公开(公告)号：US09931357B2

公开(公告)日：2018-04-03

申请号：US15515328

申请日：2015-10-02

申请人： CYTOSORBENTS CORPORATION

发明人： Humayra Begum Ali ,  Thomas D. Golobish ,  Vincent J. Capponi ,  Phillip P. Chan ,  Wei-Tai Young ,  Andrew Robert Scheirer

IPC分类号： A61M31/00 ,  A61K31/74 ,  A61K31/765 ,  A61K9/00

CPC分类号： A61K31/765 ,  A61K9/0053 ,  A61K31/75 ,  A61K31/79 ,  A61P1/00 ,  A61P1/04 ,  A61P1/06

摘要： Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).

公开(公告)号：US20180055875A1

公开(公告)日：2018-03-01

申请号：US15804961

申请日：2017-11-06

申请人： DEVIREX AG

发明人： Peter Vitins ,  Marcel Langenauer ,  Paul Martin Scherer

IPC分类号： A61K31/765 ,  A61K31/77

CPC分类号： A61K31/765 ,  A61K31/77

摘要： The present invention pertains generally to the field of therapy, and more specifically to the field of therapy for herpes simplex and herpes zoster, and more particularly, to methods of reducing the rate of relapse, delaying relapse, and/or preventing relapse of herpes labialis (cold sores on the lips), herpes genitalis (genital herpes), and herpes zoster (shingles, zona), by topical administration of polyethylene glycol (PEG), or a composition comprising PEG.

公开(公告)号：US09884074B2

公开(公告)日：2018-02-06

申请号：US15069188

申请日：2016-03-14

申请人： Eyeon Particle Sciences LLC

发明人： Eugene Rex Cooper ,  David Maxwell Kleinman ,  Andrew Loxley ,  Mark A. Mitchnick

IPC分类号： A61K31/785 ,  A61K9/00 ,  A61K9/51 ,  A61K31/74 ,  A61K47/34 ,  A61K35/02 ,  A61K31/765 ,  A61K45/06 ,  G02C7/04 ,  A61K9/50 ,  A61K31/045 ,  A61K31/7036

CPC分类号： A61K31/785 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0048 ,  A61K9/0051 ,  A61K9/0073 ,  A61K9/5031 ,  A61K9/5146 ,  A61K31/045 ,  A61K31/7036 ,  A61K31/74 ,  A61K31/765 ,  A61K35/02 ,  A61K45/06 ,  A61K47/34 ,  G02C7/04

摘要： The invention contemplates a copolymer which is a graft or block copolymer useful to change wettability and surface characteristics of biological surfaces. Methods for use of these formulations and coatings to change wettability and sterically stabilize, and lubricate biological surfaces in a subject, for example, in the treatment of dry eye syndrome, and to prevent adherence of unwanted proteins, for example in the treatment of contact lens intolerance, are provided.

公开(公告)号：US09867841B2

公开(公告)日：2018-01-16

申请号：US14650102

申请日：2013-12-05

申请人： GLYCOMIMETICS, INC.

发明人： John L. Magnani

IPC分类号： A61K31/7034 ,  A61K31/7052 ,  A61K31/7056 ,  A61K31/765 ,  A61K31/7048 ,  A61K45/06

CPC分类号： A61K31/7034 ,  A61K31/7048 ,  A61K31/7052 ,  A61K31/7056 ,  A61K31/765 ,  A61K45/06

摘要： Methods are provided herein for use of E-selectin antagonists for mobilizing cells, such as hematopoietic cells, hematopoietic stem cells and progenitor cells, white blood cells, and malignant cells, and hematopoietic tumor cells from the bone marrow. More specifically, methods are provided for using E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers, and peptides for mobilizing cells from the bone marrow to the peripheral vasculature and tissues.

公开(公告)号：US20180008629A1

公开(公告)日：2018-01-11

申请号：US15545386

申请日：2016-01-27

申请人： Yale University

发明人： Vishwa Deep Dixit

IPC分类号： A61K31/765 ,  A61K31/19 ,  A61K9/127 ,  A61K45/06

CPC分类号： A61K31/765 ,  A61K9/1271 ,  A61K31/19 ,  A61K45/06 ,  A61K47/6911 ,  A61K47/6951 ,  A61K2300/00

摘要： The present invention provides compositions and methods for treating or preventing an NLRP3 immunosome-related disorder. In one embodiment, the method includes administering a therapeutically effective amount of a composition comprising at least one NLRP3 inflammasome inhibitor to a subject in need thereof.

