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公开(公告)号：US20170145112A1
公开(公告)日：2017-05-25
申请号：US15335847
申请日：2016-10-27
Applicant: GENENTECH, INC.
Inventor： Robert F. Kelley , Whitney Shatz , Devin Tesar , Justin M. Scheer , Michelle Dion
IPC: C07K16/40 , C07K16/22 , C07K16/28 , A61K39/395
CPC classification number: C07K16/40 , A61K39/3955 , A61K39/39591 , A61K47/60 , A61K2039/505 , A61K2039/54 , C07K16/18 , C07K16/22 , C07K16/2863 , C07K2317/24 , C07K2317/34 , C07K2317/35 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
Abstract: The invention provides anti-Factor D antibodies and conjugates and methods of using the same.
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公开(公告)号：US10407510B2
公开(公告)日：2019-09-10
申请号：US15335847
申请日：2016-10-27
Applicant: GENENTECH, INC.
Inventor： Robert F. Kelley , Whitney Shatz , Devin Tesar , Justin M. Scheer , Michelle Dion
Abstract: The invention provides anti-Factor D antibodies and conjugates and methods of using the same.
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公开(公告)号：US10654932B2
公开(公告)日：2020-05-19
申请号：US15336522
申请日：2016-10-27
Applicant: Genentech, Inc.
Inventor： Philip E. Hass , Robert F. Kelley , Justin M. Scheer , Whitney Shatz , Devin Tesar , Menno van Lookeren Campagne
Abstract: The disclosure relates to antibody-polymer conjugates comprising one or more anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.
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公开(公告)号：US10961313B2
公开(公告)日：2021-03-30
申请号：US16730018
申请日：2019-12-30
Applicant: Genentech, Inc.
Inventor： Philip E. Hass , Robert F. Kelley , Justin M. Scheer , Whitney Shatz , Devin Tesar , Menno van Lookeren Campagne
Abstract: The disclosure relates to antibody-polymer conjugates comprising one or more anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.
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Patent Agency Ranking
公开(公告)号：US20160017052A1
公开(公告)日：2016-01-21
申请号：US14700853
申请日：2015-04-30
Applicant: GENENTECH, INC.
Inventor： Robert F. Kelley , Menno van Lookeren Campagne , Justin M. Scheer , Philip E. Hass , Devin Tesar
IPC: C07K16/40 , A61K9/00 , A61K39/395
CPC classification number: C07K16/40 , A61K9/0048 , A61K2039/505 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The invention relates to anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.
Abstract translation: 本发明涉及抗因子D抗体变体，其生产及其在制备用于治疗与过量或不受控补体活化相关的疾病和病症的组合物和药物中的用途。
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公开(公告)号：US10179821B2
公开(公告)日：2019-01-15
申请号：US14700853
申请日：2015-04-30
Applicant: Genentech, Inc.
Inventor： Robert F Kelley , Menno van Lookeren Campagne , Justin M Scheer , Philip E Hass , Devin Tesar
IPC: A61K39/395 , C07K16/40 , A61K9/00 , A61K39/00
Abstract: The invention relates to anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.
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公开(公告)号：US09803191B2
公开(公告)日：2017-10-31
申请号：US13934570
申请日：2013-07-03
Applicant: Genentech, Inc.
Inventor： Devin Tesar , Xiaocheng Chen , Mark Dennis , Isidro Hotzel
CPC classification number: C12N15/1037 , C07K16/00 , C07K2319/02 , C07K2319/40 , C07K2319/735 , C12N15/70 , C12N15/74 , C12N15/85 , C12N2820/10 , C12N2820/55 , C12N2820/85 , C12N2830/42 , C12N2830/55 , C12N2830/85 , C12P21/02
Abstract: The invention provides an expression and secretion system, and methods of using the same, for the expression and secretion of one fusion protein in prokaryotic cells and a second fusion protein in eukaryotic cells. Also provided herein are nucleic acid molecules, vectors and host cells comprising such vectors and nucleic acid molecules.
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公开(公告)号：US20170143843A1
公开(公告)日：2017-05-25
申请号：US15336522
申请日：2016-10-27
Applicant: Genentech, Inc.
Inventor： Philip E. Hass , Robert F. Kelley , Justin M. Scheer , Whitney Shatz , Devin Tesar , Menno van Lookeren Campagne
CPC classification number: C07K16/2863 , A61K9/0048 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K16/18 , C07K16/22 , C07K2317/55 , C07K2317/92 , C07K2317/94
Abstract: The disclosure relates to antibody-polymer conjugates comprising one or more anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.
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公开(公告)号：US20140011981A1
公开(公告)日：2014-01-09
申请号：US13934570
申请日：2013-07-03
Applicant: Genentech, Inc.
Inventor： Devin Tesar , Xiaocheng Chen , Mark Dennis , Isidro Hotzel
CPC classification number: C12N15/1037 , C07K16/00 , C07K2319/02 , C07K2319/40 , C07K2319/735 , C12N15/70 , C12N15/74 , C12N15/85 , C12N2820/10 , C12N2820/55 , C12N2820/85 , C12N2830/42 , C12N2830/55 , C12N2830/85 , C12P21/02
Abstract: The invention provides an expression and secretion system, and methods of using the same, for the expression and secretion of one fusion protein in prokaryotic cells and a second fusion protein in eukaryotic cells. Also provided herein are nucleic acid molecules, vectors and host cells comprising such vectors and nucleic acid molecules.
Abstract translation: 本发明提供了表达和分泌系统及其使用方法，用于在真核细胞中的原核细胞和第二融合蛋白中表达和分泌一种融合蛋白。 本文还提供了包含这种载体和核酸分子的核酸分子，载体和宿主细胞。
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