公开(公告)号：US06139856A

公开(公告)日：2000-10-31

申请号：US988729

申请日：1997-12-11

Applicant: Grazyna Kaminska ,  Nancy Girard ,  Ming Fan ,  H. Ralph Rawls

Inventor： Grazyna Kaminska ,  Nancy Girard ,  Ming Fan ,  H. Ralph Rawls

IPC: A61L29/00 ,  A01N25/24 ,  A01N25/34 ,  A61K31/155 ,  A61K31/573 ,  A61K31/7135 ,  A61K33/38 ,  A61K38/22 ,  A61K45/00 ,  A61L26/00 ,  A61L31/00 ,  A61L31/04 ,  A61P7/02 ,  A61P7/04 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61K31/00

CPC classification number: A61L31/041 ,  A01N25/24

Abstract: This invention relates to an improved polyvinylidene fluoride-based composition useful for forming a flexible, tack-free, nonflammable, substantially fluid resistant barrier film with substantially improved durability and skin-adhesion properties. The composition providing a long-lasting protective barrier film capable of disinfecting the skin surface of normally present microorganisms upon initial application, and said film imparting continuous and prolonged antimicrobial properties to the skin surface through sustained release of an encapsulated antimicrobial agent. The barrier film is further capable of remaining substantially adherent to the skin surface after prolonged exposure to biological fluids. A kit and methods of use for the composition are disclosed.

Abstract translation: 本发明涉及一种改进的基于聚偏二氟乙烯的组合物，其可用于形成具有显着改善的耐久性和表皮粘合性能的柔性，无粘性，不可燃，基本上耐流体的阻隔膜。 所述组合物提供能够在初次使用时消毒正常存在的微生物的皮肤表面的长效保护性屏障膜，并且所述膜通过包封的抗微生物剂的持续释放赋予皮肤表面持续和延长的抗微生物性能。 阻隔膜还能够在长时间暴露于生物流体之后保持基本上粘附于皮肤表面。 公开了用于组合物的试剂盒和使用方法。

公开(公告)号：US6099563A

公开(公告)日：2000-08-08

申请号：US209328

申请日：1998-12-11

Applicant: Sheng-Ping Zhong

Inventor： Sheng-Ping Zhong

IPC: A61M25/00 ,  A61L29/00 ,  A61L29/08 ,  A61L29/16 ,  A61L31/00 ,  A61L31/10 ,  A61L31/16 ,  C03C17/32 ,  C08J7/04 ,  C08L33/02 ,  C08L75/00 ,  C08L75/04 ,  C09D201/00 ,  A61I2/00 ,  A61L27/00 ,  A61L33/00

CPC classification number: A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/208 ,  A61L2300/21 ,  A61L2300/236 ,  A61L2300/25 ,  A61L2300/42 ,  A61L2300/608 ,  A61L2300/61 ,  Y10S623/92

Abstract: Disclosed is a method of enhancing the biocompatibility of a substrate by providing the substrate with a continuous bio-active surface coating. This method includes applying to the substrate a first coating which includes an aqueous dispersion or emulsion of a polymer containing an organic acid functional group and an excess of a polyfunctional cross-linking agent which is reactive with the organic acid groups of the polymer. A continuous bio-active surface coating is then formed over the dried first coating by applying thereover a bio-active agent containing an organic acid functional group or metal salt thereof. The first and second coatings are then dried to covalently bond the organic acid functional groups of the bio-active agent to the polymer through the excess unreacted polyfunctional cross-linking agent.

Abstract translation: 公开了通过向基材提供连续的生物活性表面涂层来提高基底的生物相容性的方法。 该方法包括向基材施加第一涂层，该涂层包括含有有机酸官能团的聚合物的水性分散体或乳液，以及过量的与聚合物的有机酸基团反应的多官能交联剂。 然后通过在其上施加含有有机酸官能团或其金属盐的生物活性剂，在干燥的第一涂层上形成连续的生物活性表面涂层。 然后干燥第一和第二涂层，以通过过量的未反应的多官能交联剂将生物活性剂的有机酸官能团与聚合物共价键合。

公开(公告)号：US6093463A

公开(公告)日：2000-07-25

申请号：US45483

申请日：1998-03-20

Applicant: Ashok R. Thakrar

Inventor： Ashok R. Thakrar

IPC: A61L29/00 ,  A61L29/04 ,  A61L29/06 ,  A61L29/14

CPC classification number: A61L29/141 ,  A61L29/049 ,  A61L29/06 ,  Y10T428/139 ,  Y10T428/1393 ,  Y10T428/1397

Abstract: Disclosed are medical devices including a composition that includes an aliphatic polyketone and a thermoplastic polymer.

