公开(公告)号：US20070164209A1

公开(公告)日：2007-07-19

申请号：US10514098

申请日：2003-05-30

Applicant: Michael Balogh

Inventor： Michael Balogh

IPC: H01J49/00

CPC classification number: H01J49/168 ,  H01J49/145 ,  H01J49/165

Abstract: The present invention combines ionization modes produced by, for example, electrospray (ESI), atmospheric pressure chemical ionization (APCI), and thermospray for analysis of molecules. Specifically, this invention relates to the creation of a new source apparatus combining APCI and ESI which will interface with existing mass spectrometers, as well as the creation of new mass spectrometers where the present invention would be the ionization source. Furthermore, the present invention relates to an ionization source for a mass spectrometer which features an ion chamber defining an ion path, an electrospray probe for ionizing a sample using electrospray ionization, a corona discharge needle for ionizing a sample using atmospheric pressure chemical ionization, a power supply for applying an electrical potential to one of said electrospray probe and said corona discharge needle, and a solid state switch for directing the electrical potential from the power supply to one of the electrospray probe and said corona discharge needle.

Abstract translation: 本发明结合了由例如电喷雾（ESI），大气压化学电离（APCI）和热喷雾产生的电离模式，用于分析分子。 具体地说，本发明涉及一种将APCI和ESI组合起来的新的源装置，它将与现有的质谱仪相结合，以及新型质谱仪的创建，其中本发明将是电离源。 此外，本发明涉及一种质谱仪的电离源，其特征在于，具有限定离子通道的离子室，使用电喷雾离子化电离样品的电喷雾探针，用于使用大气压化学电离使样品电离的电晕放电针， 用于将电位施加到所述电喷雾探针和所述电晕放电针中的一个的电源，以及用于将电源从电源引导到电喷雾探针和所述电晕放电针之一的固态开关。

公开(公告)号：US20070023677A1

公开(公告)日：2007-02-01

申请号：US11172177

申请日：2005-06-29

Applicant: Patrick Perkins ,  Steven Fischer

Inventor： Patrick Perkins ,  Steven Fischer

IPC: H01J49/10

CPC classification number: H01J49/165 ,  H01J49/107 ,  H01J49/145 ,  H01J49/162 ,  H01J49/168

Abstract: The present invention provides an apparatus and method for use with a mass spectrometer. The multimode ionization source of the present invention provides one or more atmospheric pressure ionization sources (e.g., electrospray, atmospheric pressure chemical ionization and/or atmospheric pressure photoionization) for ionizing natural product and organic molecules. A method of producing ions using the multimode ionization source is also disclosed. The apparatus and method provide the advantages of the combined ion sources without the inherent disadvantages of the individual sources. In an embodiment, the multimode ionization source includes an infrared emitter enclosed in an inner chamber for drying a charged aerosol. ESI/APCI multimode sources may include a corona needle shield and/or an auxiliary electrode.

Abstract translation: 本发明提供了一种与质谱仪一起使用的装置和方法。 本发明的多模电离源提供用于电离天然产物和有机分子的一种或多种大气压电离源（例如电喷雾，大气压化学电离和/或大气压光电离）。 还公开了使用多模电离源产生离子的方法。 该装置和方法提供了组合离子源的优点，而没有各个源的固有缺点。 在一个实施例中，多模式电离源包括封闭在内室中用于干燥带电气溶胶的红外发射器。 ESI / APCI多模式源可以包括电晕针护罩和/或辅助电极。

公开(公告)号：US20070018114A1

公开(公告)日：2007-01-25

申请号：US11185141

申请日：2005-07-20

Applicant: Kenneth Purser ,  Albert Litherland ,  Norman Turner

Inventor： Kenneth Purser ,  Albert Litherland ,  Norman Turner

IPC: H01J27/00

CPC classification number: H01J37/08 ,  H01J37/3171 ,  H01J49/145 ,  H01J2237/0815 ,  H01J2237/31705 ,  H05H3/02

Abstract: The present invention comprehends a compact and economical apparatus for producing high intensities of a wide variety of wanted positive and negative molecular and atomic ion beams that have been previously impossible to previously produce at useful intensities. In addition, the invention provides a substantial rejection of companion background ions that are frequently simultaneously emitted with the wanted ions. The principle underlying the present invention is resonance ionization-transfer where energy differences between resonant and non-resonant processes are exploited to enhance or attenuate particular charge-changing processes. This new source technique is relevant to the fields of Accelerator Mass Spectroscopy; Molecular Ion Implantation; Generation of Directed Neutral Beams; and Production of Electrons required for Ion Beam Neutralization within magnetic fields. An example having commercial importance is ionization of the decaborane molecule, B10H14 where an almost perfect ionization resonance match occurs between decaborane molecules and arsenic atoms.

