公开(公告)号：US20230151077A1

公开(公告)日：2023-05-18

申请号：US17917420

申请日：2021-04-09

申请人： MASKER MED TECH AB

发明人： György MARKO-VARGA ,  Balazs DÖME ,  Viktoria LASZLO ,  Peter DÖME ,  Yutaka SUGIHARA ,  Jeovanis GIL VALDES ,  Roger APPELQVIST ,  Johan MALM

IPC分类号： C07K14/72 ,  A61P31/14

CPC分类号： C07K14/72 ,  A61P31/14

摘要： In the invention is provided a polypeptide comprising at least 75 amino acids and having an amino acid sequence having at least 90%, such as at least 95%, 96%, 97, 98%, or 99%, such as 100% sequence identity (% SI) with human Angiotensin-converting enzyme 2 (ACE2) (SEQ ID NO 1), for use in the treatment of COVID19, SARS, or MERS, characterized in that the polypeptide is administered pulmonary and/or nasally. Further is provided the polypeptide for use in reducing the number of active virus particles being exhaled by a treated subject infected by SARS-CoV-2, SARS-CoV, or Mers-CoV. Also a dry powder or an aerosol comprising the polypeptide.

公开(公告)号：US20230414726A1

公开(公告)日：2023-12-28

申请号：US18035458

申请日：2021-11-09

申请人： MASKER MED TECH AB

发明人： György MARKO-VARGA ,  Yutaka SUGIHARA ,  Jeovanis GIL VALDÉS ,  Roger APPELQVIST ,  Johan MALM

IPC分类号： A61K38/48 ,  A61K9/00 ,  A61P31/14 ,  A61K47/18 ,  A61K47/26 ,  A61K47/02 ,  A61K47/12

CPC分类号： A61K38/48 ,  A61K9/0078 ,  C12Y304/17023 ,  A61P31/14 ,  A61K47/183 ,  A61K47/26 ,  A61K47/02 ,  A61K47/12

摘要： A respirable aqueous pharmaceutical composition comprising a neutralizing affinity binder for a virus binding to angiotensin-converting enzyme 2 (ACE2), a buffer, and a solubilizer.