Abstract translation: 公开了包括包含脂族聚酮和热塑性聚合物的组合物的医疗装置。

公开(公告)号：US6086556A

公开(公告)日：2000-07-11

申请号：US129029

申请日：1998-08-04

Applicant: Bruce Hamilton ,  Ronald A. Sahatjian

Inventor： Bruce Hamilton ,  Ronald A. Sahatjian

IPC: A61F2/958 ,  A61L29/00 ,  A61L29/04 ,  A61M25/00 ,  A61M29/00

CPC classification number: A61M25/1029 ,  A61L29/049 ,  A61M25/0045 ,  A61M25/1002 ,  A61M2025/1075 ,  A61M25/1038

Abstract: A dilatation balloon and catheter for insertion into a bodily conduit. The catheter (10) includes shaft (12) and a dilatation balloon (24) at the distal end of the shaft. The balloon is inflated via a central lumen (14) in the shaft for delivery of a fluid inflation media. The balloon is fabricated from a combination of a thermoplastic elastomer (TPE), preferably an engineering thermoplastic elastomer (ETE), with a non-compliant structural polymeric material. The combination may be a blend of the non-compliant structural polymer and the TPE. Alternatively, the combination may be a layered balloon having, for example, a non-compliant structural polymer inner layer and a soft, abrasion resistant, elastomeric outer layer. Methods for fabricating the balloon from the combination of a TPE and a non-compliant structural polymer are also disclosed.

Abstract translation: 用于插入身体导管的扩张球囊和导管。 导管（10）在轴的远端包括轴（12）和膨胀气球（24）。 气球通过轴中的中心腔（14）膨胀，用于输送流体充气介质。 气球由热塑性弹性体（TPE），优选工程热塑性弹性体（ETE）与非柔顺结构聚合材料的组合制成。 该组合可以是不顺应结构聚合物和TPE的混合物。 或者，组合可以是具有例如不顺应结构聚合物内层和柔软，耐磨损的弹性体外层的分层气囊。 还公开了从TPE和不顺应结构聚合物的组合制造球囊的方法。

公开(公告)号：US6050979A

公开(公告)日：2000-04-18

申请号：US110126

申请日：1998-07-06

Applicant: Hugo Haemmerle ,  Fritz Schindler

Inventor： Hugo Haemmerle ,  Fritz Schindler

IPC: A61L29/00 ,  A61L31/10 ,  A61L31/12 ,  A61M25/02 ,  A61M25/16 ,  A61M5/32

CPC classification number: A61L31/10 ,  A61L31/129 ,  A61M2025/0266 ,  A61M2025/0286 ,  A61M25/02

Abstract: A transcutaneous medical device which has on its surface a fibrous material with free collagen fibers which are present in a natural structure. The transcutaneous medical device is prepared by applying to the surface of such a device a fibrous material with free collagen fibers present in a natural structure.

Abstract translation: 一种经皮医疗装置，其表面上具有以自然结构存在的自由胶原纤维的纤维材料。 经皮医疗装置通过将具有自然结构中存在的游离胶原纤维的纤维材料应用于该装置的表面来制备。

公开(公告)号：US6036697A

公开(公告)日：2000-03-14

申请号：US112387

申请日：1998-07-09

Applicant: Fernando DiCaprio

Inventor： Fernando DiCaprio

IPC: A61M25/00 ,  A61F2/06 ,  A61F2/82 ,  A61F2/84 ,  A61L29/00 ,  A61L29/04 ,  A61L29/06 ,  A61M25/10 ,  A61F11/00

CPC classification number: A61F2/958 ,  A61L29/041 ,  A61L29/06 ,  A61M25/10 ,  A61M2025/1059 ,  C08L23/06 ,  C08L23/10 ,  C08L67/00 ,  C08L77/00

Abstract: A balloon catheter is provided having an expandable distal portion, said expandable portion having a proximal end, a distal end and distal expansion means, said expandable portion being adapted for expansion at its distal end, from its distal end to its proximal end. A stent delivery system is provided to facilitate introduction and placement of a stent, and includes a catheter having an expandable distal portion constructed and arranged for expanding the outer diameter of the catheter from a contracted state to an expanded state, said distal portion further comprising a balloon, and a stent positioned around the distal portion of the catheter around the balloon, said stent having a proximal end and a distal end and further having a contracted condition, said stent being sized in the contracted condition to closely surround the balloon in the contracted state, and being adapted to expand to an expanded condition from its distal end to its proximal end in response to expansion of the balloon member from its distal end.

