公开(公告)号：US10407510B2

公开(公告)日：2019-09-10

申请号：US15335847

申请日：2016-10-27

Applicant: GENENTECH, INC.

Inventor： Robert F. Kelley ,  Whitney Shatz ,  Devin Tesar ,  Justin M. Scheer ,  Michelle Dion

IPC: C07K16/40 ,  A61K39/395 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  A61K47/60 ,  A61K39/00

Abstract: The invention provides anti-Factor D antibodies and conjugates and methods of using the same.

公开(公告)号：US10961313B2

公开(公告)日：2021-03-30

申请号：US16730018

申请日：2019-12-30

Applicant: Genentech, Inc.

Inventor： Philip E. Hass ,  Robert F. Kelley ,  Justin M. Scheer ,  Whitney Shatz ,  Devin Tesar ,  Menno van Lookeren Campagne

IPC: A61K47/60 ,  A61K9/00 ,  A61K45/06 ,  C07K16/18 ,  C07K16/28 ,  C07K16/22 ,  A61K39/00

Abstract: The disclosure relates to antibody-polymer conjugates comprising one or more anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.

公开(公告)号：US12030926B2

公开(公告)日：2024-07-09

申请号：US17171962

申请日：2021-02-09

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Whitney Shatz ,  Domingos Ng

IPC: C07K16/00 ,  C07K16/46 ,  C12N15/79 ,  C12N15/90

CPC classification number: C07K16/00 ,  C07K16/468 ,  C07K2317/14 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/526 ,  C07K2317/53 ,  C12N15/79 ,  C12N15/907

Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes located on a single molecule or located on different molecules.

公开(公告)号：US20170143843A1

公开(公告)日：2017-05-25

申请号：US15336522

申请日：2016-10-27

Applicant: Genentech, Inc.

Inventor： Philip E. Hass ,  Robert F. Kelley ,  Justin M. Scheer ,  Whitney Shatz ,  Devin Tesar ,  Menno van Lookeren Campagne

IPC: A61K39/00 ,  A61K9/00 ,  C07K16/28 ,  A61K45/06 ,  C07K16/18 ,  C07K16/22

CPC classification number: C07K16/2863 ,  A61K9/0048 ,  A61K45/06 ,  A61K47/60 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/22 ,  C07K2317/55 ,  C07K2317/92 ,  C07K2317/94

Abstract: The disclosure relates to antibody-polymer conjugates comprising one or more anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.

公开(公告)号：US20180293360A1

公开(公告)日：2018-10-11

申请号：US15766319

申请日：2016-10-05

Applicant: Genentech, Inc.

Inventor： Robert Kelley ,  Justin Scheer ,  Whitney Shatz

IPC: G06F19/00 ,  G06F17/18

Abstract: Disclosed are systems and methods for estimating the vitreal half-life of a therapeutic agent. In particular, systems and methods are disclosed for predicting the vitreal half-life of a therapeutic agent conjugated to a polymer that make use of an empirically-derived relationship of vitreal half-life to the hydrodynamic radius of a candidate therapeutic agent-polymer conjugate. The present disclosure is further directed to the use of the systems and methods disclosed herein to design a candidate therapeutic agent-polymer conjugate with a preselected vitreal half-life.

公开(公告)号：US20170145112A1

公开(公告)日：2017-05-25

申请号：US15335847

申请日：2016-10-27

Applicant: GENENTECH, INC.

Inventor： Robert F. Kelley ,  Whitney Shatz ,  Devin Tesar ,  Justin M. Scheer ,  Michelle Dion

IPC: C07K16/40 ,  C07K16/22 ,  C07K16/28 ,  A61K39/395

CPC classification number: C07K16/40 ,  A61K39/3955 ,  A61K39/39591 ,  A61K47/60 ,  A61K2039/505 ,  A61K2039/54 ,  C07K16/18 ,  C07K16/22 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention provides anti-Factor D antibodies and conjugates and methods of using the same.

公开(公告)号：US10941190B2

公开(公告)日：2021-03-09

申请号：US15344123

申请日：2016-11-04

Applicant: Genentech, Inc.

Inventor： Justin Scheer ,  Whitney Shatz ,  Domingos Ng

IPC: C07K16/00 ,  C07K16/46 ,  C07K1/00 ,  C07K1/02 ,  C12P21/02 ,  C12P21/00 ,  C12N15/79 ,  C12N15/90

Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes located on a single molecule or located on different molecules.

公开(公告)号：US10654932B2

公开(公告)日：2020-05-19

申请号：US15336522

申请日：2016-10-27

Applicant: Genentech, Inc.

Inventor： Philip E. Hass ,  Robert F. Kelley ,  Justin M. Scheer ,  Whitney Shatz ,  Devin Tesar ,  Menno van Lookeren Campagne

IPC: A61K45/06 ,  A61K9/00 ,  A61K47/60 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  A61K39/00

Abstract: The disclosure relates to antibody-polymer conjugates comprising one or more anti-Factor D antibody variants, their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation.