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    Perfusate for preserving organ to be transplanted and preserving method
    54.
    发明授权
    Perfusate for preserving organ to be transplanted and preserving method 失效
    用于保存器官的移植和保存方法

    公开(公告)号：US4186253A

    公开(公告)日：1980-01-29

    申请号：US950071

    申请日：1978-10-10

    申请人： Kazumasa Yokoyama ,  Masakazu Iwai ,  Hiroyuki Okamoto ,  Noboru Yamada

    发明人： Kazumasa Yokoyama ,  Masakazu Iwai ,  Hiroyuki Okamoto ,  Noboru Yamada

    IPC分类号： A01N1/00 ,  A01N1/02 ,  C12B3/00 ,  A61K31/025

    CPC分类号： A01N1/02 ,  A01N1/0226

    摘要： An organ to be transplanted, such as kidney, can effectively be preserved by perfusion for a considerably long time by the use of a perfusate which is made by mixing a Ringer's solution modified by increasing potassium ion to 8-20 meq/l, a stable perfluorocarbon compound emulsion and albumin, so that the concentration of the perfluorocarbon compound is 7.5 to 12.5% (W/V) and that of albumin is 1-8% (W/V) based on the perfusate.

    摘要翻译： 通过使用通过将通过增加钾离子修饰的林格氏溶液混合至8-20meq / l而制成的灌注液，可以通过灌注相当长的时间来有效地保存要移植的器官，例如肾脏，稳定的 全氟化碳化合物乳液和白蛋白，使得全氟化碳化合物的浓度为7.5至12.5％（W / V），而白蛋白的浓度为基于灌注液的1-8％（W / V）。

    Process for preparing haptoglobin aqueous solution using strong anion exchanger
    55.
    发明授权
    Process for preparing haptoglobin aqueous solution using strong anion exchanger 失效
    使用强阴离子交换剂制备触珠蛋白水溶液的方法

    公开(公告)号：US4137307A

    公开(公告)日：1979-01-30

    申请号：US788921

    申请日：1977-04-19

    申请人： Satoshi Funakoshi ,  Takao Omura ,  Takeshi Ohshiro

    发明人： Satoshi Funakoshi ,  Takao Omura ,  Takeshi Ohshiro

    IPC分类号： A61L2/00 ,  C07K14/47 ,  A61K37/04 ,  A61K37/06 ,  C07G7/00

    CPC分类号： A61L2/0023 ,  C07K14/47 ,  Y10S530/806 ,  Y10S530/83 ,  Y10S530/831

    摘要： An aqueous solution of haptoglobin is obtained by subjecting an aqueous solution of .alpha. and .beta.-globulin fractions of human blood plasma to further fractionation by use of ammonium sulfate, collecting fractions precipitated at a concentration between 30% and 40% saturation of ammonium sulfate, contacting a reconstituted aqueous solution of the collected fractions with an anion exchanger to adsorb haptoglobin on said anion exchanger, selectively eluting the haptoglobin from the anion exchanger, and then concentrating the resulting aqueous eluate solution. The aqueous solution of haptoglobin is subjected to heat treatment in the presence of a selected stabilizing agent for inactivating hepatitis B virus at an optional step of the process.The thus obtained aqueous solution of haptoglobin has less than 10% hypotensive activity, highly stable during storage, and free from the risk of hepatitis B virus infection. This haptoglobin preparation is used for prevention and treatment of renal disorders caused by hemolysis.

    摘要翻译： 接触球蛋白的水溶液是通过使人血浆的α和β-球蛋白部分的水溶液通过使用硫酸铵进一步分级而获得的，收集以硫酸铵的30％至40％饱和浓度沉淀的级分，接触 用阴离子交换剂重新收集的级分的水溶液以吸附所述阴离子交换剂上的触珠蛋白，从阴离子交换剂中选择性洗脱触珠蛋白，然后浓缩所得的水性洗脱液。 在所选择的用于灭活乙型肝炎病毒的稳定剂的存在下，在该方法的任选步骤，对触珠蛋白的水溶液进行热处理。

    HBsAG Particle composed of single polypeptide subunits and the preparation procedure
    56.
    发明授权
    HBsAG Particle composed of single polypeptide subunits and the preparation procedure 失效
    HBsAG颗粒由单个多肽亚基组成，其制备方法

    公开(公告)号：US4113712A

    公开(公告)日：1978-09-12

    申请号：US664983

    申请日：1976-03-08

    申请人： Satoshi Funakoshi

    发明人： Satoshi Funakoshi

    IPC分类号： A61K39/00 ,  C07K14/02 ,  G01N33/576 ,  G01N33/96 ,  A61K39/12 ,  A61K39/42 ,  C07G7/00 ,  G01N33/16

    CPC分类号： C07K14/005 ,  G01N33/5764 ,  G01N33/96 ,  A61K39/00 ,  C12N2730/10122 ,  Y10S436/82 ,  Y10S436/826 ,  Y10S530/806 ,  Y10S530/831