Abstract translation: 提供了具有可扩展远端部分的气囊导管，所述可扩张部分具有近端，远端和远侧扩张装置，所述可扩张部分适于在其远端处从其远端到其近端膨胀。 提供支架输送系统以便于引入和放置支架，并且包括导管，其具有被构造和布置成用于将导管的外径从收缩状态扩大到扩张状态的可扩展远端部分，所述远端部分还包括 气囊和围绕球囊定位在导管的远端部分周围的支架，所述支架具有近端和远端并且还具有收缩状态，所述支架的尺寸在收缩状态下以在收缩状态下紧密围绕气囊 状态，并且响应于球囊构件从其远端的膨胀而适于从其远端扩展到扩展状态到其近端。

公开(公告)号：US6020071A

公开(公告)日：2000-02-01

申请号：US973250

申请日：1997-11-26

Applicant: Jeremy Watson

Inventor： Jeremy Watson

IPC: A61L29/00 ,  A61L29/08 ,  A61L31/00 ,  C08G18/08 ,  C08G18/10 ,  B32B27/40 ,  B05D3/02 ,  B05D5/08

CPC classification number: A61L29/085 ,  C08G18/0852 ,  C08G18/10 ,  A61L2400/10

Abstract: A hydrophilic lubricious coating for an article comprising a non-toxic, cross-linked, hydrophilic polyurethane. The invention includes a method for preparing said lubricious coating, as well as a method for coating an article with said hydrophilic lubricious coating.

Abstract translation: PCT No.PCT / GB96 / 01314 Sec。 371日期：1997年11月26日 102（e）1997年11月26日PCT PCT 1996年6月3日PCT公布。 出版物WO96 / 39204 日期1996年12月12日一种用于制品的亲水性润滑涂层，其包含无毒的交联的亲水性聚氨酯。 本发明包括一种制备所述润滑涂层的方法，以及用所述亲水性润滑涂层涂覆制品的方法。

公开(公告)号：US5998551A

公开(公告)日：1999-12-07

申请号：US867362

申请日：1997-06-02

Applicant: Charles J. O'Neil ,  Lawrence A. Acquarulo, Jr.

Inventor： Charles J. O'Neil ,  Lawrence A. Acquarulo, Jr.

IPC: A61M25/00 ,  A61F2/958 ,  A61L29/00 ,  A61L29/06 ,  A61M25/16 ,  C08G69/40 ,  C08G69/42 ,  C08G69/44 ,  C08G69/48

CPC classification number: A61M25/1036 ,  A61L29/06 ,  C08G69/40 ,  C08G69/42 ,  C08G69/44 ,  C08G69/48

Abstract: A crosslinked nylon block copolymer comprising a copolymer containing a polyamide block and an elastomeric block, irradiation crosslinked, including a compound which promotes crosslinking therein. In process form, the present invention comprises supplying a nylon block copolymer, containing a polyamide block and an elastomeric block, along with crosslinking promotor and exposing the block copolymer to irradiation, sufficient to crosslink the copolymer and improve mechanical properties therein. The crosslinked nylon block copolymers here have particular utility in both the medical and wire and cable industries.

Abstract translation: 一种交联的尼龙嵌段共聚物，其包含含有聚酰胺嵌段和弹性体嵌段的共聚物，辐照交联，包括促进其中交联的化合物。 在工艺形式中，本发明包括与交联促进剂一起提供含有聚酰胺嵌段和弹性体嵌段的尼龙嵌段共聚物，并将嵌段共聚物暴露于照射下，足以使共聚物交联并改善其中的机械性能。 交联的尼龙嵌段共聚物在医疗和电线电缆行业都具有特殊的用途。

