公开(公告)号：US20190263973A1

公开(公告)日：2019-08-29

申请号：US16340835

申请日：2017-10-13

Applicant: Cambridge Enterprise Limited

Inventor： Oren Scherman ,  Ji Liu

IPC: C08G83/00 ,  C08J3/24 ,  C08J3/075 ,  C08G73/06

Abstract: The invention provides a polymerizable composition and a hydrogel obtained or obtainable from the polymerizable composition. The polymerizable composition comprises cucurbituril and a first monomer having a guest for the cucurbituril, wherein the total monomer concentration, Cmon, within the polymerizable composition is at least 0.5 M. The composition may be an aqueous composition.

公开(公告)号：US11491227B2

公开(公告)日：2022-11-08

申请号：US14379109

申请日：2013-02-20

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Oren Scherman ,  Eric Appel ,  Xian Jun Loh ,  Frank Biedermann ,  Matthew Rowland

IPC: A61K47/32 ,  A61K38/38 ,  A61K38/47 ,  C08L39/00 ,  C08J3/075 ,  C08B11/12 ,  C08G18/71 ,  C08L1/02 ,  C08B11/08 ,  C08J3/24 ,  C08B37/08 ,  C08L5/08 ,  C08L5/16 ,  C08L1/28 ,  C08G18/64 ,  C08B37/16

Abstract: The invention provides hydrogel, wherein the hydrogel has a supramolecular cross-linked network obtainable or obtained from the complexation of an aqueous composition including a host, such as cucurbituril, and one or more polymers having suitable guest functionality. One or more polymers in the aqueous composition may have a molecular weight of 50 kDa or more, such as 200 kDa or more. The hydrogel may hold a component, such as a therapeutic compound or a biological molecule. The hydrogels are suitable for use in medicine.

公开(公告)号：US11479644B2

公开(公告)日：2022-10-25

申请号：US16340835

申请日：2017-10-13

Applicant: Cambridge Enterprise Limited

Inventor： Oren Scherman ,  Ji Liu

IPC: C08G83/00 ,  C08G73/06 ,  C08J3/075 ,  C08J3/24 ,  A61K47/58 ,  A61L24/04 ,  A61L24/00

Abstract: The invention provides a polymerizable composition and a hydrogel obtained or obtainable from the polymerizable composition. The polymerizable composition comprises cucurbituril and a first monomer having a guest for the cucurbituril, wherein the total monomer concentration, Cmon, within the polymerizable composition is at least 0.5 M. The composition may be an aqueous composition.

公开(公告)号：US10189955B2

公开(公告)日：2019-01-29

申请号：US14763071

申请日：2014-01-30

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Jing Zhang ,  Roger Coulston ,  Richard Parker ,  Christopher Abell ,  Oren Scherman ,  Ziyi Yu

IPC: C08G83/00 ,  B01J13/16 ,  B01J13/14 ,  C08J3/075 ,  B01J13/22 ,  C09B67/02 ,  C09B69/10 ,  A61K9/48

Abstract: A nested capsule having a first capsule held within a second capsule. Each of the first and second capsules has a shell that is a supramolecular cross-linked network, such as a cucurbituril supramolecular cross-linked network. Each capsule shell is obtained or is obtainable from the complexation of a composition including a host, such as cucurbituril, and one or more building blocks having suitable guest functionality for the host, thereby to form a supramolecular cross-linked network. The nested capsules are suitable for delivering and selectively releasing an encapsulant at a location.

公开(公告)号：US20150110772A1

公开(公告)日：2015-04-23

申请号：US14379109

申请日：2013-02-20

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Oren Scherman ,  Eric Appel ,  Xian Jun Loh ,  Frank Biedermann ,  Matthew Rowland

IPC: A61K47/32 ,  A61K38/38 ,  C08L39/00 ,  A61K38/47

CPC classification number: A61K47/32 ,  A61K38/385 ,  A61K38/47 ,  C08B11/08 ,  C08B11/12 ,  C08B37/0015 ,  C08B37/0072 ,  C08G18/6484 ,  C08G18/71 ,  C08G2210/00 ,  C08J3/075 ,  C08J3/246 ,  C08J2300/10 ,  C08J2300/204 ,  C08J2300/208 ,  C08J2300/21 ,  C08J2301/28 ,  C08J2305/08 ,  C08J2305/16 ,  C08J2329/04 ,  C08J2375/02 ,  C08L1/02 ,  C08L1/284 ,  C08L1/286 ,  C08L5/08 ,  C08L5/16 ,  C08L39/00 ,  C12Y302/01017

Abstract: The invention provides hydrogel, wherein the hydrogel has a supramolecular cross-linked network obtainable or obtained from the complexation of an aqueous composition including a host, such as cucurbituril, and one or more polymers having suitable guest functionality. One or more polymers in the aqueous composition may have a molecular weight of 50 kDa or more, such as 200 kDa or more. The hydrogel may hold a component, such as a therapeutic compound or a biological molecule. The hydrogels are suitable for use in medicine.

Abstract translation: 本发明提供了一种水凝胶，其中该水凝胶具有超分子交联网络，该网络可由包含宿主如葫芦素的水性组合物与一种或多种具有合适的客体官能团的聚合物络合而获得或获得。 含水组合物中的一种或多种聚合物可以具有50kDa或更高分子量，例如200kDa或更多。 水凝胶可以含有组分，例如治疗化合物或生物分子。 水凝胶适用于医药。