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公开(公告)号:US20230338968A1
公开(公告)日:2023-10-26
申请号:US18144447
申请日:2023-05-08
Applicant: Applied Cells Inc.
Inventor: Yuchen Zhou
CPC classification number: B03C1/288 , H01F7/0205 , B03C1/01 , B03C1/0332 , B01L3/502761 , B03C2201/26 , B03C2201/18 , B01L2200/0652 , B01L2300/123 , B01L2400/0439
Abstract: A process for magnetically sorting biological objects includes the steps of applying a magnetic field generated by a magnetic assembly to a flexible conduit; flowing a sample fluid containing magnetically labeled biological objects through the flexible conduit to collect the magnetically labeled biological objects on a conduit wall; removing the magnetic field from the flexible conduit; and mechanically deforming the flexible conduit to loosen the magnetically labeled biological objects collected on the conduit wall.
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42.
公开(公告)号:US20230333020A1
公开(公告)日:2023-10-19
申请号:US17927352
申请日:2021-05-28
Applicant: Oxford Nanoimaging Limited
Inventor: Bo Jing , Liyana Valiya Peedikakkal , Matthias Steiner
CPC classification number: G01N21/6486 , B01L3/502761 , G01N21/6458 , G01N21/6428 , B01L2200/0652 , G01N2021/6419 , B01L2300/0681 , G01N2021/6421 , G01N2021/6439 , B01L2300/021 , B01L2300/0867 , B01L2400/0622 , G01N2021/6467 , G01N2021/6484
Abstract: A detection system suitable for detecting pathogens present in a sample is presented. The detection system includes: a microfluidic channel configured to receive a sample solution containing a target biochemical component and configured to support a flow of the sample solution; an imaging lens; an excitation light source configured to emit an excitation light into a focal volume of the imaging lens; and a detector. The microfluidic channel comprises an observation section where the flow is aligned with respect to a central axis of the imaging lens such that the focal volume is within the observation section and the target biochemical component moves through a focal plane of the imaging lens during a movement along the observation section. The detector is configured to detect a light signal emitted by the target biochemical component on excitation with the excitation light.
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43.
公开(公告)号:US20230323488A1
公开(公告)日:2023-10-12
申请号:US18298540
申请日:2023-04-11
Inventor: Govind RAO , Xudong GE , Douglas D. FREY , Sai Sathish RAMAMURTHY , Dipanjan PAN
IPC: C12Q1/70 , C12Q1/6844 , G01N33/569 , G01N1/40 , B01L3/00 , G01N33/543
CPC classification number: C12Q1/701 , C12Q1/6844 , G01N33/56983 , G01N1/40 , B01L3/502761 , G01N33/54386 , G01N2333/165 , B01L2200/0652 , B01L2200/16
Abstract: The present invention relates to the use of a condensate collector such as portable or stationary dehumidifier placed in a defined testing space or area and used as a readily available and affordable tool to collect airborne virus particles in collected condensate from the testing atmosphere in the defined testing space or area, wherein the collected condensate is analyzed for virus biomarkers to identify viruses, such as SARS-CoV-2 or mutants or variants thereof, in the testing atmosphere.
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公开(公告)号:US11781954B2
公开(公告)日:2023-10-10
申请号:US16933035
申请日:2020-07-20
Applicant: International Business Machines Corporation
Inventor: Robert Dean Lovchik , Marie Salva , Yuksel Temiz , Emmanuel Delamarche
CPC classification number: G01N1/4077 , B01D29/03 , B01D39/1623 , B01D39/18 , B01L3/502761 , G01N1/10 , B01D2201/202 , B01L2200/0631 , B01L2200/0652 , B01L2300/0681 , B01L2400/0406 , G01N2001/4088
Abstract: According to a first aspect, the present invention is embodied as a method of processing a filtered liquid with a microfluidic device. The method includes positioning a porous filtering medium with respect to the microfluidic device, so as to allow a flow path between the filtering medium and a channel of the microfluidic device. The method further includes introducing a liquid in the porous filtering medium for the liquid to advance along the filtering medium and be filtered by the medium. The method further includes applying compression to the filtering medium to extract a given volume of the filtered liquid from the filtering medium, where the extracted liquid volume reaches said channel via the flow path. The method further includes processing the extracted volume with the microfluidic device.
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45.
公开(公告)号:US20230314371A1
公开(公告)日:2023-10-05
申请号:US18173248
申请日:2023-02-23
Applicant: University of Notre Dame du Lac
Inventor: Satyajyoti Senapati , Hsueh-Chia Chang , Himani Sharma , David Go
IPC: G01N27/447 , B01L3/00 , G01N33/543
CPC classification number: G01N27/44795 , G01N27/44791 , G01N27/44782 , B01L3/502761 , G01N33/54386 , B01L2200/0652 , B01L2300/0864 , B01L2400/0406 , B01L2300/0645
Abstract: Described herein is a bias-free high-throughput and high-yield continuous isoelectric fractionation (CIF) nanocarrier fractionation technique based on distinct isoelectric points. The nanocarrier fractionation platform is enabled by a robust and tunable linear pH profile provided by water-splitting at a bipolar membrane and stabilized by flow without ampholytes.
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公开(公告)号:US11768137B2
公开(公告)日:2023-09-26
申请号:US16571785
申请日:2019-09-16
Applicant: VENTANA MEDICAL SYSTEMS, INC.
