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    Antimicrobial suturing ring for heart valve
    51.
    发明授权
    Antimicrobial suturing ring for heart valve 失效
    心脏瓣膜抗菌缝合环

    公开(公告)号：US06585767B1

    公开(公告)日：2003-07-01

    申请号：US09197808

    申请日：1998-11-23

    申请人： Steven Holley ,  John E. Barry ,  Jeffrey A. Trogolo

    发明人： Steven Holley ,  John E. Barry ,  Jeffrey A. Trogolo

    IPC分类号： A61F224

    CPC分类号： A61F2/2409 ,  A61F2210/0004 ,  A61L27/34 ,  A61L27/507 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/102 ,  A61L2300/404 ,  A61L2300/606 ,  Y10S623/926 ,  C08L89/06

    摘要： A suturing ring to attach the body of an implantable heart valve to heart tissue by sutures is composed of a fabric containing an inorganic antimicrobial agent. The fabric can have a material coating the fibers of the fabric in which particles of the agent are embedded. The coating material can be elastomeric and the fabric porous, to improve its flexibility, or non-porous and the fabric ring can be coated with a tissue compatible substance such as collagen. One type of ring has an annular top part to fit over one of top and bottom surfaces of the valve body and defining an opening to the heart valve, a step wall depending from the annular top part to extend along said valve body wall and an outwardly extending flange through which the sutures are to be sewn.

    摘要翻译： 通过缝合将可植入心脏瓣膜的主体附接到心脏组织的缝合环由含有无机抗微生物剂的织物组成。 织物可以具有涂覆织物的纤维的材料，其中嵌入有药剂的颗粒。 涂层材料可以是弹性体，并且织物多孔，以改善其柔性或非多孔，并且织物环可以用诸如胶原的组织相容物质涂覆。 一种类型的环具有环形顶部以配合在阀体的顶表面和底表面中的一个上并且限定到心脏瓣膜的开口;梯形壁，其从环形顶部部分垂直延伸以沿着所述阀体壁延伸， 延伸法兰，通过缝合线缝合缝线。

    Medical device chemically modified by plasma polymerization
    53.
    发明申请
    Medical device chemically modified by plasma polymerization 有权
    通过等离子体聚合法化学修饰的医疗器械

    公开(公告)号：US20020146557A1

    公开(公告)日：2002-10-10

    申请号：US09827887

    申请日：2001-04-06

    申请人： Advanced Cardiovascular Systems, Inc.

    发明人： Charles D. Claude ,  Jeong S. Lee

    IPC分类号： B32B027/06

    CPC分类号： C08J7/123 ,  A61L29/085 ,  A61L31/10 ,  A61M25/0009 ,  A61M25/0014 ,  A61M25/1027 ,  A61M25/1029 ,  A61M25/1034 ,  B05D1/62 ,  Y10S623/926 ,  Y10T428/26 ,  Y10T428/263 ,  Y10T428/265 ,  Y10T428/31504 ,  Y10T428/3154 ,  Y10T428/31544 ,  Y10T428/31551 ,  Y10T428/31663 ,  Y10T428/31721 ,  Y10T428/31855

    摘要： Medical devices, and particularly intracorporeal devices for therapeutic or diagnostic uses, having a component chemically modified by plasma polymerization. The medical device comprises a substrate with a plasma polymerized functionality bonded to a surface of at least a section thereof. The plasma polymerized film on a first component of the medical device allows for bonding an agent or a second component to the first component. In one embodiment, the plasma polymerized film facilitates fusion or adhesive bonding of a first component to a second component formed of a material which is dissimilar to, incompatible with, or otherwise not readily bondable to the substrate material of the first component. In another embodiment, a bioactive agent is bonded to the plasma polymerized film on the component, for presenting or delivering the bioactive agent within a body lumen of the patient.

