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148 条记录 (耗时 0.026 秒)

    Mitogenic oxygenase regulators
    51.
    发明授权
    Mitogenic oxygenase regulators 有权
    有丝分裂加氧酶调节剂

    公开(公告)号：US07202052B2

    公开(公告)日：2007-04-10

    申请号：US10850060

    申请日：2004-05-20

    申请人： J. David Lambeth ,  Guangjie Cheng

    发明人： J. David Lambeth ,  Guangjie Cheng

    IPC分类号： C12Q1/26 ,  C12P3/00 ,  C12N9/02

    CPC分类号： C12N9/0036 ,  A01K2217/05 ,  C07K16/40 ,  C12N9/0004 ,  C12N2799/026 ,  G01N33/573 ,  G01N2333/90209

    摘要： The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention also provides vectors containing these genes, cells transfected with these vectors, antibodies raised against these novel proteins, kits for detection, localization and measurement of these genes and proteins, and methods to determine the activity of drugs to affect the activity of the proteins of the present invention.

    摘要翻译： 本发明涉及编码产生影响细胞分裂的活性氧中间体的新型nox酶蛋白的新基因。 本发明还提供含有这些基因的载体，用这些载体转染的细胞，针对这些新蛋白产生的抗体，用于检测，定位和测量这些基因和蛋白质的试剂盒，以及确定药物活性以影响其活性的方法 本发明的蛋白质。

    Uses of thioredoxin
    53.
    发明授权
    Uses of thioredoxin 失效
    硫氧还蛋白的使用

    公开(公告)号：US06689775B2

    公开(公告)日：2004-02-10

    申请号：US09875578

    申请日：2001-06-06

    申请人： Garth Powis

    发明人： Garth Powis

    IPC分类号： A61K31545

    CPC分类号： A61K38/44 ,  A61K48/00 ,  G01N33/5011 ,  G01N33/573 ,  G01N2333/90209

    摘要： The present invention relates to the use of thioredoxin as, inter alia, a cell growth stimulator, as well as a screen for agents that are useful in reducing or preventing thioredoxin-associated apoptosis inhibition and agents that are useful in inhibiting thioredoxin stimulated cell growth.

    摘要翻译： 本发明涉及硫氧还蛋白作为细胞生长刺激剂的用途，以及可用于减少或预防硫氧还蛋白相关凋亡抑制的试剂的筛选和可用于抑制硫氧还蛋白刺激的细胞生长的试剂的使用。

    Common ligand universal enzyme assay and compositions for use therein
    54.
    发明申请
    Common ligand universal enzyme assay and compositions for use therein 审中-公开
    普通配体通用酶测定法及其中使用的组合物

    公开(公告)号：US20030228621A1

    公开(公告)日：2003-12-11

    申请号：US10189327

    申请日：2002-07-02

    发明人： Yong Qin ,  Lin Yu ,  Mark R. Hansen ,  Eduard Sergienko ,  Bonnie Bertolaet ,  Daniel S. Sem

    IPC分类号： G01N033/53 ,  C12Q001/26

    CPC分类号： C12N9/001 ,  C12Y103/01026 ,  G01N33/566 ,  G01N2333/90209 ,  G01N2500/02

    摘要： The present invention provides compositions containing a common ligand linked to a detectable moiety and provides methods for the preparation of such compositions. The present invention also provides methods for screening candidate ligands for binding to a NAD binding receptor, which include contacting a receptor with a candidate ligand and a composition of the invention followed by evaluation of receptor binding. The screening method of the present invention has broad applicability and can be used to screen large numbers of a wide variety of ligands. The present invention further provides methods for detecting the binding activity of a putative receptor, which include combining the putative receptor with a composition of the invention and evaluating the level of detectable moiety. The invention also provides kits useful for detection of receptors having NAD binding activity and for screening of candidate ligands that bind to a NAD binding receptor.

