-
公开(公告)号：US20180185486A1
公开(公告)日：2018-07-05
申请号：US15899612
申请日：2018-02-20
Applicant: Genentech, Inc.
Inventor： Peter Dragovich , Thomas Pillow , Jack Sadowsky , Mark X. Sliwkowski , BinQing Wei
IPC: A61K45/06 , C07D519/00 , A61K47/68 , C07K16/32 , C07K16/28 , A61K31/5517
CPC classification number: A61K45/06 , A61K31/5517 , A61K47/6803 , A61K47/6851 , A61K47/6855 , A61K47/6889 , C07D519/00 , C07K16/2803 , C07K16/32 , C07K2317/40 , C07K2317/522 , C07K2317/567
Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a pyrrolobenzodiazepine drug moiety via a disulfide linker, pyrrolobenzodiazepine linker-drug intermediates, and methods of using the antibody-drug conjugates.
-
公开(公告)号：US09518118B2
公开(公告)日：2016-12-13
申请号：US14851001
申请日：2015-09-11
Applicant: Genentech, Inc.
Inventor： Xiaocheng Chen , Mark Dennis , Jagath Reddy Junutula , Gail Lewis Phillips , Thomas Harden Pillow , Mark X. Sliwkowski
IPC: C07K16/28 , A61K47/48 , C07K16/32 , A61K39/395 , G01N33/574
CPC classification number: C07K16/32 , A61K31/5517 , A61K31/675 , A61K31/704 , A61K39/3955 , A61K47/68 , A61K47/6809 , A61K47/6849 , A61K47/6855 , A61K47/6863 , A61K49/00 , C07K16/2863 , C07K16/3015 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , G01N33/57415 , G01N33/57446 , G01N33/57492 , G01N2333/82
Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗HER2抗体和免疫缀合物及其使用方法。
-
公开(公告)号：US20140193414A1
公开(公告)日：2014-07-10
申请号：US14100211
申请日：2013-12-09
Applicant: Genentech, Inc.
Inventor： Germaine Fuh , Lauric Haber , Gabriele Schaefer , Mark X. Sliwkowski
CPC classification number: C07K16/28 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92
Abstract: The invention provides anti-HER antibodies, including multispecific anti-HER antibodies, compositions comprising and methods of using these antibodies. Also provided herein are EGFR/HER3 multispecific antibodies that are less toxic than traditional EGFR antagonists.
-
公开(公告)号：US20230041134A1
公开(公告)日：2023-02-09
申请号：US17720717
申请日：2022-04-14
Applicant: Genentech, Inc.
Inventor： Xiaocheng Chen , Mark Dennis , Jagath Reddy Junutula , Gail Lewis Phillips , Thomas Harden Pillow , Mark X. Sliwkowski
IPC: C07K16/32 , A61K47/68 , A61K39/395 , C07K16/28 , G01N33/574 , A61K31/5517 , A61K31/675 , A61K31/704 , A61K49/00 , C07K16/30
Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
-
公开(公告)号：US20190177429A1
公开(公告)日：2019-06-13
申请号：US16170819
申请日：2018-10-25
Applicant: Genentech, Inc.
Inventor： Xiaocheng Chen , Mark Dennis , Jagath Reddy Junutula , Gail Lewis Phillips , Thomas Harden Pillow , Mark X. Sliwkowski
IPC: C07K16/32 , G01N33/574 , A61K49/00 , A61K39/395 , A61K31/704 , A61K31/675 , A61K31/5517 , C07K16/30 , A61K47/68 , C07K16/28
Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
-
Patent Agency Ranking
公开(公告)号：US10058613B2
公开(公告)日：2018-08-28
申请号：US15281830
申请日：2016-09-30
Applicant: Genentech, Inc.