    摘要： Hepatitis B surface antigen particles composed of single polypeptide subunits having a molecular weight of about 55,000 dalton are prepared by heating hepatitis B surface antigen in isotonic sodium chloride solution at about neutral pH containing a surfactant capable of delipidation such as alkali-metal salts of bile acids or of lauroylsarcosinic acid, or poloxyethylene alkylphenol containing an average oxyethylene of 7 to 10 molecules, or polyoxyethylene sorbitan monoalkylester containing an average oxyethylene of 20 molecules.A uniform hepatitis B surface antigen particle thus obtained has a spherical form 18 to 22 nm in diameter with an empty core, a molecular weight of about 2,200,000 dalton, and the characteristic of low toxicity.This hepatitis B surface antigen particle is useful for the preparation of vaccines, as a standard antigen reagent for testing hepatitis B surface antigen and the antibody, and as an antigen for immunizing animals to obtain a highly specific and strong antibody.

    摘要翻译： 由分子量约55,000道尔顿的单个多肽亚单位组成的乙型肝炎表面抗原颗粒是通过在含有能够脱脂的表面活性剂的等渗氯化钠溶液中加热乙肝表面抗原来制备的，所述表面活性剂含有能够脱脂的表面活性剂，例如胆汁酸的碱金属盐 或月桂酰肌氨酸或含有7〜10分子的平均氧化乙烯的聚氧乙烯烷基苯酚，或含有20分子的平均氧化乙烯的聚氧乙烯山梨糖醇酐单烷基酯。

    Process for producing human lysozyme
    57.
    发明授权
    Process for producing human lysozyme 失效
    生产人溶菌酶的方法

    公开(公告)号：US4104125A

    公开(公告)日：1978-08-01

    申请号：US815359

    申请日：1977-07-13

    申请人： Kazuo Takechi ,  Tsuyoshi Takahashi ,  Toyoaki Inaba ,  Eiichi Hasegawa

    发明人： Kazuo Takechi ,  Tsuyoshi Takahashi ,  Toyoaki Inaba ,  Eiichi Hasegawa

    IPC分类号： A61K38/00 ,  C12N9/36 ,  C07G7/026

    CPC分类号： C12N9/2462 ,  A61K38/00 ,  Y10S435/815 ,  Y10S530/83 ,  Y10S530/831

    摘要： It has been discovered that lysozyme in the blood is concentrated into the albumin fraction when the blood is fractionated by the alcohol fractionation method at lowered temperature or the ammonium sulfate fractionation method. Lysozyme can be produced by contacting the albumin fraction with a weakly acidic cation-exchanger such as CM-cellulose to adsorb selectively the lysozyme with the cation-exchanger and then eluting the lysozyme adsorbed from the cation-exchanger.

    摘要翻译： 已经发现，当血液在降低的温度下通过醇分馏法或硫酸铵分级法分离时，将血液中的溶菌酶浓缩成白蛋白部分。 可以通过使白蛋白部分与弱酸性阳离子交换剂如CM-纤维素接触来产生溶菌酶，以便用阳离子交换剂选择性地吸附溶菌酶，然后洗脱从阳离子交换器吸附的溶菌酶。

    Process for preparing stable oxygen transferable emulsion
    58.
    发明授权
    Process for preparing stable oxygen transferable emulsion 失效
    制备稳定的可转印乳液的方法

    公开(公告)号：US3993581A

    公开(公告)日：1976-11-23

    申请号：US485318

    申请日：1974-07-02

    申请人： Kazumasa Yokoyama ,  Koichi Yamanouchi ,  Ryoichiro Murashima ,  Ryozo Watanabe

    发明人： Kazumasa Yokoyama ,  Koichi Yamanouchi ,  Ryoichiro Murashima ,  Ryozo Watanabe

    IPC分类号： A61K9/00 ,  A61K31/02 ,  B01J13/00

    CPC分类号： A61K9/0026 ,  A61K31/02 ,  Y10S516/06

    摘要： Oxygen-transferable perfluorocarbon compounds having 9 to 11 carbon atoms such as perfluorodecalin, perfluoro(C.sub.3.sub.-5 -alkylcyclohexanes), perfluoro(C.sub.4.sub.-6 -alkyl tetrahydropyrans), perfluoro(C.sub.5.sub.-7 -alkyltetrahydrofurans), perfluoro(C.sub.5.sub.-7 -alkylmorpholins) and perfluoro(C.sub.9.sub.-11 -trialkylamines) are emulsified in a physiologically acceptable aqueous solution such as Ringer's solution by the aid of a phospholipid as emulsifier and a fatty acid of 8 to 22 carbon atoms, alkali metal salt or monoglyceride thereof as emulsifying adjuvant. The emulsion is stable for a considerable period of time and contains particles having a particle size ranging from 0.05 to 0.3 .mu.. It is usable as a blood substitute or a perfurate for preservation of the internal organs.

