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公开(公告)号:US10588614B2
公开(公告)日:2020-03-17
申请号:US15190332
申请日:2016-06-23
申请人: The Foundry, LLC
发明人: Darin C. Gittings , Mark Deem , Michael Hendricksen , Vivek Shenoy , Hanson S. Gifford, III , Stephen Boyd
摘要: A knotless suture anchoring system includes an outer anchor having a central channel and a distal tip adapted to penetrate tissue. An inner anchor is positionable in the central channel of the outer anchor and a locking feature on one or both of the inner and outer anchors retains the inner anchor within the central channel. A continuous length of suture is coupled with the inner and outer suture anchors and has a free end. At least one of the inner and the outer anchors also has a cinching mechanism that allows the suture to be tensioned by passage of the suture through the cinching mechanism in a first direction while movement of the suture through the cinching mechanism in a second direction opposite the first direction is constrained.
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公开(公告)号:US10582919B2
公开(公告)日:2020-03-10
申请号:US14585654
申请日:2014-12-30
申请人: The Foundry, LLC
摘要: Various devices, systems and methods for knotless anchoring of sutures to repair bodily tissue are disclosed. These devices allow sutures to be anchored to bone or other tissues, and more specifically provide a suture anchor which eliminates the need for the operator to knot the suture to secure the suture under tension. Thus, damaged tissue may be re-attached to a substrate tissue. The anchors have a minimum of moving parts and find particular utility in hip and shoulder arthroscopy, e.g. labral reattachment, rotator cuff repair, and similar procedures.
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公开(公告)号:US20200046955A1
公开(公告)日:2020-02-13
申请号:US16659893
申请日:2019-10-22
申请人: The Foundry, LLC
发明人: Mark E. Deem , Hanson Gifford
IPC分类号: A61M37/00 , A61K41/00 , A61N5/10 , A61B18/18 , A61B18/14 , A61N7/00 , A61N1/30 , A61K9/00 , A61N1/32 , A61N1/08 , A61K38/48 , A61K38/16
摘要: Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.
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公开(公告)号:US10052465B2
公开(公告)日:2018-08-21
申请号:US15615344
申请日:2017-06-06
申请人: The Foundry, LLC
发明人: Mark E. Deem , Hanson Gifford
IPC分类号: A61K9/22 , A61N1/30 , A61M31/00 , A61M29/02 , A61K38/48 , A61M25/10 , A61M35/00 , A61N1/05 , A61N1/32 , A61K9/00 , A61M29/00 , A61B18/14 , A61B17/00 , A61M25/00 , A61N7/00 , A61N7/02 , A61B18/18
CPC分类号: A61M31/00 , A61B17/12104 , A61B17/12136 , A61B17/12159 , A61B17/24 , A61B17/3478 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/003 , A61B2018/0022 , A61B2018/00327 , A61K9/0043 , A61K38/4886 , A61K38/4893 , A61M29/02 , A61M37/0092 , A61M2025/1013 , A61M2025/105 , A61M2210/0618 , A61N1/0546 , A61N1/325 , A61N1/327 , A61N5/02 , A61N5/045 , A61N7/00 , A61N7/02 , A61N7/022 , A61N2007/0043 , C12Y304/24069
摘要: Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.
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公开(公告)号:US20180206887A1
公开(公告)日:2018-07-26
申请号:US15927829
申请日:2018-03-21
申请人: The Foundry, LLC
发明人: Vivek Shenoy , Hanson S. Gifford, III , Mark Deem
CPC分类号: A61B17/56 , A61B17/562 , A61B17/8872 , A61B2017/564 , A61B2017/565 , A61F2/3886
摘要: Pathology of the human knee can arise from excessive and/or uneven loading of regions within the joint. Methods and apparatus are disclosed that enable displacement of soft tissue around the knee, without displacing or severing bone thereby altering the mechanical load distribution within the joint in a less invasive manner than previous techniques.
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公开(公告)号:US20170266422A1
公开(公告)日:2017-09-21
申请号:US15615344
申请日:2017-06-06
申请人: The Foundry, LLC
发明人: Mark E. Deem , Hanson Gifford
IPC分类号: A61M31/00 , A61K38/48 , A61K9/00 , A61M25/10 , A61M29/00 , A61M29/02 , A61M35/00 , A61N1/05 , A61N1/32 , A61B17/00 , A61B18/14 , A61B18/18 , A61M25/00 , A61N7/00 , A61N7/02
CPC分类号: A61M31/00 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00765 , A61B2018/0022 , A61B2018/00327 , A61K9/0043 , A61K38/4886 , A61K38/4893 , A61M25/007 , A61M25/0084 , A61M25/10 , A61M29/00 , A61M29/02 , A61M35/00 , A61M2025/0008 , A61M2025/0057 , A61M2025/0096 , A61M2025/105 , A61M2210/0618 , A61N1/05 , A61N1/0546 , A61N1/0568 , A61N1/327 , A61N5/02 , A61N5/045 , A61N7/00 , A61N7/02 , A61N7/022 , A61N2007/0043 , C12Y304/24069
摘要: Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.