Inventor： Peter Dragovich , Thomas Pillow , Jack Sadowsky , Mark X. Sliwkowski , BinQing Wei
IPC: C07K16/00 , A61K45/06 , C07K16/28 , C07D519/00 , C07K16/32 , A61K31/5517 , A61K47/68
CPC classification number: A61K45/06 , A61K31/5517 , A61K47/6803 , A61K47/6851 , A61K47/6855 , A61K47/6889 , C07D519/00 , C07K16/2803 , C07K16/32 , C07K2317/40 , C07K2317/522 , C07K2317/567
Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a pyrrolobenzodiazepine drug moiety via a disulfide linker, pyrrolobenzodiazepine linker-drug intermediates, and methods of using the antibody-drug conjugates.
-
公开(公告)号：US09327035B2
公开(公告)日：2016-05-03
申请号：US14066258
申请日：2013-10-29
Applicant: Genentech, Inc.
Inventor： Germaine Fuh , Lauric Haber , Gabriele Schaefer , Mark X. Sliwkowski
CPC classification number: A61K47/48569 , A61K2039/505 , A61K2039/507 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92
Abstract: The invention provides anti-HER antibodies, including multispecific anti-HER antibodies, compositions comprising and methods of using these antibodies. Also provided herein are EGFR/HER3 multispecific antibodies that are less toxic than traditional EGFR antagonists.
Abstract translation: 本发明提供抗HER抗体，包括多特异性抗HER抗体，组合物和使用这些抗体的方法。 本文还提供了比传统EGFR拮抗剂毒性小的EGFR / HER3多特异性抗体。
-
公开(公告)号：US10179820B2
公开(公告)日：2019-01-15
申请号：US15296454
申请日：2016-10-18
Applicant: Genentech, Inc.
Inventor： Xiaocheng Chen , Mark Dennis , Jagath Reddy Junutula , Gail Lewis Phillips , Thomas Harden Pillow , Mark X. Sliwkowski
IPC: C07K16/32 , A61K39/395 , C07K16/28 , G01N33/574 , A61K31/5517 , A61K31/675 , A61K31/704 , A61K49/00 , C07K16/30 , A61K47/68
Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
-
公开(公告)号：US20180326062A1
公开(公告)日：2018-11-15
申请号：US16036575
申请日：2018-07-16
Applicant: Genentech, Inc.
Inventor： Peter Dragovich , Thomas Pillow , Jack Sadowsky , Mark X. Sliwkowski , BinQing Wei
IPC: A61K45/06 , A61K47/68 , A61K31/5517 , C07K16/32 , C07D519/00 , C07K16/28
CPC classification number: A61K45/06 , A61K31/5517 , A61K47/6803 , A61K47/6851 , A61K47/6855 , A61K47/6889 , C07D519/00 , C07K16/2803 , C07K16/32 , C07K2317/40 , C07K2317/522 , C07K2317/567
Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a pyrrolobenzodiazepine drug moiety via a disulfide linker, pyrrolobenzodiazepine linker-drug intermediates, and methods of using the antibody-drug conjugates.
-
公开(公告)号：US20170174782A1
公开(公告)日：2017-06-22
申请号：US15296454
申请日：2016-10-18
Applicant: Genentech, Inc.
Inventor： Xiaocheng Chen , Mark Dennis , Jagath Reddy Junutula , Gail Lewis Phillips , Thomas Harden Pillow , Mark X. Sliwkowski
IPC: C07K16/32 , C07K16/30 , A61K31/675 , A61K31/704 , A61K31/5517 , G01N33/574 , A61K49/00
CPC classification number: C07K16/32 , A61K31/5517 , A61K31/675 , A61K31/704 , A61K39/3955 , A61K47/68 , A61K47/6809 , A61K47/6849 , A61K47/6855 , A61K47/6863 , A61K49/00 , C07K16/2863 , C07K16/3015 , C07K2317/24 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , G01N33/57415 , G01N33/57446 , G01N33/57492 , G01N2333/82
Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
-
-
-
-
-
-
-
-
-
Search Results
25
records
(took 0.037 seconds)
