted sulfamoyl, optionally substituted aryl, optionally substituted arylalkyl, and optionally substituted heteroaryl R5 may be hydrogen, an optionally substituted alkyl, preferably CH3 or, NR4R5 may form an optionally substituted saturated or partially saturated 4-7 membered ring with the general formula (II). Wherein; X2 is C(═O), CH2, CH(R6) or C(R6)(R6), X3 is CH2, CH(R7), C(R7)(R7), NH, N(R8), O or S Each R6 independently represents optionally substituted amino, optionally substituted amino carbonyl, hydroxyl, optionally substituted acyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalky, optionally substituted aryl or optionally substituted heteroaryl; Each R7 independently represents optionally substituted amino, optionally substituted amino carbonyl, hydroxyl, optionally substituted acyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalky, optionally substituted aryl or optionally substituted hetero aryl R8 is optionally substituted acyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalkyl, optionally substituted aryl or optionally substituted heteroaryl; R24 and R25 are the same or different and each represents hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalkyl, optionally substituted aryl or optionally substituted heteroaryl, n=1 or 2 m=1, 2 or 3 With the proviso that when X1 is C═O and R5 is H then R4 is not: Or Or Where R4a, R5a and R6a are each independently H, C1-6alkyl, aryl, heteroaryl, cycloalkyl, or aryl-C1-6alkyl; R10a is H or C1-6alkyl; and R11a is C1-6alkyl or aryl-C1-6alkyl and when X1 is C═O or CH2 and R5 is H then R4 is not: Where q is 0 to 5, R3b is H, OH or alkoxy and R4b is NH2, phenyl or a C3-10 heterocycle. The compounds are useful as potassium ion channel inhibitors.

公开(公告)号：US20100041695A1

公开(公告)日：2010-02-18

申请号：US12543151

申请日：2009-08-18

申请人： John FORD ,  Nicholas John PALMER ,  John Frederick ATHERALL ,  David John MADGE ,  Derek JOHN

发明人： John FORD ,  Nicholas John PALMER ,  John Frederick ATHERALL ,  David John MADGE ,  Derek JOHN

IPC分类号： A61K31/4436 ,  A61P9/06 ,  A61P19/02 ,  A61P29/00 ,  A61P1/00 ,  A61P3/10

CPC分类号： C07D495/04 ,  C07D333/36 ,  C07D333/38 ,  C07D409/12

摘要： The invention provides compounds of the formula: wherein R1 is aryl, heteroaryl, cycloalkyl or alkyl; R2 is H, alkyl, nitro, CO2R7, CONR5R6 or halo; R3 and R4 are H, NR5R6, NC(O)R7, halo, trifluoromethyl, alkyl, CONR5R6, CO2R7, nitrile or alkoxy; R5 and R6 may be the same or different and may be H, alkyl, aryl, heteroaryl or cycloalkyl; or R5 and R6 may together form a saturated, unsaturated or partially saturated 4 to 7 member ring, wherein said ring may optionally comprise one or more further heteroatoms selected from N, O or S; R7 is H or alkyl; A is H, halo, or a group of formula X-L-Y; X is O, S or NR8; R8 is H or alkyl; L is (CH2)n, where n is 0, 1, 2, 3 or 4; and Y is aryl, a heterocyclic group, alkyl, alkenyl or cycloalkyl; the products of mono- and di-oxidation of sulphur and/or mono-oxidation of nitrogen moieties in compounds of formula I; or a pharmaceutically acceptable salt thereof. These compounds find use as inhibitors of potassium ion channels and thus are useful in the treatment of various conditions including arrhythmia and type-2 diabetes mellitus.