    摘要翻译： 可全氟（C 5-8 - 烷基环己烷），全氟（C 5-6 - 烷基四氢吡喃），全氟（C 5-7 - 烷基四氢呋喃），全氟（C 5-7 - 烷基四氢呋喃），全氟 ）和全氟（C9-11-三烷基胺）在生理学上可接受的水溶液如林格氏溶液中借助于磷脂作为乳化剂和8-22个碳原子的脂肪酸，其碱金属盐或其单甘油酯作为乳化助剂乳化 。 该乳液在相当长的一段时间内是稳定的并且含有粒度范围为0.05-0.3μm的颗粒。 它可用作血液替代物或用于保存内脏的胃酸。

    Preparation of human placental hyaluronidase
    59.
    发明授权
    Preparation of human placental hyaluronidase 失效
    人胎盘透明质酸酶的制备

    公开(公告)号：US3945889A

    公开(公告)日：1976-03-23

    申请号：US500939

    申请日：1974-08-27

    申请人： Yasuhiro Mima ,  Masaaki Yamada

    发明人： Yasuhiro Mima ,  Masaaki Yamada

    IPC分类号： C12N9/24 ,  A61K38/00 ,  C12N9/26 ,  C12N9/88 ,  C07G7/026

    CPC分类号： C12N9/2408 ,  A61K38/00 ,  Y10S435/815 ,  Y10S435/816

    摘要： Human placental hyaluronidase preparation is prepared by extracting hyaluronidase from human placenta with an aqueous alkaline solution, harvesting globulin fraction from the extract, selectively adsorbing hyaluronidase contained in the fraction on an anion exchanger such as DEAE-Cellulose and eluting it, gel-filtrating the eluate, and lyophilizing the filtrate into powder. The hyaluronidase thus obtained has a molecular weight of about 70,000, with isoelectric point of pH 5.2, and enzymatic optical pH ranging 3.6 - 4.0, differing from conventional bovin testicular hyaluronidase. The preparation contains no heterogeneous proteins which cause ill-effect to human body.

    摘要翻译： 人胎盘透明质酸酶制剂是通过用碱性水溶液从人胎盘中提取透明质酸酶制备的，从提取物中收获球蛋白部分，选择性地将包含在该级分中的透明质酸酶吸附在阴离子交换剂如DEAE-纤维素上并进行洗脱，凝胶过滤洗脱液 ，并将滤液冻干成粉末。 所得到的透明质酸酶具有约70,000的分子量，等电点为pH5.2，酶学光学pH范围为3.6-4.0，不同于常规的vin睾丸透明质酸酶。 该制剂不含有对人体造成不良影响的异质蛋白质。

    Medical appliance made of plastic
    60.
    发明授权
    Medical appliance made of plastic 失效
    塑料医疗器具

    公开(公告)号：US3940802A

    公开(公告)日：1976-03-02

    申请号：US544008

    申请日：1975-01-24

    申请人： Eiji Sako ,  Hisasi Sasamoto

    发明人： Eiji Sako ,  Hisasi Sasamoto

    IPC分类号： A61L27/26 ,  A61F1/24 ,  A61F1/00 ,  A61F1/22 ,  A61M5/14

    CPC分类号： A61L27/26

    摘要： A medical appliance suitable for use in direct or indirect contact with blood, such as an artificial valve, artificial blood vessel, blood transfusion set, solution infusion set, or blood bag characterized by being composed of 100 parts by weight of polyvinyl chloride and as plasticizer 50 to 100 parts by weight of thermoplastic polyurethane of the polyester type, said polyurethane having a softening point of about 70.degree.C and giving no spot other than that of the origin at the same position loaded the test sample onto the plate in thin-layer chromatogram.

    摘要翻译： 适用于与血液直接或间接接触的医疗器具，例如人造瓣膜，人造血管，输血器，溶液输注器，或血袋，其特征在于由100重量份的聚氯乙烯和作为增塑剂 50〜100重量份的聚酯类热塑性聚氨酯，所述聚氨酯的软化点约为70℃，并且在相同的位置上不提供原点的点，而将测试样品加载到薄层上的板上 色谱。