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公开(公告)号：US10123814B2
公开(公告)日：2018-11-13
申请号：US15799030
申请日：2017-10-31
发明人： Riyaz Bashir , Nick A. Green
IPC分类号： A61M25/00 , A61B17/221 , A61B17/22 , A61B18/00 , A61M25/01 , A61B17/3207 , A61B17/00
摘要： An infusion catheter has an elongate flexible shaft including a wall and a lumen extending between a proximal end and a distal end. The catheter also has a sealing member within the shaft lumen including a wall and a lumen. The catheter also has a slidable, retractable elongate central axis member extending through the shaft and sealing member lumens connected to an end cap. The catheter also has a plurality of eluting arms extending radially around the central axis member, including lumens fluidly connected to the shaft lumen and the distal end cap. A method for treating a thrombus is also disclosed.
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52.发明申请公开(公告)号：US20180312927A1
公开(公告)日：2018-11-01
申请号：US15769157
申请日：2016-10-19
IPC分类号： C12Q1/6886
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/154 , G01N33/57426 , G01N2800/52
摘要： The invention provides AML-specific methylation biomarkers (SP140, MCCC1, EHMT1 and MTSS1). In one embodiment, a biomarker is differentially methylated, specifically in AML.
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公开(公告)号：US20180296703A1
公开(公告)日：2018-10-18
申请号：US15753003
申请日：2016-08-17
摘要： The present invention features methods and compositions for treatment of heart failure. The compositions can include an isolated nucleic acid encoding a BAG3 polypeptide or fragment thereof.
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公开(公告)号：US20180228876A1
公开(公告)日：2018-08-16
申请号：US15950236
申请日：2018-04-11
发明人： Kamel Khalili , Wenhui Hu
CPC分类号： A61K38/465 , A61K9/0034 , A61K35/12 , A61K45/06 , A61K48/00 , A61K48/005 , C12N7/00 , C12N9/22 , C12N15/111 , C12N2310/20 , C12N2320/30 , C12N2740/16063 , C12Y301/21
摘要： A method of preventing transmission of a retrovirus from a mother to her offspring, by administering to the mother a therapeutically effective amount of a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and the two or more different multiplex gRNAs, wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of proviral DNA of the virus that is unique from the genome of the host cell, cleaving a double strand of the proviral DNA at a first target protospacer sequence with the CRISPR-associated endonuclease, cleaving a double strand of the proviral DNA at a second target protospacer sequence with the CRISPR-associated endonuclease, excising an entire HIV-1 proviral genome, eradicating the HIV-1 proviral DNA from the host cell, and preventing transmission of the proviral DNA to the offspring.
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公开(公告)号：US20180200343A1
公开(公告)日：2018-07-19
申请号：US15902263
申请日：2018-02-22
发明人： Kamel KHALILI , Wenhui HU
CPC分类号： A61K38/465 , A61K9/0034 , A61K35/12 , A61K45/06 , A61K48/00 , A61K48/005 , C12N7/00 , C12N9/22 , C12N15/111 , C12N2310/20 , C12N2320/30 , C12N2740/16063 , C12Y301/21
摘要： A method of treating a subject having or at risk for having a virus infection, by administering a therapeutically effective amount of a composition comprising a vector encoding a CRISPR-associated endonuclease and at least two guide RNAs that are complementary to two target sequences spanning from the 5′- to 3′-LTRs of the sequence in the virus, and completely excising a fragment of greater than 9000-bp of integrated proviral DNA that spanned from its 5′- to 3′-LTRs. A method of treating a subject having or at risk for having a genetic caused disease, by administering a therapeutically effective amount of a composition comprising a vector encoding a CRISPR-associated endonuclease and at least two guide RNAs that are complementary to two target sequences spanning from the sequence of the subjects DNA greater than 9000-bp that is chromosomally integrated and causes the genetic caused disease, and excising the chromosomally integrated sequence.
