公开(公告)号：US11857577B2

公开(公告)日：2024-01-02

申请号：US16172825

申请日：2018-10-28

申请人： Labyrinth Holdings, LLC

发明人： Elizabeth McKenna

IPC分类号： A61K35/74 ,  A61K38/48 ,  A61K35/742 ,  A61K35/744 ,  A61K9/00 ,  A61K9/68

CPC分类号： A61K35/74 ,  A61K35/742 ,  A61K35/744 ,  A61K38/482 ,  C12Y304/21043 ,  A61K9/0056 ,  A61K9/0058 ,  Y02A50/30

摘要： The disclosure provides oral compositions and methods of using such compositions in treating subjects infected with one or more hepatic disorders. The compositions include lysates or cell wall extracts of one or more gram positive bacteria, exhibit particular activity against hepatitis C virus (HCV), and may be useful in treating those infected with HCV as well as other hepatic diseases or disorders. Also described are methods of treating a hepatic disease or disorder by administering a therapeutically effective amount of at least one therapeutically active agent capable of upregulating or downregulating the Complement system pathway, wherein the therapeutically active agent enhances the formation of one or more convertase enzymes.

公开(公告)号：US20230414728A1

公开(公告)日：2023-12-28

申请号：US18249097

申请日：2021-10-18

申请人： MEDIWOUND LTD.

发明人： Lior ROSENBERG ,  Dafna GEBLINGER ,  Eilon ASCULAI

IPC分类号： A61K38/48 ,  A61K9/00 ,  A61K9/06 ,  A61K47/36 ,  A61K47/26 ,  A61K47/02 ,  A61K47/10 ,  A61P35/00 ,  A61P17/02

CPC分类号： A61K38/4873 ,  A61K9/0014 ,  A61K9/06 ,  A61K47/36 ,  A61K47/26 ,  A61K47/02 ,  A61K47/10 ,  A61P35/00 ,  A61P17/02 ,  C12Y304/22032

摘要： The present invention provides methods for treating skin cancers utilizing pharmaceutical formulations in the form of a hydrogel that includes a proteolytic enzyme mixture obtained from bromelain and a water-soluble gelling agent. In particular, the method is useful for treating non-melanoma skin cancers, pre-cancerous skin lesions, and benign skin lesions.

公开(公告)号：US20230414727A1

公开(公告)日：2023-12-28

申请号：US18295991

申请日：2023-04-05

申请人： DiaMedica Inc.

发明人： Rick PAULS ,  David Wambeke ,  Nick Paulson

IPC分类号： A61K38/48 ,  A61P13/12 ,  C12Q1/6883 ,  C12Q1/37

CPC分类号： A61K38/4853 ,  A61P13/12 ,  C12Q2600/156 ,  C12Q1/37 ,  C12Y304/21035 ,  C12Q1/6883

摘要： Provided are methods of using human tissue kallikrein-1 (KLK1) to treat chronic kidney disease (CKD) in patients having salt-sensitive hypertension and low KLK1 levels, including methods of identifying and treating optimal sub-populations of CKD patients based on selected genotypes and/or phenotypes.

公开(公告)号：US20230414726A1

公开(公告)日：2023-12-28

申请号：US18035458

申请日：2021-11-09

申请人： MASKER MED TECH AB

发明人： György MARKO-VARGA ,  Yutaka SUGIHARA ,  Jeovanis GIL VALDÉS ,  Roger APPELQVIST ,  Johan MALM

IPC分类号： A61K38/48 ,  A61K9/00 ,  A61P31/14 ,  A61K47/18 ,  A61K47/26 ,  A61K47/02 ,  A61K47/12

CPC分类号： A61K38/48 ,  A61K9/0078 ,  C12Y304/17023 ,  A61P31/14 ,  A61K47/183 ,  A61K47/26 ,  A61K47/02 ,  A61K47/12

摘要： A respirable aqueous pharmaceutical composition comprising a neutralizing affinity binder for a virus binding to angiotensin-converting enzyme 2 (ACE2), a buffer, and a solubilizer.

公开(公告)号：US20230413826A1

公开(公告)日：2023-12-28

申请号：US18212471

申请日：2023-06-21

申请人： Matoke Holdings Limited

发明人： Thomas Hall ,  Sophie Constance Cox ,  Liam Michael Grover ,  David Kershaw

IPC分类号： A01N59/00 ,  A61K9/06 ,  A61K38/36 ,  A61K38/44 ,  A61K38/48 ,  A61K47/26 ,  A61K47/32 ,  A61K47/40 ,  A61L26/00 ,  A01N63/50

CPC分类号： A01N59/00 ,  A61K9/06 ,  A61K38/363 ,  A61K38/443 ,  A61K38/4833 ,  A61K47/26 ,  A61K47/32 ,  A61K47/40 ,  A61L26/0014 ,  A61L26/0042 ,  A61L26/0047 ,  A61L26/0066 ,  A61L26/008 ,  A61L26/0095 ,  A01N63/50 ,  C12Y101/03004

摘要： A composition has an enzyme that is able to convert a substrate to release hydrogen peroxide; a substrate for the enzyme; and a superabsorbent component, such as a superabsorbent polymer. The composition is in the form of a powder and may form a gel on contact with water.