    摘要翻译： 本发明提供含有与可检测部分连接的共同配体的组合物，并提供制备这种组合物的方法。 本发明还提供了筛选用于结合NAD结合受体的候选配体的方法，其包括使受体与候选配体和本发明的组合物接触，然后评估受体结合。 本发明的筛选方法具有广泛的适用性，可用于筛选大量各种配体。 本发明还提供了用于检测推定受体的结合活性的方法，其包括将推定的受体与本发明的组合物结合并评估可检测部分的水平。 本发明还提供了可用于检测具有NAD结合活性的受体并用于筛选结合NAD结合受体的候选配体的试剂盒。

    Substituted chalcones as therapeutic compounds
    55.
    发明申请
    Substituted chalcones as therapeutic compounds 失效
    取代的查尔酮作为治疗化合物

    公开(公告)号：US20030100538A1

    公开(公告)日：2003-05-29

    申请号：US10239757

    申请日：2002-09-26

    发明人： Gerard Andrew Potter ,  Paul Crispin Butler ,  Elugba Wanogho

    IPC分类号： A61K031/66 ,  C07F009/02 ,  A61K031/44 ,  A61K031/401 ,  A61K031/18 ,  A61K031/12 ,  A61K031/235

    CPC分类号： G01N33/574 ,  A61K31/12 ,  A61K31/15 ,  A61K31/222 ,  C07C69/017 ,  C07C251/40 ,  C07C305/24 ,  C07F9/12 ,  G01N2333/90209

    摘要： This invention pertains to substituted chalcones, specifically substituted 1-(4-methoxyphenyl)-3-(3,5-dimethoxyphenyl)prop-1-en-3-ones, which have therapeutic application, for example, as potent antiproliferative agents and antiinflammatory agents, and which have the formula (I) wherein: X is nullH, nullOH, nullOC(nullO)R3, nullOS(nullO)2OH, or nullOP(nullO)2(OH)2; Y is nullH or a C1-4alkyl group; Z is nullH or nullOCH3; R1 is nullH, a C1-4alkyl group, or C1-4fluoroalkyl group; R2 is nullH, a C1-4alkyl group, or C1-4fluoroalkyl group; and, R3 is nullH, a C1-6alkyl group, a C3-20 heterocyclyl group, or a C5-20aryl group; and pharmaceutically acceptable salts, esters, and protected forms thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, for both diagnosis and treatment of, for example, proliferative conditions, such as cancer, and inflammatory conditions.

    摘要翻译： 本发明涉及具有治疗应用的取代的查尔酮，特异性取代的1-（4-甲氧基苯基）-3-（3,5-二甲氧基苯基）丙-1-烯-3-酮，例如作为有效的抗增殖剂和抗炎药 （O）2 OH或-OP（= O）2（OH）2）的化合物，其具有式（I）其中：X为-H，-OH，-OC（= O） Y是-H或C 1-4烷基; Z是-H或-OCH 3; R1是-H，C1-4烷基或C1-4氟烷基; R2是-H，C1-4烷基或C1-4氟烷基; 且R 3为-H，C 1-6烷基，C 3-20杂环基或C 5-20芳基; 和其药学上可接受的盐，酯和保护形式。 本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内用于诊断和治疗例如增生性疾病如癌症和炎性病症的用途。

    Date-rape drug detector
    60.
    发明授权
    Date-rape drug detector 有权
    日期强奸药物检测仪

    公开(公告)号：US09029098B1

    公开(公告)日：2015-05-12

    申请号：US14156249

    申请日：2014-01-15

    申请人： Kathy Barbosa Holcombe

    发明人： Kathy Barbosa Holcombe

    IPC分类号： C12Q1/26 ,  C12M1/40 ,  G01N21/77

    CPC分类号： C12Q1/26 ,  G01N21/78 ,  G01N21/8483 ,  G01N33/94 ,  G01N2021/7759 ,  G01N2333/90209

    摘要： A date-rape drug detector includes an elongated shaft having an upper end and a lower end. The upper end of the shaft is bendable and includes a plurality of notches that grip the upper rim of a beverage container. Proximal the lower end is a chamber having a testing strip therein that is deployable to a perpendicular position relative to the shaft. Along the length of the strip are a plurality of reactive spots that change color in the presence of a date-rape drug. Each successive spot is covered with a progressively thicker layer of water-soluble material than a preceding spot so that each spot requires a different submersion time in order to be exposed. Therefore, a user can test a beverage for the presence of a date-rape drug at progressive intervals.

    摘要翻译： 日期强奸药物检测器包括具有上端和下端的细长轴。 轴的上端是可弯曲的并且包括夹紧饮料容器的上边缘的多个凹口。 近端下端是具有其中具有测试条的室，其可以相对于轴展开到垂直位置。 沿着条带的长度是在日期强奸药物存在下改变颜色的多个反应性斑点。 每个连续的点被比前一个点逐渐变厚的水溶性材料覆盖，使得每个点需要不同的浸没时间才能被暴露。 因此，用户可以逐渐地间隔地测试饮料以了解强奸药物的存在。