公开(公告)号：US5997517A

公开(公告)日：1999-12-07

申请号：US791440

申请日：1997-01-27

Applicant: Richard J. Whitbourne

Inventor： Richard J. Whitbourne

IPC: A61L29/00 ,  A61L29/08 ,  A61L31/00 ,  A61L31/10 ,  A61M25/16 ,  A61M25/00 ,  A61K9/32 ,  A61M5/32

CPC classification number: A61L29/085 ,  A61L31/10 ,  A61L2420/08 ,  Y10S623/901

Abstract: A medical device is coated with a thin coherent bond coat of acrylics, epoxies, acetals, ethylene copolymers, vinyl polymers, polymers containing hydroxyl, amine, carboxyl, amide, or other reactive groups, and copolymers thereof. Outer layers may be applied and remain adherent to the substrate in water for an extended period. The bond coat may comprise cross linkers such as urea resins, melamines, isocyanates, and phenolics. Preferred polymers include vinylpyrrolidone-vinyl acetate, styrene acrylic polymer, ethylene acrylic acid copolymer, carboxyl function acrylic polymer, hydroxyl function acrylic polymer, and acrylic dispersion polymer. The coatings may be applied to inert metal or plastic surfaces of medical devices such as needles, guide wires, catheters, surgical instruments, equipment for endoscopy, wires, stents, angioplasty balloons, wound drains, arteriovenous shunts, gastroenteric tubes, urethral inserts, laparoscopic equipment, pellets, and implants. Methods of coating and coating liquids are provided.

Abstract translation: 医疗装置涂覆有丙烯酸树脂，环氧树脂，缩醛，乙烯共聚物，乙烯基聚合物，含羟基，胺，羧基，酰胺或其它反应性基团的聚合物的薄相干粘合涂层及其共聚物。 可以施加外层并且在水中保持粘附到基底长时间。 粘合涂层可以包括交联剂，例如尿素树脂，三聚氰胺，异氰酸酯和酚醛树脂。 优选的聚合物包括乙烯基吡咯烷酮 - 乙酸乙烯酯，苯乙烯丙烯酸聚合物，乙烯丙烯酸共聚物，羧基官能丙烯酸聚合物，羟基官能丙烯酸聚合物和丙烯酸分散体聚合物。 涂层可以应用于医疗装置的惰性金属或塑料表面，例如针，导丝，导管，手术器械，内窥镜检查设备，电线，支架，血管成形术球囊，伤口排液管，动静脉分流器，胃肠管，尿道插入物，腹腔镜 设备，颗粒和植入物。 提供涂布和涂布液体的方法。

公开(公告)号：US5980514A

公开(公告)日：1999-11-09

申请号：US690183

申请日：1996-07-26

Applicant: David Kupiecki ,  Clifford Teoh ,  Hong Doan ,  Son M. Gia ,  Erik T. Engelson ,  Uriel Hiram Chee ,  Mehran Bashiri ,  Joseph C. Eder

Inventor： David Kupiecki ,  Clifford Teoh ,  Hong Doan ,  Son M. Gia ,  Erik T. Engelson ,  Uriel Hiram Chee ,  Mehran Bashiri ,  Joseph C. Eder

IPC: A61B17/00 ,  A61B17/12 ,  A61F2/00 ,  A61F2/06 ,  A61F2/82 ,  A61F2/88 ,  A61L29/00 ,  A61M31/00

CPC classification number: A61F2/88 ,  A61B17/12022 ,  A61B17/12118 ,  A61B17/12145 ,  A61B17/12154 ,  A61B2017/1205 ,  A61B2017/12063 ,  A61F2002/30092 ,  A61F2210/0014 ,  A61F2250/0039 ,  A61F2310/00023

Abstract: This is an artificial occlusion kit for implanting and retaining an artificial occlusion device in a body space adjacent to and extending from a body lumen in a mammal. The includes at least one occlusion device and a retaining device for blocking the migration of the occlusion device out of the occlusion site. The retaining device is radially expandable at a retaining site adjacent the body space to be occluded to a diameter that is sufficient to engage the body lumen wall at the retaining site and form a barrier across the entrance zone of the body space to be occluded. The expanded retaining device also forms a lumen for flow through body lumen at the retaining site. At least one semi-penetrable space may also be provided in the retaining device, allowing introduction of occlusion devices into the body space to be occluded, but preventing subsequent migration of the occlusion devices out of the body space. This semi-penetrable space may also be distensible to allow for delivery of occlusion devices therethrough. An introducer wire or a tapered-tip delivery catheter may be used to distend the distensible space and deliver the occlusion devices. The retaining device structure may further include a radiopaque metal wire wound into a primary helix over an inner core member made of a superelastic alloy of nickel and titanium. An implantable medical device assembly is also provided, having the structure described for the retaining device of the novel artificial occlusion kit, and which is attached to an elongate pusher via a sacrificial link that is electrolytically dissolvable.