    摘要翻译： 医疗装置，特别是用于治疗或诊断用途的体内装置，其具有通过等离子体聚合化学改性的组分。 医疗装置包括具有等离子体聚合功能性的基底，其结合至少部分的表面。 医疗装置的第一部件上的等离子体聚合膜允许将试剂或第二组分粘合到第一组分。 在一个实施方案中，等离子体聚合膜促进第一组分与由与第一组分的衬底材料不相容，不相容或不容易粘合的材料形成的第二组分的熔融或粘合。 在另一个实施方案中，生物活性剂与组分上的等离子体聚合膜结合，用于在患者的体腔内呈递或递送生物活性剂。

    Crosslinkable macromers
    55.
    发明授权
    Crosslinkable macromers 失效
    可交联的大分子单体

    公开(公告)号：US06410044B1

    公开(公告)日：2002-06-25

    申请号：US09571525

    申请日：2000-05-16

    申请人： Stephen J. Chudzik ,  David L. Clapper

    发明人： Stephen J. Chudzik ,  David L. Clapper

    IPC分类号： A61F206

    CPC分类号： A61K9/1647 ,  A61K9/1641 ,  A61K38/1875 ,  A61K2035/128 ,  A61L24/0031 ,  A61L24/0042 ,  A61L27/34 ,  A61L29/085 ,  A61L31/148 ,  Y10S623/92 ,  Y10S623/921 ,  Y10S623/923 ,  Y10S623/926

    摘要： A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.

    摘要翻译： 一种可交联的大分子单体系统和相关的制备该系统的方法以及在组织部位和植入物制品例如组织植入物或假体装置的多孔表面之间使用交联基质形式的系统。 大分子单体体系包括两个或多个聚合物侧基可聚合基团和一个或多个引发剂基团（例如聚合物 - 侧基引发剂基团）。 当聚合物侧链可聚合基团和引发剂基团可以悬挂在相同或不同的聚合物主链上。 大分子单体体系提供优于使用可聚合的大分子单体和分离的低分子量引发剂，包括关于无毒性，效率和溶解性等性质的优点。 本发明的大分子单体系统可以以足以允许组织生长通过交联基质和组织部位和植入物之间的方式用作组织部位和植入物之间的界面。 在优选的实施方案中，用于大分子单体体系中的具有侧链可聚合基团的聚合物通过使多糖聚合物与有机极性溶剂如甲酰胺中的反应性部分反应来制备。

    Resorbable interbody spinal fusion devices
    57.
    发明申请
    Resorbable interbody spinal fusion devices 失效
    可再生体内脊柱融合装置

    公开(公告)号：US20010008980A1

    公开(公告)日：2001-07-19

    申请号：US09785593

    申请日：2001-02-16

    申请人： CAMBRIDGE SCIENTIFIC, INC.

    发明人： Joseph D. Gresser ,  Debra J. Trantolo ,  Robert S. Langer ,  Kai-Uwe Lewandrowski ,  Alexander M. Klibanov ,  Donald L. Wise

    IPC分类号： A61F002/44

    CPC分类号： A61F2/4455 ,  A61F2/30965 ,  A61F2/442 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30112 ,  A61F2002/30133 ,  A61F2002/30153 ,  A61F2002/30179 ,  A61F2002/30217 ,  A61F2002/30772 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30868 ,  A61F2002/30904 ,  A61F2002/30957 ,  A61F2210/0004 ,  A61F2230/0004 ,  A61F2230/0015 ,  A61F2230/0019 ,  A61F2230/0058 ,  A61F2230/0067 ,  Y10S623/926

    摘要： A resorbable interbody fusion device for use in spinal fixation is disclosed. The device is composed of 25-100% bioresorbable or resorbable material. The interbody fusion device of the invention can be in any convenient form, such as a wedge, screw or cage. Preferably, the resorbable device of the invention is in the shape of a tapered wedge or cone, which further desirably incorporates structural features such as serrations or threads better to anchor the device in the adjoining vertebrae. The preferred device further comprises a plurality of peripheral voids and more desirably a central void space therein, which may desirably be filled with a grafting material for facilitating bony development and/or spinal fusion, such as an autologous grafting material. As the preferred material from which the resorbable interbody fusion device is manufactured is most likely to be a polymer that can produce acidic products upon hydrolytic degradation, the device preferably further includes a neutralization compound, or buffer, in sufficiently high concentration to decrease the rate of pH change as the device degrades, in order to prevent sterile abscess formation caused by the accumulation of unbuffered acidic products in the area of the implant.

