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公开(公告)号:US20240210288A1
公开(公告)日:2024-06-27
申请号:US18599067
申请日:2024-03-07
Applicant: Ventana Medical Systems, Inc.
Inventor: Nelson Alexander , Aoune Barhoumi , Melinda Day , Lisa Gallegos , Katherine Leith , Samantha Rajkovich , Esteban Roberts , Stacey Stanislaw , Eric Walk
IPC: G01N1/28 , A01N1/02 , G01N1/30 , G01N1/36 , G01N33/483
CPC classification number: G01N1/286 , A01N1/0226 , A01N1/0278 , G01N1/30 , G01N1/36 , G01N33/4833 , G01N2001/2866 , G01N2001/368
Abstract: The disclosure generally relates to the preparation of representative samples from clinical samples, e.g., tumors (whole or in part), lymph nodes, metastases, cysts, polyps, or a combination or portion thereof, using mechanical and/or biochemical dissociation methods to homogenize intact samples or large portions thereof. The resulting homogenate provides the ability to obtain a correct representative sample despite spatial heterogeneity within the sample, increasing detection likelihood of low prevalence subclones, and is suitable for use in various diagnostic assays as well as the production of therapeutics, especially “personalized” anti-tumor vaccines or immune cell based therapies.
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公开(公告)号:US11959838B2
公开(公告)日:2024-04-16
申请号:US15965786
申请日:2018-04-27
Applicant: Ventana Medical Systems, Inc.
Inventor: Nelson Alexander , Aoune Barhoumi , Melinda Day , Lisa Gallegos , Katherine Leith , Samantha Rajkovich , Esteban Roberts , Stacey Stanislaw , Eric Walk
IPC: G01N1/28 , A01N1/02 , G01N1/30 , G01N1/36 , G01N33/483
CPC classification number: G01N1/286 , A01N1/0226 , A01N1/0278 , G01N1/30 , G01N1/36 , G01N33/4833 , G01N2001/2866 , G01N2001/368
Abstract: The disclosure generally relates to the preparation of representative samples from clinical samples, e.g., tumors (whole or in part), lymph nodes, metastases, cysts, polyps, or a combination or portion thereof, using mechanical and/or biochemical dissociation methods to homogenize intact samples or large portions thereof. The resulting homogenate provides the ability to obtain a correct representative sample despite spatial heterogeneity within the sample, increasing detection likelihood of low prevalence subclones, and is suitable for use in various diagnostic assays as well as the production of therapeutics, especially “personalized” anti-tumor vaccines or immune cell based therapies.
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公开(公告)号:US11768137B2
公开(公告)日:2023-09-26
申请号:US16571785
申请日:2019-09-16
Applicant: VENTANA MEDICAL SYSTEMS, INC.
Inventor: Nelson Alexander , Aoune Barhoumi , Lisa Gallegos , Stacey Stanislaw
IPC: G01N1/40 , B01L3/00 , C12Q1/6886 , G01N1/28 , G01N33/574
CPC classification number: G01N1/4077 , B01L3/502753 , B01L3/502761 , C12Q1/6886 , G01N1/286 , G01N33/57496 , B01L2200/0652 , B01L2300/0681 , B01L2400/0403 , B01L2400/086 , G01N2001/2866 , G01N2001/4088
Abstract: The present disclosure provides a method of separating cellular particles from a tissue sample and then sorting the cellular particles into two or more cellular particle populations.
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公开(公告)号:US20200049599A1
公开(公告)日:2020-02-13
申请号:US15965786
申请日:2018-04-27
Applicant: Ventana Medical Systems, Inc.
Inventor: Nelson Alexander , Aoune Barhoumi , Melinda Day , Lisa Gallegos , Katherine Leith , Samantha Rajkovich , Esteban Roberts , Stacey Stanislaw , Eric Walk
IPC: G01N1/28 , A01N1/02 , G01N33/483 , G01N1/30 , G01N1/36
Abstract: The disclosure generally relates to the preparation of representative samples from clinical samples, e.g., tumors (whole or in part), lymph nodes, metastases, cysts, polyps, or a combination or portion thereof, using mechanical and/or biochemical dissociation methods to homogenize intact samples or large portions thereof. The resulting homogenate provides the ability to obtain a correct representative sample despite spatial heterogeneity within the sample, increasing detection likelihood of low prevalence subclones, and is suitable for use in various diagnostic assays as well as the production of therapeutics, especially “personalized” anti-tumor vaccines or immune cell based therapies.
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公开(公告)号:US20240077391A1
公开(公告)日:2024-03-07
申请号:US18448360
申请日:2023-08-11
Applicant: Ventana Medical Systems, Inc.
Inventor: Nelson Alexander , Aoune Barhoumi , Lisa Gallegos , Stacey Stanislaw
IPC: G01N1/40 , B01L3/00 , C12Q1/6886 , G01N1/28 , G01N33/574
CPC classification number: G01N1/4077 , B01L3/502753 , B01L3/502761 , C12Q1/6886 , G01N1/286 , G01N33/57496 , B01L2200/0652 , B01L2300/0681 , B01L2400/0403 , B01L2400/086 , G01N2001/2866 , G01N2001/4088
Abstract: The present disclosure provides a method of separating cellular particles from a tissue sample and then sorting the cellular particles into two or more cellular particle populations.
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公开(公告)号:US20200011775A1
公开(公告)日:2020-01-09
申请号:US16571785
申请日:2019-09-16
Applicant: VENTANA MEDICAL SYSTEMS, INC.
Inventor: Nelson Alexander , Aoune Barhoumi , Lisa Gallegos , Stacey Stanislaw
IPC: G01N1/40 , G01N1/28 , G01N33/574 , B01L3/00 , C12Q1/6886
Abstract: The present disclosure provides a method of separating cellular particles from a tissue sample and then sorting the cellular particles into two or more cellular particle populations.