公开(公告)号：US09844564B2

公开(公告)日：2017-12-19

申请号：US14432114

申请日：2013-09-30

申请人： Industrial Cooperation Foundation Chonbuk National University ,  Beth Israel Deaconess Medical Center

发明人： Dong Won Lee ,  Dong Hyun Hong ,  Peter M. Kang

IPC分类号： A61K31/765 ,  A61K9/14 ,  A61K49/00 ,  C08G63/133

CPC分类号： A61K31/765 ,  A61K9/14 ,  A61K49/0093 ,  C08G63/133

摘要： The present invention includes a vanillyl alcohol-containing copolyoxalate copolymer (PVAX). The present invention also includes a PVAX microparticle comprising PVAX. In one aspect, the compositions of the invention can be used as a drug delivery system, an antioxidant or anti-inflammatory composition, a composition for preventing or treating ischemic disease, a composition for inhibiting the side effects of anticancer drugs, a contrast agent, and/or a composition for diagnosing ischemic disease.

公开(公告)号：US09763975B1

公开(公告)日：2017-09-19

申请号：US14789669

申请日：2015-07-01

申请人： Denis Bragin ,  Edwin Nemoto ,  Marina V. Kameneva

发明人： Denis Bragin ,  Edwin Nemoto ,  Marina V. Kameneva

IPC分类号： A61K31/765

CPC分类号： A61K31/765

摘要： Methods and compositions for the treatment of acute or chronic cerebral ischemia by delivery of linear, blood soluble, non-toxic macromolecules.

公开(公告)号：US09750765B2

公开(公告)日：2017-09-05

申请号：US15377084

申请日：2016-12-13

申请人： W. L. Gore & Associates, Inc.

发明人： Tiffany J. Brown ,  Adam S. Lafleur ,  Kenneth Mazich ,  Jeffrey C. Towler ,  Ji Zhang

IPC分类号： A61K31/765 ,  A61K33/40 ,  A61L27/34 ,  A61L27/50 ,  A61L27/58 ,  A61L2/08 ,  A61L31/14 ,  A61L31/16 ,  A61L31/06 ,  A61L27/54

CPC分类号： A61K41/0057 ,  A61K31/765 ,  A61K33/40 ,  A61L2/081 ,  A61L2/082 ,  A61L2/087 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  A61L31/06 ,  A61L31/10 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  A61L2202/24 ,  A61L2400/18 ,  C08L67/04

摘要： Materials capable of delivering stabilized free radicals to targeted treatment sites. The materials comprise semi-crystalline, hydrolytically degradable polymers that are subjected to ionizing radiation to create stabilized free radicals therein. Upon exposure to oxygen containing aqueous media, the materials generate reactive oxidative species which are useful in biological processes.

公开(公告)号：US09737486B2

公开(公告)日：2017-08-22

申请号：US14194559

申请日：2014-02-28

申请人： THE JOHNS HOPKINS UNIVERSITY ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人： Corinne Bright ,  Rachel Bright ,  Eric Churchill ,  Kam W. Leong ,  Daria Mochly-Rosen

IPC分类号： A61K9/14 ,  A61K9/127 ,  A61K9/51 ,  A61K31/765 ,  A61K31/78 ,  A61K45/06

CPC分类号： A61K9/14 ,  A61K9/5138 ,  A61K31/765 ,  A61K31/78 ,  A61K45/06

摘要： A method for protection of tissues subject to ischemic and/or reperfusion damage is provided. The method includes administering to the tissue a composition comprising nanodevices. The nanodevices can take the form of, for example, polymeric nanoparticles or lipidic nanoparticles. The nanodevices also find use in methods for reducing ischemic injury in tissue at risk of such injury, such as heart and brain tissue.

公开(公告)号：US20170143757A1

公开(公告)日：2017-05-25

申请号：US15361661

申请日：2016-11-28

申请人： Rush University Medical Center ,  The Board of Trustees of the University of Illinois

发明人： Robert A. Anderson, JR. ,  Xiao-Hui Diao ,  Lourens J.D. Zaneveld ,  Calvin J. Chany, II ,  Aleksej Krunic ,  Donald P. Waller ,  Duane L. Venton ,  Sanjay Jain

IPC分类号： A61K31/765 ,  C08G61/02

CPC分类号： A61K31/765 ,  C07C51/347 ,  C07C59/48 ,  C07C59/50 ,  C07C67/465 ,  C07C69/616 ,  C07C2601/16 ,  C08G61/02 ,  C08G2261/11 ,  C08G2261/1426 ,  C08G2261/20 ,  C08G2261/3424 ,  C08G2261/42 ,  C08G2261/90

摘要： Disclosed herein are compounds and compositions useful for reducing the risk of infection. In particular, disclosed herein are mandelic acid condensation polymers, compositions comprising such compounds, processes for producing such compounds, and methods of using such compounds.