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公开(公告)号:US09700707B2
公开(公告)日:2017-07-11
申请号:US14841514
申请日:2015-08-31
申请人: The Foundry LLC
发明人: Mark E. Deem , Hanson Gifford
IPC分类号: A61K9/22 , A61N1/30 , A61M31/00 , A61K38/48 , A61M25/10 , A61M35/00 , A61N1/05 , A61N1/32 , A61M29/00 , A61M29/02 , A61K9/00 , A61B18/14 , A61B18/18 , A61B17/00 , A61M25/00 , A61N7/00 , A61N7/02
CPC分类号: A61M31/00 , A61B18/1492 , A61B18/18 , A61B2017/00765 , A61K9/0043 , A61K38/4886 , A61K38/4893 , A61M25/007 , A61M25/0084 , A61M25/10 , A61M29/00 , A61M29/02 , A61M35/00 , A61M2025/0008 , A61M2025/0057 , A61M2025/0096 , A61M2025/105 , A61M2210/0618 , A61N1/05 , A61N1/0546 , A61N1/0568 , A61N1/327 , A61N7/00 , A61N7/022 , C12Y304/24069 , Y02A50/471
摘要: Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.
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公开(公告)号:US20170072176A1
公开(公告)日:2017-03-16
申请号:US15358187
申请日:2016-11-22
申请人: The Foundry, LLC
CPC分类号: A61M37/00 , A61B18/1492 , A61B18/1815 , A61B2018/0016 , A61B2018/00214 , A61B2018/00434 , A61B2018/1861 , A61K9/0021 , A61K9/0078 , A61K38/164 , A61K38/168 , A61K38/4893 , A61K41/00 , A61K41/0028 , A61K41/0047 , A61M37/0092 , A61M2210/1035 , A61N1/08 , A61N1/303 , A61N1/327 , A61N5/10 , A61N7/00 , A61N2007/003 , C12Y304/24069 , Y02A50/471 , A61K2300/00
摘要: Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.
摘要翻译: 提供了用于施用神经毒素片段的方法和装置,例如肉毒杆菌毒素(BoNT)的活性轻链(LC),如血清型A,B,C,D,E,F或G肉毒毒素之一 通过靶向细胞膜的透化以使肉毒杆菌神经毒素轻链(BoNT-LC)分子穿过目标细胞膜转移到在哺乳动物系统中产生治疗反应的细胞溶质中。 所述方法和装置包括使用基于导管的递送系统,非侵入性递送系统和透皮递送系统。
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59.
公开(公告)号:US20170021148A9
公开(公告)日:2017-01-26
申请号:US14841514
申请日:2015-08-31
申请人: The Foundry LLC
发明人: Mark E. Deem , Hanson Gifford
CPC分类号: A61M31/00 , A61B18/1492 , A61B18/18 , A61B2017/00765 , A61K9/0043 , A61K38/4886 , A61K38/4893 , A61M25/007 , A61M25/0084 , A61M25/10 , A61M29/00 , A61M29/02 , A61M35/00 , A61M2025/0008 , A61M2025/0057 , A61M2025/0096 , A61M2025/105 , A61M2210/0618 , A61N1/05 , A61N1/0546 , A61N1/0568 , A61N1/327 , A61N7/00 , A61N7/022 , C12Y304/24069 , Y02A50/471
摘要: Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.
摘要翻译: 将毒素和毒素片段输送到患者的鼻腔的方法和系统提供毒素的释放和能量的释放,所述能量选择性地对靶细胞进行培养以增强毒素的摄取。 使用能量介导的递送对于缺乏细胞结合能力的轻链片段毒素是特别有利的。
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公开(公告)号:US09498283B2
公开(公告)日:2016-11-22
申请号:US14601529
申请日:2015-01-21
申请人: The Foundry, LLC
发明人: Mark E. Deem , Hanson Gifford
IPC分类号: C12M1/00 , A61B18/14 , A61K38/16 , A61K38/48 , A61K41/00 , A61N1/08 , A61N1/32 , A61N1/30 , A61N7/00 , A61K9/00 , A61B18/18 , A61N5/10 , A61B18/00
CPC分类号: A61M37/00 , A61B18/1492 , A61B18/1815 , A61B2018/0016 , A61B2018/00214 , A61B2018/00434 , A61B2018/1861 , A61K9/0021 , A61K9/0078 , A61K38/164 , A61K38/168 , A61K38/4893 , A61K41/00 , A61K41/0028 , A61K41/0047 , A61M37/0092 , A61M2210/1035 , A61N1/08 , A61N1/303 , A61N1/327 , A61N5/10 , A61N7/00 , A61N2007/003 , C12Y304/24069 , Y02A50/471 , A61K2300/00
摘要: Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enable translocation of the botulinum neurotoxin light chain (BoNT-LC) molecule across the targeted cell membrane to the cell cytosol where a therapeutic response is produced in a mammalian system. The methods and apparatus include use of catheter based delivery systems, non-invasive delivery systems, and transdermal delivery systems.
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