摘要翻译： 本发明提供下式的化合物：其中R1是芳基，杂芳基，环烷基或烷基; R2是H，烷基，硝基，CO 2 R 7，CONR 5 R 6或卤素; R3和R4是H，NR5R6，NC（O）R7，卤素，三氟甲基，烷基，CONR5R6，CO2R7，腈或烷氧基; R5和R6可以相同或不同，可以是H，烷基，芳基，杂芳基或环烷基; 或R 5和R 6可以一起形成饱和的，不饱和的或部分饱和的4至7元环，其中所述环可任选地包含一个或多个选自N，O或S的其它杂原子; R7是H或烷基; A是H，卤素或式X-L-Y基团; X是O，S或NR8; R8是H或烷基; L是（CH 2）n，其中n是0,1,2,3或4; Y为芳基，杂环基，烷基，链烯基或环烷基; 式I化合物中硫的单和二氧化和/或氮部分的单氧化的产物; 或其药学上可接受的盐。 这些化合物可用作钾离子通道的抑制剂，因此可用于治疗各种病症，包括心律失常和2型糖尿病。

公开(公告)号：US20070222433A1

公开(公告)日：2007-09-27

申请号：US11386449

申请日：2006-03-21

申请人： Timothy Tiernan ,  John Ford

发明人： Timothy Tiernan ,  John Ford

IPC分类号： H01L41/00 ,  G01B7/30 ,  G01V3/00

CPC分类号： G01R33/3415 ,  A61B5/04005 ,  A61B5/04007 ,  A61B5/062 ,  A61B5/6852 ,  A61B5/6853 ,  A61B5/687 ,  A61B2562/043 ,  G01R33/286 ,  G01R33/323 ,  G01R33/34084 ,  G01R33/3806 ,  G01R33/5617

摘要： The present invention generally provides improved devices, systems, and methods for measuring materials with NMR and/or MRI. Exemplary embodiments provide a sensor array for NMR mapping of the material. For example tissue can be measured with the sensor array mounted on a probe body having a distal portion which can be inserted through a minimally invasive aperture. While many tissues can be measured and/or diagnosed, one exemplary embodiment includes a probe adapted for insertion into a lumen of a blood vessel. The sensor array can provide improved spatial resolution of tissue and/or tissue structures positioned near the sensor array to diagnose potentially life threatening diseases, for example a fibrous cap covering a vulnerable plaque. In specific embodiments, the sensors are attached to an expandable member, for example a balloon, which can be inflated to urge the probe sensors radially outward to position the sensors near the tissue structures.

摘要翻译： 本发明通常提供用NMR和/或MRI测量材料的改进的装置，系统和方法。 示例性实施例提供用于材料的NMR映射的传感器阵列。 例如，可以用传感器阵列测量组织，传感器阵列安装在具有远端部分的探针主体上，该远端部分可插入通过微创孔径。 虽然可以测量和/或诊断许多组织，但是一个示例性实施例包括适于插入血管内腔的探针。 传感器阵列可以提供设置在传感器阵列附近的组织和/或组织结构的改进的空间分辨率，以诊断潜在的威胁生命的疾病，例如覆盖易损斑块的纤维帽。 在具体实施例中，传感器附接到可膨胀构件，例如球囊，其可以被膨胀以将探针传感器径向向外推动以将传感器定位在组织结构附近。

公开(公告)号：US20060204521A1

公开(公告)日：2006-09-14

申请号：US11435142

申请日：2006-05-17

申请人： John Hermon-Taylor ,  Tim Doran ,  Douglas Millar ,  Mark Tizard ,  Mark Loughlin ,  Nazira Sumar ,  John Ford

发明人： John Hermon-Taylor ,  Tim Doran ,  Douglas Millar ,  Mark Tizard ,  Mark Loughlin ,  Nazira Sumar ,  John Ford

IPC分类号： A61K39/02 ,  C07H21/02 ,  C12N1/21 ,  C12N15/86 ,  C12N15/74 ,  C07H21/04

CPC分类号： C07K14/35 ,  A61K38/00

摘要： The invention provides a nucleotide sequence representing a pathogenicity island found in species of pathogenic mycobacteria. The islands are shown as SEQ ID NOS: 3 and 4 and comprises several open reading frames encoding polypeptides. These polypeptides and their use in diagnosis and therapy form a further aspect of the invention.

摘要翻译： 本发明提供了表示在致病性分枝杆菌种中发现的致病性岛的核苷酸序列。 这些岛被显示为SEQ ID NO：3和4，并且包含编码多肽的几个开放阅读框。 这些多肽及其在诊断和治疗中的用途形成本发明的另一方面。

公开(公告)号：US07074835B2

公开(公告)日：2006-07-11

申请号：US10507483

申请日：2003-03-17

申请人： William Alexander Denny ,  Laurence Hylton Patterson ,  Gavin William Halbert ,  Steven John Ford

发明人： William Alexander Denny ,  Laurence Hylton Patterson ,  Gavin William Halbert ,  Steven John Ford

IPC分类号： C07C291/04 ,  A61K47/02 ,  A61K47/12 ,  A61P35/00

CPC分类号： C07C225/36 ,  A61K9/0019 ,  A61K47/02 ,  A61K47/12 ,  C07C291/04 ,  C07C2603/24

摘要： A compound of formula (I): in which A is a C alkylene group with a chain length between NH and N(O)R′R″ of at least 2 carbon atoms and R′ and R″ are each separately selected from C1-4 alkyl groups and C2-4 hydroxyalkyl and C2-4 dihydroxyalkyl groups, or R′ and R″ together are a C2-6 alkylene group, is formulated so that upon dissolution in aqueous solution the pH of the solution is in the range of 5 to 9. The compound may be in the form of salt with a physiologically acceptable acid having a pKa in the range of −3.0 (minus 3.0) to 9.0

摘要翻译： 式（I）化合物：其中A是具有NH和至少2个碳原子的N（O）R'R“之间的链长的C亚烷基，R'和R”分别选自 C 1-4烷基和C 2-4 2-4羟基烷基和C 2-4 2-4羟基烷基，或者R'和R“一起是 配制C 2-6亚烷基，使得当溶解在水溶液中时，溶液的pH在5至9的范围内。该化合物可以是与生理学上的盐的形式 具有-3.0（减3.0）至9.0范围内的pK 的可接受的酸

公开(公告)号：US07001731B2

公开(公告)日：2006-02-21

申请号：US10101673

申请日：2002-03-18

申请人： John Ford ,  George Yeung

发明人： John Ford ,  George Yeung

IPC分类号： G01N33/53 ,  C07K16/00 ,  C07K21/08

CPC分类号： C07K14/7158

摘要： The invention provides novel polynucleotides isolated from cDNA libraries of human fetal liver-spleen and fetal liver as well as polypeptides encoded by these polynucleotides. The polypeptide is a human chemokine receptor that is a member of a family of G protein-coupled receptors characterized by seven transmembrane domains. Other aspects of the invention include vectors containing polynucleotides of the invention and related host cells as well a processes for producing chemokine receptor polypeptides, and antibodies specific for such polypeptides.

公开(公告)号：US20050288664A1

公开(公告)日：2005-12-29

申请号：US11145743

申请日：2005-06-06

申请人： John Ford ,  Scott West ,  John Gaiser ,  Patrick Rimroth

发明人： John Ford ,  Scott West ,  John Gaiser ,  Patrick Rimroth

IPC分类号： A61B18/14 ,  A61B18/18

CPC分类号： A61B18/1477 ,  A61B18/1492 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00494 ,  A61B2018/00916 ,  A61B2018/1425

摘要： Systems and methods deploy an electrode from a catheter assembly. The systems and methods provide a catheter handle having a trigger lever adapted to carry an actuator rod. The actuator rod is adapted to cause movement of the electrode between a retracted position and an extended position. A pinion is carried by the trigger lever for engagement with a rack carried by the actuator rod. Compression of the trigger lever moves the rack along the actuator rod between a first position corresponding to the electrodes being in the retracted position and a second position corresponding to either the primed electrode firing position or the electrodes being in an extended position.

摘要翻译： 系统和方法从导管组件部署电极。 该系统和方法提供了具有适于承载致动器杆的触发杆的导管手柄。 致动器杆适于使电极在缩回位置和延伸位置之间移动。 小齿轮由触发杆承载，用于与由致动器杆承载的齿条接合。 触发杆的压缩沿着致动器杆在对应于处于缩回位置的电极的第一位置和对应于引脚电极触发位置或电极处于伸出位置的第二位置之间移动机架。

公开(公告)号：US06547903B1

公开(公告)日：2003-04-15

申请号：US10034178

申请日：2001-12-18

申请人： Patrick Sean McNichols ,  Thomas David Ehlert ,  Timothy James Blenke ,  Tauhid Husain ,  Barton Andrew Laughlin ,  Paul Gordon Klemp ,  John Ford Condron ,  Harold Norbert Heller

发明人： Patrick Sean McNichols ,  Thomas David Ehlert ,  Timothy James Blenke ,  Tauhid Husain ,  Barton Andrew Laughlin ,  Paul Gordon Klemp ,  John Ford Condron ,  Harold Norbert Heller

IPC分类号： B29C6508

CPC分类号： B29C66/83511 ,  B06B3/00 ,  B29C65/087 ,  B29C66/1122 ,  B29C66/21 ,  B29C66/344 ,  B29C66/43 ,  B29C66/729 ,  B29C66/7294 ,  B29C66/73921 ,  B29C66/80 ,  B29C66/81433 ,  B29C66/816 ,  B29C66/8223 ,  B29C66/8246 ,  B29C66/83411 ,  B29C66/83413 ,  B29C66/83415 ,  B29C66/92211 ,  B29C66/92431 ,  B29C66/92611 ,  B29C66/929 ,  B29C66/93411 ,  B29C66/93431 ,  B29C66/93441 ,  B29C66/93451 ,  B29C66/939 ,  B29C66/949 ,  B29C66/9513 ,  B29C66/9592 ,  B29C66/961 ,  B29L2031/4878 ,  G10K11/025 ,  Y10T156/1741

摘要： An ultrasonic processing method and apparatus (20) can include a rotatable, ultrasonic horn member (28) that is operatively joined to an isolation member (42) which has high rigidity. A rotatable anvil member (86) can be cooperatively positioned to provide a selected horn-anvil gap (106), and an automated drive (130) can be connected to an actuator (110), or other transfer device, to automatically adjust the horn-anvil gap (106). An electronic processor (128) can be configured to monitor an intermittent gap force detected from an output provided by a force sensor (126), and can provide a drive signal to the automated drive (130) to thereby adjust the horn-anvil gap (106) to operatively maintain a target, gap force value.

摘要翻译： 超声波处理方法和装置（20）可以包括可操作地连接到具有高刚性的隔离构件（42）的可旋转超声波喇叭构件（28）。 可旋转的砧构件（86）可以协同地定位以提供选定的角砧间隙（106），并且自动驱动器（130）可以连接到致动器（110）或其它传送装置，以自动调节喇叭 -anvil间隙（106）。 电子处理器（128）可以被配置为监测从力传感器（126）提供的输出检测到的间歇性间隙力，并且可以向自动驱动器（130）提供驱动信号，从而调整喇叭砧座间隙（ 106）以可操作地保持目标，间隙力值。

公开(公告)号：US06502905B2

公开(公告)日：2003-01-07

申请号：US09836749

申请日：2001-04-17

申请人： Albert B. Cheris ,  John Ford ,  Michael Goluszka

发明人： Albert B. Cheris ,  John Ford ,  Michael Goluszka

IPC分类号： A47C1602

CPC分类号： B60N3/063 ,  A47C16/02 ,  B60N3/04 ,  Y10T428/24008 ,  Y10T428/24314

摘要： A plastic floor mat and foot rest unit is disclosed in which a front edge of the support surface of the foot rest is inserted through a slotted opening in the floor mat to the underside of the floor mat, and a latching projection is also inserted through the opening to latch the front edge of the support surface in the opening, yet permit its ready removal if desired. The rear edge of the support surface is also supported by a support plate to permit the incline angle of the foot rest support surface to be adjusted and to support the rear edge by the pile of the carpet upon which the floor mat and foot rest unit is to be used.

摘要翻译： 公开了一种塑料地板垫和脚踏板单元，其中脚垫的支撑表面的前边缘通过地板垫中的开槽开口插入到地板垫的下侧，并且闩锁突起也插入通过 打开以将开口中的支撑表面的前边缘锁定，但如果需要，允许其准备移除。 支撑表面的后边缘还由支撑板支撑，以允许脚踏支撑表面的倾斜角度被调节，并且通过地板垫和脚踏板单元所在的地毯的绒头来支撑后边缘 要使用的。