Abstract translation: 本发明包括一种紧凑且经济的装置，用于产生以前不可能以有用强度预先产生的各种各样的所需正，负分子和原子离子束的强度。 此外，本发明提供了与所需离子频繁同时发射的伴随背景离子的显着排除。 本发明的基本原理是谐振电离转移，其中利用共振和非共振过程之间的能量差异来增强或减弱特定的电荷变化过程。 这种新的源技术与加速器质谱技术相关; 分子离子注入 定向中性梁的生成 和磁场中离子束中和所需的电子的生产。 具有商业重要性的实例是十硼烷分子的电离，其中在十硼烷分子和砷原子之间发生几乎完美的电离谐振匹配的B 10 H 14 N 14。

公开(公告)号：US07129478B2

公开(公告)日：2006-10-31

申请号：US11126218

申请日：2005-05-11

Applicant: Takashi Baba ,  Hiroyuki Satake ,  Yasuaki Takada

Inventor： Takashi Baba ,  Hiroyuki Satake ,  Yasuaki Takada

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/145 ,  H01J49/0095 ,  H01J49/063

Abstract: A mass spectrometer having an ion source section capable of creating positive ions and negative ions at high efficiency. The ion source is comprised of an ion source section for creating ions of a sample gas, a mass spectrometric section for conducting mass separation of created ions, linear RF generating multipole electrodes, magnetic fields generation means, a sample gas introduction system, a reaction gas introduction system and an electron source in which the linear RF generating multipole electrodes generate linear RF multipole electric fields. A static magnetic fields is applied in parallel on the center axis where the linear RF multipole electric fields are zero. A sample gas and a reagent gas are introduced into the ion source section. Electrons are injected for creating reaction of the positive ions or negative ions.

Abstract translation: 具有能够以高效率产生正离子和负离子的离子源部的质谱仪。 离子源包括用于产生样品气体的离子的离子源部分，用于导出所产生的离子的质量分离的质谱部分，线性RF产生多极电极，磁场产生装置，样品气体引入系统，反应气体 引入系统和电子源，其中线性RF产生多极电极产生线性RF多极电场。 在线性RF多极电场为零的中心轴上并行施加静态磁场。 样品气体和反应气体被引入离子源部分。 注入电子以产生正离子或负离子的反应。

公开(公告)号：US07009175B2

公开(公告)日：2006-03-07

申请号：US11000412

申请日：2004-12-01

Applicant: Armin Hansel ,  Armin Wisthaler

Inventor： Armin Hansel ,  Armin Wisthaler

IPC: H01J49/42 ,  H01J44/10 ,  H01M8/02

CPC classification number: H01J49/04 ,  H01J49/145 ,  H01J49/26

Abstract: In a method for obtaining an output ion current substantially comprised of only a single ionic species, ions formed in the ionization of a source gas in an ionization region (A) and/or ions extracted from the ionization region (A) are allowed to react in a region (A, B, C), in which is located a source gas, until substantially only one or several source ionic species are present, which do not react with the source gas. To a reaction region (C) located outside of the ionization region (A) and in which ions of the one or several source ionic species are present, a reactant gas, differing from the source gas, is supplied, which reacts with the ions of the one or several source ionic species, and the ions of the one or several source ionic species are substantially converted into the single ionic species forming the output ion current.

Abstract translation: 在获得基本上仅由单一离子物质组成的输出离子电流的方法中，允许在离子化区域（A）中的源气体的离子化和/或从电离区域（A）提取的离子中形成的离子发生反应 在其中位于源气体的区域（A，B，C）中，直到基本上仅存在一种或多种源离子物质，其不与源气体反应。 向位于电离区域（A）外侧并且存在一个或多个源离子种类的离子的反应区域（C）提供与源气体不同的反应气体，其与离子源 一个或多个源离子种类和一个或多个源离子种类的离子基本上转化成形成输出离子电流的单一离子种类。