公开(公告)号：US20230390366A1

公开(公告)日：2023-12-07

申请号：US18249182

申请日：2021-10-18

申请人： ONELIFE S.A. ,  UNIVERSITE CATHOLIQUE DE LOUVAIN

发明人： Laetitia FONTAINE ,  Aline LARDINOIS ,  Houssein CHALHOUB ,  Françoise VAN BAMBEKE ,  Albert RUIZ-SORRIBAS

IPC分类号： A61K38/46 ,  A61K8/65 ,  A61K38/47 ,  A61K38/44 ,  A61K38/48 ,  A61K45/06 ,  A01N63/50 ,  A01P1/00 ,  A61Q3/00 ,  A61Q11/00 ,  A61P31/04

CPC分类号： A61K38/465 ,  A61K8/65 ,  A61K38/47 ,  A61K38/44 ,  A61K38/48 ,  A61K45/06 ,  A01N63/50 ,  A01P1/00 ,  A61Q3/00 ,  A61Q11/00 ,  A61K38/482 ,  A61P31/04

摘要： A parapharmaceutical or pharmaceutical composition is administrable to living beings, and in particular to human beings. The composition includes at least one endoribonuclease enzyme chosen from the EC 3.1.30 and EC 3.1.31 classes, preferably in a content of from 10 to 1000 U/ml, preferably 50 to 500 U/ml, preferably from 100 to 500 U/ml. The composition is for curative or preventive treatment for dermatological infections or for infections which develop on superficial or deep burns and wounds.

公开(公告)号：US11826404B2

公开(公告)日：2023-11-28

申请号：US16625335

申请日：2018-06-22

申请人： PROMETIC BIOTHERAPEUTICS, INC.

发明人： Lyne Gagnon ,  Brigitte Grouix ,  Pierre Laurin

IPC分类号： A61K38/48 ,  A61P11/00 ,  A61K31/4418

CPC分类号： A61K38/484 ,  A61K31/4418 ,  A61P11/00

摘要： The present invention concerns the use of plasminogen, a variant thereof, or an analog thereof having a plasminogen activity, for the prevention or treatment of a condition or a disease that is characterized with an increased PAI-1 level. The conditions and diseases that are characterized with an increased PAI-1 level, are regrouped within two categories: the diseases associated with an impaired vascular or tissue remodeling capacity, and the metabolic and hormonal disorders associated with an increased PAI-1 level.

公开(公告)号：US20230357741A1

公开(公告)日：2023-11-09

申请号：US18318455

申请日：2023-05-16

申请人： Hansa Biopharma AB

发明人： Christian Kjellman ,  Sofia Jarnum ,  Emma Andersson Nordahl

IPC分类号： C12N9/54 ,  C12N9/52 ,  A61K38/48

CPC分类号： C12N9/54 ,  C12N9/52 ,  A61K38/48 ,  A61K38/00

摘要： The present invention relates to a novel polypeptide which displays IgG cysteine protease activity, and in vivo and ex vivo uses thereof. Uses of the polypeptide include methods for the prevention or treatment of diseases and conditions mediated by IgG, and methods for the analysis of IgG.

公开(公告)号：US11807666B2

公开(公告)日：2023-11-07

申请号：US18059929

申请日：2022-11-29

申请人： Cytiva BioProcess R&D AB

发明人： Martin Hall ,  Karolina Busson ,  Jean-Luc Maloisel ,  Helena Skoglar

IPC分类号： C07K1/18 ,  B01J41/20 ,  B01D15/36 ,  B01D15/38 ,  A61K38/36 ,  A61K38/48 ,  A61K35/16 ,  C12N9/64 ,  B01D15/34 ,  C07K14/47 ,  C07K14/755 ,  C07K14/765 ,  C07K16/00 ,  A61K38/00

CPC分类号： C07K1/18 ,  A61K35/16 ,  A61K38/36 ,  A61K38/4846 ,  B01D15/34 ,  B01D15/363 ,  B01D15/3847 ,  B01J41/20 ,  C07K14/472 ,  C07K14/755 ,  C07K14/765 ,  C07K16/00 ,  C12N9/644 ,  C12N9/6424 ,  C12Y304/21022 ,  A61K38/00

摘要： The present invention relates to the field of chromatography. More closely, the invention relates to a chromatographic method for purification of proteins, such as Factor VIII, von Willebrand factor and Factor IX. The chromatographic method is performed on a matrix comprising an inner porous core and outer porous lid surrounding said core.

公开(公告)号：US11793864B2

公开(公告)日：2023-10-24

申请号：US16217957

申请日：2018-12-12

申请人： DERMADIS SA ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： David Deperthes ,  Christoph Kundig ,  Alain Hovnanian ,  Celine Deraison

IPC分类号： A61K38/49 ,  A61K8/64 ,  A61Q19/00 ,  A61K38/57 ,  A61K38/48 ,  C12Q1/37 ,  G01N33/50

CPC分类号： A61K38/49 ,  A61K8/64 ,  A61K38/482 ,  A61K38/484 ,  A61K38/486 ,  A61K38/4826 ,  A61K38/4853 ,  A61K38/57 ,  A61Q19/00 ,  C12Q1/37 ,  G01N33/502 ,  A61K2800/782 ,  G01N2333/96455 ,  G01N2500/04

摘要： This invention relates to therapeutic compounds which are inhibitors of serine proteases, to pharmaceutical compositions thereof and to their use in the treatment of the human or animal body. More specifically, the present invention relates to a method for the treatment, diagnosis or prognosis of skin diseases comprising the administration to a subject in need thereof of a therapeutically effective amount of a Serine protease inhibitor.