公开(公告)号：US20140011981A1

公开(公告)日：2014-01-09

申请号：US13934570

申请日：2013-07-03

Applicant: Genentech, Inc.

Inventor： Devin Tesar ,  Xiaocheng Chen ,  Mark Dennis ,  Isidro Hotzel

IPC: C12N15/10 ,  C07K16/00 ,  C12P21/02 ,  C12N15/70 ,  C12N15/85

CPC classification number: C12N15/1037 ,  C07K16/00 ,  C07K2319/02 ,  C07K2319/40 ,  C07K2319/735 ,  C12N15/70 ,  C12N15/74 ,  C12N15/85 ,  C12N2820/10 ,  C12N2820/55 ,  C12N2820/85 ,  C12N2830/42 ,  C12N2830/55 ,  C12N2830/85 ,  C12P21/02

Abstract: The invention provides an expression and secretion system, and methods of using the same, for the expression and secretion of one fusion protein in prokaryotic cells and a second fusion protein in eukaryotic cells. Also provided herein are nucleic acid molecules, vectors and host cells comprising such vectors and nucleic acid molecules.

Abstract translation: 本发明提供了表达和分泌系统及其使用方法，用于在真核细胞中的原核细胞和第二融合蛋白中表达和分泌一种融合蛋白。 本文还提供了包含这种载体和核酸分子的核酸分子，载体和宿主细胞。

公开(公告)号：US11939396B2

公开(公告)日：2024-03-26

申请号：US16916822

申请日：2020-06-30

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Janet Jackman ,  James T. Koerber ,  Mason Lu ,  Henry R. Maun ,  Kathila Rajapaksa ,  Saroja Ramanujan ,  Tracy Staton ,  Lawren Wu ,  Tangsheng Yi

IPC: C07K16/40 ,  A61K39/395 ,  C07K16/24 ,  A61K39/00 ,  A61K45/06 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26

CPC classification number: C07K16/40 ,  A61K39/3955 ,  A61K39/39591 ,  C07K16/244 ,  C12Y304/21059 ,  A61K2039/505 ,  A61K45/06 ,  A61K47/10 ,  A61K47/183 ,  A61K47/22 ,  A61K47/26 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.

公开(公告)号：US10941215B2

公开(公告)日：2021-03-09

申请号：US16131591

申请日：2018-09-14

Applicant: Genentech, Inc.

Inventor： Mark Dennis ,  Ryan Jefferson Watts ,  Yunhua Yu Zuchero ,  Yin Zhang

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/18 ,  C07K16/40 ,  A61K47/68 ,  A61K39/00

Abstract: The present invention relates to antibodies that bind blood brain barrier receptors (BBB-R) and methods of using the same.

公开(公告)号：US10738131B2

公开(公告)日：2020-08-11

申请号：US15893238

申请日：2018-02-09

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Janet Jackman ,  James T. Koerber ,  Mason Lu ,  Henry R. Maun ,  Kathila Rajapaksa ,  Saroja Ramanujan ,  Tracy Staton ,  Lawren Wu ,  Tangsheng Yi

IPC: C07K16/40 ,  A61K39/395 ,  A61K47/18 ,  A61K47/22 ,  A61K47/26 ,  A61K47/10 ,  A61K45/06 ,  C07K16/24 ,  A61K39/00

Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.

公开(公告)号：US20200048354A1

公开(公告)日：2020-02-13

申请号：US16358874

申请日：2019-03-20

Applicant: Genentech, Inc.

Inventor： Sherman Fong ,  Mark Dennis

IPC: C07K16/28 ,  C07K16/18

Abstract: The invention provides therapeutic anti-beta7 antibodies, compositions comprising, and methods of using these antibodies.

公开(公告)号：US10179820B2

公开(公告)日：2019-01-15

申请号：US15296454

申请日：2016-10-18

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Jagath Reddy Junutula ,  Gail Lewis Phillips ,  Thomas Harden Pillow ,  Mark X. Sliwkowski

IPC: C07K16/32 ,  A61K39/395 ,  C07K16/28 ,  G01N33/574 ,  A61K31/5517 ,  A61K31/675 ,  A61K31/704 ,  A61K49/00 ,  C07K16/30 ,  A61K47/68

Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20180251567A1

公开(公告)日：2018-09-06

申请号：US15983361

申请日：2018-05-18

Applicant: Genentech, Inc.

Inventor： Mark Dennis ,  Bonnee Rubinfeld ,  Paul Polakis

IPC: C07K16/30 ,  G01N33/574 ,  A61K47/68 ,  A61K31/537 ,  A61K45/06 ,  C07K16/18 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/30 ,  A61K31/537 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6817 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6857 ,  A61K47/6869 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/28 ,  C07K16/3023 ,  C07K16/3069 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57423 ,  G01N33/57449 ,  G01N33/57492

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20180201679A1

公开(公告)日：2018-07-19

申请号：US15803495

申请日：2017-11-03

Applicant: GENENTECH, INC.

Inventor： Yvonne Chen ,  Mark Dennis ,  Kristi Elkins ,  Jagath Reddy Junutula ,  Andrew Polson ,  Bing Zheng

IPC: C07K16/28 ,  A61K39/395 ,  A61K51/10 ,  A61K47/68 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K39/39541 ,  A61K39/39558 ,  A61K47/6849 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/2896 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/92 ,  Y02A50/412

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US09994643B2

公开(公告)日：2018-06-12

申请号：US15341261

申请日：2016-11-02

Applicant: Genentech, Inc.

Inventor： Mark Dennis ,  Bonnee Rubinfeld ,  Paul Polakis

IPC: C07K16/30 ,  A61K47/48 ,  C07K16/28 ,  G01N33/574 ,  A61K45/06 ,  C07K16/18 ,  A61K31/537 ,  A61K39/00

CPC classification number: C07K16/30 ,  A61K31/537 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6813 ,  A61K47/6817 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6857 ,  A61K47/6869 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/28 ,  C07K16/3023 ,  C07K16/3069 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/57423 ,  G01N33/57449 ,  G01N33/57492

Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20180094056A1

公开(公告)日：2018-04-05

申请号：US15842590

申请日：2017-12-14

Applicant: Genentech, Inc.

Inventor： Mary Mathieu ,  Mark Dennis

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/32 ,  A61P35/00

CPC classification number: C07K16/2809 ,  A61K39/39558 ,  A61P35/00 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention provides anti-HER2 antibodies, including anti-HER2 antibodies of improved stability or affinity, and methods of using the same.