公开(公告)号：US06982416B2

公开(公告)日：2006-01-03

申请号：US10433370

申请日：2001-12-14

Applicant: Johannes Villinger ,  Werner Federer

Inventor： Johannes Villinger ,  Werner Federer

IPC: B01D59/44 ,  H01J49/00

CPC classification number: H01J49/145

Abstract: The invention relates to a method for assessing the state of organisms and natural products wherein one or more substances are determined in a gaseous mixture, determination being effected by a mass spectrometer wherein an ion beam acts on the sample of gaseous mixture in high vacuum in such a way that the test molecules are ionized with the aid of the internal energy of the ions of the ion beam, and the values obtained upon determination are evaluated for assessing the state.Further, the invention relates to a method for analyzing a gaseous mixture with one or more main components and one or more secondary components wherein at least one main component is determined in the concentration range greater than or equal to 0.1 percent by volume and one secondary component in the concentration range of less than or equal to 0.1 percent by volume by a mass spectrometer wherein an ion beam acts on the sample of gaseous mixture in high vacuum in such a way that the test molecules are ionized with the aid of the internal energy of the ions of the ion beam, and to an apparatus for analyzing a gaseous mixture comprising a mass spectrometer with a gas delivery system wherein a molecular beam is produced in an intermediate vacuum from the sample of gaseous mixture under analysis, a second molecular beam then being produced from said beam in high vacuum by means of a pressure gradient in a capillary and the test molecules of the second molecular beam ionized, the pressure of the intermediate vacuum being kept constant.

Abstract translation: 本发明涉及一种用于评估生物体和天然产物的状态的方法，其中一种或多种物质在气体混合物中测定，通过质谱仪进行测定，其中离子束在高真空中作用在气体混合物样品中 借助于离子束离子的内部能量离子化测试分子的方法，并评估测定得到的值以评估状态。 此外，本发明涉及一种用一种或多种主要组分和一种或多种次要组分分析气态混合物的方法，其中至少一种主要组分在大于或等于0.1体积％的浓度范围内测定，一种次要组分 在质谱仪的浓度范围小于或等于0.1体积％，其中离子束在高真空中作用在气体混合物的样品上，使得测试分子借助于内部能量 离子束的离子，以及用于分析气体混合物的装置，其中包括具有气体输送系统的质谱仪，其中分子束在分析中的气体混合物样品的中间真空中产生，然后第二分子束 通过毛细管中的压力梯度在高真空中由所述光束产生，并且第二分子束的测试分子被电离，压力 的中间真空保持恒定。

公开(公告)号：US06770877B2

公开(公告)日：2004-08-03

申请号：US10457426

申请日：2003-06-10

Applicant: Toshihiko Ohta ,  Kenji Kusumoto ,  Yasuaki Takada ,  Hisashi Nagano

Inventor： Toshihiko Ohta ,  Kenji Kusumoto ,  Yasuaki Takada ,  Hisashi Nagano

IPC: H01J4910

CPC classification number: H01J49/145

Abstract: A method and apparatus for analyzing vapors generated from explosives in which vapors containing nitrogen monoxide and/or nitrogen dioxide are generated by decomposing explosives by increasing the temperature of the explosives, primary ions and neutral molecules are generated from air. The generated primary ions and the nitrogen monoxide and/or nitrogen dioxide contained in the generated vapors are allowed to react with each other in an area inhibited or prevented from being penetrated by the generated neutral molecules, and the nitrogen monoxide and/or nitrogen dioxide contained in the generated vapors is ionized. The ionized nitrogen monoxide and/or nitrogen dioxide is subjected to mass spectrometry, and an amount of the nitrogen monoxide and/or nitrogen dioxide contained in the generated vapors by decomposing the explosives is determined.

Abstract translation: 用于分析由爆炸物产生的蒸汽的方法和装置，其中通过从空气中产生爆炸物，初级离子和中性分子的温度来分解包含一氧化氮和/或二氧化氮的蒸气而产生的蒸气。 产生的初级离子和产生的蒸气中含有的一氧化氮和/或二氧化氮在被产生的中性分子渗透的区域中彼此反应，并且含有一氧化氮和/或二氧化氮 在产生的蒸气中电离。 对离子化的一氧化氮和/或二氧化氮进行质谱分析，并确定通过分解爆炸物而产生的蒸汽中所含的一氧化氮和/或二氧化氮的量。