Inventor: Nelson Alexander , Aoune Barhoumi , Lisa Gallegos , Stacey Stanislaw
IPC: G01N1/40 , B01L3/00 , C12Q1/6886 , G01N1/28 , G01N33/574
CPC classification number: G01N1/4077 , B01L3/502753 , B01L3/502761 , C12Q1/6886 , G01N1/286 , G01N33/57496 , B01L2200/0652 , B01L2300/0681 , B01L2400/0403 , B01L2400/086 , G01N2001/2866 , G01N2001/4088
Abstract: The present disclosure provides a method of separating cellular particles from a tissue sample and then sorting the cellular particles into two or more cellular particle populations.
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公开(公告)号:US20230296603A1
公开(公告)日:2023-09-21
申请号:US18006560
申请日:2021-07-23
Applicant: Minh Van PHAN , Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
Inventor: MINH VAN PHAN , LUAN D. VU , STEPHANIA A. CORMIER , MANAS GARTIA , ANH THI QUYNH PHAN
IPC: G01N33/569 , G01N33/543 , G01N21/77
CPC classification number: G01N33/56983 , G01N33/54373 , G01N21/7703 , G01N2333/165 , G01N2469/10 , B01L2300/0654 , B01L2200/0652 , G01N2021/7716 , G01N2021/757
Abstract: The present disclosure presents nanostructure-based localized surface plasmon resonance systems and related methods. In this regard, a method comprises applying a body fluid sample to a metal surface of the nanostructure-based LSPR biosensor with linker, intermediate, and capture/probe antibodies; illuminating the metal surface of the nanostructure-based LSPR biosensor with the monochromatic, broadband, or laser light; measuring an intensity or spectrum of absorbed, reflected, transmitted, or scattered exiting light from the nanostructure-based LSPR biosensor having the body fluid sample and comparing the measured intensity or spectrum with a reference intensity; detecting a spectral shift of exiting light from the nanostructure-based LSPR biosensor having the body fluid sample; and signaling that the body fluid sample is positive for a presence of a particular biomaterial in response to detecting the spectral shift of the exiting light, wherein the biomaterial has binded or adsorbed to the metal surface of the nanostructure-based LSPR biosensor.
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公开(公告)号:US20230288301A1
公开(公告)日:2023-09-14
申请号:US17802925
申请日:2020-03-09
Applicant: Hitachi High-Tech Corporation
Inventor: Masataka SHIRAI , Tomoyuki SAKAI
CPC classification number: G01N1/34 , B01L3/502761 , B01L2200/0652 , B01L2200/0642 , B01L2300/0654 , B01L2400/022
Abstract: A microparticle filling method of the present disclosure is a method of filling at least one or more containers with microparticles, including: sucking a suspension of the microparticles into a nozzle; concentrating the microparticles in the suspension to form a high-concentration suspension having a predetermined microparticle concentration at a tip of the nozzle; bringing the high-concentration suspension in contact with an inner wall of the container; and separating the nozzle from the container after the contact to fill the container with the high-concentration suspension.
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公开(公告)号:US20230285972A1
公开(公告)日:2023-09-14
申请号:US18014010
申请日:2021-06-22
Inventor: Kyusang LEE , Hee Chul Park , Ju Young CHOI , Yoon Kyoung CHO
CPC classification number: B01L3/502761 , B01D61/147 , B01D61/20 , B01D63/087 , B01D71/50 , B01L2200/0652 , B01L2300/0654 , B01L2300/0681 , B01L2300/168
Abstract: A particle filtration device according to an embodiment of the present invention as a particle filtration device of a lab-on-disk of a rotation type includes: a filtration film that separates particles by filtering a sample; a main chamber connected to the inlet surface of the filtration film and supplying the sample to the inlet surface of the filtration film; an outlet chamber that is connected to the outlet surface of the filtration film and accommodates the filtration fluid from which particles are separated while passing through the filtration film; and a waste fluid chamber connected to the outlet chamber and storing the filtration fluid, wherein the particle filtration device includes a first flow path that connects between the outlet chamber and the waste fluid chamber, and a second flow path that connects between the outlet chamber and the waste fluid chamber but is positioned farther from the center of the lab-on-disk than the first flow path.
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50.
公开(公告)号:US20230280339A1
公开(公告)日:2023-09-07
申请号:US18176056
申请日:2023-02-28
Inventor: Zhenpeng Qin , Dennis I. Robbins , Nadine va Zyl , Haihang Ye , Peiyuan Kang
IPC: G01N33/543 , B01L3/00 , G01N33/569
CPC classification number: G01N33/54373 , G01N33/54346 , B01L3/502761 , G01N33/56983 , B01L2200/16 , B01L2300/0636 , B01L2200/0652
Abstract: A biochemical assay device including a detection channel, a light source and a hydrophone. The detection channel fluidly coupleable to a specimen source to receive an analyte sample that can include a biological target bound to a bioreceptor gold nanoparticle conjugate. The light source situated to send a light to the detection channel, where the light includes one or more wavelengths absorbable by the bioreceptor gold nanoparticle conjugate bound to the biological target to thereby generate a photoacoustic signal indicative of an individual acoustic detection event from the bioreceptor gold nanoparticle conjugates to the biological target in the analyte sample. The hydrophone to detect and convert a summation of the photoacoustic digital signals into an electrical signal.
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