公开(公告)号：US11602721B2

公开(公告)日：2023-03-14

申请号：US16735251

申请日：2020-01-06

Applicant: THE SECANT GROUP, LLC

Inventor： Steven Lu ,  Peter D. Gabriele ,  Julia Donnelly ,  Brian Ginn ,  Charles Brendan Nicholson ,  Jeremy J. Harris ,  Michael S. Flemmens

IPC: B01J13/08 ,  A61L27/56 ,  A61L27/54 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L15/42 ,  A61L15/44 ,  A61L15/64 ,  A61L15/22 ,  C09J133/06 ,  C09J123/20 ,  A61L27/58 ,  C08J9/24 ,  A61L31/04 ,  A61L27/14 ,  A61L24/00 ,  A61L24/04

Abstract: A method of forming cured microparticles includes providing a poly(glycerol sebacate) resin in an uncured state. The method also includes forming the composition into a plurality of uncured microparticles and curing the uncured microparticles to form the plurality of cured microparticles. The uncured microparticles are free of a photo-induced crosslinker. A method of forming a scaffold includes providing microparticles including poly(glycerol sebacate) in a three-dimensional arrangement. The method also includes stimulating the microparticles in the three-dimensional arrangement to sinter the microparticles, thereby forming the scaffold having a plurality of pores. A scaffold is formed of a plurality of microparticles including a poly(glycerol sebacate) thermoset resin in a three-dimensional arrangement. The scaffold has a plurality of pores.

公开(公告)号：US11596710B2

公开(公告)日：2023-03-07

申请号：US16705811

申请日：2019-12-06

Applicant: C.P. MEDICAL CORPORATION

Inventor： Syed H. Askari ,  Yeon S. Choi

IPC: A61K8/00 ,  A61L26/00 ,  A61L27/18 ,  A61L27/52 ,  A61L27/54 ,  A61L24/00 ,  A61L24/04 ,  A61L27/58 ,  A61K9/00 ,  A61K47/18 ,  A61K47/20 ,  A61K47/32 ,  A61K47/38 ,  A61K9/70 ,  A61K51/12 ,  A61F9/007

Abstract: Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch.

公开(公告)号：US11590255B2

公开(公告)日：2023-02-28

申请号：US16346655

申请日：2017-11-10

Applicant: Avery Dennison Corporation

Inventor： Xianbo Hu ,  Neal Carty

IPC: A61L15/58 ,  A61L15/44 ,  A61L24/00 ,  A61L24/04 ,  C08K5/01 ,  C08K5/103 ,  C08K5/29 ,  C09J125/10

Abstract: Adhesives comprising rubber, tackifier, oil, and optionally absorbent and active ingredient are described. The adhesives are suitable for medical applications as they are repositionable on skin. Also described are medical articles using the adhesives.

公开(公告)号：US11571492B2

公开(公告)日：2023-02-07

申请号：US17059100

申请日：2019-05-30

Applicant: HCS Innovation, LLC

Inventor： Ronnie Michael Hanes ,  Adele Lamping Hanes

IPC: A61L24/04 ,  A61L24/00 ,  A61L24/08 ,  C09J105/00 ,  C09J105/08 ,  C08L5/04 ,  C08L5/08 ,  C09J105/04

Abstract: A tissue adhesive for contacting a tissue site, the tissue adhesive comprising: a mixture of natural polymers; and an activating agent enhancing the adhesive properties of the mixture of natural polymers. And a tissue adhesive for contacting a tissue site, the tissue adhesive comprising: a mixture of natural polymers; and an aqueous solution of a water soluble starch or a water soluble starch derivative which forms a gel with the addition of the mixture of natural polymers.

公开(公告)号：US11559441B2

公开(公告)日：2023-01-24

申请号：US16495232

申请日：2018-03-21

Applicant: Mölnlycke Health Care AB

Inventor： Ulf Johannison ,  Steen Jörgensen ,  Magnus Paledzki

IPC: A61F13/00 ,  A61F13/02 ,  A61L15/42 ,  A61L24/00 ,  A61L24/04 ,  B26D7/10 ,  B26F1/24

Abstract: A method for manufacturing a wound dressing having a substrate, and a wound dressing manufactured by such a method are described. The method has a step of providing a sacrificial layer of material to be perforated by means of a hot pin perforator, in order to remove any molten residues on the heated pins of the hot pin perforator, before the same pins are used to make holes in the substrate. The presented method is cost effective, robust and reduces the risk of contaminating substances being embedded in the substrate during the hole making process.