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公开(公告)号：US20180169193A1
公开(公告)日：2018-06-21
申请号：US15879877
申请日：2018-01-25
发明人： Kamel KHALILI , Wenhui HU
CPC分类号： A61K38/465 , A61K9/0034 , A61K35/12 , A61K45/06 , A61K48/00 , A61K48/005 , C12N7/00 , C12N9/22 , C12N15/111 , C12N2310/20 , C12N2320/30 , C12N2740/16063 , C12Y301/21
摘要： Methods of inactivating a proviral DNA genome or a DNA genome integrated into the genome of a host cell latently infected with a retrovirus, by treating the host cell with a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and two or more different multiplex guide RNAs (gRNAs), wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of the proviral DNA that is unique from the genome of the host cell, cleaving a double strand of the proviral DNA at a first target protospacer sequence with the CRISPR-associated endonuclease, cleaving a double strand of the proviral DNA at a second target protospacer sequence with the CRISPR-associated endonuclease, excising an entire proviral genome of the proviral DNA, and eradicating the proviral DNA from the host cell.
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公开(公告)号：US09925248B2
公开(公告)日：2018-03-27
申请号：US14838057
申请日：2014-08-29
发明人： Kamel Khalili , Wenhui Hu
IPC分类号： A61K48/00 , A61K38/46 , A61K9/00 , A61K35/12 , A61K45/06 , C12N7/00 , C12N9/22 , C12N15/11 , A61K39/21 , C12N15/55 , C12N15/79 , C12N15/85 , C12N15/86
CPC分类号： A61K38/465 , A61K9/0034 , A61K35/12 , A61K45/06 , A61K48/00 , A61K48/005 , C12N7/00 , C12N9/22 , C12N15/111 , C12N2310/20 , C12N2320/30 , C12N2740/16063 , C12Y301/21
摘要： A method of inactivating a proviral DNA integrated into the genome of a host cell latently infected with a retrovirus by treating the host cell with a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and two or more different guide RNAs (gRNAs), wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) in the proviral DNA, and inactivating the proviral DNA. A composition for use in inactivating a proviral DNA integrated into the genome of a host cell latently infected with a retrovirus including isolated nucleic acid sequences comprising a CRISPR-associated endonuclease and a guide RNA, wherein the guide RNA is complementary to a target sequence in a human immunodeficiency virus.
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公开(公告)号：US20180073019A1
公开(公告)日：2018-03-15
申请号：US15559902
申请日：2016-03-18
发明人： Kamel Khalili
CPC分类号： C12N15/111 , A61K45/06 , A61K48/005 , A61K48/0075 , C12N7/00 , C12N9/22 , C12N15/11 , C12N15/1132 , C12N15/86 , C12N2310/20 , C12N2310/3519 , C12N2320/30 , C12N2740/16062 , C12N2800/107 , C12N2800/22 , C12N2830/00 , C12N2830/30 , C12N2830/60
摘要： Compositions and methods are provided for Tat-inducible expression of a CRISPR-associated endonuclease by a truncated HIV LTR promoter containing at least a core region and a TAR region of a HIV LTR promoter. The compositions may be used as a therapeutic treatment for the treatment and/or prevention of HIV.
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公开(公告)号：US20180008565A1
公开(公告)日：2018-01-11
申请号：US15545371
申请日：2016-01-21
CPC分类号： A61K31/19 , A61K9/0053 , A61K35/744 , A61K35/747 , A61P35/00
摘要： The invention relates to compositions for preventing or delaying the onset of hepatocellular cancer. The compositions of the invention may comprise short chain fatty acids. The compositions of the invention may also comprise probiotic bacteria. The compositions of the invention include compositions for preventing or delaying the onset of hepatocellular cancer by treating or preventing liver inflammation, liver disease, and precancerous lesions.
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公开(公告)号：US20170349628A1
公开(公告)日：2017-12-07
申请号：US15515416
申请日：2015-10-02
发明人： Won Hyuk Suh , Geunwoo Jin
IPC分类号： C07K7/06 , A61K9/107 , A61K31/519 , C12N5/0793 , A61K47/64 , A61K38/08 , A61K31/203
CPC分类号： C07K7/06 , A61K9/107 , A61K31/203 , A61K31/519 , A61K38/08 , A61K47/64 , C07K2319/10 , C07K2319/60 , C12N5/0619 , C12N2501/385
摘要： The present invention provides a novel cell penetrating peptide that transports proteins into cells and/or into nuclei and a pharmaceutical containing the peptide.
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