公开(公告)号：US10407510B2

公开(公告)日：2019-09-10

申请号：US15335847

申请日：2016-10-27

Applicant: GENENTECH, INC.

Inventor： Robert F. Kelley ,  Whitney Shatz ,  Devin Tesar ,  Justin M. Scheer ,  Michelle Dion

IPC: C07K16/40 ,  A61K39/395 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  A61K47/60 ,  A61K39/00

Abstract: The invention provides anti-Factor D antibodies and conjugates and methods of using the same.

公开(公告)号：US10654932B2

公开(公告)日：2020-05-19

申请号：US15336522

申请日：2016-10-27

Applicant: Genentech, Inc.

Inventor： Philip E. Hass ,  Robert F. Kelley ,  Justin M. Scheer ,  Whitney Shatz ,  Devin Tesar ,  Menno van Lookeren Campagne

IPC: A61K45/06 ,  A61K9/00 ,  A61K47/60 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  A61K39/00

Abstract: The disclosure relates to antibody-polymer conjugates comprising one or more anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.

公开(公告)号：US20170143843A1

公开(公告)日：2017-05-25

申请号：US15336522

申请日：2016-10-27

Applicant: Genentech, Inc.

Inventor： Philip E. Hass ,  Robert F. Kelley ,  Justin M. Scheer ,  Whitney Shatz ,  Devin Tesar ,  Menno van Lookeren Campagne

IPC: A61K39/00 ,  A61K9/00 ,  C07K16/28 ,  A61K45/06 ,  C07K16/18 ,  C07K16/22

CPC classification number: C07K16/2863 ,  A61K9/0048 ,  A61K45/06 ,  A61K47/60 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/22 ,  C07K2317/55 ,  C07K2317/92 ,  C07K2317/94

Abstract: The disclosure relates to antibody-polymer conjugates comprising one or more anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.

公开(公告)号：US20170145112A1

公开(公告)日：2017-05-25

申请号：US15335847

申请日：2016-10-27

Applicant: GENENTECH, INC.

Inventor： Robert F. Kelley ,  Whitney Shatz ,  Devin Tesar ,  Justin M. Scheer ,  Michelle Dion

IPC: C07K16/40 ,  C07K16/22 ,  C07K16/28 ,  A61K39/395

CPC classification number: C07K16/40 ,  A61K39/3955 ,  A61K39/39591 ,  A61K47/60 ,  A61K2039/505 ,  A61K2039/54 ,  C07K16/18 ,  C07K16/22 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention provides anti-Factor D antibodies and conjugates and methods of using the same.

公开(公告)号：US20240158513A1

公开(公告)日：2024-05-16

申请号：US18413682

申请日：2024-01-16

Applicant: Genentech, Inc.

Inventor： J. Michael ELLIOTT ,  Justin M. Scheer

IPC: C07K16/28 ,  C07K16/24 ,  C07K16/46

CPC classification number: C07K16/2863 ,  C07K16/244 ,  C07K16/247 ,  C07K16/468

Abstract: Described herein are Fc variants and methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins). Heteromultimeric proteins may be capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.

公开(公告)号：US10961313B2

公开(公告)日：2021-03-30

申请号：US16730018

申请日：2019-12-30

Applicant: Genentech, Inc.

Inventor： Philip E. Hass ,  Robert F. Kelley ,  Justin M. Scheer ,  Whitney Shatz ,  Devin Tesar ,  Menno van Lookeren Campagne

IPC: A61K47/60 ,  A61K9/00 ,  A61K45/06 ,  C07K16/18 ,  C07K16/28 ,  C07K16/22 ,  A61K39/00

Abstract: The disclosure relates to antibody-polymer conjugates comprising one or more anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.

公开(公告)号：US20160017052A1

公开(公告)日：2016-01-21

申请号：US14700853

申请日：2015-04-30

Applicant: GENENTECH, INC.

Inventor： Robert F. Kelley ,  Menno van Lookeren Campagne ,  Justin M. Scheer ,  Philip E. Hass ,  Devin Tesar

IPC: C07K16/40 ,  A61K9/00 ,  A61K39/395

CPC classification number: C07K16/40 ,  A61K9/0048 ,  A61K2039/505 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention relates to anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.

Abstract translation: 本发明涉及抗因子D抗体变体，其生产及其在制备用于治疗与过量或不受控补体活化相关的疾病和病症的组合物和药物中的用途。