公开(公告)号：US20040007673A1

公开(公告)日：2004-01-15

申请号：US10448182

申请日：2003-05-29

Inventor： Joshua J. Coon ,  Willard W. Harrison

IPC: H01J027/00

CPC classification number: H01J49/145 ,  H01J49/0463

Abstract: The subject invention pertains to a methods and devices for ionizing a sample material. The subject invention also relates to an ionization source and to a method of sampling gas-phase ions from a sample. An ionization source in accordance with the subject invention can be used in conjunction with mass spectrometry or other sampling techniques. The subject invention can utilize a means for desorbing gas-phase ions and neutral molecules from a sample and a means to generate reagent ions where the reagent ions ionize the desorbed neutral molecules so as to increase the population of gas-phase ions. The subject invention can incorporate laser radiation for desorbing gas-phase ions and neutral molecules from a sample. In a specific embodiment, the subject invention provides an ionization source that uses a pulsed laser for desorption, so as to produce a population of desorbed neutral molecules from a sample, as well as a number of gas-phase sample ions. In a further specific embodiment, the pulsed laser radiation can be adjusted such that neutral molecules are desorbed without the production of gas-phase sample ions by the laser radiation.

Abstract translation: 本发明涉及用于电离样品材料的方法和装置。 本发明还涉及电离源和从样品中取样气相离子的方法。 根据本发明的电离源可以与质谱法或其他取样技术结合使用。 本发明可以利用从样品中解吸气相离子和中性分子的手段以及产生试剂离子的手段，其中试剂离子将解吸的中性分子离子化，从而增加气相离子的数量。 本发明可以包括用于从样品解吸气相离子和中性分子的激光辐射。 在具体实施方案中，本发明提供了使用脉冲激光解吸的电离源，以便从样品中产生解吸的中性分子群，以及多个气相样品离子。 在另一个具体实施例中，可以调节脉冲激光辐射，使得中性分子被解吸，而不会通过激光辐射产生气相样品离子。

公开(公告)号：US06653626B2

公开(公告)日：2003-11-25

申请号：US10155364

申请日：2002-05-23

Applicant: Steven M. Fischer ,  Darrell L. Gourley ,  Patricia H. Cormia ,  James L. Bertsch

Inventor： Steven M. Fischer ,  Darrell L. Gourley ,  Patricia H. Cormia ,  James L. Bertsch

IPC: H01J4926

CPC classification number: G01N30/7253 ,  H01J27/24 ,  H01J49/0431 ,  H01J49/145 ,  H01J49/162

Abstract: An atmospheric pressure ion source, e.g. for a mass spectrometer, that produces ions by atmospheric pressure photoionization (APPI). It includes a vaporizer, a photon source for photoionizing vapor molecules upon exit from the vaporizer, a passageway for transporting ions to, for example, a mass spectrometer system, and a means for directing the ions into the passageway. The center axis of the vaporizer and the center axis of the passageway form an angle that may be about 90 degrees. Included in the invention is a method for creating ions by atmospheric pressure photoionization along an axis and directing them into a passageway oriented at an angle to that axis.

公开(公告)号：US20030111600A1

公开(公告)日：2003-06-19

申请号：US10316933

申请日：2002-12-12

Applicant: MDS Inc., doing business as MDS Sciex

Inventor： Bruce A. Thomson ,  Charles L. Jolliffe

IPC: H01J049/10

CPC classification number: H01J49/0463 ,  H01J49/145

Abstract: This invention comprises an apparatus and method for generating sample ions from sample molecules in which a mixture of a sample and a matrix are vaporized by a laser beam and subsequently ionized by reagent corona ions. The decoupling of the vaporization and ionization steps allows each process to be separately optimized. The vaporization and ionization steps can be done in a sub-atmospheric pressure region. Alternatively, the vaporization and ionization steps can be done in a higher pressure region. In addition, the reagent corona ions can be generated in a vacuum chamber or a chamber at atmospheric pressure. Alternatively, the reagent ions can be generated in a sub-atmospheric region while the laser desorption occurs in an atmospheric region.

Abstract translation: 本发明包括用于从样品分子产生样品离子的装置和方法，其中样品和基质的混合物被激光束蒸发并随后被试剂电晕离子电离。 蒸发和离子化步骤的去耦允许每个过程分别优化。 蒸发和电离步骤可以在低于大气压的区域进行。 或者，蒸发和电离步骤可以在更高的压力区域中进行。 此外，试剂电晕离子可以在真空室或大气压下的室中产生。 或者，试剂离子可以在亚大气压区域中产生，而激光解吸发生在大气区域。