公开(公告)号：US20230001046A1

公开(公告)日：2023-01-05

申请号：US17787563

申请日：2020-12-21

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Paul SANTERRE ,  Eli SONE ,  Michael FLOROS

IPC: A61L24/04 ,  C08G18/12 ,  C08G18/32 ,  C08G18/42 ,  C09J175/06

Abstract: A biocompatible adhesive is provided comprising one or more water insoluble compounds of structure (1) wherein B is an oligomer derived from a polyester, polyether, polyalkylene glycol, polysilicone or polycarbonate with a MW

公开(公告)号：US11534524B2

公开(公告)日：2022-12-27

申请号：US17164270

申请日：2021-02-01

Applicant: The Brigham and Women's Hospital, Inc.

Inventor： Steven James Mentzer ,  Cristian David Valenzuela ,  Alexandra Brooke Ysasi ,  Andrew Barrett Servais

IPC: A61L24/04 ,  A61L24/00

Abstract: This disclosure relates to pectin-based polymer compositions and methods of use thereof to cover, protect, and seal injuries, e.g., surgical wounds, in a mesothelial tissue. The methods include obtaining a bioadhesive pectin-based polymer composition including a complex of high-methoxyl pectin (HMP) and carboxymethylcellulose (CMC) in a ratio from about 10 to 1 to 1 to 10 by weight; applying the composition to an injured mesothelial tissue; and applying pressure for at least one minute to enable the composition to bind to the mesothelial tissue.

公开(公告)号：US20220395608A1

公开(公告)日：2022-12-15

申请号：US17787531

申请日：2020-12-21

Applicant: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Inventor： Paul SANTERRE ,  Eli SONE ,  Michael FLOROS

IPC: A61L24/04 ,  A61L24/00

Abstract: A water soluble biocompatible adhesive is provided comprising one or more compounds of structure 1 wherein B is an oligomer derived from a polyether or polyalkylene glycol, with a MW

公开(公告)号：US11479644B2

公开(公告)日：2022-10-25

申请号：US16340835

申请日：2017-10-13

Applicant: Cambridge Enterprise Limited

Inventor： Oren Scherman ,  Ji Liu

IPC: C08G83/00 ,  C08G73/06 ,  C08J3/075 ,  C08J3/24 ,  A61K47/58 ,  A61L24/04 ,  A61L24/00

Abstract: The invention provides a polymerizable composition and a hydrogel obtained or obtainable from the polymerizable composition. The polymerizable composition comprises cucurbituril and a first monomer having a guest for the cucurbituril, wherein the total monomer concentration, Cmon, within the polymerizable composition is at least 0.5 M. The composition may be an aqueous composition.

公开(公告)号：US11471141B2

公开(公告)日：2022-10-18

申请号：US16894294

申请日：2020-06-05

Applicant: BMG Incorporated

Inventor： Motoki Fujimura ,  Shinichi Osada ,  Yusuke Kojitani ,  Woogi Hyon ,  Suong-Hyu Hyon

IPC: A61B17/00 ,  A61L24/04

Abstract: A powder spray device includes a funnel member, a first three-way joint, an air-current supply tube, a discharge tube, a vibration motor, a bypass air-current tube, and a switching mechanism. The first three-way joint has a first opening connected to an outlet at a lower end of the funnel member. The air-current supply tube and discharge tube are respectively connected to second and third openings of the first three-way joint. The vibration motor is fixed onto an outer surface of a funnel body of the funnel member. The bypass air-current tube branches off from the air-current supply tube and is connected to the discharge tube. The switching mechanism switches from and to standby state, in which compressed gas is sent only through the bypass air-current tube, to and from spray-coating state, in which compressed gas is sent out through the air-current supply tube, and also through the bypass air-current tube.