    摘要翻译： 公开了一种用于脊柱固定的可再吸收体内融合装置。 该装置由25-100％的生物可吸收或可再吸收材料组成。 本发明的体内融合装置可以是任何方便的形式，例如楔形物，螺钉或笼子。 优选地，本发明的可再吸收装置是锥形楔形或锥形的形状，其进一步期望地包括诸如锯齿或线的结构特征，以更好地将装置锚定在相邻的椎骨中。 优选的装置还包括多个周边空隙，并且更期望地为其中的中心空隙空间，其可期望地填充有用于促进骨发育和/或脊柱融合的接枝材料，例如自体移植材料。 作为制造可再吸收的体内融合装置的优选材料最可能是在水解降解时可以产生酸性产物的聚合物，该装置优选还包含足够高浓度的中和化合物或缓冲剂，以降低 pH值随器械降解而改变，以防止在植入物区域积聚无缓冲酸性产物引起的无菌性脓肿形成。

    Intraocular lenses made from polymeric compositions
    58.
    发明授权
    Intraocular lenses made from polymeric compositions 有权
    由聚合物组合物制成的人造眼镜

    公开(公告)号：US06241766B1

    公开(公告)日：2001-06-05

    申请号：US09265720

    申请日：1999-03-09

    申请人： Xiugao Liao ,  Joseph I. Weinschenk

    发明人： Xiugao Liao ,  Joseph I. Weinschenk

    IPC分类号： A61F216

    CPC分类号： G02B1/043 ,  A61L27/16 ,  A61L2430/16 ,  Y10S623/926 ,  C08L33/06

    摘要： Ophthalmic lenses, such as intraocular lenses, include cross-linked polymeric materials having a first constituent derived from a first monomeric component selected from the group consisting of acrylates, methacrylates and mixtures thereof, and a second constituent derived from a second component in an amount effective as a cross linker in the cross-linked polymeric material. The cross-linked polymeric material has branched chain alkyl groups, preferably included with at least a portion of the first monomeric component, in an amount effective to reduce the tackiness of the cross-linked polymeric material relative to a substantially identical cross-linked polymeric material without the branched chain alkyl groups.

    摘要翻译： 眼睛透镜，例如眼内透镜，包括具有衍生自选自丙烯酸酯，甲基丙烯酸酯及其混合物的第一单体组分的第一组分的交联聚合物材料和衍生自有效量的第二组分的第二组分 作为交联聚合物材料中的交联剂。 交联的聚合物材料具有支链烷基，优选包含在至少一部分第一单体组分中，其量可以有效地降低交联聚合物材料相对于基本相同的交联聚合物材料的粘性 没有支链烷基。

    Intraocular lens coating compositions
    59.
    发明授权
    Intraocular lens coating compositions 失效
    人工晶状体涂层组合物

    公开(公告)号：US06187042B1

    公开(公告)日：2001-02-13

    申请号：US09283701

    申请日：1999-04-01

    申请人： John W. Sheets, Jr. ,  Albert R. Leboeuf ,  Anilbhai S. Patel ,  Mutlu Karakelle ,  Stephen J. Van Noy

    发明人： John W. Sheets, Jr. ,  Albert R. Leboeuf ,  Anilbhai S. Patel ,  Mutlu Karakelle ,  Stephen J. Van Noy

    IPC分类号： A61F216

    CPC分类号： A61L27/16 ,  Y10S623/926 ,  C08L33/04

    摘要： Intraocular lens coating compositions for reducing the risk of posterior capsule opacification are disclosed. The coating materials, which differ from the substrate material, consist essentially of at least two aryl acrylic hydrophobic monomers of the formula wherein: X is H or CH3; m is 0-10; Y is nothing, O, S, or NR wherein R is H, CH3, CnH2n+1 (n=1−10) iso OC3H7, C6H5, or CH2C6H5; Ar is any aromatic ring which can be unsubstituted or substituted with CH3, C2H5, n-C3H7, iso-C3H7, OCH3, C6H11, Cl, Br, C6H5, or CH2C6H5.

    摘要翻译： 公开了用于降低后囊混浊风险的眼内透镜涂层组合物。 与衬底材料不同的涂层材料基本上由至少两种芳族化合物的芳基丙烯酸疏水性单体组成：X是H或CH 3; m是0-10; Y不是O，S或NR，其中R是 H，CH 3，C n H 2n + 1（n = 1-10）异OC 3 H 7，C 6 H 5或CH 2 C 6 H 5; Ar是可以被未取代或被CH 3，C 2 H 5，n-C 3 H 7，异-C 3 H 7，OCH 3，C 6 H 11， Cl，Br，C6H5或CH2C6H5。